GREMLIN Database
RFAF - ADP-heptose--LPS heptosyltransferase 2
UniProt: P37692 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12210
Length: 348 (313)
Sequences: 5647 (4549)
Seq/√Len: 257.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_D81_Y4.7421.00
184_G262_C4.2811.00
53_E79_K3.7881.00
185_F206_A3.1411.00
25_Q52_N3.0181.00
32_I53_E2.8681.00
314_V326_S2.8481.00
203_A234_A2.8241.00
208_Q336_L2.8221.00
311_Y314_V2.8021.00
201_H332_P2.7301.00
251_Q254_Q2.6171.00
273_M285_A2.6061.00
311_Y326_S2.5911.00
129_P137_A2.5471.00
202_Y268_N2.4891.00
225_H229_N2.4711.00
199_H230_E2.4691.00
184_G259_I2.4141.00
184_G219_F2.3711.00
32_I52_N2.3151.00
198_P201_H2.3041.00
14_M45_L2.2921.00
3_I31_A2.2851.00
205_L336_L2.2211.00
205_L266_V2.2191.00
255_A272_L2.1921.00
197_W201_H2.1311.00
267_T273_M2.1041.00
34_D52_N2.1011.00
181_P263_K2.0971.00
228_G247_A2.0461.00
42_R46_S2.0161.00
183_I209_L1.9981.00
182_M261_A1.9761.00
180_R215_Q1.8901.00
34_D53_E1.8821.00
17_S87_L1.8781.00
20_L87_L1.8681.00
218_L228_G1.8641.00
104_H119_D1.8431.00
4_L36_M1.8411.00
207_K235_L1.8271.00
325_Q329_D1.8181.00
208_Q212_E1.8011.00
39_A58_P1.7811.00
197_W202_Y1.7721.00
183_I214_Y1.7381.00
256_V275_V1.7201.00
34_D55_I1.7141.00
182_M263_K1.7011.00
182_M262_C1.6961.00
210_I242_W1.6811.00
197_W335_V1.6561.00
137_A140_Y1.6341.00
139_A144_I1.6301.00
163_S166_E1.6261.00
265_I281_R1.6221.00
34_D79_K1.6201.00
307_L334_R1.6171.00
331_T334_R1.6141.00
207_K236_N1.5911.00
201_H204_E1.5911.00
5_V21_Y1.5851.00
333_Q337_E1.5841.00
70_R74_H1.5561.00
183_I264_A1.5561.00
208_Q333_Q1.5551.00
220_G248_G1.5371.00
229_N233_A1.5011.00
182_M217_V1.4901.00
43_P46_S1.4881.00
259_I279_L1.4831.00
324_H327_L1.4731.00
204_E207_K1.4521.00
98_F105_R1.4091.00
84_A97_P1.3991.00
186_C270_S1.3611.00
22_R26_A1.3531.00
186_C267_T1.3441.00
182_M215_Q1.3391.00
189_A196_R1.3391.00
187_P218_L1.3201.00
264_A284_V1.3101.00
228_G245_N1.3001.00
25_Q33_I1.2911.00
229_N245_N1.2891.00
181_P214_Y1.2891.00
28_Y31_A1.2861.00
195_K269_D1.2841.00
157_W160_L1.2791.00
245_N248_G1.2781.00
22_R50_E1.2781.00
83_R106_T1.2681.00
265_I276_A1.2651.00
188_G224_D1.2631.00
219_F255_A1.2531.00
133_E298_L1.2521.00
35_V45_L1.2471.00
197_W205_L1.2401.00
208_Q332_P1.2381.00
102_I105_R1.2281.00
209_L336_L1.2211.00
204_E208_Q1.2151.00
203_A207_K1.2121.00
215_Q244_R1.2041.00
42_R54_A1.1971.00
303_R338_E1.1971.00
208_Q211_D1.1871.00
86_V93_S1.1721.00
171_C261_A1.1651.00
21_Y35_V1.1651.00
20_L139_A1.1601.00
196_R227_A1.1591.00
