GREMLIN Database
RMLD - dTDP-4-dehydrorhamnose reductase
UniProt: P37760 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12411
Length: 299 (271)
Sequences: 56921 (39639)
Seq/√Len: 2407.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_K28_A3.1211.00
229_L283_Q2.8321.00
2_N25_N2.8221.00
195_C215_L2.7401.00
213_Y274_N2.6731.00
19_A194_D2.6601.00
211_G270_K2.5621.00
47_A94_E2.3951.00
79_L83_T2.3901.00
281_D284_V2.3881.00
57_I200_I2.3221.00
73_E76_F2.2751.00
232_E283_Q2.1881.00
102_Y196_T2.1851.00
269_E273_Q2.1731.00
19_A23_L2.0961.00
98_W145_K2.0741.00
19_A197_A2.0501.00
29_F38_G2.0231.00
60_N101_H2.0161.00
272_Q278_V2.0151.00
42_N45_G2.0021.00
59_V200_I1.9911.00
6_F60_N1.9551.00
233_E287_K1.9431.00
38_G45_G1.9351.00
23_L201_R1.9091.00
5_L17_Q1.8801.00
4_L55_P1.8791.00
27_I55_P1.8681.00
224_Y228_A1.8581.00
229_L232_E1.8041.00
155_Y285_G1.8031.00
194_D198_H1.7891.00
2_N27_I1.7761.00
151_T196_T1.7741.00
190_E288_R1.7681.00
222_T225_D1.7531.00
117_L120_D1.7391.00
218_S272_Q1.7201.00
149_F199_A1.6771.00
168_R172_E1.6691.00
139_L146_H1.6391.00
16_L193_A1.6311.00
23_L197_A1.5921.00
16_L59_V1.5901.00
86_E138_A1.5871.00
41_S79_L1.5331.00
78_Q134_A1.5321.00
118_E270_K1.5201.00
188_G288_R1.5181.00
86_E90_K1.5121.00
43_P90_K1.4911.00
47_A91_A1.4901.00
19_A22_P1.4821.00
197_A201_R1.4791.00
27_I36_Y1.4701.00
83_T86_E1.4611.00
229_L233_E1.4611.00
287_K291_N1.4551.00
19_A193_A1.4421.00
271_F275_F1.4411.00
149_F196_T1.4381.00
268_T272_Q1.4371.00
12_V154_V1.4311.00
133_L137_K1.4291.00
75_E79_L1.4251.00
17_Q28_A1.4121.00
16_L61_A1.4111.00
58_I92_A1.4061.00
103_S107_V1.4011.00
48_E52_S1.3871.00
225_D228_A1.3821.00
122_T133_L1.3691.00
98_W147_L1.3681.00
60_N85_V1.3621.00
52_S55_P1.3601.00
151_T192_L1.3531.00
280_P288_R1.3491.00
85_V135_G1.3371.00
59_V196_T1.3281.00
128_Y132_K1.3151.00
89_A142_Y1.3071.00
189_A193_A1.3001.00
188_G285_G1.2941.00
61_A102_Y1.2911.00
92_A97_A1.2811.00
47_A95_V1.2671.00
108_F214_H1.2631.00
284_V287_K1.2631.00
81_N131_T1.2551.00
187_T192_L1.2541.00
45_G48_E1.2531.00
137_K140_Q1.2491.00
20_L197_A1.2491.00
18_R158_K1.2461.00
211_G274_N1.2271.00
185_A218_S1.2241.00
90_K93_N1.2221.00
88_I99_V1.2131.00
102_Y151_T1.2021.00
8_K17_Q1.1991.00
169_L174_E1.1941.00
152_S266_L1.1921.00
43_P87_A1.1891.00
48_E51_R1.1801.00
183_F220_T1.1751.00
90_K94_E1.1731.00
284_V288_R1.1711.00
43_P47_A1.1701.00
117_L267_N1.1541.00
50_V55_P1.1531.00
143_C146_H1.1491.00
140_Q148_I1.1361.00
51_R95_V1.1271.00
130_E134_A1.1261.00
140_Q212_L1.1161.00
268_T279_L1.1101.00
92_A99_V1.0911.00
15_E190_E1.0831.00
270_K274_N1.0831.00
4_L29_F1.0801.00
3_I20_L1.0771.00
101_H135_G1.0771.00
113_D117_L1.0741.00
195_C271_F1.0641.00
194_D277_L1.0601.00
40_F84_S1.0581.00
188_G280_P1.0561.00
231_F237_A1.0531.00
150_R212_L1.0521.00
221_T282_W1.0511.00
280_P284_V1.0441.00
140_Q146_H1.0441.00
50_V58_I1.0391.00
