GLF - ECOLI - GREMLIN Contacts

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GLF - UDP-galactopyranose mutase

UniProt:	P37747	Sequences: MYDYIIVGSGLFGAVCANELKKLNKKVLVIEKRNHIGGNAYTEDCEGIQIHKYGAHIFHTNDKYIWDYVNDLVEFNRFTNSPLAIYKDKLFNLPFNMNTFHQMWGVKDPQEAQNIINAQKKKYGDKVPENLEEQAISLVGEDLYQALIKGYTEKQWGRSAKELPAFIIKRIPVRFTFDNNYFSDRYQGIPVGGYTKLIEKMLEGVDVKLGIDFLKDKDSLASKAHRIIYTGPIDQYFDYRFGALEYRSLKFETERHEFPNFQGNAVINFTDANVPYTRIIEHKHFDYVETKHTVVTKEYPLEWKVGDEPYYPVNDNKNMELFKKYRELASREDKVIFGGRLAEYKYYDMHQVISAALYQVKNIMSTD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11981
Length:	367 (348)
Sequences:	17701 (14264)
Seq/√Len:	764.6

ECOLI - GLF
BACSU - PPOX YOBN
HALSA - Q9HP54 Q9HRU3 Q9HSE1 Q9HP88 Q9HPD8 Q9HRN2
SULSO - Q97W24 Q97UT6 Q97YW3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
3_D	26_K	4.454	1.00
5_I	224_A	4.060	1.00
28_L	208_K	3.830	1.00
32_K	212_D	3.753	1.00
36_I	209_L	3.392	1.00
3_D	225_H	3.375	1.00
229_Y	236_Y	3.140	1.00
16_C	228_I	2.986	1.00
5_I	30_I	2.885	1.00
196_K	199_E	2.846	1.00
34_N	210_G	2.748	1.00
36_I	202_L	2.731	1.00
356_A	360_V	2.671	1.00
30_I	222_S	2.591	1.00
195_T	199_E	2.543	1.00
226_R	336_I	2.501	1.00
26_K	206_D	2.378	1.00
4_Y	25_K	2.370	1.00
216_D	219_S	2.294	1.00
19_E	357_L	2.291	1.00
9_S	36_I	2.275	1.00
74_E	191_V	2.262	1.00
208_K	211_I	2.256	1.00
108_D	111_E	2.203	1.00
7_V	229_Y	2.177	1.00
230_T	338_G	2.164	1.00
15_V	353_I	2.130	1.00
5_I	222_S	2.116	1.00
3_D	28_L	2.072	1.00
200_K	203_E	2.056	1.00
30_I	224_A	1.995	1.00
132_E	136_I	1.988	1.00
30_I	208_K	1.956	1.00
7_V	231_G	1.933	1.00
35_H	41_Y	1.906	1.00
12_F	230_T	1.903	1.00
11_L	349_M	1.886	1.00
129_E	137_S	1.881	1.00
19_E	22_K	1.834	1.00
202_L	207_V	1.794	1.00
22_K	71_D	1.770	1.00
18_N	204_G	1.766	1.00
141_E	145_Q	1.737	1.00
18_N	22_K	1.726	1.00
208_K	220_L	1.725	1.00
28_L	224_A	1.713	1.00
231_G	236_Y	1.671	1.00
217_K	220_L	1.665	1.00
4_Y	226_R	1.622	1.00
296_T	299_Y	1.606	1.00
132_E	161_K	1.590	1.00
19_E	361_K	1.579	1.00
108_D	112_A	1.571	1.00
63_K	67_D	1.569	1.00
4_Y	20_L	1.527	1.00
296_T	300_P	1.508	1.00
208_K	222_S	1.507	1.00
309_P	312_P	1.498	1.00
130_N	133_E	1.498	1.00
28_L	206_D	1.489	1.00
17_A	29_V	1.479	1.00
196_K	200_K	1.477	1.00
