RFAF - ECOLI - GREMLIN Contacts

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RFAF - ADP-heptose--LPS heptosyltransferase 2

UniProt:	P37692	Sequences: MKILVIGPSWVGDMMMSQSLYRTLQARYPQAIIDVMAPAWCRPLLSRMPEVNEAIPMPLGHGALEIGERRKLGHSLREKRYDRAYVLPNSFKSALVPFFAGIPHRTGWRGEMRYGLLNDVRVLDKEAWPLMVERYIALAYDKGIMRTAQDLPQPLLWPQLQVSEGEKSYTCNQFSLSSERPMIGFCPGAEFGPAKRWPHYHYAELAKQLIDEGYQVVLFGSAKDHEAGNEILAALNTEQQAWCRNLAGETQLDQAVILIAACKAIVTNDSGLMHVAAALNRPLVALYGPSSPDFTPPLSHKARVIRLITGYHKVRKGDAAEGYHQSLIDITPQRVLEELNALLLQEEA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12210
Length:	348 (313)
Sequences:	5647 (4549)
Seq/√Len:	257.1

ECOLI - RFAF RFAQ RFAC YEEL WAAU

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
34_D	81_Y	4.742	1.00
184_G	262_C	4.281	1.00
53_E	79_K	3.788	1.00
185_F	206_A	3.141	1.00
25_Q	52_N	3.018	1.00
32_I	53_E	2.868	1.00
314_V	326_S	2.848	1.00
203_A	234_A	2.824	1.00
208_Q	336_L	2.822	1.00
311_Y	314_V	2.802	1.00
201_H	332_P	2.730	1.00
251_Q	254_Q	2.617	1.00
273_M	285_A	2.606	1.00
311_Y	326_S	2.591	1.00
129_P	137_A	2.547	1.00
202_Y	268_N	2.489	1.00
225_H	229_N	2.471	1.00
199_H	230_E	2.469	1.00
184_G	259_I	2.414	1.00
184_G	219_F	2.371	1.00
32_I	52_N	2.315	1.00
198_P	201_H	2.304	1.00
14_M	45_L	2.292	1.00
3_I	31_A	2.285	1.00
205_L	336_L	2.221	1.00
205_L	266_V	2.219	1.00
255_A	272_L	2.192	1.00
197_W	201_H	2.131	1.00
267_T	273_M	2.104	1.00
34_D	52_N	2.101	1.00
181_P	263_K	2.097	1.00
228_G	247_A	2.046	1.00
42_R	46_S	2.016	1.00
183_I	209_L	1.998	1.00
182_M	261_A	1.976	1.00
180_R	215_Q	1.890	1.00
34_D	53_E	1.882	1.00
17_S	87_L	1.878	1.00
20_L	87_L	1.868	1.00
218_L	228_G	1.864	1.00
104_H	119_D	1.843	1.00
4_L	36_M	1.841	1.00
207_K	235_L	1.827	1.00
325_Q	329_D	1.818	1.00
208_Q	212_E	1.801	1.00
39_A	58_P	1.781	1.00
197_W	202_Y	1.772	1.00
183_I	214_Y	1.738	1.00
256_V	275_V	1.720	1.00
34_D	55_I	1.714	1.00
182_M	263_K	1.701	1.00
182_M	262_C	1.696	1.00
210_I	242_W	1.681	1.00
197_W	335_V	1.656	1.00
137_A	140_Y	1.634	1.00
139_A	144_I	1.630	1.00
163_S	166_E	1.626	1.00
265_I	281_R	1.622	1.00
34_D	79_K	1.620	1.00
307_L	334_R	1.617	1.00
331_T	334_R	1.614	1.00
207_K	236_N	1.591	1.00
201_H	204_E	1.591	1.00
5_V	21_Y	1.585	1.00
333_Q	337_E	1.584	1.00
70_R	74_H	1.556	1.00
