GREMLIN Database
YDDE - Uncharacterized isomerase YddE
UniProt: P37757 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11825
Length: 297 (260)
Sequences: 4093 (3020)
Seq/√Len: 187.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
81_Y287_I3.6001.00
250_R268_T3.5561.00
31_S34_Q3.3271.00
224_V263_G3.0061.00
170_P173_D2.8341.00
177_L198_P2.7791.00
172_V176_A2.6561.00
8_V82_V2.5991.00
117_S282_S2.5851.00
28_D52_H2.5311.00
50_L79_A2.4671.00
95_W102_K2.4231.00
60_I98_S2.4171.00
119_E278_K2.4101.00
7_H289_F2.2681.00
13_S284_T2.2531.00
14_Q17_R2.2451.00
181_L220_V2.1871.00
59_R97_T2.1771.00
115_R266_E2.0661.00
233_G267_V1.9491.00
268_T280_T1.9451.00
53_S59_R1.9361.00
93_T106_T1.9261.00
4_Q292_E1.8941.00
171_E175_D1.8881.00
252_K264_M1.8491.00
169_K173_D1.8481.00
4_Q290_H1.8321.00
93_T104_R1.8261.00
254_H262_D1.7841.00
210_G229_N1.7771.00
180_D183_A1.7481.00
57_D97_T1.7351.00
9_D41_E1.7161.00
25_F50_L1.7121.00
38_I293_W1.7101.00
48_A79_A1.7021.00
12_T17_R1.6681.00
252_K266_E1.6511.00
254_H258_A1.6421.00
224_V265_I1.6211.00
70_P99_L1.6201.00
120_Q230_G1.6161.00
108_E117_S1.5931.00
117_S280_T1.5891.00
35_M61_R1.5851.00
105_V116_I1.5781.00
53_S97_T1.5781.00
115_R284_T1.5761.00
139_N183_A1.5601.00
12_T286_V1.5511.00
163_K194_N1.5431.00
183_A186_A1.5291.00
225_T228_A1.5201.00
30_L38_I1.5181.00
59_R99_L1.5101.00
143_L168_L1.5091.00
233_G269_V1.5051.00
168_L173_D1.4921.00
6_Y82_V1.4871.00
229_N253_G1.4781.00
5_V289_F1.4621.00
254_H264_M1.4601.00
39_A47_T1.4481.00
270_T280_T1.4271.00
30_L34_Q1.4191.00
163_K212_M1.4051.00
34_Q38_I1.3951.00
32_E35_M1.3891.00
167_P199_F1.3791.00
105_V118_L1.3621.00
71_I227_N1.3541.00
60_I79_A1.3491.00
168_L174_I1.3391.00
175_D258_A1.3291.00
6_Y290_H1.3211.00
119_E280_T1.3041.00
237_V269_V1.3031.00
141_L166_I1.2991.00
171_E202_R1.2981.00
57_D102_K1.2911.00
72_C75_A1.2781.00
158_T162_S1.2761.00
17_R262_D1.2761.00
253_G265_I1.2731.00
97_T102_K1.2721.00
7_H44_H1.2711.00
61_R68_E1.2641.00
21_A78_A1.2601.00
84_A107_I1.2591.00
84_A116_I1.2481.00
32_E36_Q1.2461.00
197_F229_N1.2331.00
114_Y284_T1.2281.00
195_G212_M1.2151.00
108_E113_D1.2071.00
106_T280_T1.2071.00
265_I281_I1.2061.00
81_Y85_K1.2031.00
22_G42_L1.1821.00
266_E282_S1.1811.00
5_V42_L1.1741.00
24_V293_W1.1631.00
250_R266_E1.1551.00
208_T232_M1.1441.00
135_A139_N1.1431.00
171_E209_D1.1431.00
168_L198_P1.1391.00
36_Q39_A1.1371.00
229_N265_I1.1291.00
140_A184_L1.1281.00
163_K195_G1.1261.00
6_Y25_F1.1231.00
215_P219_I1.1231.00
29_N51_L1.1111.00
45_S223_P1.1101.00
137_I164_V1.1081.00
209_D258_A1.1031.00
214_S219_I1.0991.00
92_C107_I1.0871.00
67_V217_I1.0841.00
115_R282_S1.0771.00
36_Q40_R1.0681.00
60_I96_Q1.0621.00
165_M231_P1.0551.00
33_A37_L1.0511.00
174_I200_Q1.0491.00
167_P235_W1.0481.00
5_V291_A1.0471.00