228_I	363_I	1.461	1.00
76_N	191_V	1.448	1.00
67_D	71_D	1.437	1.00
214_L	217_K	1.435	1.00
111_E	114_N	1.427	1.00
21_K	205_V	1.423	1.00
40_A	198_I	1.413	1.00
304_K	308_E	1.413	1.00
114_N	118_A	1.410	1.00
3_D	25_K	1.408	1.00
299_Y	302_E	1.407	1.00
294_V	300_P	1.406	1.00
42_T	49_Q	1.405	1.00
296_T	303_W	1.398	1.00
293_T	296_T	1.394	1.00
211_I	220_L	1.391	1.00
103_M	106_V	1.380	1.00
212_D	217_K	1.377	1.00
297_K	300_P	1.368	1.00
36_I	207_V	1.360	1.00
194_Y	349_M	1.358	1.00
283_K	286_D	1.357	1.00
102_Q	106_V	1.356	1.00
325_Y	328_L	1.352	1.00
109_P	112_A	1.350	1.00
232_P	235_Q	1.348	1.00
294_V	299_Y	1.336	1.00
298_E	301_L	1.332	1.00
211_I	218_D	1.331	1.00
324_K	327_E	1.327	1.00
359_Q	362_N	1.316	1.00
6_I	17_A	1.312	1.00
101_H	104_W	1.311	1.00
216_D	220_L	1.310	1.00
326_R	329_A	1.299	1.00
294_V	298_E	1.285	1.00
36_I	198_I	1.278	1.00
336_I	359_Q	1.275	1.00
5_I	28_L	1.263	1.00
100_F	103_M	1.251	1.00
64_Y	357_L	1.246	1.00
112_A	118_A	1.239	1.00
312_P	316_N	1.238	1.00
21_K	27_V	1.236	1.00
66_W	70_N	1.235	1.00
29_V	207_V	1.232	1.00
13_G	230_T	1.221	1.00
354_S	358_Y	1.213	1.00
99_T	102_Q	1.210	1.00
30_I	213_F	1.210	1.00
67_D	357_L	1.204	1.00
112_A	115_I	1.203	1.00
44_D	47_G	1.203	1.00
192_G	196_K	1.201	1.00
129_E	133_E	1.201	1.00
44_D	49_Q	1.201	1.00
275_P	278_R	1.199	1.00
114_N	117_N	1.197	1.00
136_I	145_Q	1.196	1.00
293_T	298_E	1.192	1.00
264_N	267_I	1.191	1.00
294_V	297_K	1.191	1.00
115_I	118_A	1.189	1.00
211_I	216_D	1.188	1.00
12_F	355_A	1.187	1.00
48_I	255_R	1.184	1.00
266_V	269_F	1.181	1.00
82_P	85_I	1.176	1.00
295_V	298_E	1.167	1.00
100_F	104_W	1.162	1.00
293_T	299_Y	1.154	1.00
226_R	334_K	1.154	1.00
295_V	299_Y	1.151	1.00
309_P	313_V	1.149	1.00
293_T	297_K	1.140	1.00
170_R	173_V	1.134	1.00
100_F	105_G	1.131	1.00
199_E	203_E	1.129	1.00
342_A	358_Y	1.128	1.00
83_L	86_Y	1.121	1.00
102_Q	105_G	1.117	1.00
199_E	202_L	1.115	1.00
292_H	298_E	1.112	1.00
289_E	292_H	1.105	1.00
211_I	222_S	1.087	1.00
336_I	362_N	1.087	1.00
19_E	356_A	1.086	1.00
6_I	13_G	1.085	1.00
214_L	219_S	1.084	1.00
298_E	303_W	1.083	1.00
108_D	115_I	1.081	1.00
284_H	287_Y	1.073	1.00
42_T	195_T	1.070	1.00
136_I	141_E	1.066	1.00
110_Q	114_N	1.062	1.00
358_Y	362_N	1.061	1.00
300_P	303_W	1.060	1.00
