GREMLIN Database
RFBX - Putative O-antigen transporter
UniProt: P37746 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11980
Length: 415 (396)
Sequences: 17296 (14807)
Seq/√Len: 744.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
283_R286_G4.7051.00
211_R215_A3.3251.00
143_K146_W3.2881.00
106_M109_L3.0041.00
46_G251_N2.9601.00
328_V332_M2.9341.00
357_Y360_E2.9341.00
77_S80_K2.9321.00
142_E277_S2.7791.00
309_L332_M2.7171.00
359_K363_K2.7031.00
114_N117_A2.6171.00
313_S317_K2.4231.00
71_I140_G2.2841.00
307_I311_G2.2811.00
368_A399_V2.2441.00
312_A328_V2.2311.00
222_I362_S2.1381.00
234_I250_F2.1381.00
333_I386_I2.1331.00
278_T286_G2.1261.00
112_E115_K2.0711.00
277_S281_L2.0431.00
288_I292_K2.0421.00
340_L397_C2.0411.00
243_G246_S2.0361.00
238_L242_S2.0121.00
14_Y145_K2.0051.00
38_G41_N1.9941.00
312_A332_M1.9901.00
249_N326_N1.9801.00
234_I376_I1.9681.00
364_I402_L1.9571.00
314_I317_K1.9511.00
242_S246_S1.9361.00
330_V385_E1.9341.00
69_Q73_K1.9251.00
35_R321_G1.9121.00
70_S216_D1.8831.00
83_S206_S1.8481.00
104_T121_W1.7931.00
237_I380_T1.7721.00
47_F239_G1.7681.00
383_F390_I1.7591.00
371_L398_L1.7491.00
311_G314_I1.7371.00
171_D174_I1.7201.00
375_L391_T1.7011.00
290_I351_V1.6881.00
380_T388_A1.6871.00
279_L355_H1.6811.00
143_K197_E1.6731.00
322_P325_D1.6711.00
137_L141_K1.6671.00
80_K83_S1.6621.00
145_K149_L1.6581.00
333_I393_L1.6391.00
301_G342_S1.6381.00
207_L211_R1.6351.00
379_L391_T1.6301.00
237_I376_I1.6201.00
142_E274_R1.6091.00
316_V331_L1.5931.00
67_A88_V1.5831.00
313_S328_V1.5811.00
378_P381_T1.5761.00
226_A366_I1.5641.00
45_F49_Q1.5621.00
313_S332_M1.5551.00
73_K356_N1.5501.00
329_I386_I1.5421.00
305_S339_F1.5341.00
287_V351_V1.5331.00
245_T249_N1.5151.00
308_L335_S1.5041.00
278_T289_L1.5011.00
257_R334_I1.4981.00
242_S385_E1.4891.00
377_F381_T1.4891.00
379_L383_F1.4801.00
121_W125_P1.4761.00
158_I182_A1.4621.00
34_V252_A1.4611.00
316_V327_A1.4491.00
237_I377_F1.4481.00
157_A185_V1.4451.00
219_H362_S1.4431.00
378_P382_L1.4281.00
253_A327_A1.4251.00
82_T86_W1.4231.00
329_I332_M1.4191.00
333_I390_I1.4191.00
376_I380_T1.4121.00
374_L378_P1.4081.00
206_S209_N1.4081.00
170_S174_I1.4071.00
311_G315_L1.4041.00
238_L247_V1.4001.00
41_N44_I1.3981.00
340_L400_T1.3941.00
330_V389_A1.3941.00
372_S376_I1.3911.00
291_K295_T1.3861.00
271_I293_S1.3801.00
401_S405_M1.3741.00
103_L124_V1.3731.00
234_I392_L1.3631.00
107_T121_W1.3591.00
174_I178_I1.3591.00
85_F137_L1.3421.00
286_G289_L1.3361.00
363_K367_A1.3211.00
66_T216_D1.3131.00
