GREMLIN Database
GLF - UDP-galactopyranose mutase
UniProt: P37747 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11981
Length: 367 (348)
Sequences: 17701 (14264)
Seq/√Len: 764.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
3_D26_K4.4541.00
5_I224_A4.0601.00
28_L208_K3.8301.00
32_K212_D3.7531.00
36_I209_L3.3921.00
3_D225_H3.3751.00
229_Y236_Y3.1401.00
16_C228_I2.9861.00
5_I30_I2.8851.00
196_K199_E2.8461.00
34_N210_G2.7481.00
36_I202_L2.7311.00
356_A360_V2.6711.00
30_I222_S2.5911.00
195_T199_E2.5431.00
226_R336_I2.5011.00
26_K206_D2.3781.00
4_Y25_K2.3701.00
216_D219_S2.2941.00
19_E357_L2.2911.00
9_S36_I2.2751.00
74_E191_V2.2621.00
208_K211_I2.2561.00
108_D111_E2.2031.00
7_V229_Y2.1771.00
230_T338_G2.1641.00
15_V353_I2.1301.00
5_I222_S2.1161.00
3_D28_L2.0721.00
200_K203_E2.0561.00
30_I224_A1.9951.00
132_E136_I1.9881.00
30_I208_K1.9561.00
7_V231_G1.9331.00
35_H41_Y1.9061.00
12_F230_T1.9031.00
11_L349_M1.8861.00
129_E137_S1.8811.00
19_E22_K1.8341.00
202_L207_V1.7941.00
22_K71_D1.7701.00
18_N204_G1.7661.00
141_E145_Q1.7371.00
18_N22_K1.7261.00
208_K220_L1.7251.00
28_L224_A1.7131.00
231_G236_Y1.6711.00
217_K220_L1.6651.00
4_Y226_R1.6221.00
296_T299_Y1.6061.00
132_E161_K1.5901.00
19_E361_K1.5791.00
108_D112_A1.5711.00
63_K67_D1.5691.00
4_Y20_L1.5271.00
296_T300_P1.5081.00
208_K222_S1.5071.00
309_P312_P1.4981.00
130_N133_E1.4981.00
28_L206_D1.4891.00
17_A29_V1.4791.00
196_K200_K1.4771.00
228_I363_I1.4611.00
76_N191_V1.4481.00
67_D71_D1.4371.00
214_L217_K1.4351.00
111_E114_N1.4271.00
21_K205_V1.4231.00
40_A198_I1.4131.00
304_K308_E1.4131.00
114_N118_A1.4101.00
3_D25_K1.4081.00
299_Y302_E1.4071.00
294_V300_P1.4061.00
42_T49_Q1.4051.00
296_T303_W1.3981.00
293_T296_T1.3941.00
211_I220_L1.3911.00
103_M106_V1.3801.00
212_D217_K1.3771.00
297_K300_P1.3681.00
36_I207_V1.3601.00
194_Y349_M1.3581.00
283_K286_D1.3571.00
102_Q106_V1.3561.00
325_Y328_L1.3521.00
109_P112_A1.3501.00
232_P235_Q1.3481.00
294_V299_Y1.3361.00
298_E301_L1.3321.00
211_I218_D1.3311.00
324_K327_E1.3271.00
359_Q362_N1.3161.00
6_I17_A1.3121.00
101_H104_W1.3111.00
216_D220_L1.3101.00
326_R329_A1.2991.00
294_V298_E1.2851.00
36_I198_I1.2781.00
336_I359_Q1.2751.00
5_I28_L1.2631.00
100_F103_M1.2511.00
64_Y357_L1.2461.00
112_A118_A1.2391.00
312_P316_N1.2381.00
21_K27_V1.2361.00
66_W70_N1.2351.00
29_V207_V1.2321.00
13_G230_T1.2211.00
354_S358_Y1.2131.00
99_T102_Q1.2101.00
30_I213_F1.2101.00
67_D357_L1.2041.00
112_A115_I1.2031.00
44_D47_G1.2031.00
192_G196_K1.2011.00
129_E133_E1.2011.00
44_D49_Q1.2011.00
275_P278_R1.1991.00
114_N117_N1.1971.00
136_I145_Q1.1961.00
293_T298_E1.1921.00
264_N267_I1.1911.00
294_V297_K1.1911.00
115_I118_A1.1891.00
211_I216_D1.1881.00
12_F355_A1.1871.00
48_I255_R1.1841.00
266_V269_F1.1811.00