183_I	264_A	1.556	1.00
208_Q	333_Q	1.555	1.00
220_G	248_G	1.537	1.00
229_N	233_A	1.501	1.00
182_M	217_V	1.490	1.00
43_P	46_S	1.488	1.00
259_I	279_L	1.483	1.00
324_H	327_L	1.473	1.00
204_E	207_K	1.452	1.00
98_F	105_R	1.409	1.00
84_A	97_P	1.399	1.00
186_C	270_S	1.361	1.00
22_R	26_A	1.353	1.00
186_C	267_T	1.344	1.00
182_M	215_Q	1.339	1.00
189_A	196_R	1.339	1.00
187_P	218_L	1.320	1.00
264_A	284_V	1.310	1.00
228_G	245_N	1.300	1.00
25_Q	33_I	1.291	1.00
229_N	245_N	1.289	1.00
181_P	214_Y	1.289	1.00
28_Y	31_A	1.286	1.00
195_K	269_D	1.284	1.00
157_W	160_L	1.279	1.00
245_N	248_G	1.278	1.00
22_R	50_E	1.278	1.00
83_R	106_T	1.268	1.00
265_I	276_A	1.265	1.00
188_G	224_D	1.263	1.00
219_F	255_A	1.253	1.00
133_E	298_L	1.252	1.00
35_V	45_L	1.247	1.00
197_W	205_L	1.240	1.00
208_Q	332_P	1.238	1.00
102_I	105_R	1.228	1.00
209_L	336_L	1.221	1.00
204_E	208_Q	1.215	1.00
203_A	207_K	1.212	1.00
215_Q	244_R	1.204	1.00
42_R	54_A	1.197	1.00
303_R	338_E	1.197	1.00
208_Q	211_D	1.187	1.00
86_V	93_S	1.172	1.00
171_C	261_A	1.165	1.00
21_Y	35_V	1.165	1.00
20_L	139_A	1.160	1.00
196_R	227_A	1.159	1.00
47_R	253_D	1.158	1.00
230_E	234_A	1.154	1.00
198_P	328_I	1.154	1.00
67_G	71_K	1.150	1.00
16_M	295_T	1.148	1.00
169_Y	173_Q	1.145	1.00
158_P	161_Q	1.143	1.00
18_Q	48_M	1.142	1.00
42_R	56_P	1.140	1.00
184_G	258_L	1.138	1.00
205_L	208_Q	1.137	1.00
170_T	174_F	1.133	1.00
37_A	54_A	1.112	1.00
195_K	290_S	1.105	1.00
84_A	102_I	1.102	1.00
292_P	306_R	1.099	1.00
166_E	254_Q	1.097	1.00
4_L	81_Y	1.093	1.00
73_G	77_R	1.086	1.00
232_L	245_N	1.085	1.00
3_I	33_I	1.084	1.00
200_Y	328_I	1.077	1.00
10_W	190_E	1.077	1.00
83_R	104_H	1.075	1.00
206_A	218_L	1.074	1.00
25_Q	31_A	1.073	1.00
199_H	231_I	1.073	1.00
306_R	312_H	1.071	1.00
169_Y	254_Q	1.070	1.00
330_I	334_R	1.069	1.00
259_I	281_R	1.068	1.00
334_R	338_E	1.068	1.00
207_K	211_D	1.059	1.00
205_L	332_P	1.058	1.00
225_H	249_E	1.055	1.00
220_G	245_N	1.045	1.00
219_F	262_C	1.043	1.00
206_A	235_L	1.042	1.00
203_A	231_I	1.039	1.00
27_R	144_I	1.030	1.00
132_V	298_L	1.029	1.00
267_T	285_A	1.028	1.00
14_M	41_C	1.028	1.00
226_E	229_N	1.028	1.00
140_Y	145_M	1.018	1.00
188_G	227_A	1.016	1.00
188_G	196_R	1.005	1.00
230_E	233_A	1.004	1.00
160_L	167_K	0.996	1.00
185_F	266_V	0.993	1.00
