GREMLIN Database
YDIF - Acetate CoA-transferase YdiF
UniProt: P37766 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12432
Length: 531 (463)
Sequences: 1030 (667)
Seq/√Len: 31.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
492_Q497_D5.8411.00
188_A197_A5.5191.00
197_A224_M4.6631.00
485_I491_L4.5571.00
46_L185_F4.5461.00
85_E110_K4.3181.00
26_P29_A4.3061.00
148_R165_L4.0641.00
193_S231_K3.8681.00
138_D171_K3.8561.00
51_A84_Q3.4491.00
382_D386_N3.4001.00
89_K112_I3.3221.00
506_S509_L3.2921.00
27_D59_T3.2881.00
383_Q445_R3.2841.00
153_K161_D3.1141.00
82_L87_L3.0801.00
19_Q52_D3.0071.00
104_E108_Q3.0041.00
201_D227_Q2.9951.00
148_R172_E2.9771.00
186_I242_I2.9701.00
127_A135_I2.9611.00
164_K169_D2.9141.00
235_L240_V2.8731.00
186_I224_M2.8441.00
190_T230_V2.8171.00
445_R500_D2.7471.00
465_R483_I2.6041.00
380_E448_P2.5961.00
367_H404_D2.5671.00
66_I179_I2.5190.99
136_I166_V2.4930.99
16_L249_I2.4860.99
194_E232_K2.4540.99
139_I408_T2.4420.99
31_L185_F2.4340.99
45_T256_Q2.3760.99
224_M242_I2.3760.99
476_K481_H2.3700.99
441_K500_D2.3630.99
197_A242_I2.3620.99
474_T483_I2.3570.99
263_A346_A2.3100.99
481_H506_S2.3050.99
90_W112_I2.2920.99
42_E47_I2.2880.99
184_A215_V2.2230.99
17_S20_E2.2090.99
28_E62_N2.1850.99
25_I50_L2.1610.98
165_L172_E2.1090.98
127_A132_Q2.0940.98
105_L110_K2.0700.98
16_L22_V2.0470.98
134_G175_Y2.0230.98
190_T200_E2.0130.97
18_A49_A1.9970.97
201_D272_D1.9190.97
120_V137_S1.9190.97
499_M503_P1.9170.97
50_L185_F1.9130.97
190_T228_K1.9030.96
381_V443_F1.8880.96
465_R474_T1.8680.96
236_H239_S1.8400.96
505_I509_L1.8360.96
265_V272_D1.8090.95
331_T366_Y1.7930.95
64_S92_L1.7900.95
128_A179_I1.7900.95
441_K498_K1.7600.94
142_G456_I1.7570.94
221_I249_I1.7350.94
231_K234_T1.7100.93
198_T235_L1.7020.93
29_A182_D1.6980.93
474_T481_H1.6940.93
167_E172_E1.6860.93
22_V25_I1.6800.93
221_I224_M1.6800.93
194_E354_R1.6560.92
188_A224_M1.5790.90
481_H504_V1.5530.90
476_K479_G1.5520.90
20_E23_N1.5510.90
116_Y162_L1.5500.90
473_F482_L1.5470.89
109_N156_E1.5340.89
199_F208_A1.5330.89
142_G459_E1.5300.89
492_Q502_T1.5220.89
149_Q450_I1.5200.89
32_C211_I1.5160.88
175_Y178_A1.5110.88
15_V229_M1.4910.88
29_A183_I1.4900.88
358_D361_S1.4890.88
62_N89_K1.4830.87
136_I175_Y1.4760.87
88_V102_I1.4670.87
169_D177_K1.4590.86
491_L495_I1.4580.86
211_I215_V1.4470.86
399_T451_T1.4420.86
245_Y337_I1.4280.85
33_V71_L1.4180.85
479_G504_V1.4150.85
491_L496_L1.4030.84