275_I287_V1.3091.00
337_L393_L1.3081.00
20_G24_L1.3011.00
21_S152_I1.2961.00
30_F255_T1.2931.00
387_G391_T1.2781.00
391_T395_T1.2761.00
39_P249_N1.2731.00
333_I389_A1.2491.00
246_S385_E1.2441.00
379_L382_L1.2431.00
126_A130_N1.2421.00
31_P35_R1.2341.00
285_K288_I1.2281.00
232_T235_V1.2271.00
34_V320_I1.2271.00
253_A330_V1.2231.00
298_S302_G1.2201.00
27_L31_P1.2151.00
326_N329_I1.2141.00
113_Y116_H1.2071.00
125_P128_V1.1941.00
150_S190_A1.1941.00
252_A320_I1.1931.00
29_T159_I1.1871.00
384_K387_G1.1821.00
321_G324_Y1.1761.00
308_L331_L1.1751.00
233_G373_L1.1701.00
46_G248_G1.1631.00
219_H359_K1.1621.00
275_I354_T1.1621.00
312_A331_L1.1601.00
74_A80_K1.1591.00
191_L195_V1.1571.00
119_I176_G1.1551.00
238_L388_A1.1541.00
72_A140_G1.1531.00
88_V213_S1.1521.00
290_I347_Y1.1521.00
47_F247_V1.1491.00
39_P323_G1.1481.00
305_S309_L1.1451.00
53_L57_M1.1451.00
386_I389_A1.1441.00
284_V355_H1.1441.00
24_L28_L1.1431.00
226_A369_G1.1381.00
42_F46_G1.1351.00
226_A362_S1.1251.00
279_L287_V1.1201.00
316_V328_V1.1191.00
243_G247_V1.1171.00
218_F222_I1.1161.00
120_I124_V1.1111.00
87_A210_V1.1101.00
163_F167_N1.1051.00
336_P393_L1.1031.00
160_P164_I1.1031.00
39_P248_G1.0981.00
212_R356_N1.0971.00
91_S210_V1.0951.00
216_D358_K1.0931.00
18_V148_T1.0891.00
372_S395_T1.0861.00
173_A176_G1.0861.00
100_L104_T1.0851.00
112_E117_A1.0851.00
45_F175_A1.0831.00
70_S212_R1.0801.00
94_V98_I1.0771.00
238_L250_F1.0771.00
150_S189_I1.0761.00
370_L374_L1.0761.00
128_V131_L1.0761.00
274_R277_S1.0751.00
364_I403_M1.0711.00
22_N155_R1.0701.00
177_F180_S1.0691.00
108_L121_W1.0671.00
81_V141_K1.0641.00
188_I192_A1.0611.00
60_E64_N1.0611.00
11_N142_E1.0611.00
337_L389_A1.0591.00
179_Q183_N1.0501.00
161_L178_I1.0481.00
383_F387_G1.0471.00
330_V386_I1.0451.00
63_F88_V1.0431.00
112_E116_H1.0421.00
12_V270_A1.0421.00
100_L103_L1.0391.00
343_L400_T1.0331.00
44_I244_P1.0271.00
223_S361_F1.0241.00
249_N327_A1.0221.00
144_M270_A1.0221.00
30_F320_I1.0211.00
66_T213_S1.0201.00
32_Y36_T1.0201.00
325_D328_V1.0201.00
7_S10_R1.0191.00
337_L340_L1.0151.00
272_Y276_S1.0111.00
366_I370_L1.0081.00
134_P191_L1.0061.00
237_I241_I1.0051.00
303_A306_L1.0031.00
16_A266_P1.0021.00
68_T136_W1.0011.00
25_L159_I0.9991.00
83_S87_A0.9971.00
162_T178_I0.9951.00
105_S108_L0.9911.00
287_V355_H0.9841.00
230_Y372_S0.9811.00
104_T108_L0.9801.00
73_K212_R0.9761.00
363_K366_I0.9751.00
71_I81_V0.9741.00
19_Q23_Y0.9731.00
253_A334_I0.9711.00
121_W124_V0.9711.00
15_L270_A0.9711.00
353_L361_F0.9591.00
31_P34_V0.9581.00