23_T	26_A	0.990	1.00
196_R	268_N	0.989	1.00
160_L	163_S	0.986	1.00
11_V	41_C	0.984	1.00
159_Q	162_V	0.977	1.00
203_A	235_L	0.975	1.00
105_R	118_N	0.971	1.00
299_S	302_A	0.971	1.00
68_E	71_K	0.970	1.00
224_D	227_A	0.968	1.00
212_E	336_L	0.967	1.00
166_E	253_D	0.965	1.00
14_M	35_V	0.963	1.00
286_L	330_I	0.954	1.00
35_V	51_V	0.951	1.00
189_A	268_N	0.944	1.00
309_T	314_V	0.942	1.00
222_A	225_H	0.940	1.00
171_C	174_F	0.939	1.00
167_K	260_A	0.939	1.00
237_T	242_W	0.938	1.00
186_C	219_F	0.935	1.00
162_V	167_K	0.933	1.00
273_M	287_Y	0.933	1.00
163_S	167_K	0.929	1.00
3_I	83_R	0.924	1.00
43_P	253_D	0.918	1.00
130_L	296_P	0.913	1.00
160_L	164_E	0.911	1.00
186_C	265_I	0.905	1.00
229_N	232_L	0.904	1.00
7_G	10_W	0.901	1.00
6_I	36_M	0.898	1.00
4_L	84_A	0.892	1.00
23_T	27_R	0.891	1.00
129_P	133_E	0.888	1.00
182_M	214_Y	0.886	1.00
85_Y	142_K	0.884	1.00
266_V	284_V	0.883	1.00
286_L	305_I	0.883	1.00
235_L	243_C	0.881	1.00
259_I	265_I	0.881	1.00
46_S	253_D	0.878	1.00
221_S	224_D	0.878	1.00
256_V	279_L	0.876	1.00
204_E	332_P	0.873	1.00
197_W	332_P	0.873	1.00
334_R	337_E	0.872	1.00
113_R	116_L	0.871	1.00
217_V	258_L	0.865	1.00
162_V	166_E	0.860	1.00
183_I	266_V	0.857	0.99
308_I	312_H	0.856	0.99
200_Y	230_E	0.855	0.99
169_Y	172_N	0.854	0.99
65_E	68_E	0.851	0.99
117_L	120_V	0.843	0.99
15_M	275_V	0.843	0.99
7_G	14_M	0.835	0.99
257_I	260_A	0.834	0.99
201_H	331_T	0.832	0.99
250_T	258_L	0.832	0.99
260_A	281_R	0.831	0.99
210_I	216_V	0.829	0.99
31_A	82_D	0.826	0.99
188_G	268_N	0.823	0.99
113_R	117_L	0.819	0.99
284_V	303_R	0.817	0.99
269_D	287_Y	0.812	0.99
284_V	338_E	0.808	0.99
84_A	100_A	0.804	0.99
47_R	257_I	0.802	0.99
213_G	216_V	0.801	0.99
214_Y	263_K	0.800	0.99
206_A	231_I	0.798	0.99
39_A	42_R	0.793	0.99
74_H	78_E	0.793	0.99
130_L	298_L	0.792	0.99
204_E	333_Q	0.791	0.99
11_V	252_L	0.786	0.99
168_S	172_N	0.784	0.99
226_E	230_E	0.780	0.99
187_P	231_I	0.778	0.99
307_L	312_H	0.776	0.99
25_Q	50_E	0.776	0.99
19_S	136_I	0.773	0.99
164_E	167_K	0.771	0.99
101_G	105_R	0.769	0.99
95_L	99_F	0.769	0.99
250_T	254_Q	0.761	0.99
333_Q	336_L	0.759	0.99
246_L	249_E	0.754	0.99
131_M	294_F	0.753	0.99
207_K	237_T	0.753	0.99
246_L	250_T	0.752	0.99
23_T	136_I	0.752	0.99
21_Y	50_E	0.750	0.99
286_L	335_V	0.746	0.99
