GREMLIN Database
RMLA1 - Glucose-1-phosphate thymidylyltransferase 1
UniProt: P37744 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11978
Length: 293 (241)
Sequences: 22570 (13881)
Seq/√Len: 894.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_E188_K3.7871.00
34_K42_S3.1641.00
150_E158_I2.9611.00
38_Y67_L2.9061.00
150_E159_S2.8381.00
51_D77_N2.6241.00
152_D156_T2.5941.00
5_K51_D2.5881.00
87_D91_Q2.5851.00
139_H170_N2.5601.00
61_T65_Q2.5521.00
186_M210_Q2.4661.00
126_A134_T2.4161.00
6_G49_I2.3761.00
51_D79_Q2.3201.00
104_D180_D2.3081.00
186_M206_I2.2371.00
6_G44_L2.2201.00
152_D158_I2.1611.00
56_S61_T2.1131.00
41_L52_I2.1061.00
139_H218_M2.0661.00
94_I97_E2.0221.00
61_T82_V1.9751.00
205_R209_E1.9381.00
150_E169_S1.8901.00
206_I210_Q1.8861.00
159_S205_R1.8651.00
81_K95_I1.8591.00
62_P66_Q1.8461.00
10_A54_I1.8401.00
93_F107_L1.8091.00
7_I96_G1.7831.00
225_L235_E1.7601.00
206_I209_E1.7561.00
44_L108_V1.7391.00
38_Y42_S1.7041.00
163_K167_P1.6881.00
120_P124_E1.6681.00
151_F171_Y1.6651.00
24_V30_P1.6531.00
18_Y22_M1.6531.00
142_D145_R1.6451.00
132_G180_D1.6321.00
24_V63_R1.6151.00
104_D127_V1.6031.00
65_Q82_V1.5821.00
53_L99_F1.5791.00
132_G212_R1.5701.00
124_E128_N1.5201.00
35_P38_Y1.5071.00
137_A149_V1.5011.00
79_Q99_F1.4931.00
28_L63_R1.4681.00
63_R66_Q1.4651.00
131_S214_S1.4231.00
91_Q95_I1.4201.00
121_K124_E1.4181.00
125_A129_K1.4181.00
182_D185_Q1.4131.00
53_L81_K1.4061.00
233_L237_S1.3991.00
202_D205_R1.3911.00
100_I105_C1.3471.00
149_V157_A1.3451.00
133_A179_Y1.3021.00
104_D181_N1.2971.00
69_G80_Y1.2941.00
105_C181_N1.2901.00
94_I188_K1.2901.00
122_L136_F1.2861.00
229_T232_S1.2841.00
189_N206_I1.2671.00
52_I76_L1.2671.00
91_Q94_I1.2631.00
150_E161_E1.2621.00
161_E168_K1.2581.00
189_N210_Q1.2531.00
152_D155_G1.2361.00
179_Y204_N1.2341.00
186_M203_I1.2281.00
122_L178_F1.2061.00
60_D63_R1.1941.00
186_M189_N1.1931.00
185_Q188_K1.1731.00
106_A178_F1.1661.00
53_L96_G1.1661.00
185_Q189_N1.1631.00
125_A217_M1.1601.00
121_K125_A1.1561.00
131_S212_R1.1501.00
240_I244_E1.1471.00
88_G201_T1.1441.00
71_G74_W1.1421.00
227_T236_A1.1411.00
115_Y243_I1.1401.00
125_A128_N1.1271.00
13_S86_P1.1251.00
109_L175_G1.1131.00
38_Y71_G1.1121.00
182_D212_R1.1101.00
56_S65_Q1.1061.00
171_Y218_M1.1051.00
137_A171_Y1.1051.00
65_Q80_Y1.1041.00
34_K39_Y1.0961.00
118_D121_K1.0941.00
156_T213_L1.0931.00
104_D178_F1.0901.00
49_I106_A1.0901.00
103_D181_N1.0851.00
17_L29_L1.0771.00
56_S64_F1.0701.00
137_A215_V1.0641.00
28_L67_L1.0621.00
234_I238_N1.0621.00
36_M227_T1.0601.00
186_M212_R1.0501.00
37_I68_L1.0501.00
232_S235_E1.0481.00
7_I105_C1.0451.00