27_D61_R1.4000.84
420_A437_E1.3980.84
181_P215_V1.3940.84
485_I509_L1.3930.84
312_A377_S1.3920.84
85_E108_Q1.3860.83
22_V50_L1.3820.83
127_A130_A1.3700.83
476_K506_S1.3660.83
289_K321_E1.3520.82
76_D80_S1.3490.82
193_S234_T1.3420.81
443_F480_L1.3350.81
36_A334_T1.3280.81
381_V480_L1.3270.81
269_I346_A1.3130.80
101_R104_E1.3060.80
21_A53_K1.3040.79
336_P350_N1.2930.79
32_C181_P1.2890.79
49_A53_K1.2880.79
487_P511_L1.2870.79
123_Q132_Q1.2840.78
22_V53_K1.2740.78
185_F223_M1.2730.78
163_I174_L1.2650.77
183_I221_I1.2580.77
289_K322_E1.2580.77
45_T48_T1.2500.76
64_S90_W1.2390.76
184_A224_M1.2300.75
247_V250_V1.2250.75
381_V387_V1.2200.75
25_I185_F1.2160.74
299_M305_G1.2160.74
257_T260_Y1.2120.74
379_A392_F1.2080.74
142_G455_K1.2080.74
183_I215_V1.2060.74
50_L87_L1.2050.74
378_F387_V1.2040.74
472_V484_E1.2010.73
413_I467_I1.1960.73
22_V223_M1.1950.73
133_P173_Y1.1910.73
494_D498_K1.1600.71
420_A439_R1.1550.71
24_Y29_A1.1520.70
502_T505_I1.1440.70
191_C247_V1.1360.69
223_M251_V1.1340.69
437_E498_K1.1310.69
122_T359_M1.1300.69
495_I505_I1.1270.69
291_V311_I1.1270.69
378_F381_V1.1260.69
25_I29_A1.1250.68
32_C125_L1.1210.68
136_I168_F1.1180.68
90_W162_L1.1080.67
378_F416_G1.1040.67
24_Y249_I1.1020.67
109_N157_V1.1010.67
300_R303_A1.1000.67
288_R311_I1.0990.67
199_F242_I1.0970.66
66_I92_L1.0890.66
51_A81_P1.0860.66
419_T469_E1.0860.66
485_I495_I1.0850.66
45_T253_D1.0830.65
230_V273_F1.0730.65
36_A312_A1.0700.64
128_A180_A1.0700.64
315_I375_Y1.0690.64
96_W106_A1.0680.64
72_G376_L1.0650.64
165_L174_L1.0610.64
384_H455_K1.0610.64
380_E444_I1.0540.63
190_T198_T1.0530.63
411_K465_R1.0480.63
471_A509_L1.0460.63
155_N159_K1.0420.62
253_D256_Q1.0370.62
470_R498_K1.0360.62
98_Q309_V1.0300.61
236_H272_D1.0160.60
295_A375_Y1.0060.60
491_L509_L1.0050.60
478_D504_V1.0000.59
115_N399_T0.9960.59
46_L50_L0.9940.59
93_C96_W0.9910.58
466_Y475_L0.9820.58
263_A266_N0.9810.58
156_E159_K0.9790.58
145_V403_I0.9770.57
294_R484_E0.9690.57
288_R314_G0.9680.57
263_A269_I0.9620.56
93_C98_Q0.9600.56
23_N27_D0.9560.56
283_L314_G0.9560.56
292_A315_I0.9470.55
375_Y415_C0.9410.55
80_S98_Q0.9390.54
486_A512_M0.9380.54
16_L24_Y0.9360.54
365_F370_G0.9330.54
116_Y121_L0.9300.54
167_E170_N0.9300.54
36_A309_V0.9280.53
437_E441_K0.9270.53
193_S232_K0.9270.53
504_V508_E0.9240.53
205_Y358_D0.9190.53
231_K274_T0.9180.53
83_A105_L0.9170.53
374_C412_I0.9130.52
80_S309_V0.9100.52