47_R253_D1.1581.00
230_E234_A1.1541.00
198_P328_I1.1541.00
67_G71_K1.1501.00
16_M295_T1.1481.00
169_Y173_Q1.1451.00
158_P161_Q1.1431.00
18_Q48_M1.1421.00
42_R56_P1.1401.00
184_G258_L1.1381.00
205_L208_Q1.1371.00
170_T174_F1.1331.00
37_A54_A1.1121.00
195_K290_S1.1051.00
84_A102_I1.1021.00
292_P306_R1.0991.00
166_E254_Q1.0971.00
4_L81_Y1.0931.00
73_G77_R1.0861.00
232_L245_N1.0851.00
3_I33_I1.0841.00
200_Y328_I1.0771.00
10_W190_E1.0771.00
83_R104_H1.0751.00
206_A218_L1.0741.00
25_Q31_A1.0731.00
199_H231_I1.0731.00
306_R312_H1.0711.00
169_Y254_Q1.0701.00
330_I334_R1.0691.00
259_I281_R1.0681.00
334_R338_E1.0681.00
207_K211_D1.0591.00
205_L332_P1.0581.00
225_H249_E1.0551.00
220_G245_N1.0451.00
219_F262_C1.0431.00
206_A235_L1.0421.00
203_A231_I1.0391.00
27_R144_I1.0301.00
132_V298_L1.0291.00
267_T285_A1.0281.00
14_M41_C1.0281.00
226_E229_N1.0281.00
140_Y145_M1.0181.00
188_G227_A1.0161.00
188_G196_R1.0051.00
230_E233_A1.0041.00
160_L167_K0.9961.00
185_F266_V0.9931.00
23_T26_A0.9901.00
196_R268_N0.9891.00
160_L163_S0.9861.00
11_V41_C0.9841.00
159_Q162_V0.9771.00
203_A235_L0.9751.00
105_R118_N0.9711.00
299_S302_A0.9711.00
68_E71_K0.9701.00
224_D227_A0.9681.00
212_E336_L0.9671.00
166_E253_D0.9651.00
14_M35_V0.9631.00
286_L330_I0.9541.00
35_V51_V0.9511.00
189_A268_N0.9441.00
309_T314_V0.9421.00
222_A225_H0.9401.00
171_C174_F0.9391.00
167_K260_A0.9391.00
237_T242_W0.9381.00
186_C219_F0.9351.00
162_V167_K0.9331.00
273_M287_Y0.9331.00
163_S167_K0.9291.00
3_I83_R0.9241.00
43_P253_D0.9181.00
130_L296_P0.9131.00
160_L164_E0.9111.00
186_C265_I0.9051.00
229_N232_L0.9041.00
7_G10_W0.9011.00
6_I36_M0.8981.00
4_L84_A0.8921.00
23_T27_R0.8911.00
129_P133_E0.8881.00
182_M214_Y0.8861.00
85_Y142_K0.8841.00
266_V284_V0.8831.00
286_L305_I0.8831.00
235_L243_C0.8811.00
259_I265_I0.8811.00
46_S253_D0.8781.00
221_S224_D0.8781.00
256_V279_L0.8761.00
204_E332_P0.8731.00
197_W332_P0.8731.00
334_R337_E0.8721.00
113_R116_L0.8711.00
217_V258_L0.8651.00
162_V166_E0.8601.00
183_I266_V0.8570.99
308_I312_H0.8560.99
200_Y230_E0.8550.99
169_Y172_N0.8540.99
65_E68_E0.8510.99
117_L120_V0.8430.99
15_M275_V0.8430.99
7_G14_M0.8350.99
257_I260_A0.8340.99
201_H331_T0.8320.99
250_T258_L0.8320.99
260_A281_R0.8310.99
210_I216_V0.8290.99
31_A82_D0.8260.99
188_G268_N0.8230.99
113_R117_L0.8190.99
284_V303_R0.8170.99
269_D287_Y0.8120.99
284_V338_E0.8080.99
84_A100_A0.8040.99
47_R257_I0.8020.99
213_G216_V0.8010.99
214_Y263_K0.8000.99
206_A231_I0.7980.99
39_A42_R0.7930.99
74_H78_E0.7930.99