67_D	70_N	1.057	1.00
216_D	222_S	1.056	1.00
108_D	118_A	1.056	1.00
315_D	318_N	1.050	1.00
332_E	335_V	1.050	1.00
11_L	40_A	1.049	1.00
30_I	211_I	1.048	1.00
282_H	286_D	1.047	1.00
6_I	27_V	1.046	1.00
336_I	363_I	1.044	1.00
323_K	326_R	1.044	1.00
281_E	284_H	1.042	1.00
101_H	106_V	1.042	1.00
80_N	83_L	1.042	1.00
12_F	352_V	1.040	1.00
224_A	227_I	1.038	1.00
311_Y	315_D	1.037	1.00
112_A	116_I	1.032	1.00
338_G	359_Q	1.029	1.00
18_N	201_M	1.025	1.00
12_F	338_G	1.021	1.00
111_E	118_A	1.017	1.00
323_K	327_E	1.013	1.00
111_E	115_I	1.011	1.00
277_T	281_E	1.010	1.00
43_E	53_Y	1.009	1.00
263_G	266_V	1.006	1.00
283_K	287_Y	1.005	1.00
82_P	86_Y	0.997	1.00
202_L	209_L	0.995	1.00
159_S	162_E	0.993	1.00
115_I	119_Q	0.993	1.00
64_Y	67_D	0.991	1.00
298_E	302_E	0.987	1.00
104_W	107_K	0.983	1.00
357_L	361_K	0.983	1.00
28_L	222_S	0.983	1.00
174_R	181_Y	0.976	1.00
16_C	356_A	0.970	1.00
108_D	119_Q	0.964	1.00
64_Y	354_S	0.962	1.00
9_S	29_V	0.960	1.00
293_T	301_L	0.954	1.00
310_Y	313_V	0.953	1.00
292_H	299_Y	0.952	1.00
19_E	23_L	0.951	1.00
153_E	159_S	0.950	1.00
68_Y	72_L	0.944	1.00
11_L	198_I	0.942	1.00
226_R	363_I	0.939	1.00
103_M	107_K	0.938	1.00
343_E	346_Y	0.936	1.00
281_E	286_D	0.930	1.00
322_F	325_Y	0.930	1.00
25_K	28_L	0.930	1.00
19_E	71_D	0.929	1.00
101_H	107_K	0.927	1.00
277_T	280_I	0.926	1.00
21_K	206_D	0.925	1.00
33_R	41_Y	0.922	1.00
296_T	301_L	0.922	1.00
239_Y	243_A	0.920	1.00
113_Q	117_N	0.914	1.00
299_Y	303_W	0.908	1.00
261_F	264_N	0.908	1.00
109_P	116_I	0.908	1.00
239_Y	242_G	0.907	1.00
257_E	292_H	0.906	1.00
297_K	303_W	0.905	1.00
238_D	242_G	0.903	1.00
100_F	106_V	0.902	1.00
108_D	116_I	0.899	1.00
229_Y	335_V	0.892	1.00
293_T	300_P	0.892	1.00
98_N	101_H	0.888	1.00
164_P	167_I	0.885	1.00
145_Q	149_K	0.883	1.00
101_H	105_G	0.882	1.00
18_N	71_D	0.881	1.00
310_Y	315_D	0.879	1.00
256_H	260_N	0.879	1.00
282_H	285_F	0.877	1.00
253_T	256_H	0.876	1.00
214_L	218_D	0.874	1.00
109_P	113_Q	0.874	1.00
109_P	118_A	0.873	1.00
291_K	294_V	0.872	1.00
322_F	326_R	0.872	1.00
3_D	224_A	0.867	1.00
117_N	120_K	0.867	1.00
280_I	286_D	0.866	1.00
278_R	282_H	0.865	1.00
160_A	167_I	0.861	1.00
81_S	86_Y	0.861	1.00
80_N	86_Y	0.860	1.00
325_Y	329_A	0.855	1.00