82_P85_I1.1761.00
295_V298_E1.1671.00
100_F104_W1.1621.00
293_T299_Y1.1541.00
226_R334_K1.1541.00
295_V299_Y1.1511.00
309_P313_V1.1491.00
293_T297_K1.1401.00
170_R173_V1.1341.00
100_F105_G1.1311.00
199_E203_E1.1291.00
342_A358_Y1.1281.00
83_L86_Y1.1211.00
102_Q105_G1.1171.00
199_E202_L1.1151.00
292_H298_E1.1121.00
289_E292_H1.1051.00
211_I222_S1.0871.00
336_I362_N1.0871.00
19_E356_A1.0861.00
6_I13_G1.0851.00
214_L219_S1.0841.00
298_E303_W1.0831.00
108_D115_I1.0811.00
284_H287_Y1.0731.00
42_T195_T1.0701.00
136_I141_E1.0661.00
110_Q114_N1.0621.00
358_Y362_N1.0611.00
300_P303_W1.0601.00
67_D70_N1.0571.00
216_D222_S1.0561.00
108_D118_A1.0561.00
315_D318_N1.0501.00
332_E335_V1.0501.00
11_L40_A1.0491.00
30_I211_I1.0481.00
282_H286_D1.0471.00
6_I27_V1.0461.00
336_I363_I1.0441.00
323_K326_R1.0441.00
281_E284_H1.0421.00
101_H106_V1.0421.00
80_N83_L1.0421.00
12_F352_V1.0401.00
224_A227_I1.0381.00
311_Y315_D1.0371.00
112_A116_I1.0321.00
338_G359_Q1.0291.00
18_N201_M1.0251.00
12_F338_G1.0211.00
111_E118_A1.0171.00
323_K327_E1.0131.00
111_E115_I1.0111.00
277_T281_E1.0101.00
43_E53_Y1.0091.00
263_G266_V1.0061.00
283_K287_Y1.0051.00
82_P86_Y0.9971.00
202_L209_L0.9951.00
159_S162_E0.9931.00
115_I119_Q0.9931.00
64_Y67_D0.9911.00
298_E302_E0.9871.00
104_W107_K0.9831.00
357_L361_K0.9831.00
28_L222_S0.9831.00
174_R181_Y0.9761.00
16_C356_A0.9701.00
108_D119_Q0.9641.00
64_Y354_S0.9621.00
9_S29_V0.9601.00
293_T301_L0.9541.00
310_Y313_V0.9531.00
292_H299_Y0.9521.00
19_E23_L0.9511.00
153_E159_S0.9501.00
68_Y72_L0.9441.00
11_L198_I0.9421.00
226_R363_I0.9391.00
103_M107_K0.9381.00
343_E346_Y0.9361.00
281_E286_D0.9301.00
322_F325_Y0.9301.00
25_K28_L0.9301.00
19_E71_D0.9291.00
101_H107_K0.9271.00
277_T280_I0.9261.00
21_K206_D0.9251.00
33_R41_Y0.9221.00
296_T301_L0.9221.00
239_Y243_A0.9201.00
113_Q117_N0.9141.00
299_Y303_W0.9081.00
261_F264_N0.9081.00
109_P116_I0.9081.00
239_Y242_G0.9071.00
257_E292_H0.9061.00
297_K303_W0.9051.00
238_D242_G0.9031.00
100_F106_V0.9021.00
108_D116_I0.8991.00
229_Y335_V0.8921.00
293_T300_P0.8921.00
98_N101_H0.8881.00
164_P167_I0.8851.00
145_Q149_K0.8831.00
101_H105_G0.8821.00
18_N71_D0.8811.00
310_Y315_D0.8791.00
256_H260_N0.8791.00
282_H285_F0.8771.00
253_T256_H0.8761.00
214_L218_D0.8741.00
109_P113_Q0.8741.00
109_P118_A0.8731.00
291_K294_V0.8721.00
322_F326_R0.8721.00
3_D224_A0.8671.00
117_N120_K0.8671.00
280_I286_D0.8661.00
278_R282_H0.8651.00
160_A167_I0.8611.00
81_S86_Y0.8611.00
80_N86_Y0.8601.00
325_Y329_A0.8551.00
315_D320_E0.8551.00
68_Y71_D0.8521.00
265_A268_N0.8501.00
164_P168_I0.8431.00
111_E119_Q0.8411.00
65_I69_V0.8411.00
254_E257_E0.8381.00
271_D274_V0.8361.00
289_E293_T0.8361.00
200_K204_G0.8351.00
158_R162_E0.8351.00
111_E117_N0.8351.00
116_I120_K0.8351.00