19_A190_E1.0371.00
9_T30_D1.0351.00
18_R22_P1.0331.00
40_F62_A1.0221.00
138_A141_E1.0211.00
119_T270_K1.0141.00
15_E189_A1.0121.00
113_D120_D1.0041.00
11_Q156_A1.0031.00
188_G191_L0.9981.00
145_K209_V0.9901.00
101_H139_L0.9881.00
216_V266_L0.9881.00
89_A99_V0.9881.00
91_A95_V0.9861.00
47_A51_R0.9791.00
136_E150_R0.9781.00
283_Q287_K0.9751.00
228_A231_F0.9731.00
233_E290_L0.9701.00
69_K73_E0.9661.00
27_I52_S0.9621.00
61_A196_T0.9611.00
220_T263_N0.9611.00
155_Y188_G0.9591.00
101_H148_I0.9551.00
116_W120_D0.9531.00
150_R214_H0.9371.00
2_N56_D0.9361.00
213_Y270_K0.9351.00
44_E48_E0.9341.00
191_L217_A0.9331.00
14_W158_K0.9331.00
32_H35_D0.9331.00
100_I149_F0.9321.00
234_A290_L0.9271.00
46_V91_A0.9251.00
11_Q189_A0.9241.00
2_N55_P0.9221.00
3_I57_I0.9191.00
270_K273_Q0.9181.00
147_L199_A0.9161.00
183_F222_T0.9151.00
80_I84_S0.9121.00
90_K142_Y0.9121.00
221_T225_D0.9101.00
64_H80_I0.9091.00
83_T87_A0.9081.00
21_A26_L0.9071.00
99_V139_L0.9051.00
154_V192_L0.9021.00
220_T265_R0.9011.00
224_Y248_A0.8981.00
162_F166_M0.8901.00
77_A131_T0.8881.00
78_Q82_A0.8821.00
44_E47_A0.8821.00
6_F88_I0.8781.00
198_H275_F0.8761.00
216_V268_T0.8711.00
148_I212_L0.8701.00
89_A139_L0.8691.00
233_E286_V0.8681.00
6_F62_A0.8681.00
195_C277_L0.8681.00
3_I59_V0.8631.00
134_A137_K0.8581.00
29_F46_V0.8551.00
288_R291_N0.8521.00
50_V91_A0.8511.00
50_V95_V0.8481.00
198_H201_R0.8431.00
87_A90_K0.8421.00
103_S136_E0.8411.00
15_E18_R0.8351.00
190_E280_P0.8351.00
149_F215_L0.8321.00
36_Y49_T0.8291.00
233_E283_Q0.8281.00
199_A275_F0.8231.00
219_G281_D0.8191.00
91_A94_E0.8171.00
154_V187_T0.8171.00
17_Q26_L0.8121.00
45_G49_T0.8111.00
231_F239_I0.8111.00
208_D211_G0.8101.00
29_F49_T0.8101.00
93_N142_Y0.8061.00
16_L20_L0.8051.00
29_F45_G0.8051.00
43_P94_E0.8041.00
87_A91_A0.8001.00
218_S268_T0.7971.00
12_V192_L0.7941.00
82_A134_A0.7931.00
269_E272_Q0.7871.00
3_I200_I0.7871.00
78_Q83_T0.7841.00
32_H37_C0.7831.00
168_R171_K0.7811.00
57_I98_W0.7801.00
280_P285_G0.7801.00
194_D280_P0.7801.00
152_S216_V0.7771.00
89_A138_A0.7771.00
231_F236_K0.7761.00
36_Y52_S0.7731.00
198_H277_L0.7721.00
221_T226_Y0.7701.00
165_T168_R0.7651.00
15_E193_A0.7611.00
183_F263_N0.7601.00
161_N164_K0.7601.00
31_V39_D0.7551.00
140_Q144_A0.7541.00
76_F79_L0.7521.00
15_E19_A0.7511.00
78_Q131_T0.7511.00
21_A24_G0.7501.00
137_K141_E0.7451.00
85_V89_A0.7441.00
199_A271_F0.7411.00
76_F80_I0.7391.00
84_S87_A0.7371.00
41_S80_I0.7331.00
194_D197_A0.7311.00
165_T169_L0.7291.00
85_V139_L0.7281.00
170_A231_F0.7281.00
134_A138_A0.7261.00
16_L196_T0.7261.00
64_H76_F0.7231.00
107_V122_T0.7211.00
114_M120_D0.7201.00
109_P123_A0.7151.00
58_I88_I0.7131.00
124_P129_G0.7111.00
50_V92_A0.7101.00
118_E271_F0.7041.00
111_N116_W0.7021.00
215_L271_F0.6991.00
74_P130_E0.6971.00
198_H276_A0.6951.00
233_E291_N0.6931.00
33_S37_C0.6921.00
228_A232_E0.6911.00
229_L282_W0.6911.00