315_D	320_E	0.855	1.00
68_Y	71_D	0.852	1.00
265_A	268_N	0.850	1.00
164_P	168_I	0.843	1.00
111_E	119_Q	0.841	1.00
65_I	69_V	0.841	1.00
254_E	257_E	0.838	1.00
271_D	274_V	0.836	1.00
289_E	293_T	0.836	1.00
200_K	204_G	0.835	1.00
158_R	162_E	0.835	1.00
111_E	117_N	0.835	1.00
116_I	120_K	0.835	1.00
339_G	355_A	0.833	1.00
109_P	114_N	0.830	1.00
19_E	68_Y	0.829	1.00
278_R	281_E	0.827	1.00
352_V	356_A	0.824	1.00
261_F	265_A	0.822	1.00
113_Q	116_I	0.821	1.00
262_Q	265_A	0.818	1.00
15_V	356_A	0.816	1.00
26_K	225_H	0.815	1.00
281_E	285_F	0.814	1.00
66_W	69_V	0.813	1.00
311_Y	314_N	0.809	1.00
142_D	146_A	0.809	1.00
142_D	145_Q	0.808	1.00
3_D	222_S	0.807	1.00
20_L	360_V	0.807	1.00
237_F	240_R	0.804	1.00
141_E	144_Y	0.803	1.00
314_N	318_N	0.801	1.00
280_I	283_K	0.795	1.00
22_K	204_G	0.791	1.00
9_S	209_L	0.790	1.00
17_A	205_V	0.790	1.00
317_K	320_E	0.789	1.00
264_N	268_N	0.789	1.00
296_T	302_E	0.784	1.00
279_I	282_H	0.784	1.00
98_N	102_Q	0.783	1.00
74_E	77_R	0.780	1.00
312_P	315_D	0.776	1.00
93_L	96_N	0.774	1.00
108_D	114_N	0.774	1.00
190_P	197_L	0.773	1.00
289_E	298_E	0.770	1.00
99_T	106_V	0.769	1.00
283_K	288_V	0.768	1.00
149_K	153_E	0.767	1.00
73_V	77_R	0.766	1.00
11_L	352_V	0.764	1.00
292_H	297_K	0.760	1.00
65_I	353_I	0.758	1.00
99_T	103_M	0.758	1.00
183_S	186_Y	0.754	1.00
72_L	201_M	0.749	1.00
313_V	317_K	0.748	1.00
15_V	19_E	0.748	1.00
324_K	329_A	0.747	1.00
292_H	296_T	0.747	1.00
265_A	269_F	0.746	1.00
171_I	174_R	0.745	1.00
277_T	282_H	0.744	1.00
233_I	342_A	0.744	1.00
28_L	225_H	0.742	1.00
3_D	223_K	0.741	1.00
132_E	149_K	0.737	1.00
69_V	72_L	0.736	1.00
298_E	304_K	0.734	1.00
80_N	84_A	0.733	1.00
105_G	108_D	0.732	1.00
324_K	328_L	0.730	1.00
227_I	334_K	0.730	1.00
263_G	268_N	0.728	1.00
11_L	353_I	0.726	1.00
276_Y	281_E	0.725	1.00
297_K	302_E	0.723	1.00
295_V	300_P	0.722	1.00
21_K	204_G	0.721	1.00
228_I	359_Q	0.719	1.00
294_V	303_W	0.717	1.00
75_F	78_F	0.716	1.00
198_I	202_L	0.713	1.00
98_N	104_W	0.709	1.00
323_K	328_L	0.707	1.00
149_K	160_A	0.707	1.00
211_I	217_K	0.707	1.00
310_Y	314_N	0.704	1.00
134_Q	138_L	0.703	1.00
322_F	329_A	0.702	1.00
81_S	84_A	0.702	1.00
290_T	293_T	0.701	1.00
43_E	52_K	0.700	1.00
23_L	361_K	0.699	1.00
