GREMLIN Database
WBBK - Putative glycosyltransferase WbbK
UniProt: P37751 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11985
Length: 372 (330)
Sequences: 55262 (47107)
Seq/√Len: 2593.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
202_F274_S4.5811.00
230_K257_H3.6381.00
149_A171_I3.2291.00
240_N244_K3.1031.00
277_V293_A3.0561.00
200_T232_L2.9031.00
222_K330_V2.7611.00
232_L259_L2.7191.00
353_R358_L2.7111.00
218_S246_I2.6401.00
198_E230_K2.6091.00
203_Y213_Y2.5701.00
226_Q334_I2.5031.00
224_K255_N2.3631.00
339_G342_K2.2381.00
158_K162_I2.1931.00
218_S326_D2.1851.00
212_N215_L2.1831.00
38_I86_A2.1281.00
199_L337_K2.1141.00
246_I250_A2.0761.00
304_D309_R2.0701.00
38_I84_L2.0441.00
239_E242_Y2.0371.00
332_L335_D2.0291.00
234_T270_C2.0111.00
90_I107_Y2.0001.00
232_L257_H1.9931.00
200_T230_K1.9861.00
222_K327_D1.9661.00
220_A231_F1.9061.00
200_T273_I1.9041.00
351_I356_N1.8991.00
199_L275_D1.8871.00
201_I276_I1.8661.00
312_L318_K1.8651.00
335_D342_K1.8361.00
313_G316_E1.8271.00
317_K353_R1.8251.00
297_G351_I1.8091.00
343_K347_D1.8061.00
335_D339_G1.7831.00
248_S253_L1.7781.00
319_A332_L1.7691.00
212_N282_R1.7631.00
38_I57_I1.7571.00
236_S240_N1.7461.00
221_R250_A1.7191.00
322_D328_M1.7141.00
155_F158_K1.7081.00
304_D322_D1.6921.00
334_I338_K1.6711.00
363_E367_F1.6701.00
262_L266_K1.6701.00
216_I231_F1.6661.00
277_V298_K1.6481.00
155_F310_E1.6471.00
158_K172_V1.6361.00
313_G353_R1.6301.00
204_P267_I1.6201.00
176_E361_F1.5951.00
152_V170_I1.5941.00
220_A229_I1.5721.00
106_V147_N1.5551.00
316_E349_N1.5371.00
319_A335_D1.5241.00
352_Y357_V1.5161.00
216_I278_C1.5141.00
342_K345_I1.5131.00
155_F172_V1.5031.00
328_M332_L1.4811.00
158_K170_I1.4751.00
345_I349_N1.4621.00
313_G317_K1.4551.00
214_E246_I1.4541.00
325_N328_M1.4501.00
23_K27_A1.4421.00
28_A31_N1.4371.00
28_A362_D1.4291.00
215_L282_R1.4271.00
210_F283_L1.4221.00
38_I55_K1.4221.00
223_L334_I1.4171.00
215_L326_D1.4111.00
234_T259_L1.4001.00
33_E366_N1.3901.00
302_A308_T1.3871.00
262_L270_C1.3861.00
266_K269_H1.3821.00
232_L270_C1.3631.00
274_S298_K1.3631.00
321_F332_L1.3551.00
152_V158_K1.3371.00
268_D296_R1.3351.00
263_D266_K1.3331.00
349_N352_Y1.3321.00
200_T275_D1.3281.00
28_A365_V1.3181.00
203_Y216_I1.3161.00
232_L274_S1.3111.00
234_T262_L1.2971.00
326_D330_V1.2901.00
222_K326_D1.2841.00
245_Y249_L1.2781.00
219_A329_L1.2771.00
213_Y233_L1.2741.00
207_P233_L1.2671.00
201_I278_C1.2631.00
202_F234_T1.2601.00
259_L262_L1.2501.00
201_I333_I1.2491.00
246_I249_L1.2451.00
91_C104_R1.2391.00
328_M331_K1.2091.00
155_F159_E1.2061.00
286_W291_S1.1991.00
199_L276_I1.1911.00
272_N296_R1.1881.00
330_V334_I1.1781.00
182_K296_R1.1701.00
