GREMLIN Database
RMLB1 - dTDP-glucose 4,6-dehydratase 1
UniProt: P37759 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12412
Length: 361 (298)
Sequences: 49725 (34621)
Seq/√Len: 2005.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_G30_N3.2961.00
272_T324_E3.0711.00
242_A258_I2.8151.00
19_H241_R2.7431.00
254_E310_K2.5971.00
2_K27_S2.5531.00
98_E102_V2.5421.00
76_A247_V2.4731.00
66_A113_N2.4171.00
92_G95_A2.4041.00
256_Y314_A2.3131.00
276_L328_R2.2861.00
131_I243_L2.2711.00
19_H244_Y2.2291.00
275_D324_E2.1571.00
19_H23_N2.1511.00
127_R188_P2.1431.00
241_R320_Q2.1181.00
312_G318_K2.1061.00
31_V57_A2.1051.00
322_T325_S2.0821.00
194_C243_L2.0231.00
79_H130_H2.0161.00
61_D64_A2.0011.00
57_A64_A1.9941.00
78_M247_V1.9681.00
6_T79_H1.9681.00
267_I271_L1.9431.00
29_V53_V1.9191.00
241_R245_T1.9081.00
29_V74_P1.8981.00
192_T246_V1.8981.00
237_E329_K1.8961.00
272_T275_D1.8851.00
265_K268_D1.8461.00
309_E313_R1.8251.00
198_Y326_G1.8241.00
4_L74_P1.8131.00
23_N244_Y1.7631.00
5_V17_V1.7561.00
178_V189_T1.7441.00
29_V55_E1.7371.00
23_N248_T1.7191.00
16_V240_A1.7151.00
16_V78_M1.6991.00
213_L217_E1.6951.00
66_A110_A1.6921.00
156_T159_T1.6821.00
105_Y177_L1.6811.00
60_C98_E1.6701.00
235_Y329_K1.6341.00
244_Y248_T1.5831.00
27_S53_V1.5811.00
19_H22_N1.5671.00
172_A176_H1.5601.00
16_V80_L1.5551.00
132_S136_V1.5411.00
62_A109_E1.5411.00
102_V105_Y1.5351.00
311_I315_L1.5351.00
261_H312_G1.5301.00
34_L54_F1.5271.00
97_I173_S1.5031.00
328_R332_E1.5021.00
104_T174_S1.4921.00
94_A98_E1.4921.00
245_T249_E1.4821.00
105_Y109_E1.4531.00
272_T276_L1.4471.00
18_R201_Y1.4411.00
235_Y326_G1.4291.00
194_C239_H1.4281.00
161_Y172_A1.4151.00
75_D126_F1.4071.00
19_H240_A1.3861.00
17_V30_N1.3811.00
214_N219_K1.3651.00
12_I197_N1.3611.00
127_R190_I1.3501.00
62_A106_V1.3431.00
308_A312_G1.3421.00
66_A114_Y1.3411.00
321_E329_K1.3401.00
78_M243_L1.3351.00
195_S306_I1.3351.00
268_D271_L1.3171.00
77_V111_A1.3131.00
64_A67_R1.3101.00
192_T243_L1.3081.00
131_I194_C1.2881.00
3_I26_D1.2861.00
130_H174_S1.2801.00
2_K29_V1.2771.00
80_L131_I1.2731.00
234_L239_H1.2701.00
167_Y171_K1.2671.00
179_R191_V1.2651.00
137_Y257_N1.2591.00
62_A66_A1.2581.00
236_V240_A1.2441.00
325_S328_R1.2391.00
230_I263_E1.2371.00
8_G17_V1.2261.00
23_N26_D1.2201.00
19_H237_E1.2151.00
100_N170_S1.2151.00
220_A292_T1.2081.00
232_D261_H1.2071.00
70_A114_Y1.2021.00
79_H104_T1.2011.00