139_V	148_I	0.699	1.00
64_Y	69_V	0.698	1.00
160_A	163_L	0.698	1.00
294_V	301_L	0.698	1.00
311_Y	316_N	0.696	1.00
276_Y	279_I	0.692	1.00
240_R	244_L	0.691	1.00
356_A	359_Q	0.691	1.00
320_E	323_K	0.687	1.00
110_Q	113_Q	0.682	1.00
282_H	287_Y	0.681	1.00
69_V	190_P	0.680	1.00
156_W	168_I	0.677	1.00
129_E	134_Q	0.674	1.00
343_E	355_A	0.674	1.00
14_A	198_I	0.672	1.00
289_E	294_V	0.672	1.00
112_A	119_Q	0.670	1.00
291_K	297_K	0.667	1.00
52_K	194_Y	0.666	1.00
297_K	301_L	0.665	1.00
40_A	349_M	0.663	1.00
122_K	125_D	0.662	1.00
25_K	226_R	0.660	1.00
170_R	174_R	0.660	1.00
231_G	235_Q	0.659	1.00
313_V	316_N	0.658	1.00
52_K	57_I	0.654	1.00
303_W	308_E	0.654	1.00
291_K	298_E	0.652	1.00
359_Q	363_I	0.652	1.00
65_I	68_Y	0.652	1.00
342_A	352_V	0.650	1.00
39_N	54_G	0.650	1.00
91_F	96_N	0.650	1.00
7_V	213_F	0.647	1.00
358_Y	361_K	0.645	1.00
321_L	324_K	0.645	1.00
18_N	205_V	0.644	1.00
101_H	116_I	0.644	1.00
134_Q	165_A	0.643	1.00
237_F	241_F	0.640	1.00
6_I	16_C	0.636	1.00
295_V	303_W	0.632	1.00
182_F	186_Y	0.629	1.00
77_R	188_G	0.629	1.00
280_I	285_F	0.629	1.00
35_H	195_T	0.625	1.00
293_T	303_W	0.624	1.00
338_G	356_A	0.623	1.00
294_V	302_E	0.617	1.00
190_P	196_K	0.616	1.00
116_I	119_Q	0.615	1.00
292_H	295_V	0.615	1.00
64_Y	353_I	0.613	1.00
193_G	196_K	0.610	1.00
85_I	90_L	0.605	1.00
315_D	321_L	0.605	1.00
16_C	20_L	0.604	1.00
165_A	169_K	0.603	1.00
289_E	301_L	0.603	1.00
140_G	144_Y	0.601	1.00
62_D	354_S	0.597	1.00
41_Y	53_Y	0.596	1.00
295_V	301_L	0.596	1.00
311_Y	317_K	0.595	1.00
11_L	15_V	0.595	1.00
110_Q	115_I	0.593	1.00
107_K	111_E	0.593	1.00
103_M	108_D	0.591	1.00
278_R	286_D	0.591	1.00
261_F	266_V	0.590	1.00
279_I	283_K	0.590	1.00
313_V	318_N	0.590	1.00
40_A	55_A	0.589	1.00
233_I	244_L	0.589	1.00
104_W	108_D	0.589	1.00
309_P	315_D	0.588	1.00
322_F	328_L	0.584	1.00
151_Y	154_K	0.582	1.00
254_E	297_K	0.581	1.00
106_V	109_P	0.579	1.00
45_C	48_I	0.579	1.00
253_T	257_E	0.576	1.00
282_H	288_V	0.575	1.00
295_V	302_E	0.574	1.00
245_E	315_D	0.571	1.00
273_N	277_T	0.570	1.00
280_I	287_Y	0.570	1.00
102_Q	107_K	0.570	1.00
68_Y	353_I	0.569	1.00
217_K	222_S	0.567	1.00
14_A	29_V	0.565	1.00
251_F	254_E	0.565	1.00
113_Q	120_K	0.564	1.00
18_N	72_L	0.564	1.00
150_G	154_K	0.563	1.00