373_V411_K0.9090.52
65_I88_V0.9070.52
27_D62_N0.9050.52
471_A495_I0.9040.52
316_G319_A0.9010.51
241_R358_D0.8990.51
357_L362_Q0.8900.50
289_K293_R0.8870.50
207_D360_T0.8860.50
123_Q135_I0.8860.50
456_I459_E0.8850.50
421_G439_R0.8820.50
298_E465_R0.8790.50
169_D175_Y0.8780.49
37_G313_D0.8770.49
445_R502_T0.8760.49
504_V507_P0.8750.49
181_P184_A0.8690.49
141_I146_D0.8680.49
309_V313_D0.8660.48
124_T179_I0.8650.48
41_L206_L0.8640.48
281_L284_P0.8640.48
184_A211_I0.8630.48
481_H507_P0.8630.48
197_A247_V0.8630.48
489_V494_D0.8560.48
60_P240_V0.8560.48
303_A373_V0.8560.48
44_T81_P0.8550.48
116_Y163_I0.8520.47
266_N269_I0.8510.47
470_R494_D0.8500.47
293_R467_I0.8490.47
494_D497_D0.8460.47
129_A399_T0.8410.46
200_E228_K0.8400.46
387_V399_T0.8390.46
17_S21_A0.8390.46
37_G67_S0.8380.46
467_I483_I0.8370.46
49_A52_D0.8370.46
413_I465_R0.8330.46
15_V319_A0.8330.46
380_E446_E0.8320.46
204_M334_T0.8280.45
309_V334_T0.8270.45
141_I172_E0.8270.45
332_V336_P0.8260.45
30_T180_A0.8250.45
73_D80_S0.8250.45
295_A467_I0.8230.45
32_C65_I0.8220.45
94_G115_N0.8220.45
298_E411_K0.8200.45
85_E105_L0.8200.45
384_H446_E0.8200.45
43_A47_I0.8180.45
476_K504_V0.8160.44
116_Y152_G0.8140.44
22_V49_A0.8070.44
509_L513_D0.8060.44
309_V359_M0.8040.43
212_A242_I0.8030.43
375_Y406_S0.7990.43
373_V413_I0.7990.43
43_A46_L0.7990.43
419_T437_E0.7990.43
89_K160_E0.7960.43
437_E489_V0.7950.43
495_I508_E0.7950.43
32_C346_A0.7940.43
161_D177_K0.7910.42
187_R253_D0.7900.42
64_S89_K0.7900.42
67_S71_L0.7890.42
394_G397_M0.7890.42
125_L211_I0.7880.42
22_V249_I0.7860.42
285_L322_E0.7830.42
124_T178_A0.7820.42
19_Q23_N0.7820.42
24_Y221_I0.7820.42
293_R322_E0.7790.42
287_Q469_E0.7790.42
189_T200_E0.7770.41
118_Q359_M0.7770.41
403_I451_T0.7750.41
68_P125_L0.7740.41
126_R364_D0.7730.41
312_A415_C0.7730.41
31_L211_I0.7690.41
486_A489_V0.7670.41
41_L227_Q0.7670.41
146_D174_L0.7660.41
41_L97_G0.7660.41
154_L203_V0.7630.40
229_M252_V0.7610.40
230_V276_D0.7580.40
118_Q122_T0.7580.40
34_L43_A0.7580.40
99_S103_S0.7580.40
256_Q260_Y0.7570.40
118_Q207_D0.7540.40
307_V330_L0.7520.39
149_Q446_E0.7470.39
191_C229_M0.7460.39
147_P496_L0.7450.39
256_Q259_L0.7450.39
470_R489_V0.7410.39
299_M487_P0.7390.38
115_N397_M0.7380.38
333_E363_F0.7370.38
68_P121_L0.7370.38
73_D76_D0.7360.38
126_R130_A0.7350.38
33_V65_I0.7340.38
389_V451_T0.7340.38
203_V362_Q0.7330.38
26_P108_Q0.7300.38
36_A377_S0.7300.38
337_I357_L0.7290.38