126_N129_G0.6881.00
149_F195_C0.6851.00
107_V136_E0.6851.00
208_D274_N0.6811.00
58_I99_V0.6811.00
225_D229_L0.6761.00
60_N88_I0.6761.00
14_W18_R0.6751.00
105_D152_S0.6731.00
143_C210_A0.6711.00
157_G288_R0.6711.00
173_R176_L0.6711.00
4_L58_I0.6661.00
4_L38_G0.6661.00
226_Y282_W0.6651.00
20_L200_I0.6611.00
130_E137_K0.6591.00
169_L172_E0.6571.00
167_L171_K0.6551.00
64_H77_A0.6551.00
78_Q130_E0.6551.00
146_H210_A0.6531.00
127_V130_E0.6521.00
157_G188_G0.6451.00
219_G283_Q0.6441.00
105_D266_L0.6441.00
135_G139_L0.6431.00
71_E127_V0.6431.00
23_L198_H0.6411.00
46_V87_A0.6411.00
130_E141_E0.6401.00
193_A197_A0.6351.00
138_A142_Y0.6311.00
49_T52_S0.6271.00
131_T135_G0.6271.00
167_L290_L0.6251.00
42_N46_V0.6251.00
39_D42_N0.6221.00
112_G120_D0.6211.00
9_T32_H0.6181.00
182_Q223_W0.6181.00
49_T55_P0.6171.00
272_Q279_L0.6161.00
118_E214_H0.6121.00
227_A231_F0.6111.00
115_P267_N0.6101.00
60_N99_V0.6091.00
140_Q143_C0.6071.00
191_L280_P0.6051.00
192_L215_L0.6041.00
173_R236_K0.6041.00
4_L49_T0.6021.00
100_I200_I0.6001.00
63_A81_N0.5981.00
57_I100_I0.5961.00
17_Q21_A0.5951.00
122_T137_K0.5941.00
185_A217_A0.5911.00
175_E240_P0.5891.00
124_P133_L0.5871.00
89_A93_N0.5851.00
191_L194_D0.5831.00
167_L230_V0.5821.00
100_I199_A0.5821.00
64_H81_N0.5821.00
163_A166_M0.5781.00
46_V50_V0.5781.00
16_L197_A0.5771.00
23_L194_D0.5761.00
27_I49_T0.5761.00
157_G190_E0.5731.00
70_A77_A0.5731.00
18_R190_E0.5721.00
15_E158_K0.5701.00
151_T154_V0.5701.00
153_W184_G0.5701.00
229_L286_V0.5671.00
106_Y129_G0.5641.00
74_P127_V0.5631.00
5_L28_A0.5621.00
117_L269_E0.5621.00
9_T28_A0.5611.00
177_A180_N0.5601.00
38_G46_V0.5581.00
197_A200_I0.5571.00
86_E142_Y0.5571.00
161_N165_T0.5571.00
213_Y271_F0.5551.00
185_A220_T0.5521.00
85_V101_H0.5521.00
139_L148_I0.5501.00
173_R177_A0.5481.00
36_Y45_G0.5451.00
115_P265_R0.5431.00
183_F265_R0.5421.00
141_E144_A0.5421.00
231_F234_A0.5401.00
155_Y217_A0.5391.00
221_T229_L0.5391.00
38_G49_T0.5391.00
147_L207_P0.5381.00
100_I196_T0.5381.00
92_A95_V0.5381.00
20_L59_V0.5331.00
122_T212_L0.5331.00
5_L20_L0.5291.00
236_K239_I0.5281.00
4_L50_V0.5271.00
81_N128_Y0.5241.00
148_I210_A0.5211.00
104_T132_K0.5201.00
147_L213_Y0.5201.00
127_V131_T0.5161.00
209_V213_Y0.5151.00
50_V88_I0.5071.00
17_Q24_G0.5071.00
261_P264_S0.5061.00
102_Y149_F0.5051.00
8_K30_D0.5041.00
51_R94_E0.5031.00
103_S148_I0.5021.00
257_P260_R0.5011.00
230_V286_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1n2sA 2 0.9866 100 0.163 Contact Map
3sc6A 3 0.9298 100 0.222 Contact Map
1sb8A 2 0.9599 100 0.226 Contact Map
1vl0A 3 0.9298 100 0.227 Contact Map
3rufA 2 0.9465 100 0.236 Contact Map
1rpnA 4 0.9599 100 0.239 Contact Map
1rkxA 3 0.9498 100 0.241 Contact Map
2pzmA 2 0.9431 100 0.241 Contact Map
1oc2A 2 0.9465 100 0.242 Contact Map
2ydyA 1 0.8462 100 0.247 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0106 seconds.