225_L239_F1.0451.00
222_Y239_F1.0411.00
129_K214_S1.0401.00
107_L179_Y1.0391.00
56_S82_V1.0291.00
124_E127_V1.0271.00
147_G162_E1.0011.00
11_G55_I1.0001.00
237_S241_A0.9941.00
35_P67_L0.9841.00
56_S80_Y0.9821.00
156_T214_S0.9811.00
37_I54_I0.9791.00
45_M76_L0.9771.00
241_A245_E0.9711.00
231_Q235_E0.9691.00
53_L79_Q0.9671.00
42_S45_M0.9561.00
144_E163_K0.9521.00
212_R215_V0.9341.00
115_Y118_D0.9341.00
5_K103_D0.9331.00
126_A178_F0.9271.00
37_I64_F0.9261.00
207_Y212_R0.9251.00
47_A120_P0.9181.00
239_F245_E0.9141.00
106_A123_M0.9111.00
62_P65_Q0.9101.00
5_K53_L0.9091.00
225_L236_A0.9031.00
148_V172_A0.9021.00
30_P35_P0.9011.00
157_A216_A0.8981.00
5_K100_I0.8961.00
94_I187_A0.8941.00
239_F243_I0.8931.00
57_T60_D0.8851.00
157_A215_V0.8801.00
130_E180_D0.8781.00
173_V177_Y0.8751.00
5_K101_G0.8731.00
27_Q110_G0.8731.00
41_L68_L0.8711.00
112_N224_W0.8711.00
213_L216_A0.8611.00
65_Q69_G0.8601.00
145_R232_S0.8591.00
34_K38_Y0.8591.00
238_N241_A0.8571.00
17_L21_T0.8561.00
234_I237_S0.8531.00
144_E165_L0.8481.00
137_A216_A0.8481.00
4_R127_V0.8461.00
81_K99_F0.8431.00
41_L78_L0.8401.00
167_P170_N0.8381.00
97_E184_V0.8361.00
123_M127_V0.8361.00
32_Y237_S0.8331.00
54_I78_L0.8331.00
108_V119_L0.8311.00
21_T29_L0.8271.00
36_M40_P0.8251.00
9_L109_L0.8221.00
8_I110_G0.8221.00
203_I206_I0.8181.00
33_D39_Y0.8171.00
201_T205_R0.8131.00
133_A137_A0.8101.00
50_R77_N0.8101.00
126_A180_D0.8101.00
145_R163_K0.8061.00
4_R103_D0.8021.00
134_T137_A0.8001.00
125_A216_A0.7991.00
235_E238_N0.7981.00
159_S166_E0.7961.00
239_F242_T0.7851.00
25_S63_R0.7851.00
134_T138_Y0.7711.00
133_A207_Y0.7711.00
89_L109_L0.7661.00
117_H120_P0.7651.00
129_K132_G0.7631.00
235_E239_F0.7631.00
244_E247_Q0.7581.00
158_I161_E0.7581.00
43_T47_A0.7481.00
123_M178_F0.7371.00
20_V230_H0.7371.00
45_M50_R0.7361.00
45_M52_I0.7331.00
101_G181_N0.7311.00
7_I55_I0.7281.00
160_L173_V0.7271.00
145_R229_T0.7271.00
32_Y39_Y0.7251.00
182_D210_Q0.7231.00
29_L233_L0.7191.00
191_K194_A0.7181.00
240_I245_E0.7181.00
239_F244_E0.7171.00
54_I68_L0.7171.00
182_D186_M0.7161.00
39_Y42_S0.7101.00
131_S156_T0.7061.00
93_F183_V0.7051.00
46_L120_P0.6991.00
49_I123_M0.6991.00
6_G52_I0.6981.00
121_K217_M0.6971.00
150_E168_K0.6951.00
129_K134_T0.6941.00
241_A244_E0.6931.00
66_Q69_G0.6921.00
20_V23_A0.6911.00
81_K96_G0.6901.00
72_S76_L0.6901.00
68_L78_L0.6881.00
20_V24_V0.6871.00
39_Y240_I0.6851.00
9_L89_L0.6851.00
42_S74_W0.6811.00
35_P39_Y0.6771.00
132_G182_D0.6761.00
132_G136_F0.6741.00
16_R26_K0.6721.00
30_P33_D0.6711.00
190_L194_A0.6681.00
86_P91_Q0.6641.00
100_I184_V0.6631.00
190_L198_L0.6621.00