158_T161_D0.7260.37
459_E477_E0.7260.37
66_I128_A0.7250.37
44_T51_A0.7250.37
48_T256_Q0.7240.37
41_L78_G0.7240.37
113_A350_N0.7230.37
62_N65_I0.7190.37
413_I505_I0.7190.37
187_R421_G0.7170.37
124_T128_A0.7170.37
40_I203_V0.7160.37
380_E469_E0.7150.37
95_H313_D0.7150.37
23_N300_R0.7140.37
80_S93_C0.7140.37
197_A226_V0.7130.36
228_K252_V0.7120.36
39_G73_D0.7090.36
443_F501_F0.7080.36
273_F276_D0.7050.36
213_Q361_S0.7040.36
285_L289_K0.7020.36
164_K167_E0.7020.36
313_D379_A0.7000.35
75_A92_L0.6990.35
153_K158_T0.6970.35
313_D316_G0.6970.35
230_V233_A0.6970.35
113_A214_A0.6950.35
492_Q498_K0.6950.35
320_R323_G0.6950.35
197_A250_V0.6940.35
473_F503_P0.6940.35
58_Q61_R0.6910.35
312_A343_Q0.6910.35
342_S349_A0.6910.35
50_L82_L0.6900.35
33_V47_I0.6890.35
277_D280_K0.6880.35
323_G444_I0.6870.35
31_L82_L0.6860.34
138_D173_Y0.6860.34
95_H397_M0.6850.34
191_C235_L0.6850.34
205_Y361_S0.6840.34
377_S415_C0.6830.34
299_M318_V0.6830.34
452_F475_L0.6830.34
497_D502_T0.6820.34
482_L505_I0.6810.34
37_G99_S0.6810.34
225_Q240_V0.6800.34
15_V500_D0.6800.34
21_A251_V0.6790.34
315_I467_I0.6790.34
122_T181_P0.6780.34
23_N53_K0.6780.34
390_H451_T0.6740.34
274_T352_N0.6740.34
324_C327_D0.6740.34
504_V509_L0.6720.33
34_L97_G0.6700.33
68_P359_M0.6680.33
446_E492_Q0.6660.33
97_G178_A0.6660.33
132_Q137_S0.6650.33
106_A113_A0.6640.33
168_F175_Y0.6630.33
198_T230_V0.6630.33
86_G105_L0.6620.33
34_L206_L0.6610.33
47_I67_S0.6600.33
112_I129_A0.6580.32
419_T438_G0.6570.32
99_S123_Q0.6560.32
471_A485_I0.6560.32
73_D77_R0.6560.32
52_D84_Q0.6540.32
22_V59_T0.6530.32
415_C450_I0.6530.32
66_I125_L0.6510.32
71_L397_M0.6510.32
124_T180_A0.6510.32
313_D343_Q0.6500.32
42_E67_S0.6500.32
242_I247_V0.6480.32
471_A489_V0.6470.32
46_L215_V0.6470.32
189_T201_D0.6460.32
389_V392_F0.6450.32
386_N393_N0.6450.32
445_R510_K0.6420.31
507_P510_K0.6390.31
92_L121_L0.6370.31
30_T66_I0.6370.31
477_E506_S0.6370.31
330_L341_T0.6370.31
229_M337_I0.6370.31
134_G178_A0.6360.31
319_A404_D0.6360.31
287_Q417_T0.6350.31
132_Q135_I0.6340.31
182_D511_L0.6340.31
257_T261_G0.6330.31
353_T356_I0.6320.31
485_I511_L0.6310.31
15_V273_F0.6290.30
304_V365_F0.6280.30
443_F466_Y0.6280.30
322_E352_N0.6280.30
105_L108_Q0.6250.30
76_D101_R0.6250.30
380_E482_L0.6250.30
25_I411_K0.6240.30
28_E31_L0.6240.30
483_I506_S0.6240.30
50_L250_V0.6230.30
458_L476_K0.6230.30
72_G371_L0.6230.30
342_S404_D0.6220.30
39_G94_G0.6210.30