282_R324_N1.1671.00
195_N198_E1.1651.00
344_D348_A1.1591.00
21_I288_L1.1531.00
279_F290_L1.1371.00
347_D350_F1.1311.00
244_K248_S1.1301.00
267_I271_Y1.1301.00
214_E218_S1.1291.00
159_E162_I1.1281.00
181_D268_D1.1221.00
363_E366_N1.1221.00
151_F368_I1.1181.00
221_R225_E1.1171.00
342_K346_S1.1171.00
290_L308_T1.1161.00
236_S261_Y1.0931.00
215_L218_S1.0891.00
215_L303_S1.0841.00
153_Q157_M1.0831.00
241_A244_K1.0751.00
199_L229_I1.0741.00
361_F364_L1.0741.00
360_G363_E1.0721.00
321_F329_L1.0721.00
271_Y296_R1.0721.00
297_G348_A1.0711.00
200_T274_S1.0681.00
314_S332_L1.0651.00
241_A245_Y1.0601.00
153_Q175_P1.0591.00
222_K226_Q1.0561.00
336_F346_S1.0541.00
279_F289_P1.0481.00
303_S321_F1.0421.00
199_L228_N1.0411.00
302_A320_F1.0391.00
215_L324_N1.0371.00
298_K347_D1.0371.00
264_K267_I1.0361.00
340_N343_K1.0331.00
259_L270_C1.0251.00
30_N34_N1.0211.00
152_V161_F1.0211.00
331_K335_D1.0201.00
198_E228_N1.0191.00
268_D272_N1.0171.00
319_A346_S1.0171.00
218_S250_A1.0101.00
348_A352_Y1.0011.00
352_Y356_N1.0001.00
208_R238_T0.9991.00
109_H288_L0.9951.00
280_P329_L0.9861.00
75_V79_K0.9861.00
247_I258_F0.9851.00
204_P271_Y0.9841.00
347_D351_I0.9821.00
340_N344_D0.9811.00
294_K300_V0.9791.00
214_E242_Y0.9771.00
222_K225_E0.9751.00
232_L273_I0.9731.00
287_G308_T0.9721.00
159_E163_K0.9701.00
24_K27_A0.9691.00
319_A336_F0.9681.00
290_L302_A0.9681.00
105_Y151_F0.9651.00
152_V157_M0.9611.00
281_S284_E0.9601.00
182_K268_D0.9571.00
201_I220_A0.9551.00
202_F270_C0.9541.00
214_E282_R0.9491.00
302_A312_L0.9471.00
277_V289_P0.9471.00
307_F310_E0.9441.00
216_I280_P0.9391.00
204_P234_T0.9371.00
104_R147_N0.9351.00
153_Q285_T0.9271.00
293_A298_K0.9271.00
247_I252_G0.9251.00
223_L333_I0.9241.00
301_L321_F0.9231.00
206_V210_F0.9151.00
160_K164_K0.9151.00
215_L329_L0.9121.00
223_L229_I0.9121.00
175_P288_L0.9101.00
147_N150_V0.9081.00
178_K181_D0.9061.00
78_K82_K0.9021.00
24_K361_F0.9001.00
160_K163_K0.9001.00
26_L39_A0.9001.00
230_K255_N0.9001.00
217_I247_I0.8991.00
346_S349_N0.8951.00
294_K350_F0.8931.00
220_A255_N0.8911.00
306_P309_R0.8901.00
294_K317_K0.8891.00
16_G19_F0.8891.00
28_A33_E0.8821.00
290_L300_V0.8811.00
344_D347_D0.8801.00
103_K148_T0.8751.00
91_C106_V0.8701.00
203_Y233_L0.8681.00
20_T24_K0.8621.00
319_A342_K0.8611.00
223_L337_K0.8601.00
331_K334_I0.8551.00
284_E287_G0.8551.00
317_K350_F0.8541.00
26_L30_N0.8531.00
242_Y245_Y0.8511.00
38_I42_H0.8481.00
20_T264_K0.8481.00
279_F308_T0.8471.00
364_L367_F0.8471.00
211_K284_E0.8451.00
364_L368_I0.8391.00
301_L332_L0.8381.00
179_L360_G0.8381.00
229_I337_K0.8361.00
223_L330_V0.8341.00
294_K353_R0.8301.00
290_L311_T0.8301.00
271_Y298_K0.8291.00
219_A330_V0.8271.00