325_S329_K1.1981.00
69_F74_P1.1951.00
157_E310_K1.1911.00
176_H179_R1.1871.00
26_D248_T1.1861.00
15_A237_E1.1841.00
242_A311_I1.1831.00
310_K314_A1.1791.00
228_D267_I1.1791.00
109_E113_N1.1791.00
112_R185_Y1.1681.00
188_P252_A1.1581.00
109_E112_R1.1571.00
20_I244_Y1.1501.00
264_K323_F1.1481.00
254_E314_A1.1461.00
151_E156_T1.1331.00
4_L31_V1.1311.00
88_R92_G1.1301.00
11_F199_G1.1271.00
30_N52_Y1.1261.00
177_L180_A1.1251.00
111_A128_F1.1241.00
108_L181_W1.1171.00
259_G306_I1.1101.00
182_K189_T1.1081.00
21_I52_Y1.1061.00
222_P292_T1.0981.00
169_A173_S1.0971.00
107_L128_F1.0921.00
9_A32_D1.0861.00
193_N255_T1.0791.00
228_D265_K1.0791.00
271_L274_C1.0701.00
59_I103_G1.0521.00
130_H191_V1.0491.00
263_E303_R1.0491.00
308_A319_P1.0421.00
14_S201_Y1.0411.00
38_G42_S1.0391.00
179_R255_T1.0361.00
235_Y321_E1.0321.00
67_R70_A1.0291.00
130_H178_V1.0181.00
55_E68_I1.0181.00
156_T307_D1.0181.00
69_F77_V1.0171.00
39_N42_S1.0121.00
18_R22_N1.0101.00
324_E328_R1.0081.00
264_K268_D1.0071.00
66_A70_A1.0061.00
83_E99_T1.0041.00
3_I20_I1.0041.00
277_L331_V1.0041.00
241_R317_W1.0031.00
179_R189_T0.9991.00
31_V64_A0.9951.00
274_C288_R0.9951.00
110_A114_Y0.9931.00
21_I51_R0.9911.00
276_L331_V0.9851.00
190_I246_V0.9831.00
179_R183_R0.9801.00
108_L128_F0.9761.00
241_R321_E0.9741.00
80_L243_L0.9721.00
245_T315_L0.9691.00
59_I81_A0.9661.00
110_A113_N0.9651.00
63_P67_R0.9631.00
230_I303_R0.9621.00
263_E305_A0.9571.00
128_F178_V0.9561.00
259_G308_A0.9441.00
245_T248_T0.9431.00
276_L324_E0.9431.00
256_Y310_K0.9391.00
193_N257_N0.9391.00
64_A68_I0.9381.00
191_V255_T0.9331.00
237_E321_E0.9321.00
238_D260_G0.9321.00
180_A184_T0.9281.00
329_K332_E0.9241.00
63_P66_A0.9181.00
111_A125_S0.9161.00
15_A236_V0.9161.00
175_D193_N0.9131.00
267_I293_Y0.9091.00
151_E159_T0.9081.00
230_I265_K0.9071.00
112_R187_L0.9051.00
242_A317_W0.9041.00
31_V68_I0.8981.00
3_I76_A0.8981.00
99_T103_G0.8971.00
220_A290_Q0.8941.00
102_V106_V0.8931.00
97_I101_I0.8921.00
108_L178_V0.8921.00
235_Y238_D0.8871.00
6_T107_L0.8841.00
31_V65_M0.8801.00
197_N239_H0.8761.00
2_K75_D0.8751.00
65_M110_A0.8731.00
332_E335_L0.8711.00
35_T56_H0.8691.00
115_W125_S0.8681.00
192_T258_I0.8681.00
40_R56_H0.8631.00
62_A113_N0.8631.00
290_Q293_Y0.8591.00
69_F114_Y0.8571.00
274_C279_E0.8531.00
11_F236_V0.8451.00
2_K74_P0.8431.00
69_F110_A0.8411.00
158_T310_K0.8381.00
15_A18_R0.8361.00