10_W	14_M	0.739	0.99
199_H	203_A	0.737	0.98
7_G	17_S	0.734	0.98
171_C	176_L	0.733	0.98
184_G	265_I	0.732	0.98
168_S	171_C	0.732	0.98
297_P	304_V	0.726	0.98
197_W	286_L	0.725	0.98
18_Q	278_A	0.725	0.98
180_R	213_G	0.723	0.98
97_P	105_R	0.722	0.98
142_K	145_M	0.721	0.98
332_P	336_L	0.719	0.98
164_E	168_S	0.718	0.98
166_E	169_Y	0.713	0.98
73_G	99_F	0.709	0.98
106_T	121_R	0.707	0.98
309_T	312_H	0.706	0.98
203_A	206_A	0.706	0.98
24_L	31_A	0.704	0.98
94_A	113_R	0.702	0.98
9_S	88_P	0.701	0.98
15_M	278_A	0.701	0.98
220_G	250_T	0.699	0.98
10_W	16_M	0.696	0.98
197_W	268_N	0.695	0.98
228_G	232_L	0.693	0.98
202_Y	206_A	0.693	0.98
177_S	180_R	0.692	0.98
245_N	249_E	0.690	0.98
131_M	134_R	0.688	0.98
3_I	28_Y	0.684	0.98
52_N	81_Y	0.684	0.98
170_T	173_Q	0.681	0.97
325_Q	328_I	0.678	0.97
32_I	81_Y	0.676	0.97
220_G	249_E	0.673	0.97
14_M	37_A	0.672	0.97
291_S	294_F	0.671	0.97
38_P	41_C	0.669	0.97
130_L	133_E	0.668	0.97
97_P	102_I	0.668	0.97
71_K	74_H	0.665	0.97
5_V	24_L	0.664	0.97
289_P	324_H	0.662	0.97
12_G	274_H	0.660	0.97
312_H	315_R	0.660	0.97
13_D	195_K	0.660	0.97
166_E	170_T	0.659	0.97
88_P	295_T	0.658	0.97
82_D	103_P	0.656	0.97
161_Q	164_E	0.655	0.97
114_Y	120_V	0.653	0.97
39_A	56_P	0.652	0.97
209_L	214_Y	0.652	0.97
69_R	73_G	0.652	0.97
245_N	250_T	0.651	0.97
22_R	159_Q	0.651	0.97
10_W	88_P	0.651	0.97
307_L	329_D	0.650	0.97
273_M	283_L	0.648	0.97
53_E	75_S	0.648	0.97
76_L	100_A	0.647	0.97
55_I	79_K	0.645	0.97
236_N	243_C	0.643	0.96
75_S	78_E	0.640	0.96
184_G	217_V	0.640	0.96
48_M	51_V	0.639	0.96
24_L	33_I	0.639	0.96
156_L	160_L	0.639	0.96
88_P	93_S	0.633	0.96
218_L	243_C	0.627	0.96
157_W	162_V	0.626	0.96
58_P	68_E	0.626	0.96
262_C	281_R	0.624	0.96
201_H	205_L	0.622	0.96
218_L	232_L	0.621	0.96
67_G	70_R	0.620	0.96
186_C	272_L	0.620	0.96
158_P	163_S	0.617	0.96
305_I	335_V	0.616	0.95
18_Q	47_R	0.616	0.95
210_I	243_C	0.614	0.95
288_G	327_L	0.614	0.95
276_A	283_L	0.612	0.95
176_L	180_R	0.611	0.95
58_P	61_H	0.610	0.95
36_M	72_L	0.607	0.95
133_E	137_A	0.606	0.95
284_V	305_I	0.605	0.95
12_G	271_G	0.605	0.95
183_I	216_V	0.604	0.95
196_R	202_Y	0.602	0.95
186_C	295_T	0.601	0.95
260_A	279_L	0.601	0.95
187_P	270_S	0.597	0.95
263_K	282_P	0.594	0.94
282_P	303_R	0.593	0.94
179_E	215_Q	0.592	0.94