375_L379_L0.9571.00
371_L375_L0.9571.00
36_T167_N0.9551.00
192_A196_H0.9531.00
292_K295_T0.9521.00
306_L310_L0.9441.00
31_P320_I0.9441.00
241_I380_T0.9441.00
299_L303_A0.9441.00
12_V267_I0.9431.00
376_I379_L0.9421.00
229_L369_G0.9411.00
214_L218_F0.9371.00
334_I389_A0.9371.00
70_S73_K0.9341.00
67_A71_I0.9341.00
66_T70_S0.9331.00
309_L312_A0.9331.00
125_P180_S0.9311.00
123_F126_A0.9291.00
202_K205_L0.9211.00
200_I203_V0.9191.00
347_Y403_M0.9171.00
214_L217_G0.9171.00
146_W193_I0.9161.00
257_R338_P0.9151.00
175_A179_Q0.9141.00
33_L175_A0.9141.00
260_L264_L0.9131.00
161_L165_F0.9061.00
79_D83_S0.9041.00
253_A331_L0.9031.00
278_T283_R0.9021.00
178_I182_A0.9001.00
347_Y404_L0.9001.00
274_R278_T0.8941.00
295_T299_L0.8941.00
189_I193_I0.8941.00
39_P245_T0.8931.00
398_L402_L0.8931.00
235_V247_V0.8931.00
332_M336_P0.8921.00
80_K209_N0.8841.00
234_I372_S0.8841.00
317_K325_D0.8811.00
15_L148_T0.8811.00
177_F181_S0.8791.00
38_G323_G0.8781.00
43_G248_G0.8761.00
165_F170_S0.8751.00
48_C123_F0.8741.00
362_S366_I0.8741.00
182_A186_A0.8691.00
309_L313_S0.8681.00
250_F334_I0.8681.00
315_L319_S0.8631.00
372_S392_L0.8621.00
252_A324_Y0.8621.00
309_L336_P0.8601.00
69_Q356_N0.8571.00
8_L12_V0.8571.00
107_T111_P0.8561.00
168_T171_D0.8541.00
38_G324_Y0.8501.00
13_I17_V0.8491.00
90_F94_V0.8471.00
66_T217_G0.8471.00
36_T166_V0.8471.00
118_V121_W0.8471.00
215_A218_F0.8461.00
105_S109_L0.8451.00
12_V16_A0.8441.00
94_V97_V0.8431.00
251_N255_T0.8411.00
62_G217_G0.8341.00
86_W90_F0.8331.00
208_H211_R0.8331.00
393_L396_E0.8331.00
325_D329_I0.8321.00
375_L394_A0.8311.00
304_F307_I0.8311.00
74_A77_S0.8281.00
98_I102_F0.8281.00
376_I392_L0.8201.00
361_F365_L0.8201.00
248_G252_A0.8191.00
373_L377_F0.8181.00
297_L342_S0.8171.00
50_A235_V0.8161.00
390_I393_L0.8151.00
239_G247_V0.8121.00
31_P319_S0.8111.00
9_R13_I0.8071.00
270_A273_P0.8071.00
9_R12_V0.8061.00
390_I394_A0.8031.00
327_A330_V0.8021.00
39_P324_Y0.8001.00
352_M361_F0.8001.00
49_Q53_L0.7981.00
102_F106_M0.7971.00
154_S158_I0.7961.00
360_E363_K0.7941.00
60_E92_K0.7941.00
129_G187_G0.7921.00
164_I167_N0.7891.00
316_V320_I0.7871.00
402_L405_M0.7861.00
161_L181_S0.7851.00
97_V101_I0.7851.00
129_G184_L0.7841.00
14_Y18_V0.7841.00
216_D220_V0.7831.00
78_K81_V0.7821.00
180_S183_N0.7791.00
71_I141_K0.7761.00
53_L56_I0.7751.00
238_L385_E0.7691.00
10_R145_K0.7671.00
150_S186_A0.7661.00
30_F34_V0.7651.00
236_I240_F0.7631.00
108_L111_P0.7611.00
40_E244_P0.7591.00
190_A194_V0.7581.00
48_C119_I0.7561.00
78_K82_T0.7531.00