218_S221_R0.8271.00
214_E239_E0.8221.00
276_I336_F0.8211.00
242_Y246_I0.8171.00
327_D331_K0.8161.00
221_R224_K0.8151.00
151_F173_S0.8151.00
299_W347_D0.8141.00
156_W159_E0.8111.00
202_F271_Y0.8091.00
80_L84_L0.8091.00
322_D325_N0.8091.00
339_G343_K0.8071.00
278_C333_I0.8031.00
219_A326_D0.8021.00
353_R359_V0.8001.00
312_L320_F0.8001.00
196_P199_L0.7991.00
176_E364_L0.7991.00
315_Y335_D0.7971.00
211_K289_P0.7951.00
21_I109_H0.7891.00
224_K227_S0.7881.00
245_Y248_S0.7871.00
203_Y280_P0.7841.00
24_K28_A0.7821.00
360_G364_L0.7801.00
142_I146_K0.7761.00
218_S222_K0.7731.00
269_H273_I0.7711.00
162_I170_I0.7691.00
262_L267_I0.7671.00
74_Y78_K0.7661.00
304_D320_F0.7641.00
209_V214_E0.7621.00
270_C273_I0.7621.00
264_K268_D0.7601.00
75_V78_K0.7581.00
22_L92_L0.7571.00
276_I333_I0.7561.00
247_I250_A0.7521.00
24_K178_K0.7521.00
36_S55_K0.7501.00
226_Q330_V0.7481.00
247_I256_V0.7471.00
162_I165_Y0.7461.00
346_S350_F0.7451.00
109_H153_Q0.7451.00
204_P277_V0.7451.00
299_W336_F0.7451.00
269_H272_N0.7451.00
105_Y149_A0.7441.00
79_K83_E0.7441.00
314_S317_K0.7441.00
174_R310_E0.7401.00
205_A213_Y0.7381.00
16_G206_V0.7381.00
221_R252_G0.7371.00
203_Y277_V0.7371.00
226_Q331_K0.7341.00
305_F308_T0.7321.00
211_K281_S0.7301.00
88_H105_Y0.7291.00
207_P240_N0.7281.00
90_I368_I0.7261.00
203_Y231_F0.7251.00
275_D343_K0.7231.00
91_C97_A0.7231.00
345_I348_A0.7221.00
153_Q288_L0.7131.00
92_L109_H0.7131.00
138_L142_I0.7131.00
341_L345_I0.7121.00
110_N210_F0.7121.00
178_K182_K0.7081.00
185_L272_N0.6991.00
279_F287_G0.6991.00
336_F343_K0.6981.00
223_L227_S0.6971.00
193_K196_P0.6971.00
20_T23_K0.6971.00
209_V282_R0.6961.00
171_I367_F0.6951.00
195_N230_K0.6941.00
301_L336_F0.6941.00
327_D330_V0.6941.00
226_Q338_K0.6891.00
362_D366_N0.6891.00
287_G290_L0.6881.00
201_I229_I0.6871.00
209_V239_E0.6861.00
171_I174_R0.6851.00
309_R320_F0.6821.00
291_S359_V0.6791.00
30_N37_F0.6781.00
156_W160_K0.6771.00
303_S329_L0.6761.00
21_I175_P0.6761.00
30_N53_W0.6761.00
361_F365_V0.6741.00
335_D338_K0.6701.00
92_L107_Y0.6641.00
138_L141_K0.6631.00
86_A102_K0.6631.00
317_K349_N0.6611.00
174_R367_F0.6541.00
199_L340_N0.6491.00
244_K258_F0.6481.00
286_W359_V0.6421.00
162_I166_S0.6411.00
173_S368_I0.6401.00
30_N35_V0.6381.00
30_N33_E0.6371.00
350_F353_R0.6371.00
21_I107_Y0.6371.00
277_V300_V0.6371.00
314_S319_A0.6341.00
217_I256_V0.6321.00
213_Y239_E0.6301.00
303_S323_S0.6301.00
205_A211_K0.6271.00
174_R359_V0.6261.00
224_K228_N0.6261.00
349_N353_R0.6231.00
220_A223_L0.6231.00
152_V172_V0.6221.00
270_C274_S0.6211.00
219_A333_I0.6201.00
25_F368_I0.6191.00
93_H96_T0.6191.00
107_Y151_F0.6181.00
141_K145_K0.6171.00
278_C329_L0.6161.00
