GREMLIN Database
WBBJ - Putative lipopolysaccharide biosynthesis O-acetyl transferase WbbJ
UniProt: P37750 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11984
Length: 196 (153)
Sequences: 3513 (2681)
Seq/√Len: 216.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
82_I88_V3.5901.00
136_G155_N2.9961.00
102_I133_V2.8581.00
73_N93_D2.7621.00
156_G172_N2.6951.00
169_I175_I2.6901.00
160_G176_A2.5961.00
155_N171_E2.4231.00
47_N69_F2.3721.00
137_Q155_N2.3361.00
79_Y99_K2.3221.00
69_F89_T2.3031.00
148_L161_A2.2651.00
141_L147_V2.0981.00
176_A183_I2.0971.00
49_G72_D2.0921.00
72_D92_R2.0131.00
157_V173_T1.9591.00
33_I36_F1.9151.00
89_T134_V1.9001.00
138_R156_G1.8621.00
157_V171_E1.8621.00
51_N73_N1.8251.00
93_D138_R1.8031.00
70_F74_V1.7471.00
173_T185_K1.6911.00
157_V169_I1.6741.00
175_I182_I1.6691.00
103_T143_E1.6031.00
102_I135_I1.6001.00
24_T31_C1.4901.00
71_S92_R1.4751.00
48_F52_F1.4631.00
159_V169_I1.4481.00
96_I102_I1.4391.00
141_L145_V1.4321.00
136_G152_I1.4291.00
173_T182_I1.4271.00
74_V92_R1.4221.00
170_P182_I1.3581.00
163_S180_A1.3211.00
91_G137_Q1.3171.00
85_I130_S1.3151.00
50_E72_D1.3141.00
69_F87_S1.3021.00
92_R137_Q1.3021.00
86_E130_S1.2841.00
134_V152_I1.2761.00
109_S158_V1.2711.00
135_I141_L1.2641.00
159_V175_I1.2511.00
52_F74_V1.2061.00
76_V80_V1.2031.00
175_I180_A1.1931.00
152_I168_S1.1741.00
182_I185_K1.1561.00
25_R30_N1.1551.00
60_L68_I1.1431.00
170_P173_T1.1361.00
124_D138_R1.1201.00
94_T137_Q1.1141.00
24_T28_Y1.1121.00
76_V96_I1.1101.00
24_T30_N1.0991.00
74_V137_Q1.0991.00
109_S174_V1.0961.00
38_C42_N1.0911.00
151_T168_S1.0761.00
100_V145_V1.0651.00
101_F144_N1.0621.00
153_I169_I1.0591.00
163_S178_V1.0431.00
90_I96_I1.0401.00
131_S150_G1.0361.00
70_F76_V1.0301.00
99_K144_N1.0241.00
81_H99_K1.0101.00
80_V100_V1.0051.00
123_P126_R1.0031.00
101_F146_T1.0021.00
139_V157_V1.0011.00
94_T155_N1.0011.00
52_F70_F0.9951.00
36_F39_Y0.9921.00
74_V94_T0.9911.00
96_I100_V0.9851.00
106_N149_P0.9821.00
102_I147_V0.9821.00
46_I69_F0.9631.00
154_G171_E0.9631.00
145_V163_S0.9541.00
70_F90_I0.9531.00
136_G157_V0.9521.00
55_G75_Q0.9310.99
170_P175_I0.9300.99
91_G136_G0.8920.99
57_G79_Y0.8890.99
164_V178_V0.8860.99
91_G134_V0.8800.99
106_N131_S0.8750.99
90_I102_I0.8740.99
136_G171_E0.8720.99
101_F143_E0.8680.99
59_R78_D0.8620.99
96_I141_L0.8620.99
51_N72_D0.8570.99
58_L68_I0.8540.99
29_R36_F0.8520.99
147_V153_I0.8450.99
151_T167_G0.8330.99
52_F92_R0.8280.99
98_S143_E0.8230.99
90_I135_I0.8170.99
42_N48_F0.8060.99
139_V171_E0.7900.98
68_I84_S0.7870.98
26_V29_R0.7840.98
97_A140_W0.7810.98
148_L166_R0.7800.98
107_H140_W0.7800.98
153_I175_I0.7740.98