254_N258_N0.7521.00
252_A255_T0.7481.00
381_T388_A0.7451.00
45_F172_I0.7451.00
25_L29_T0.7451.00
219_H358_K0.7441.00
255_T259_A0.7431.00
33_L162_T0.7421.00
215_A219_H0.7411.00
303_A307_I0.7391.00
234_I254_N0.7371.00
232_T258_N0.7361.00
309_L335_S0.7361.00
37_L41_N0.7331.00
336_P340_L0.7311.00
84_I88_V0.7301.00
17_V21_S0.7281.00
225_S229_L0.7281.00
11_N270_A0.7271.00
130_N133_Y0.7261.00
69_Q358_K0.7241.00
93_I97_V0.7231.00
371_L374_L0.7231.00
122_S125_P0.7221.00
293_S346_V0.7221.00
364_I368_A0.7201.00
336_P339_F0.7171.00
32_Y163_F0.7111.00
367_A402_L0.7101.00
278_T281_L0.7101.00
119_I123_F0.7101.00
16_A20_G0.7101.00
86_W89_I0.7081.00
209_N212_R0.7081.00
386_I390_I0.7051.00
126_A183_N0.7051.00
376_I388_A0.7051.00
164_I168_T0.7041.00
220_V358_K0.7041.00
161_L164_I0.7031.00
358_K361_F0.7021.00
159_I163_F0.7001.00
106_M110_V0.7001.00
375_L378_P0.7001.00
317_K328_V0.6991.00
228_S232_T0.6951.00
47_F50_A0.6941.00
180_S184_L0.6941.00
89_I134_P0.6941.00
256_I320_I0.6931.00
350_Q353_L0.6891.00
42_F248_G0.6881.00
233_G237_I0.6851.00
101_I105_S0.6831.00
146_W149_L0.6821.00
215_A359_K0.6811.00
289_L293_S0.6801.00
246_S249_N0.6801.00
87_A205_L0.6801.00
226_A365_L0.6771.00
337_L396_E0.6771.00
297_L346_V0.6751.00
107_T110_V0.6741.00
272_Y350_Q0.6661.00
241_I381_T0.6651.00
382_L386_I0.6631.00
272_Y354_T0.6611.00
158_I162_T0.6601.00
193_I197_E0.6601.00
317_K321_G0.6591.00
248_G251_N0.6591.00
265_N269_Q0.6581.00
235_V251_N0.6571.00
138_F194_V0.6571.00
156_L160_P0.6561.00
232_T236_I0.6551.00
68_T72_A0.6521.00
90_F93_I0.6501.00
118_V122_S0.6491.00
124_V128_V0.6481.00
210_V214_L0.6481.00
255_T258_N0.6441.00
21_S156_L0.6431.00
139_Q147_L0.6421.00
126_A129_G0.6421.00
278_T287_V0.6421.00
312_A335_S0.6411.00
276_S280_V0.6401.00
18_V152_I0.6401.00
42_F252_A0.6371.00
247_V251_N0.6371.00
174_I177_F0.6371.00
30_F42_F0.6361.00
158_I178_I0.6361.00
393_L397_C0.6361.00
40_E44_I0.6341.00
83_S209_N0.6341.00
250_F254_N0.6341.00
223_S365_L0.6321.00
154_S186_A0.6321.00
67_A84_I0.6301.00
56_I60_E0.6291.00
118_V173_A0.6261.00
149_L153_L0.6261.00
337_L392_L0.6241.00
45_F176_G0.6231.00
220_V353_L0.6231.00
68_T140_G0.6221.00
13_I20_G0.6221.00
135_I139_Q0.6211.00
32_Y167_N0.6161.00
113_Y117_A0.6161.00
96_I131_L0.6141.00
141_K197_E0.6141.00
347_Y400_T0.6111.00
15_L19_Q0.6101.00
213_S217_G0.6101.00
136_W140_G0.6061.00
397_C401_S0.6051.00
389_A393_L0.6041.00
360_E364_I0.6031.00
201_G204_T0.6031.00
344_S400_T0.5991.00
186_A190_A0.5941.00
305_S335_S0.5941.00
86_W203_V0.5941.00