127_R250_G0.8361.00
101_I173_S0.8331.00
6_T81_A0.8321.00
38_G41_E0.8301.00
76_A127_R0.8301.00
276_L327_I0.8251.00
173_S176_H0.8241.00
97_I102_V0.8211.00
106_V110_A0.8201.00
34_L56_H0.8201.00
132_S175_D0.8201.00
198_Y235_Y0.8191.00
207_L211_V0.8191.00
200_P329_K0.8151.00
3_I78_M0.8151.00
33_K58_D0.8141.00
197_N234_L0.8131.00
96_F170_S0.8121.00
227_G267_I0.8101.00
134_D195_S0.8101.00
246_V315_L0.8091.00
210_L213_L0.8091.00
93_P169_A0.8091.00
245_T317_W0.8071.00
261_H308_A0.8051.00
321_E325_S0.8031.00
21_I28_V0.8031.00
276_L332_E0.8021.00
241_R244_Y0.8001.00
60_C99_T0.7991.00
309_E312_G0.7991.00
129_H192_T0.7951.00
29_V73_Q0.7921.00
104_T178_V0.7871.00
106_V109_E0.7871.00
32_D54_F0.7861.00
134_D306_I0.7791.00
210_L214_N0.7771.00
17_V28_V0.7711.00
95_A98_E0.7691.00
95_A99_T0.7681.00
83_E95_A0.7651.00
206_K209_P0.7631.00
271_L275_D0.7621.00
169_A176_H0.7591.00
97_I170_S0.7581.00
215_A274_C0.7551.00
264_K269_V0.7551.00
272_T323_F0.7481.00
3_I247_V0.7471.00
69_F111_A0.7451.00
151_E154_L0.7441.00
292_T295_A0.7411.00
176_H180_A0.7381.00
15_A240_A0.7371.00
16_V20_I0.7361.00
79_H107_L0.7351.00
246_V311_I0.7251.00
109_E181_W0.7241.00
15_A19_H0.7181.00
268_D272_T0.7161.00
258_I311_I0.7151.00
16_V243_L0.7101.00
181_W185_Y0.7061.00
262_N322_T0.7051.00
12_I239_H0.7031.00
126_F188_P0.7001.00
83_E96_F0.6921.00
26_D75_D0.6861.00
136_V175_D0.6851.00
289_E293_Y0.6831.00
321_E326_G0.6811.00
251_K314_A0.6791.00
189_T253_G0.6781.00
14_S18_R0.6761.00
173_S177_L0.6751.00
245_T316_G0.6741.00
103_G106_V0.6721.00
238_D241_R0.6721.00
136_V161_Y0.6721.00
49_S52_Y0.6721.00
2_K26_D0.6691.00
86_V89_S0.6681.00
222_P294_V0.6661.00
156_T309_E0.6661.00
269_V323_F0.6651.00
20_I247_V0.6641.00
141_P159_T0.6631.00
138_G162_A0.6611.00
195_S259_G0.6581.00
61_D65_M0.6571.00
200_P235_Y0.6561.00
112_R181_W0.6541.00
104_T108_L0.6501.00
108_L177_L0.6471.00
212_I216_L0.6461.00
218_G279_E0.6461.00
297_R300_H0.6441.00
238_D320_Q0.6431.00
77_V107_L0.6421.00
274_C277_L0.6391.00
129_H243_L0.6371.00
194_C197_N0.6351.00
77_V128_F0.6341.00
213_L216_L0.6341.00
165_S168_S0.6321.00
212_I331_V0.6321.00
58_D61_D0.6321.00
76_A126_F0.6311.00
90_I166_P0.6311.00
192_T242_A0.6301.00
169_A180_A0.6271.00
310_K313_R0.6211.00
34_L40_R0.6201.00
212_I273_I0.6191.00
178_V191_V0.6171.00
30_N54_F0.6171.00
331_V335_L0.6161.00
111_A114_Y0.6151.00
15_A201_Y0.6141.00
23_N241_R0.6111.00
