GREMLIN Database
RMLC - dTDP-4-dehydrorhamnose 3,5-epimerase
UniProt: P37745 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11979
Length: 185 (174)
Sequences: 4541 (2990)
Seq/√Len: 226.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
145_G172_L3.3831.00
80_A102_L3.2781.00
32_Q44_S3.2371.00
125_S128_A2.7761.00
81_V130_F2.5161.00
5_R12_L2.4141.00
7_E99_V2.4081.00
139_H142_S2.3831.00
15_E109_Q2.3601.00
152_R176_D2.3491.00
61_L118_A2.3161.00
65_R144_C2.2741.00
71_D112_W2.2261.00
82_F100_G2.1851.00
36_E42_P2.1571.00
48_D133_K2.1421.00
58_L122_L2.1031.00
78_H105_A2.0921.00
51_S121_F2.0911.00
55_K126_D2.0261.00
4_I15_E1.9781.00
33_S137_Y1.9671.00
32_Q36_E1.9431.00
7_E97_K1.9411.00
77_T131_Q1.9161.00
71_D135_T1.9111.00
78_H127_I1.9021.00
115_K135_T1.8551.00
68_Y139_H1.8411.00
147_C174_T1.8331.00
2_N15_E1.8131.00
167_P171_R1.7631.00
78_H129_E1.7531.00
174_T177_E1.7271.00
13_I109_Q1.7161.00
80_A125_S1.6911.00
52_R129_E1.6711.00
50_H129_E1.6291.00
71_D115_K1.6211.00
8_I117_F1.6111.00
13_I101_V1.6041.00
167_P170_E1.5891.00
104_S107_N1.5791.00
88_I118_A1.5731.00
82_F158_P1.5461.00
63_F144_C1.5181.00
33_S37_H1.5131.00
68_Y136_N1.4991.00
11_V85_A1.4971.00
80_A104_S1.4551.00
61_L120_G1.4421.00
50_H75_R1.4341.00
18_V108_K1.3791.00
123_V128_A1.3481.00
63_F178_L1.3421.00
5_R9_E1.3301.00
81_V128_A1.3161.00
3_V12_L1.2991.00
6_T13_I1.2931.00
43_V112_W1.2861.00
68_Y142_S1.2471.00
43_V115_K1.2301.00
115_K136_N1.2281.00
25_F52_R1.2231.00
11_V99_V1.2221.00
31_N34_A1.1801.00
58_L163_L1.1771.00
2_N17_R1.1701.00
84_V157_W1.1281.00
122_L159_Q1.1241.00
118_A146_I1.1221.00
85_A99_V1.1111.00
52_R127_I1.0921.00
146_I153_I1.0761.00
67_E142_S1.0631.00
173_F177_E1.0591.00
28_E31_N1.0531.00
114_P117_F1.0331.00
122_L158_P1.0321.00
101_V111_L1.0311.00
26_F51_S1.0181.00
8_I11_V1.0101.00
50_H131_Q0.9791.00
63_F118_A0.9791.00
31_N137_Y0.9711.00
22_D167_P0.9591.00
148_W163_L0.9531.00
4_I13_I0.9491.00
3_V14_L0.9471.00
25_F50_H0.9471.00
61_L86_V0.9461.00
151_E174_T0.9441.00
83_D119_H0.9421.00
65_R142_S0.9401.00
14_L34_A0.9351.00
159_Q163_L0.9351.00
102_L124_L0.9321.00
55_K125_S0.9311.00
88_I146_I0.9281.00
122_L163_L0.9130.99
82_F98_W0.9040.99
28_E47_Q0.8970.99
152_R174_T0.8930.99
34_A37_H0.8910.99
8_I99_V0.8900.99
146_I178_L0.8860.99
29_S48_D0.8830.99
54_S127_I0.8820.99
143_D172_L0.8810.99
153_I175_L0.8670.99
28_E70_Q0.8620.99
101_V109_Q0.8620.99
17_R34_A0.8490.99
8_I94_S0.8420.99
61_L155_I0.8410.99
85_A117_F0.8370.99
63_F88_I0.8320.99
45_F48_D0.8320.99
25_F129_E0.8280.99
6_T11_V0.8280.99
49_N134_T0.8280.99
69_A142_S0.8270.99
98_W153_I0.8250.99
25_F108_K0.8170.99
147_C172_L0.8160.99
10_D94_S0.8070.99
39_L43_V0.8040.99
96_G152_R0.8010.99
20_G54_S0.7980.99
84_V155_I0.7920.99
89_R117_F0.7900.99
50_H77_T0.7900.99
46_V137_Y0.7880.99
103_L111_L0.7790.98
164_I167_P0.7780.98
123_V127_I0.7740.98
11_V111_L0.7650.98