223_S227_I0.5931.00
271_I275_I0.5911.00
123_F127_L0.5911.00
350_Q354_T0.5911.00
257_R260_L0.5911.00
348_G353_L0.5911.00
21_S25_L0.5901.00
10_R13_I0.5881.00
366_I369_G0.5861.00
224_T228_S0.5831.00
274_R289_L0.5821.00
323_G326_N0.5811.00
64_N136_W0.5801.00
301_G339_F0.5801.00
255_T320_I0.5801.00
150_S193_I0.5791.00
306_L309_L0.5791.00
392_L395_T0.5781.00
396_E399_V0.5761.00
371_L395_T0.5761.00
51_T236_I0.5751.00
26_P30_F0.5751.00
259_A263_L0.5731.00
90_F203_V0.5731.00
298_S339_F0.5701.00
96_I100_L0.5701.00
266_P269_Q0.5691.00
289_L292_K0.5661.00
74_A84_I0.5651.00
87_A91_S0.5631.00
267_I271_I0.5621.00
103_L107_T0.5621.00
230_Y369_G0.5611.00
70_S74_A0.5601.00
83_S204_T0.5581.00
263_L266_P0.5581.00
212_R216_D0.5571.00
125_P129_G0.5561.00
190_A193_I0.5561.00
246_S250_F0.5551.00
83_S86_W0.5551.00
122_S177_F0.5521.00
47_F235_V0.5511.00
153_L189_I0.5511.00
379_L387_G0.5511.00
187_G191_L0.5501.00
162_T166_V0.5481.00
223_S362_S0.5471.00
107_T124_V0.5471.00
17_V20_G0.5441.00
70_S84_I0.5441.00
157_A161_L0.5421.00
153_L157_A0.5411.00
314_I318_I0.5391.00
367_A370_L0.5391.00
15_L144_M0.5391.00
157_A160_P0.5381.00
181_S185_V0.5371.00
122_S180_S0.5361.00
90_F201_G0.5351.00
392_L396_E0.5341.00
297_L301_G0.5341.00
179_Q182_A0.5341.00
195_V199_W0.5341.00
91_S95_L0.5331.00
333_I336_P0.5331.00
348_G361_F0.5291.00
173_A177_F0.5291.00
205_L210_V0.5281.00
71_I85_F0.5271.00
331_L335_S0.5261.00
92_K96_I0.5251.00
40_E245_T0.5241.00
33_L42_F0.5231.00
317_K322_P0.5221.00
252_A327_A0.5221.00
376_I391_T0.5211.00
73_K280_V0.5201.00
235_V254_N0.5181.00
100_L124_V0.5151.00
357_Y361_F0.5151.00
43_G245_T0.5141.00
23_Y26_P0.5141.00
151_S155_R0.5131.00
281_L284_V0.5121.00
61_Y217_G0.5121.00
227_I231_S0.5121.00
374_L381_T0.5101.00
351_V355_H0.5091.00
302_G339_F0.5091.00
89_I92_K0.5091.00
34_V324_Y0.5091.00
52_M56_I0.5041.00
98_I101_I0.5041.00
301_G335_S0.5031.00
223_S226_A0.5021.00
43_G243_G0.5021.00
372_S375_L0.5021.00
146_W150_S0.5011.00
86_W202_K0.5011.00
339_F342_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lz6A 1 0.9952 100 0.332 Contact Map
3w4tA 1 0.9759 100 0.332 Contact Map
4humA 1 0.9904 100 0.339 Contact Map
3mktA 1 0.988 100 0.35 Contact Map
2cfqA 1 0.8892 61 0.931 Contact Map
3wdoA 1 0.8843 52 0.935 Contact Map
4pypA 1 0.8843 40 0.939 Contact Map
1pw4A 1 0.8916 29.8 0.943 Contact Map
4j05A 3 0.853 26 0.945 Contact Map
3giaA 1 0.4819 24.9 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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