GREMLIN Database
YFHH - Uncharacterized HTH-type transcriptional regulator YfhH
UniProt: P37767 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12308
Length: 282 (259)
Sequences: 9103 (6424)
Seq/√Len: 399.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
133_R180_D4.7451.00
211_A224_A3.7761.00
200_D223_R3.0231.00
185_A199_A2.8461.00
128_M208_K2.8081.00
191_V219_A2.7891.00
11_Y23_D2.7231.00
137_L147_A2.6341.00
125_C210_L2.3881.00
38_Q57_K2.3671.00
133_R178_S2.3321.00
199_A209_V2.3221.00
60_Y69_A2.3171.00
125_C226_H2.2931.00
203_L225_S2.2881.00
108_A112_A2.2411.00
133_R181_D2.2091.00
10_R13_G2.1861.00
134_R160_N2.1751.00
28_Q31_T2.1511.00
150_F154_L2.1471.00
127_T262_Q2.0991.00
177_S207_G2.0801.00
241_S244_A2.0491.00
178_S181_D2.0211.00
107_T111_Y2.0121.00
126_V258_A2.0001.00
201_E204_R1.9881.00
183_L202_M1.9511.00
23_D27_L1.9171.00
24_Y28_Q1.8541.00
128_M226_H1.8501.00
134_R162_A1.8431.00
182_L210_L1.8401.00
208_K225_S1.8361.00
130_R262_Q1.8291.00
199_A220_L1.8131.00
137_L150_F1.7711.00
185_A195_L1.7591.00
186_I252_T1.7331.00
132_A182_L1.7301.00
186_I212_I1.7261.00
147_A186_I1.7211.00
9_Q13_G1.7011.00
154_L259_L1.6391.00
137_L184_L1.6341.00
22_A54_F1.6161.00
202_M207_G1.6091.00
118_S121_K1.6001.00
208_K226_H1.5911.00
187_S220_L1.5851.00
18_D57_K1.5621.00
228_L251_L1.5401.00
150_F252_T1.5311.00
40_L53_K1.5281.00
164_V173_T1.5211.00
35_L43_E1.5171.00
124_E226_H1.5161.00
183_L207_G1.5151.00
121_K124_E1.5141.00
209_V224_A1.5071.00
211_A220_L1.4921.00
103_I110_M1.4881.00
68_L71_S1.4701.00
263_D266_L1.4631.00
9_Q12_Q1.4451.00
211_A227_C1.4401.00
40_L56_Q1.4361.00
35_L39_Q1.4291.00
146_V252_T1.4251.00
55_A66_L1.4221.00
61_K65_A1.4091.00
40_L57_K1.4051.00
21_L54_F1.3971.00
127_T131_S1.3891.00
110_M250_M1.3851.00
221_Q227_C1.3831.00
151_A162_A1.3781.00
138_T183_L1.3671.00
184_L212_I1.3621.00
258_A262_Q1.3591.00
11_Y19_K1.3481.00
130_R259_L1.3271.00
185_A209_V1.3211.00
113_T231_I1.3131.00
128_M182_L1.2991.00
193_R197_L1.2771.00
134_R181_D1.2741.00
130_R263_D1.2691.00
19_K23_D1.2461.00
203_L223_R1.2301.00
148_Q165_R1.2251.00
62_G65_A1.2231.00
67_K71_S1.1941.00
197_L200_D1.1821.00
17_S20_K1.1741.00
55_A73_A1.1731.00
230_T248_Q1.1701.00
63_F67_K1.1631.00
94_P97_L1.1531.00
17_S50_S1.1531.00
129_L182_L1.1491.00
66_L70_L1.1471.00
153_K253_D1.1281.00
185_A202_M1.1151.00
65_A68_L1.1111.00
144_G148_Q1.1051.00
151_A161_A1.1031.00
37_S52_V1.1021.00
31_T43_E1.1021.00
124_E128_M1.0801.00
60_Y66_L1.0641.00
113_T230_T1.0641.00
177_S181_D1.0641.00
181_D207_G1.0611.00
93_D101_K1.0601.00
258_A261_Q1.0601.00
154_L161_A1.0571.00
69_A72_E1.0521.00
24_Y44_A1.0421.00
109_A247_A1.0271.00
129_L259_L1.0261.00
142_A241_S1.0251.00
11_Y22_A1.0151.00
31_T35_L1.0131.00
121_K226_H1.0121.00
131_S208_K1.0101.00
136_I181_D1.0091.00
111_Y115_N1.0081.00