174_V186_Y0.7730.98
104_D149_P0.7680.98
37_P56_V0.7630.98
82_I102_I0.7620.98
41_R45_S0.7610.98
29_R37_P0.7580.98
86_E104_D0.7570.98
155_N172_N0.7540.98
165_V180_A0.7510.98
156_G171_E0.7510.98
106_N129_E0.7500.98
184_K187_N0.7490.98
48_F70_F0.7420.97
94_T139_V0.7310.97
87_S132_A0.7300.97
61_D85_I0.7210.97
30_N33_I0.7200.97
25_R28_Y0.7180.97
133_V149_P0.7180.97
146_T164_V0.7160.97
138_R155_N0.7130.97
27_F31_C0.7100.97
157_V170_P0.7080.97
29_R32_R0.6980.96
169_I180_A0.6960.96
153_I159_V0.6940.96
48_F72_D0.6880.96
27_F30_N0.6880.96
54_S58_L0.6820.96
96_I135_I0.6810.96
70_F94_T0.6810.96
162_N178_V0.6780.96
52_F72_D0.6760.96
29_R40_I0.6740.96
25_R29_R0.6700.95
110_F122_P0.6690.95
122_P126_R0.6680.95
139_V153_I0.6650.95
154_G168_S0.6650.95
174_V184_K0.6630.95
146_T162_N0.6600.95
94_T135_I0.6580.95
59_R79_Y0.6570.95
158_V174_V0.6540.95
74_V90_I0.6510.95
154_G170_P0.6440.94
80_V96_I0.6440.94
76_V82_I0.6390.94
87_S134_V0.6310.94
153_I168_S0.6220.93
122_P125_M0.6210.93
139_V155_N0.6200.93
168_S175_I0.6170.93
100_V141_L0.6170.93
169_I173_T0.6170.93
28_Y32_R0.6160.93
58_L80_V0.6150.93
28_Y31_C0.6110.93
26_V41_R0.6040.92
29_R33_I0.6000.92
111_K156_G0.5970.92
34_I38_C0.5960.92
177_G180_A0.5960.92
85_I105_H0.5950.92
89_T132_A0.5930.91
154_G175_I0.5840.91
109_S186_Y0.5820.91
31_C36_F0.5720.90
40_I44_G0.5720.90
49_G52_F0.5710.90
133_V153_I0.5700.90
24_T32_R0.5690.90
159_V180_A0.5680.90
103_T146_T0.5650.89
122_P127_T0.5630.89
176_A182_I0.5610.89
77_N140_W0.5580.89
90_I94_T0.5580.89
84_S104_D0.5570.89
25_R36_F0.5560.89
39_Y43_D0.5560.89
77_N97_A0.5540.88
139_V159_V0.5530.88
83_A105_H0.5460.88
169_I176_A0.5450.88
30_N34_I0.5380.87
97_A105_H0.5360.87
178_V181_K0.5350.87
157_V175_I0.5340.87
88_V133_V0.5340.87
49_G71_S0.5280.86
24_T29_R0.5250.86
101_F133_V0.5240.86
93_D137_Q0.5210.85
86_E106_N0.5180.85
107_H158_V0.5130.84
68_I88_V0.5130.84
67_V87_S0.5110.84
49_G92_R0.5110.84
29_R35_R0.5100.84
141_L159_V0.5090.84
154_G169_I0.5080.84
151_T166_R0.5080.84
124_D127_T0.5070.84
77_N98_S0.5060.84
47_N72_D0.5050.83
105_H130_S0.5040.83
163_S176_A0.5010.83
61_D83_A0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1krrA 3 0.9439 100 0.339 Contact Map
3srtA 3 0.9031 100 0.342 Contact Map
3fttA 3 0.9082 100 0.347 Contact Map
3nz2A 4 0.8929 100 0.354 Contact Map
2p2oA 3 0.898 100 0.357 Contact Map
3hjjA 3 0.9031 100 0.363 Contact Map
1ocxA 3 0.8776 100 0.393 Contact Map
3vbiA 3 0.9133 100 0.397 Contact Map
2wlgA 3 0.9439 100 0.428 Contact Map
3jqyB 3 0.9235 100 0.436 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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