77_T129_E0.7610.98
67_E139_H0.7550.98
131_Q134_T0.7480.98
85_A113_I0.7470.98
9_E93_V0.7370.98
45_F135_T0.7280.98
124_L158_P0.7220.97
4_I109_Q0.7200.97
41_Y112_W0.7170.97
3_V39_L0.7160.97
85_A111_L0.7160.97
173_F178_L0.7040.97
39_L42_P0.6990.97
5_R10_D0.6980.97
144_C173_F0.6890.97
74_V130_F0.6850.96
8_I85_A0.6850.96
36_E41_Y0.6840.96
13_I111_L0.6780.96
148_W165_L0.6770.96
41_Y115_K0.6750.96
35_F110_Q0.6750.96
35_F39_L0.6740.96
13_I99_V0.6720.96
9_E94_S0.6670.96
100_G158_P0.6670.96
20_G108_K0.6660.96
75_R131_Q0.6640.96
76_C81_V0.6620.96
43_V135_T0.6580.95
65_R178_L0.6560.95
94_S97_K0.6540.95
26_F49_N0.6500.95
160_T163_L0.6490.95
29_S50_H0.6490.95
14_L73_L0.6480.95
18_V27_Y0.6460.95
96_G175_L0.6440.95
112_W135_T0.6420.95
144_C178_L0.6410.95
80_A128_A0.6370.95
55_K160_T0.6360.95
145_G173_F0.6350.95
29_S75_R0.6350.95
76_C128_A0.6340.95
63_F146_I0.6310.94
28_E49_N0.6270.94
3_V34_A0.6270.94
34_A39_L0.6230.94
168_K172_L0.6230.94
105_A129_E0.6210.94
32_Q42_P0.6210.94
13_I107_N0.6190.94
36_E39_L0.6190.94
18_V25_F0.6170.94
99_V111_L0.6150.94
108_K129_E0.6150.94
61_L153_I0.6140.94
72_K83_D0.6110.93
6_T101_V0.6110.93
22_D164_I0.6050.93
6_T99_V0.6040.93
174_T178_L0.5980.93
138_Y143_D0.5970.93
31_N35_F0.5960.93
29_S131_Q0.5930.92
26_F132_Y0.5930.92
90_P93_V0.5920.92
11_V117_F0.5880.92
69_A115_K0.5810.92
21_D24_G0.5730.91
3_V35_F0.5680.91
58_L157_W0.5670.91
53_S57_V0.5670.91
54_S164_I0.5660.90
105_A108_K0.5630.90
86_V146_I0.5590.90
123_V126_D0.5580.90
70_Q134_T0.5580.90
46_V136_N0.5570.90
27_Y108_K0.5560.90
65_R68_Y0.5560.90
81_V121_F0.5550.90
75_R129_E0.5540.90
52_R78_H0.5540.90
35_F41_Y0.5530.89
136_N142_S0.5480.89
12_L114_P0.5480.89
29_S133_K0.5460.89
105_A125_S0.5450.89
112_W115_K0.5450.89
144_C172_L0.5450.89
86_V118_A0.5440.89
45_F133_K0.5440.89
90_P96_G0.5430.89
53_S59_R0.5400.88
143_D168_K0.5380.88
80_A105_A0.5350.88
140_P171_R0.5350.88
80_A124_L0.5340.88
7_E11_V0.5320.88
84_V100_G0.5320.88
49_N132_Y0.5320.88
56_N163_L0.5290.87
82_F124_L0.5280.87
78_H125_S0.5260.87
10_D117_F0.5260.87
17_R20_G0.5250.87
165_L170_E0.5250.87
81_V123_V0.5210.87
134_T168_K0.5210.87
57_V164_I0.5200.86
54_S57_V0.5200.86
161_S164_I0.5200.86
74_V83_D0.5200.86
102_L158_P0.5150.86
15_E107_N0.5120.86
8_I89_R0.5100.85
99_V102_L0.5090.85
49_N168_K0.5080.85
8_I111_L0.5050.85
104_S109_Q0.5020.84
16_P110_Q0.5010.84
102_L107_N0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1upiA 2 0.9946 100 0.108 Contact Map
1oi6A 2 1 100 0.109 Contact Map
2c0zA 2 0.9946 100 0.111 Contact Map
4hn1A 3 0.9892 100 0.133 Contact Map
1dzrA 2 0.9838 100 0.135 Contact Map
3rykA 2 0.9351 100 0.138 Contact Map
2ixkA 2 0.9784 100 0.142 Contact Map
1ep0A 2 0.973 100 0.154 Contact Map
1wltA 2 0.9405 100 0.19 Contact Map
5buvA 2 0.9243 100 0.198 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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