36_S39_Q1.0071.00
150_F184_L1.0021.00
177_S183_L0.9981.00
137_L154_L0.9971.00
160_N164_V0.9951.00
136_I177_S0.9931.00
100_E104_K0.9911.00
52_V62_G0.9861.00
20_K52_V0.9831.00
21_L44_A0.9771.00
135_I182_L0.9761.00
145_L148_Q0.9731.00
100_E114_L0.9691.00
125_C128_M0.9691.00
25_L66_L0.9681.00
126_V262_Q0.9631.00
201_E205_V0.9621.00
154_L256_F0.9561.00
37_S41_A0.9481.00
200_D204_R0.9461.00
149_N153_K0.9451.00
24_Y35_L0.9421.00
171_L197_L0.9351.00
128_M131_S0.9291.00
221_Q229_Y0.9281.00
29_P33_R0.9231.00
151_A155_M0.9171.00
136_I162_A0.9071.00
120_E123_H0.9031.00
129_L184_L0.9001.00
112_A115_N0.8981.00
137_L161_A0.8911.00
14_L40_L0.8911.00
72_E75_A0.8901.00
24_Y43_E0.8821.00
15_A18_D0.8761.00
137_L151_A0.8751.00
125_C228_L0.8741.00
202_M209_V0.8721.00
24_Y31_T0.8701.00
108_A111_Y0.8661.00
64_P67_K0.8621.00
134_R178_S0.8561.00
196_N219_A0.8541.00
123_H262_Q0.8531.00
149_N245_C0.8521.00
212_I252_T0.8501.00
40_L63_F0.8491.00
146_V186_I0.8411.00
40_L51_V0.8401.00
242_I245_C0.8341.00
32_A70_L0.8311.00
132_A181_D0.8311.00
107_T110_M0.8301.00
58_L72_E0.8301.00
38_Q48_Q0.8261.00
116_V119_E0.8231.00
65_A69_A0.8221.00
129_L135_I0.8181.00
156_K174_V0.8121.00
126_V130_R0.8091.00
63_F66_L0.8081.00
129_L132_A0.8051.00
68_L72_E0.8051.00
59_G62_G0.8041.00
124_E127_T0.8031.00
60_Y63_F0.7981.00
144_G163_A0.7951.00
196_N200_D0.7951.00
151_A163_A0.7901.00
187_S190_G0.7891.00
14_L19_K0.7881.00
168_H194_E0.7871.00
136_I183_L0.7871.00
33_R36_S0.7821.00
127_T130_R0.7811.00
17_S56_Q0.7811.00
55_A62_G0.7811.00
213_T221_Q0.7801.00
14_L56_Q0.7791.00
85_I88_Q0.7781.00
125_C255_L0.7731.00
99_G119_E0.7731.00
157_I256_F0.7691.00
131_S180_D0.7691.00
216_T229_Y0.7651.00
49_S52_V0.7651.00
245_C248_Q0.7641.00
226_H229_Y0.7631.00
103_I250_M0.7581.00
50_S53_K0.7561.00
86_H89_I0.7541.00
123_H258_A0.7521.00
120_E124_E0.7521.00
33_R71_S0.7511.00
97_L100_E0.7511.00
96_R100_E0.7471.00
113_T247_A0.7461.00
182_L208_K0.7451.00
154_L255_L0.7431.00
55_A70_L0.7391.00
18_D59_G0.7381.00
20_K45_G0.7381.00
85_I90_R0.7341.00
185_A198_A0.7341.00
144_G165_R0.7331.00
133_R160_N0.7321.00
14_L57_K0.7321.00
184_L210_L0.7301.00
95_L104_K0.7251.00
135_I184_L0.7251.00
238_N241_S0.7241.00
89_I93_D0.7111.00
60_Y65_A0.7111.00
21_L50_S0.7111.00
102_L106_N0.7101.00
247_A250_M0.6971.00
256_F260_I0.6951.00
53_K57_K0.6941.00
15_A57_K0.6840.99
32_A35_L0.6820.99
155_M173_T0.6790.99
69_A73_A0.6780.99
53_K56_Q0.6770.99
25_L54_F0.6770.99
153_K256_F0.6730.99
180_D208_K0.6720.99
196_N220_L0.6710.99
148_Q151_A0.6680.99
174_V205_V0.6680.99
36_S41_A0.6670.99
159_F263_D0.6670.99
139_G143_S0.6640.99
128_M132_A0.6620.99
54_F58_L0.6620.99
39_Q42_N0.6600.99
10_R14_L0.6590.99
261_Q268_P0.6570.99
21_L46_V0.6550.99
121_K125_C0.6510.99
29_P32_A0.6500.99
21_L51_V0.6490.99
106_N250_M0.6460.99