97_E105_C0.6621.00
161_E164_P0.6591.00
219_G222_Y0.6591.00
185_Q210_Q0.6581.00
99_F102_G0.6541.00
41_L54_I0.6541.00
14_G26_K0.6511.00
5_K105_C0.6481.00
242_T246_R0.6461.00
84_P87_D0.6451.00
85_S91_Q0.6421.00
193_S196_G0.6401.00
133_A204_N0.6361.00
131_S215_V0.6341.00
55_I92_A0.6341.00
190_L196_G0.6301.00
182_D211_G0.6281.00
94_I198_L0.6271.00
122_L134_T0.6231.00
137_A140_V0.6221.00
135_V149_V0.6211.00
238_N242_T0.6181.00
139_H171_Y0.6131.00
38_Y68_L0.6121.00
181_N184_V0.6121.00
192_P198_L0.6121.00
8_I108_V0.6071.00
8_I40_P0.6061.00
55_I96_G0.6061.00
204_N213_L0.6051.00
43_T176_L0.6011.00
55_I81_K0.5991.00
88_G202_D0.5991.00
7_I53_L0.5971.00
119_L122_L0.5971.00
183_V207_Y0.5941.00
190_L206_I0.5921.00
192_P195_R0.5911.00
79_Q83_Q0.5901.00
109_L112_N0.5901.00
156_T215_V0.5841.00
234_I241_A0.5831.00
78_L83_Q0.5831.00
155_G218_M0.5831.00
28_L64_F0.5791.00
39_Y43_T0.5771.00
44_L106_A0.5731.00
195_R199_E0.5721.00
98_E101_G0.5721.00
186_M207_Y0.5661.00
157_A160_L0.5651.00
231_Q245_E0.5651.00
57_T86_P0.5631.00
138_Y172_A0.5611.00
83_Q92_A0.5601.00
7_I93_F0.5601.00
235_E245_E0.5591.00
79_Q82_V0.5581.00
151_F216_A0.5571.00
56_S62_P0.5551.00
137_A157_A0.5541.00
234_I239_F0.5531.00
195_R198_L0.5531.00
174_T224_W0.5531.00
159_S209_E0.5531.00
54_I80_Y0.5501.00
166_E169_S0.5481.00
196_G199_E0.5481.00
44_L49_I0.5481.00
89_L173_V0.5471.00
151_F154_N0.5471.00
108_V176_L0.5471.00
113_I236_A0.5471.00
6_G108_V0.5441.00
45_M77_N0.5411.00
171_Y217_M0.5411.00
43_T46_L0.5411.00
190_L203_I0.5391.00
40_P108_V0.5381.00
230_H234_I0.5371.00
20_V29_L0.5371.00
93_F184_V0.5331.00
40_P43_T0.5331.00
83_Q86_P0.5281.00
25_S60_D0.5281.00
155_G158_I0.5261.00
41_L76_L0.5251.00
9_L92_A0.5221.00
202_D206_I0.5221.00
237_S245_E0.5191.00
126_A133_A0.5181.00
119_L126_A0.5181.00
26_K111_D0.5181.00
72_S75_G0.5171.00
192_P196_G0.5161.00
96_G99_F0.5161.00
42_S46_L0.5151.00
218_M221_G0.5141.00
45_M75_G0.5121.00
190_L195_R0.5071.00
138_Y174_T0.5061.00
91_Q198_L0.5061.00
56_S60_D0.5051.00
197_E200_I0.5041.00
231_Q246_R0.5041.00
243_I247_Q0.5001.00
242_T245_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1iimA 3 0.9863 100 0.306 Contact Map
1lvwA 3 0.9932 100 0.321 Contact Map
4ho4A 3 0.9898 100 0.324 Contact Map
1mc3A 3 0.9932 100 0.325 Contact Map
2e3dA 3 0.8703 100 0.364 Contact Map
3jukA 3 0.8157 100 0.374 Contact Map
3brkX 2 0.9488 100 0.374 Contact Map
1yp2A 4 0.9693 100 0.376 Contact Map
2ux8A 4 0.8737 100 0.379 Contact Map
2pa4A 3 0.8908 100 0.393 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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