135_A145_E1.0401.00
143_L177_L1.0341.00
20_S44_H1.0341.00
25_F82_V1.0331.00
7_H42_L1.0281.00
179_P213_F1.0221.00
62_Y75_A1.0141.00
172_V175_D1.0131.00
138_I145_E1.0121.00
210_G253_G1.0121.00
104_R119_E1.0040.99
46_E225_T1.0010.99
23_V82_V0.9990.99
21_A72_C0.9940.99
212_M228_A0.9910.99
70_P163_K0.9900.99
136_A139_N0.9880.99
15_P288_L0.9860.99
80_H96_Q0.9860.99
10_A21_A0.9830.99
171_E203_P0.9830.99
22_G44_H0.9820.99
10_A78_A0.9780.99
174_I209_D0.9750.99
85_K287_I0.9670.99
288_L293_W0.9570.99
171_E200_Q0.9510.99
140_A183_A0.9480.99
46_E223_P0.9460.99
214_S218_G0.9450.99
137_I166_I0.9440.99
50_L83_R0.9430.99
165_M232_M0.9420.99
269_V279_V0.9400.99
199_F235_W0.9350.99
259_L262_D0.9200.99
210_G232_M0.9160.99
51_L59_R0.9150.99
56_S102_K0.9100.99
46_E75_A0.9040.99
270_T276_P0.9030.99
108_E115_R0.8940.99
235_W239_H0.8850.99
8_V23_V0.8800.99
53_S56_S0.8770.99
123_P161_H0.8670.98
48_A60_I0.8660.98
225_T255_Q0.8560.98
8_V285_A0.8490.98
71_I100_A0.8490.98
214_S217_I0.8460.98
69_V75_A0.8450.98
83_R87_L0.8450.98
12_T284_T0.8440.98
84_A94_I0.8430.98
13_S264_M0.8430.98
165_M235_W0.8360.98
95_W104_R0.8340.98
39_A65_P0.8340.98
133_T136_A0.8310.98
42_L289_F0.8300.98
89_L94_I0.8300.98
8_V287_I0.8290.98
34_Q37_L0.8260.98
57_D95_W0.8230.98
106_T117_S0.8230.98
62_Y72_C0.8200.98
71_I103_H0.8190.98
215_P218_G0.8190.98
98_S118_L0.8160.98
207_E244_H0.8100.98
9_D16_F0.8070.98
48_A75_A0.8050.98
269_V276_P0.8040.98
10_A62_Y0.7990.97
16_F41_E0.7980.97
138_I143_L0.7970.97
129_L164_V0.7960.97
154_I166_I0.7930.97
214_S220_V0.7930.97
224_V253_G0.7850.97
26_P29_N0.7830.97
125_F234_A0.7800.97
53_S57_D0.7700.97
37_L40_R0.7660.97
81_Y285_A0.7640.97
175_D209_D0.7640.97
35_M63_F0.7630.97
208_T253_G0.7620.97
136_A183_A0.7600.97
82_V86_V0.7580.96
50_L87_L0.7580.96
164_V193_C0.7580.96
171_E258_A0.7550.96
197_F212_M0.7530.96
162_S194_N0.7530.96
29_N32_E0.7520.96
207_E251_V0.7520.96
182_N185_T0.7520.96
140_A196_F0.7480.96
206_N254_H0.7480.96
268_T282_S0.7470.96
167_P239_H0.7410.96
174_I177_L0.7370.96
117_S268_T0.7320.96
24_V42_L0.7300.96
62_Y78_A0.7290.96
173_D176_A0.7290.96
259_L263_G0.7270.96
137_I140_A0.7180.95
41_E261_R0.7170.95
212_M225_T0.7160.95
77_V227_N0.7130.95
9_D12_T0.7110.95
197_F228_A0.7100.95
206_N258_A0.7080.95
69_V161_H0.7070.95
21_A62_Y0.7060.95
6_Y86_V0.6990.94
62_Y96_Q0.6910.94
188_S216_A0.6900.94
138_I144_T0.6900.94
80_H94_I0.6890.94
134_R138_I0.6890.94
21_A75_A0.6870.94
46_E69_V0.6850.94
181_L184_L0.6800.94
56_S97_T0.6790.94
7_H20_S0.6760.93
168_L177_L0.6740.93
201_I208_T0.6700.93
181_L215_P0.6690.93
16_F261_R0.6650.93
179_P184_L0.6650.93
136_A186_A0.6650.93
184_L196_F0.6640.93
140_A187_I0.6630.93
19_N225_T0.6620.93
212_M232_M0.6600.93
167_P201_I0.6600.93
125_F157_A0.6590.93
86_V290_H0.6580.93
123_P160_G0.6580.93
28_D51_L0.6560.92