130_L298_L0.7920.99
204_E333_Q0.7910.99
11_V252_L0.7860.99
168_S172_N0.7840.99
226_E230_E0.7800.99
187_P231_I0.7780.99
307_L312_H0.7760.99
25_Q50_E0.7760.99
19_S136_I0.7730.99
164_E167_K0.7710.99
101_G105_R0.7690.99
95_L99_F0.7690.99
250_T254_Q0.7610.99
333_Q336_L0.7590.99
246_L249_E0.7540.99
131_M294_F0.7530.99
207_K237_T0.7530.99
246_L250_T0.7520.99
23_T136_I0.7520.99
21_Y50_E0.7500.99
286_L335_V0.7460.99
10_W14_M0.7390.99
199_H203_A0.7370.98
7_G17_S0.7340.98
171_C176_L0.7330.98
184_G265_I0.7320.98
168_S171_C0.7320.98
297_P304_V0.7260.98
197_W286_L0.7250.98
18_Q278_A0.7250.98
180_R213_G0.7230.98
97_P105_R0.7220.98
142_K145_M0.7210.98
332_P336_L0.7190.98
164_E168_S0.7180.98
166_E169_Y0.7130.98
73_G99_F0.7090.98
106_T121_R0.7070.98
309_T312_H0.7060.98
203_A206_A0.7060.98
24_L31_A0.7040.98
94_A113_R0.7020.98
9_S88_P0.7010.98
15_M278_A0.7010.98
220_G250_T0.6990.98
10_W16_M0.6960.98
197_W268_N0.6950.98
228_G232_L0.6930.98
202_Y206_A0.6930.98
177_S180_R0.6920.98
245_N249_E0.6900.98
131_M134_R0.6880.98
3_I28_Y0.6840.98
52_N81_Y0.6840.98
170_T173_Q0.6810.97
325_Q328_I0.6780.97
32_I81_Y0.6760.97
220_G249_E0.6730.97
14_M37_A0.6720.97
291_S294_F0.6710.97
38_P41_C0.6690.97
130_L133_E0.6680.97
97_P102_I0.6680.97
71_K74_H0.6650.97
5_V24_L0.6640.97
289_P324_H0.6620.97
12_G274_H0.6600.97
312_H315_R0.6600.97
13_D195_K0.6600.97
166_E170_T0.6590.97
88_P295_T0.6580.97
82_D103_P0.6560.97
161_Q164_E0.6550.97
114_Y120_V0.6530.97
39_A56_P0.6520.97
209_L214_Y0.6520.97
69_R73_G0.6520.97
245_N250_T0.6510.97
22_R159_Q0.6510.97
10_W88_P0.6510.97
307_L329_D0.6500.97
273_M283_L0.6480.97
53_E75_S0.6480.97
76_L100_A0.6470.97
55_I79_K0.6450.97
236_N243_C0.6430.96
75_S78_E0.6400.96
184_G217_V0.6400.96
48_M51_V0.6390.96
24_L33_I0.6390.96
156_L160_L0.6390.96
88_P93_S0.6330.96
218_L243_C0.6270.96
157_W162_V0.6260.96
58_P68_E0.6260.96
262_C281_R0.6240.96
201_H205_L0.6220.96
218_L232_L0.6210.96
67_G70_R0.6200.96
186_C272_L0.6200.96
158_P163_S0.6170.96
305_I335_V0.6160.95
18_Q47_R0.6160.95
210_I243_C0.6140.95
288_G327_L0.6140.95
276_A283_L0.6120.95
176_L180_R0.6110.95
58_P61_H0.6100.95
36_M72_L0.6070.95
133_E137_A0.6060.95
284_V305_I0.6050.95
12_G271_G0.6050.95
183_I216_V0.6040.95
196_R202_Y0.6020.95
186_C295_T0.6010.95
260_A279_L0.6010.95
187_P270_S0.5970.95
263_K282_P0.5940.94
282_P303_R0.5930.94
179_E215_Q0.5920.94
282_P301_K0.5900.94
308_I311_Y0.5890.94
284_V335_V0.5880.94
10_W270_S0.5880.94
265_I273_M0.5880.94
295_T315_R0.5830.94
115_G118_N0.5830.94