348_A351_I0.6111.00
26_L37_F0.6111.00
199_L202_F0.6091.00
154_Q157_M0.6081.00
31_N362_D0.6081.00
212_N324_N0.6081.00
201_I337_K0.6051.00
27_A52_P0.6041.00
271_Y289_P0.6001.00
179_L295_E0.6001.00
321_F328_M0.5981.00
294_K347_D0.5971.00
21_I368_I0.5971.00
156_W309_R0.5951.00
341_L344_D0.5941.00
46_E49_E0.5931.00
202_F277_V0.5921.00
239_E243_A0.5921.00
247_I253_L0.5911.00
134_M137_G0.5911.00
276_I301_L0.5891.00
202_F298_K0.5881.00
24_K288_L0.5871.00
304_D323_S0.5861.00
86_A89_W0.5861.00
33_E362_D0.5861.00
27_A31_N0.5841.00
305_F309_R0.5801.00
183_S272_N0.5781.00
343_K346_S0.5771.00
217_I243_A0.5761.00
33_E365_V0.5751.00
58_E61_E0.5741.00
215_L219_A0.5731.00
18_P93_H0.5721.00
358_L363_E0.5711.00
216_I220_A0.5711.00
207_P213_Y0.5701.00
15_T261_Y0.5691.00
199_L343_K0.5691.00
312_L317_K0.5671.00
157_M160_K0.5671.00
181_D264_K0.5671.00
155_F174_R0.5661.00
301_L333_I0.5651.00
21_I25_F0.5651.00
12_N19_F0.5611.00
194_N198_E0.5611.00
209_V242_Y0.5601.00
293_A300_V0.5601.00
228_N255_N0.5571.00
200_T270_C0.5571.00
34_N37_F0.5571.00
132_F135_L0.5551.00
275_D340_N0.5541.00
104_R148_T0.5541.00
291_S311_T0.5531.00
243_A246_I0.5531.00
142_I145_K0.5531.00
88_H103_K0.5531.00
180_S183_S0.5521.00
212_N280_P0.5511.00
81_S86_A0.5501.00
80_L83_E0.5481.00
197_S228_N0.5481.00
212_N303_S0.5471.00
244_K247_I0.5461.00
224_K229_I0.5451.00
206_V211_K0.5421.00
149_A153_Q0.5421.00
299_W343_K0.5411.00
91_C100_V0.5401.00
281_S285_T0.5401.00
41_V56_F0.5401.00
35_V87_T0.5391.00
271_Y277_V0.5391.00
173_S367_F0.5391.00
112_A115_Y0.5371.00
234_T267_I0.5361.00
227_S338_K0.5361.00
202_F232_L0.5351.00
25_F28_A0.5351.00
289_P293_A0.5301.00
109_H175_P0.5301.00
89_W102_K0.5301.00
280_P303_S0.5281.00
183_S186_T0.5261.00
287_G291_S0.5261.00
26_L54_V0.5251.00
111_P114_F0.5251.00
27_A30_N0.5241.00
55_K58_E0.5241.00
162_I169_N0.5231.00
207_P237_G0.5211.00
177_I295_E0.5201.00
297_G347_D0.5191.00
231_F256_V0.5181.00
214_E243_A0.5161.00
174_R286_W0.5161.00
52_P55_K0.5151.00
219_A223_L0.5111.00
21_I92_L0.5101.00
276_I337_K0.5101.00
157_M285_T0.5101.00
108_C111_P0.5081.00
149_A169_N0.5051.00
198_E273_I0.5031.00
221_R249_L0.5031.00
281_S287_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2r60A 1 0.9866 100 0.186 Contact Map
4n9wA 1 0.8898 100 0.195 Contact Map
3c48A 2 0.9462 100 0.202 Contact Map
2x6qA 1 0.9328 100 0.214 Contact Map
3froA 3 0.9758 100 0.219 Contact Map
3okpA 1 0.9247 100 0.225 Contact Map
1rzuA 1 0.9704 100 0.227 Contact Map
2iw1A 1 0.9328 100 0.229 Contact Map
2jjmA 4 0.9113 100 0.231 Contact Map
2x0dA 2 0.8844 100 0.238 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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