129_L132_E0.6530.92
200_Q209_D0.6500.92
4_Q22_G0.6490.92
161_H231_P0.6480.92
202_R206_N0.6460.92
35_M51_L0.6460.92
32_E61_R0.6450.92
62_Y69_V0.6450.92
197_F232_M0.6440.92
75_A78_A0.6430.92
6_Y287_I0.6370.91
194_N198_P0.6320.91
46_E65_P0.6280.91
13_S17_R0.6260.91
108_E268_T0.6210.90
171_E174_I0.6210.90
4_Q291_A0.6210.90
17_R37_L0.6200.90
4_Q86_V0.6190.90
287_I290_H0.6170.90
155_Q239_H0.6160.90
19_N226_G0.6130.90
232_M236_L0.6130.90
199_F236_L0.6100.89
165_M197_F0.6100.89
5_V288_L0.6100.89
113_D284_T0.6060.89
70_P161_H0.6040.89
24_V47_T0.6030.89
269_V277_E0.6020.89
141_L198_P0.6020.89
208_T258_A0.6010.89
224_V229_N0.6010.89
90_G93_T0.6000.89
129_L133_T0.5980.88
146_D169_K0.5970.88
20_S45_S0.5970.88
141_L196_F0.5960.88
64_T219_I0.5960.88
237_V251_V0.5920.88
21_A285_A0.5900.88
21_A60_I0.5890.88
143_L173_D0.5880.88
40_R66_T0.5880.88
43_G261_R0.5880.88
126_E155_Q0.5860.87
212_M231_P0.5860.87
10_A75_A0.5790.87
26_P30_L0.5780.87
197_F210_G0.5780.87
120_Q159_T0.5780.87
31_S35_M0.5750.86
40_R260_G0.5730.86
200_Q203_P0.5720.86
104_R107_I0.5720.86
81_Y116_I0.5720.86
25_F29_N0.5710.86
66_T218_G0.5700.86
162_S231_P0.5680.86
74_H226_G0.5660.86
207_E254_H0.5660.86
158_T161_H0.5620.85
251_V267_V0.5620.85
134_R145_E0.5610.85
233_G281_I0.5610.85
122_T279_V0.5590.85
157_A165_M0.5580.85
66_T219_I0.5560.85
98_S101_G0.5540.84
118_L230_G0.5530.84
206_N264_M0.5510.84
185_T216_A0.5510.84
27_A51_L0.5500.84
83_R94_I0.5480.84
163_K228_A0.5430.83
194_N227_N0.5410.83
202_R209_D0.5400.83
123_P230_G0.5400.83
199_F202_R0.5400.83
141_L177_L0.5390.83
42_L288_L0.5390.83
4_Q26_P0.5380.83
24_V38_I0.5370.83
166_I196_F0.5320.82
185_T220_V0.5300.82
155_Q159_T0.5300.82
123_P231_P0.5290.82
157_A160_G0.5290.82
15_P286_V0.5280.82
82_V85_K0.5250.81
161_H227_N0.5240.81
9_D14_Q0.5230.81
75_A222_D0.5220.81
157_A231_P0.5220.81
22_G72_C0.5220.81
32_E99_L0.5220.81
64_T69_V0.5210.81
167_P174_I0.5180.80
223_P263_G0.5180.80
171_E254_H0.5180.80
154_I164_V0.5170.80
267_V281_I0.5170.80
72_C225_T0.5160.80
48_A72_C0.5100.79
8_V81_Y0.5090.79
100_A103_H0.5080.79
10_A72_C0.5080.79
45_S65_P0.5070.79
62_Y71_I0.5070.79
10_A224_V0.5060.79
202_R207_E0.5040.78
80_H105_V0.5030.78
52_H58_V0.5020.78
54_D97_T0.5020.78
72_C76_T0.5010.78
258_A262_D0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1qyaA 2 0.9933 100 0.245 Contact Map
1ym5A 2 0.9529 100 0.252 Contact Map
3ednA 2 0.9832 100 0.263 Contact Map
1xubA 2 0.9293 100 0.273 Contact Map
1s7jA 1 0.8754 100 0.29 Contact Map
1u0kA 2 0.9428 100 0.292 Contact Map
4dunA 2 0.8687 100 0.311 Contact Map
4jbdA 2 0.8754 100 0.399 Contact Map
3ejxA 5 0.9091 100 0.423 Contact Map
4juuA 2 0.9024 100 0.428 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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