166_V169_D0.6210.30
185_F413_I0.6210.30
31_L62_N0.6210.30
483_I489_V0.6200.30
97_G395_K0.6200.30
496_L503_P0.6200.30
207_D359_M0.6180.30
208_A242_I0.6140.29
191_C197_A0.6140.29
191_C226_V0.6120.29
95_H379_A0.6120.29
20_E46_L0.6090.29
112_I158_T0.6090.29
129_A214_A0.6080.29
26_P183_I0.6070.29
41_L204_M0.6060.29
120_V387_V0.6050.29
67_S102_I0.6030.29
118_Q342_S0.6020.29
42_E334_T0.6020.29
80_S345_I0.6020.29
152_G162_L0.6010.29
316_G350_N0.6010.29
489_V498_K0.6000.28
16_L20_E0.6000.28
34_L211_I0.5970.28
418_L499_M0.5970.28
485_I505_I0.5970.28
288_R330_L0.5970.28
242_I281_L0.5970.28
452_F457_A0.5970.28
88_V122_T0.5960.28
48_T81_P0.5950.28
30_T64_S0.5950.28
130_A316_G0.5940.28
67_S79_I0.5930.28
81_P304_V0.5930.28
212_A299_M0.5920.28
145_V184_A0.5890.28
490_D495_I0.5890.28
76_D263_A0.5880.28
506_S511_L0.5880.28
43_A445_R0.5870.28
37_G71_L0.5860.28
359_M404_D0.5860.28
58_Q446_E0.5850.28
384_H445_R0.5850.28
91_A106_A0.5850.28
161_D165_L0.5840.27
137_S179_I0.5840.27
213_Q336_P0.5830.27
302_G411_K0.5830.27
97_G209_L0.5830.27
231_K277_D0.5800.27
71_L118_Q0.5800.27
269_I342_S0.5800.27
97_G207_D0.5790.27
110_K302_G0.5790.27
458_L478_D0.5790.27
153_K156_E0.5780.27
37_G72_G0.5770.27
149_Q453_S0.5770.27
34_L350_N0.5770.27
345_I349_A0.5740.27
91_A111_I0.5740.27
21_A249_I0.5730.27
46_L223_M0.5730.27
306_N363_F0.5720.27
506_S510_K0.5710.27
67_S345_I0.5700.27
177_K289_K0.5700.27
187_R227_Q0.5690.27
25_I87_L0.5690.27
19_Q49_A0.5680.26
161_D451_T0.5660.26
399_T403_I0.5660.26
47_I71_L0.5660.26
301_K327_D0.5650.26
146_D165_L0.5640.26
251_V358_D0.5640.26
116_Y125_L0.5630.26
88_V92_L0.5630.26
120_V376_L0.5620.26
25_I212_A0.5610.26
125_L179_I0.5610.26
191_C224_M0.5610.26
128_A181_P0.5600.26
97_G397_M0.5600.26
39_G76_D0.5590.26
53_K60_P0.5580.26
47_I82_L0.5570.26
453_S456_I0.5570.26
202_E336_P0.5560.26
142_G332_V0.5560.26
439_R455_K0.5560.26
381_V393_N0.5560.26
172_E193_S0.5550.26
371_L420_A0.5540.26
31_L384_H0.5540.26
41_L349_A0.5530.26
316_G380_E0.5530.26
495_I509_L0.5530.26
305_G373_V0.5520.25
44_T118_Q0.5520.25
319_A324_C0.5510.25
379_A393_N0.5490.25
31_L446_E0.5480.25
31_L46_L0.5480.25
475_L480_L0.5480.25
379_A451_T0.5470.25
138_D216_H0.5470.25
312_A334_T0.5460.25
43_A317_L0.5460.25
125_L361_S0.5460.25
19_Q169_D0.5460.25
265_V270_S0.5450.25
403_I407_A0.5450.25
443_F475_L0.5440.25
439_R498_K0.5440.25
299_M315_I0.5430.25
496_L504_V0.5430.25
99_S334_T0.5420.25
185_F215_V0.5410.25