165_A	168_I	0.561	1.00
147_L	150_G	0.561	1.00
352_V	355_A	0.560	1.00
342_A	355_A	0.559	1.00
73_V	78_F	0.558	1.00
250_K	253_T	0.558	1.00
9_S	31_E	0.558	1.00
16_C	359_Q	0.557	1.00
31_E	209_L	0.557	1.00
342_A	346_Y	0.556	1.00
360_V	363_I	0.555	1.00
293_T	302_E	0.554	1.00
143_L	150_G	0.553	1.00
73_V	76_N	0.552	1.00
75_F	79_T	0.552	1.00
263_G	267_I	0.552	1.00
65_I	349_M	0.551	1.00
42_T	52_K	0.548	1.00
309_P	317_K	0.548	1.00
155_Q	167_I	0.547	1.00
5_I	227_I	0.546	1.00
99_T	104_W	0.546	1.00
14_A	202_L	0.545	1.00
150_G	153_E	0.544	1.00
52_K	55_A	0.543	1.00
249_L	253_T	0.541	1.00
310_Y	317_K	0.541	1.00
127_V	130_N	0.538	1.00
108_D	113_Q	0.538	1.00
83_L	92_N	0.538	1.00
156_W	167_I	0.538	1.00
320_E	324_K	0.538	1.00
226_R	229_Y	0.537	1.00
289_E	299_Y	0.537	1.00
281_E	287_Y	0.537	1.00
182_F	187_Q	0.536	1.00
233_I	241_F	0.535	1.00
148_I	151_Y	0.535	1.00
252_E	255_R	0.534	1.00
289_E	297_K	0.534	1.00
55_A	59_H	0.533	1.00
328_L	331_R	0.530	1.00
89_K	92_N	0.529	1.00
55_A	58_F	0.528	1.00
100_F	107_K	0.528	1.00
228_I	336_I	0.528	1.00
243_A	321_L	0.528	1.00
212_D	218_D	0.528	1.00
37_G	198_I	0.526	1.00
146_A	150_G	0.524	1.00
202_L	205_V	0.523	1.00
251_F	255_R	0.519	1.00
274_V	278_R	0.517	1.00
160_A	166_F	0.517	1.00
66_W	72_L	0.515	1.00
62_D	350_H	0.514	1.00
39_N	55_A	0.512	1.00
15_V	201_M	0.512	1.00
133_E	136_I	0.512	1.00
315_D	319_M	0.511	1.00
125_D	128_P	0.509	1.00
322_F	327_E	0.507	1.00
73_V	83_L	0.507	1.00
166_F	169_K	0.506	1.00
198_I	201_M	0.506	1.00
65_I	350_H	0.505	1.00
99_T	105_G	0.504	1.00
216_D	221_A	0.503	1.00
109_P	115_I	0.503	1.00
96_N	99_T	0.502	1.00
109_P	119_Q	0.502	1.00
30_I	216_D	0.502	1.00
311_Y	318_N	0.500	1.00
292_H	300_P	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4mo2B	2	0.9946	100	0.258	Contact Map
1i8tA	2	1	100	0.269	Contact Map
2bi7A	1	0.9864	100	0.285	Contact Map
1v0jA	1	0.9891	100	0.289	Contact Map
3hdqA	4	0.9755	100	0.309	Contact Map
3i6dA	1	0.9373	100	0.372	Contact Map
4dsgA	1	0.9891	100	0.375	Contact Map
2ivdA	1	0.9809	100	0.378	Contact Map
4i59A	1	0.9809	100	0.388	Contact Map
1sezA	3	0.9782	100	0.394	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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