244_A247_A0.6430.99
140_I192_R0.6430.99
15_A40_L0.6430.99
66_L73_A0.6410.99
179_P206_G0.6370.99
196_N223_R0.6350.99
199_A223_R0.6350.99
106_N246_H0.6340.99
8_R45_G0.6330.99
191_V214_G0.6330.99
20_K51_V0.6330.99
18_D66_L0.6320.99
211_A218_N0.6300.99
219_A223_R0.6290.99
96_R119_E0.6290.99
150_F153_K0.6280.99
213_T227_C0.6240.99
126_V259_L0.6220.99
175_Q201_E0.6220.99
197_L201_E0.6200.99
161_A164_V0.6190.99
103_I113_T0.6190.99
71_S75_A0.6180.99
95_L123_H0.6150.99
48_Q52_V0.6130.99
213_T218_N0.6090.99
250_M253_D0.6090.99
119_E123_H0.6090.99
84_P87_N0.6070.99
239_S242_I0.6070.99
224_A227_C0.6020.99
63_F73_A0.6010.99
221_Q224_A0.6010.99
22_A26_L0.6010.99
257_I260_I0.5990.99
234_E237_T0.5940.99
150_F256_F0.5920.99
102_L250_M0.5890.98
14_L53_K0.5870.98
218_N221_Q0.5860.98
146_V248_Q0.5860.98
159_F163_A0.5830.98
245_C249_G0.5810.98
39_Q43_E0.5810.98
171_L201_E0.5810.98
15_A56_Q0.5810.98
35_L40_L0.5790.98
81_P84_P0.5780.98
58_L73_A0.5780.98
112_A231_I0.5780.98
20_K48_Q0.5780.98
122_L254_L0.5770.98
97_L119_E0.5750.98
113_T251_L0.5730.98
104_K111_Y0.5720.98
103_I106_N0.5670.98
189_T192_R0.5660.98
264_L267_A0.5590.98
138_T185_A0.5570.98
107_T114_L0.5570.98
84_P88_Q0.5570.98
62_G66_L0.5560.98
146_V249_G0.5540.98
135_I159_F0.5510.98
136_I164_V0.5500.98
98_V101_K0.5490.98
140_I194_E0.5480.98
257_I261_Q0.5460.98
136_I169_A0.5450.98
104_K107_T0.5440.97
25_L32_A0.5440.97
165_R168_H0.5440.97
210_L226_H0.5410.97
174_V207_G0.5410.97
123_H126_V0.5390.97
263_D267_A0.5380.97
139_G144_G0.5380.97
230_T251_L0.5380.97
114_L250_M0.5380.97
203_L209_V0.5370.97
261_Q265_E0.5360.97
133_R179_P0.5350.97
238_N244_A0.5330.97
260_I267_A0.5320.97
231_I234_E0.5300.97
236_A239_S0.5280.97
103_I254_L0.5280.97
135_I154_L0.5270.97
254_L257_I0.5260.97
238_N245_C0.5230.97
212_I230_T0.5210.97
80_S84_P0.5200.97
146_V230_T0.5190.97
185_A211_A0.5180.97
241_S246_H0.5170.97
43_E53_K0.5150.97
153_K158_G0.5140.96
199_A224_A0.5140.96
187_S211_A0.5140.96
153_K156_K0.5120.96
137_L252_T0.5080.96
249_G253_D0.5070.96
230_T247_A0.5050.96
174_V201_E0.5050.96
248_Q252_T0.5050.96
138_T177_S0.5050.96
41_A51_V0.5040.96
195_L199_A0.5040.96
8_R26_L0.5040.96
44_A51_V0.5040.96
97_L101_K0.5030.96
8_R13_G0.5020.96
106_N253_D0.5010.96
14_L22_A0.5010.96
38_Q42_N0.5010.96
148_Q163_A0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ivnA 2 0.9326 100 0.18 Contact Map
3shoA 4 0.656 100 0.531 Contact Map
2xhzA 4 0.6064 100 0.551 Contact Map
3fxaA 4 0.6738 100 0.557 Contact Map
3etnA 4 0.6525 100 0.564 Contact Map
1m3sA 4 0.6312 100 0.575 Contact Map
1jeoA 4 0.6099 99.9 0.583 Contact Map
2pocA 4 0.6631 99.9 0.583 Contact Map
1vimA 4 0.6489 99.9 0.585 Contact Map
3tbfA 2 0.6809 99.9 0.587 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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