339_G355_A0.8331.00
109_P114_N0.8301.00
19_E68_Y0.8291.00
278_R281_E0.8271.00
352_V356_A0.8241.00
261_F265_A0.8221.00
113_Q116_I0.8211.00
262_Q265_A0.8181.00
15_V356_A0.8161.00
26_K225_H0.8151.00
281_E285_F0.8141.00
66_W69_V0.8131.00
311_Y314_N0.8091.00
142_D146_A0.8091.00
142_D145_Q0.8081.00
3_D222_S0.8071.00
20_L360_V0.8071.00
237_F240_R0.8041.00
141_E144_Y0.8031.00
314_N318_N0.8011.00
280_I283_K0.7951.00
22_K204_G0.7911.00
9_S209_L0.7901.00
17_A205_V0.7901.00
317_K320_E0.7891.00
264_N268_N0.7891.00
296_T302_E0.7841.00
279_I282_H0.7841.00
98_N102_Q0.7831.00
74_E77_R0.7801.00
312_P315_D0.7761.00
93_L96_N0.7741.00
108_D114_N0.7741.00
190_P197_L0.7731.00
289_E298_E0.7701.00
99_T106_V0.7691.00
283_K288_V0.7681.00
149_K153_E0.7671.00
73_V77_R0.7661.00
11_L352_V0.7641.00
292_H297_K0.7601.00
65_I353_I0.7581.00
99_T103_M0.7581.00
183_S186_Y0.7541.00
72_L201_M0.7491.00
313_V317_K0.7481.00
15_V19_E0.7481.00
324_K329_A0.7471.00
292_H296_T0.7471.00
265_A269_F0.7461.00
171_I174_R0.7451.00
277_T282_H0.7441.00
233_I342_A0.7441.00
28_L225_H0.7421.00
3_D223_K0.7411.00
132_E149_K0.7371.00
69_V72_L0.7361.00
298_E304_K0.7341.00
80_N84_A0.7331.00
105_G108_D0.7321.00
324_K328_L0.7301.00
227_I334_K0.7301.00
263_G268_N0.7281.00
11_L353_I0.7261.00
276_Y281_E0.7251.00
297_K302_E0.7231.00
295_V300_P0.7221.00
21_K204_G0.7211.00
228_I359_Q0.7191.00
294_V303_W0.7171.00
75_F78_F0.7161.00
198_I202_L0.7131.00
98_N104_W0.7091.00
323_K328_L0.7071.00
149_K160_A0.7071.00
211_I217_K0.7071.00
310_Y314_N0.7041.00
134_Q138_L0.7031.00
322_F329_A0.7021.00
81_S84_A0.7021.00
290_T293_T0.7011.00
43_E52_K0.7001.00
23_L361_K0.6991.00
139_V148_I0.6991.00
64_Y69_V0.6981.00
160_A163_L0.6981.00
294_V301_L0.6981.00
311_Y316_N0.6961.00
276_Y279_I0.6921.00
240_R244_L0.6911.00
356_A359_Q0.6911.00
320_E323_K0.6871.00
110_Q113_Q0.6821.00
282_H287_Y0.6811.00
69_V190_P0.6801.00
156_W168_I0.6771.00
129_E134_Q0.6741.00
343_E355_A0.6741.00
14_A198_I0.6721.00
289_E294_V0.6721.00
112_A119_Q0.6701.00
291_K297_K0.6671.00
52_K194_Y0.6661.00
297_K301_L0.6651.00
40_A349_M0.6631.00
122_K125_D0.6621.00
25_K226_R0.6601.00
170_R174_R0.6601.00
231_G235_Q0.6591.00
313_V316_N0.6581.00
52_K57_I0.6541.00
303_W308_E0.6541.00
291_K298_E0.6521.00
359_Q363_I0.6521.00
65_I68_Y0.6521.00
342_A352_V0.6501.00
39_N54_G0.6501.00
91_F96_N0.6501.00
7_V213_F0.6471.00
358_Y361_K0.6451.00
321_L324_K0.6451.00
18_N205_V0.6441.00
101_H116_I0.6441.00
134_Q165_A0.6431.00
237_F241_F0.6401.00
6_I16_C0.6361.00
295_V303_W0.6321.00
182_F186_Y0.6291.00
77_R188_G0.6291.00
280_I285_F0.6291.00
35_H195_T0.6251.00
293_T303_W0.6241.00
338_G356_A0.6231.00
294_V302_E0.6171.00
190_P196_K0.6161.00
116_I119_Q0.6151.00
292_H295_V0.6151.00
64_Y353_I0.6131.00
193_G196_K0.6101.00
85_I90_L0.6051.00