311_I314_G0.5410.25
155_N158_T0.5400.25
164_K168_F0.5390.25
17_S53_K0.5380.25
294_R472_V0.5380.25
33_V82_L0.5370.25
193_S495_I0.5370.25
125_L181_P0.5370.25
230_V234_T0.5360.24
193_S233_A0.5360.24
458_L477_E0.5360.24
364_D469_E0.5360.24
168_F446_E0.5350.24
83_A94_G0.5340.24
52_D459_E0.5330.24
280_K495_I0.5330.24
198_T414_F0.5330.24
60_P496_L0.5310.24
39_G349_A0.5290.24
285_L293_R0.5290.24
190_T199_F0.5290.24
286_N289_K0.5260.24
458_L495_I0.5260.24
383_Q446_E0.5250.24
33_V43_A0.5250.24
133_P237_P0.5250.24
476_K483_I0.5250.24
30_T179_I0.5250.24
35_G334_T0.5250.24
186_I194_E0.5240.24
25_I77_R0.5240.24
53_K59_T0.5240.24
62_N510_K0.5230.24
375_Y412_I0.5230.24
96_W206_L0.5230.24
115_N348_G0.5220.24
478_D495_I0.5210.24
36_A42_E0.5210.24
146_D172_E0.5210.24
35_G473_F0.5210.24
227_Q334_T0.5200.24
46_L184_A0.5200.24
17_S22_V0.5190.23
17_S513_D0.5190.23
158_T237_P0.5190.23
60_P488_G0.5180.23
177_K478_D0.5180.23
185_F316_G0.5170.23
140_G339_G0.5170.23
332_V375_Y0.5160.23
182_D242_I0.5160.23
380_E417_T0.5160.23
276_D491_L0.5150.23
271_G352_N0.5150.23
35_G63_L0.5150.23
490_D506_S0.5150.23
328_F411_K0.5140.23
50_L327_D0.5140.23
229_M273_F0.5140.23
67_S99_S0.5140.23
203_V349_A0.5130.23
92_L214_A0.5130.23
295_A415_C0.5120.23
122_T207_D0.5120.23
105_L296_L0.5120.23
22_V455_K0.5110.23
128_A214_A0.5110.23
312_A378_F0.5100.23
204_M371_L0.5100.23
82_L344_G0.5100.23
21_A50_L0.5090.23
485_I494_D0.5090.23
197_A221_I0.5080.23
177_K240_V0.5080.23
95_H309_V0.5080.23
121_L346_A0.5080.23
411_K477_E0.5070.23
306_N377_S0.5060.23
36_A44_T0.5050.23
319_A465_R0.5050.23
260_Y346_A0.5040.23
37_G343_Q0.5040.23
17_S384_H0.5030.23
40_I208_A0.5030.23
270_S406_S0.5030.23
203_V311_I0.5020.23
41_L99_S0.5020.23
164_K177_K0.5020.23
97_G120_V0.5010.22
88_V282_S0.5010.22
92_L158_T0.5010.22
198_T250_V0.5010.22
311_I415_C0.5010.22
72_G120_V0.5010.22
175_Y309_V0.5010.22
46_L251_V0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ahuA 3 0.9699 100 0.307 Contact Map
3k6mA 2 0.8399 100 0.449 Contact Map
4kgbA 2 0.8418 100 0.45 Contact Map
2hj0A 2 0.8023 100 0.615 Contact Map
3qliA 2 0.7646 100 0.62 Contact Map
4eu9A 2 0.8192 100 0.621 Contact Map
2nvvA 2 0.7721 100 0.621 Contact Map
1xr4A 2 0.8136 100 0.623 Contact Map
2g39A 2 0.7891 100 0.624 Contact Map
3gk7A 2 0.7627 100 0.632 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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