240_A244_Y0.6111.00
112_R186_G0.6081.00
4_L68_I0.6081.00
174_S178_V0.6031.00
230_I305_A0.6021.00
135_E168_S0.6011.00
272_T327_I0.5971.00
16_V244_Y0.5971.00
196_N231_R0.5961.00
330_T333_W0.5961.00
76_A129_H0.5961.00
229_Q266_N0.5951.00
97_I169_A0.5921.00
188_P250_G0.5911.00
70_A73_Q0.5881.00
270_V274_C0.5861.00
104_T130_H0.5861.00
191_V253_G0.5861.00
24_T51_R0.5831.00
161_Y176_H0.5831.00
4_L69_F0.5821.00
65_M106_V0.5811.00
9_A34_L0.5811.00
290_Q295_A0.5811.00
292_T296_D0.5791.00
293_Y296_D0.5781.00
215_A221_L0.5781.00
26_D76_A0.5771.00
23_N245_T0.5751.00
68_I74_P0.5741.00
17_V21_I0.5731.00
129_H247_V0.5731.00
289_E292_T0.5701.00
18_R237_E0.5701.00
295_A298_P0.5671.00
82_A100_N0.5661.00
294_V297_R0.5641.00
27_S51_R0.5621.00
89_S96_F0.5611.00
200_P237_E0.5581.00
4_L77_V0.5561.00
170_S174_S0.5561.00
5_V20_I0.5551.00
157_E311_I0.5551.00
29_V68_I0.5531.00
133_T136_V0.5531.00
264_K272_T0.5521.00
268_D324_E0.5511.00
279_E289_E0.5501.00
177_L181_W0.5491.00
114_Y125_S0.5471.00
320_Q325_S0.5461.00
215_A273_I0.5441.00
87_D90_I0.5421.00
55_E64_A0.5421.00
244_Y247_V0.5411.00
202_H206_K0.5391.00
80_L194_C0.5391.00
190_I256_Y0.5391.00
129_H246_V0.5381.00
273_I327_I0.5381.00
226_K293_Y0.5381.00
214_N222_P0.5361.00
201_Y333_W0.5351.00
133_T171_K0.5341.00
79_H128_F0.5341.00
311_I319_P0.5321.00
166_P169_A0.5301.00
153_P156_T0.5301.00
4_L57_A0.5291.00
114_Y126_F0.5291.00
180_A183_R0.5281.00
139_D302_R0.5261.00
291_I294_V0.5261.00
163_P168_S0.5251.00
21_I24_T0.5251.00
208_I269_V0.5161.00
62_A110_A0.5131.00
239_H258_I0.5131.00
152_L303_R0.5101.00
251_K254_E0.5091.00
188_P251_K0.5091.00
93_P166_P0.5071.00
34_L38_G0.5061.00
290_Q294_V0.5051.00
141_P152_L0.5051.00
111_A187_L0.5041.00
216_L335_L0.5041.00
38_G43_L0.5031.00
131_I192_T0.5031.00
132_S191_V0.5031.00
136_V193_N0.5021.00
9_A30_N0.5011.00
199_G236_V0.5001.00
209_P213_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1kewA 2 0.9972 100 0.221 Contact Map
2hunA 2 0.9086 100 0.235 Contact Map
1sb8A 2 0.867 100 0.237 Contact Map
3rufA 2 0.8532 100 0.24 Contact Map
1rpnA 4 0.8753 100 0.248 Contact Map
1r6dA 2 0.8781 100 0.254 Contact Map
4egbA 5 0.8532 100 0.256 Contact Map
1orrA 3 0.8809 100 0.256 Contact Map
1oc2A 2 0.9252 100 0.256 Contact Map
1rkxA 3 0.8947 100 0.257 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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