315_D321_L0.6051.00
16_C20_L0.6041.00
165_A169_K0.6031.00
289_E301_L0.6031.00
140_G144_Y0.6011.00
62_D354_S0.5971.00
41_Y53_Y0.5961.00
295_V301_L0.5961.00
311_Y317_K0.5951.00
11_L15_V0.5951.00
110_Q115_I0.5931.00
107_K111_E0.5931.00
103_M108_D0.5911.00
278_R286_D0.5911.00
261_F266_V0.5901.00
279_I283_K0.5901.00
313_V318_N0.5901.00
40_A55_A0.5891.00
233_I244_L0.5891.00
104_W108_D0.5891.00
309_P315_D0.5881.00
322_F328_L0.5841.00
151_Y154_K0.5821.00
254_E297_K0.5811.00
106_V109_P0.5791.00
45_C48_I0.5791.00
253_T257_E0.5761.00
282_H288_V0.5751.00
295_V302_E0.5741.00
245_E315_D0.5711.00
273_N277_T0.5701.00
280_I287_Y0.5701.00
102_Q107_K0.5701.00
68_Y353_I0.5691.00
217_K222_S0.5671.00
14_A29_V0.5651.00
251_F254_E0.5651.00
113_Q120_K0.5641.00
18_N72_L0.5641.00
150_G154_K0.5631.00
165_A168_I0.5611.00
147_L150_G0.5611.00
352_V355_A0.5601.00
342_A355_A0.5591.00
73_V78_F0.5581.00
250_K253_T0.5581.00
9_S31_E0.5581.00
16_C359_Q0.5571.00
31_E209_L0.5571.00
342_A346_Y0.5561.00
360_V363_I0.5551.00
293_T302_E0.5541.00
143_L150_G0.5531.00
73_V76_N0.5521.00
75_F79_T0.5521.00
263_G267_I0.5521.00
65_I349_M0.5511.00
42_T52_K0.5481.00
309_P317_K0.5481.00
155_Q167_I0.5471.00
5_I227_I0.5461.00
99_T104_W0.5461.00
14_A202_L0.5451.00
150_G153_E0.5441.00
52_K55_A0.5431.00
249_L253_T0.5411.00
310_Y317_K0.5411.00
127_V130_N0.5381.00
108_D113_Q0.5381.00
83_L92_N0.5381.00
156_W167_I0.5381.00
320_E324_K0.5381.00
226_R229_Y0.5371.00
289_E299_Y0.5371.00
281_E287_Y0.5371.00
182_F187_Q0.5361.00
233_I241_F0.5351.00
148_I151_Y0.5351.00
252_E255_R0.5341.00
289_E297_K0.5341.00
55_A59_H0.5331.00
328_L331_R0.5301.00
89_K92_N0.5291.00
55_A58_F0.5281.00
100_F107_K0.5281.00
228_I336_I0.5281.00
243_A321_L0.5281.00
212_D218_D0.5281.00
37_G198_I0.5261.00
146_A150_G0.5241.00
202_L205_V0.5231.00
251_F255_R0.5191.00
274_V278_R0.5171.00
160_A166_F0.5171.00
66_W72_L0.5151.00
62_D350_H0.5141.00
39_N55_A0.5121.00
15_V201_M0.5121.00
133_E136_I0.5121.00
315_D319_M0.5111.00
125_D128_P0.5091.00
322_F327_E0.5071.00
73_V83_L0.5071.00
166_F169_K0.5061.00
198_I201_M0.5061.00
65_I350_H0.5051.00
99_T105_G0.5041.00
216_D221_A0.5031.00
109_P115_I0.5031.00
96_N99_T0.5021.00
109_P119_Q0.5021.00
30_I216_D0.5021.00
311_Y318_N0.5001.00
292_H300_P0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mo2B 2 0.9946 100 0.258 Contact Map
1i8tA 2 1 100 0.269 Contact Map
2bi7A 1 0.9864 100 0.285 Contact Map
1v0jA 1 0.9891 100 0.289 Contact Map
3hdqA 4 0.9755 100 0.309 Contact Map
3i6dA 1 0.9373 100 0.372 Contact Map
4dsgA 1 0.9891 100 0.375 Contact Map
2ivdA 1 0.9809 100 0.378 Contact Map
4i59A 1 0.9809 100 0.388 Contact Map
1sezA 3 0.9782 100 0.394 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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