7_G131_M0.5830.94
9_S41_C0.5820.94
167_K170_T0.5810.94
250_T255_A0.5810.94
113_R118_N0.5800.94
6_I84_A0.5780.94
115_G119_D0.5770.94
277_A298_L0.5750.94
87_L138_L0.5740.93
188_G220_G0.5730.93
255_A275_V0.5720.93
168_S261_A0.5700.93
22_R48_M0.5700.93
247_A250_T0.5690.93
193_P196_R0.5680.93
16_M130_L0.5660.93
70_R99_F0.5650.93
207_K210_I0.5620.93
111_E114_Y0.5600.93
130_L277_A0.5600.93
44_L275_V0.5590.93
25_Q30_Q0.5590.93
273_M277_A0.5580.92
262_C265_I0.5580.92
225_H245_N0.5570.92
257_I261_A0.5570.92
114_Y118_N0.5560.92
259_I275_V0.5560.92
185_F216_V0.5550.92
15_M256_V0.5550.92
167_K171_C0.5550.92
9_S38_P0.5540.92
160_L166_E0.5530.92
86_V90_S0.5530.92
131_M135_Y0.5530.92
8_P138_L0.5530.92
12_G195_K0.5530.92
219_F272_L0.5520.92
178_S215_Q0.5520.92
97_P100_A0.5510.92
185_F202_Y0.5510.92
199_H227_A0.5500.92
38_P92_K0.5490.92
21_Y51_V0.5480.92
71_K75_S0.5470.92
201_H328_I0.5470.92
6_I86_V0.5470.92
210_I237_T0.5430.91
112_M116_L0.5430.91
309_T326_S0.5430.91
312_H326_S0.5430.91
137_A141_D0.5430.91
88_P294_F0.5400.91
108_W138_L0.5390.91
131_M295_T0.5390.91
21_Y33_I0.5380.91
5_V85_Y0.5350.91
19_S22_R0.5350.91
9_S86_V0.5350.91
313_K326_S0.5340.91
185_F205_L0.5340.91
310_G326_S0.5330.91
24_L139_A0.5330.91
236_N242_W0.5320.91
218_L231_I0.5320.91
49_P161_Q0.5310.91
94_A107_G0.5310.91
330_I335_V0.5300.90
189_A270_S0.5300.90
188_G221_S0.5290.90
219_F258_L0.5280.90
283_L302_A0.5270.90
90_S93_S0.5260.90
25_Q51_V0.5240.90
187_P228_G0.5240.90
283_L297_P0.5230.90
176_L179_E0.5210.90
28_Y83_R0.5190.90
156_L159_Q0.5170.89
265_I272_L0.5160.89
136_I145_M0.5150.89
265_I283_L0.5140.89
83_R86_V0.5140.89
283_L287_Y0.5120.89
87_L139_A0.5120.89
314_V324_H0.5110.89
6_I97_P0.5100.89
173_Q254_Q0.5100.89
45_L48_M0.5100.89
259_I272_L0.5090.89
163_S253_D0.5080.89
16_M131_M0.5080.89
94_A117_L0.5080.89
289_P313_K0.5080.89
66_I70_R0.5080.89
200_Y204_E0.5070.88
197_W331_T0.5050.88
35_V90_S0.5050.88
88_P92_K0.5040.88
198_P268_N0.5030.88
9_S190_E0.5000.88
25_Q29_P0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pswA 1 0.9511 100 0.213 Contact Map
3tovA 1 0.9655 100 0.243 Contact Map
2gt1A 1 0.8937 100 0.313 Contact Map
4rapA 3 0.7816 100 0.474 Contact Map
3ot5A 2 0.8793 99.4 0.802 Contact Map
4nesA 2 0.8879 99.2 0.818 Contact Map
4rifA 2 0.8621 99.1 0.823 Contact Map
1vgvA 2 0.8994 99 0.832 Contact Map
2yjnA 2 0.8649 99 0.836 Contact Map
3dzcA 2 0.8879 99 0.836 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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