282_P	301_K	0.590	0.94
308_I	311_Y	0.589	0.94
284_V	335_V	0.588	0.94
10_W	270_S	0.588	0.94
265_I	273_M	0.588	0.94
295_T	315_R	0.583	0.94
115_G	118_N	0.583	0.94
7_G	131_M	0.583	0.94
9_S	41_C	0.582	0.94
167_K	170_T	0.581	0.94
250_T	255_A	0.581	0.94
113_R	118_N	0.580	0.94
6_I	84_A	0.578	0.94
115_G	119_D	0.577	0.94
277_A	298_L	0.575	0.94
87_L	138_L	0.574	0.93
188_G	220_G	0.573	0.93
255_A	275_V	0.572	0.93
168_S	261_A	0.570	0.93
22_R	48_M	0.570	0.93
247_A	250_T	0.569	0.93
193_P	196_R	0.568	0.93
16_M	130_L	0.566	0.93
70_R	99_F	0.565	0.93
207_K	210_I	0.562	0.93
111_E	114_Y	0.560	0.93
130_L	277_A	0.560	0.93
44_L	275_V	0.559	0.93
25_Q	30_Q	0.559	0.93
273_M	277_A	0.558	0.92
262_C	265_I	0.558	0.92
225_H	245_N	0.557	0.92
257_I	261_A	0.557	0.92
114_Y	118_N	0.556	0.92
259_I	275_V	0.556	0.92
185_F	216_V	0.555	0.92
15_M	256_V	0.555	0.92
167_K	171_C	0.555	0.92
9_S	38_P	0.554	0.92
160_L	166_E	0.553	0.92
86_V	90_S	0.553	0.92
131_M	135_Y	0.553	0.92
8_P	138_L	0.553	0.92
12_G	195_K	0.553	0.92
219_F	272_L	0.552	0.92
178_S	215_Q	0.552	0.92
97_P	100_A	0.551	0.92
185_F	202_Y	0.551	0.92
199_H	227_A	0.550	0.92
38_P	92_K	0.549	0.92
21_Y	51_V	0.548	0.92
71_K	75_S	0.547	0.92
201_H	328_I	0.547	0.92
6_I	86_V	0.547	0.92
210_I	237_T	0.543	0.91
112_M	116_L	0.543	0.91
309_T	326_S	0.543	0.91
312_H	326_S	0.543	0.91
137_A	141_D	0.543	0.91
88_P	294_F	0.540	0.91
108_W	138_L	0.539	0.91
131_M	295_T	0.539	0.91
21_Y	33_I	0.538	0.91
5_V	85_Y	0.535	0.91
19_S	22_R	0.535	0.91
9_S	86_V	0.535	0.91
313_K	326_S	0.534	0.91
185_F	205_L	0.534	0.91
310_G	326_S	0.533	0.91
24_L	139_A	0.533	0.91
236_N	242_W	0.532	0.91
218_L	231_I	0.532	0.91
49_P	161_Q	0.531	0.91
94_A	107_G	0.531	0.91
330_I	335_V	0.530	0.90
189_A	270_S	0.530	0.90
188_G	221_S	0.529	0.90
219_F	258_L	0.528	0.90
283_L	302_A	0.527	0.90
90_S	93_S	0.526	0.90
25_Q	51_V	0.524	0.90
187_P	228_G	0.524	0.90
283_L	297_P	0.523	0.90
176_L	179_E	0.521	0.90
28_Y	83_R	0.519	0.90
156_L	159_Q	0.517	0.89
265_I	272_L	0.516	0.89
136_I	145_M	0.515	0.89
265_I	283_L	0.514	0.89
83_R	86_V	0.514	0.89
283_L	287_Y	0.512	0.89
87_L	139_A	0.512	0.89
314_V	324_H	0.511	0.89
6_I	97_P	0.510	0.89
173_Q	254_Q	0.510	0.89
45_L	48_M	0.510	0.89
259_I	272_L	0.509	0.89
163_S	253_D	0.508	0.89
16_M	131_M	0.508	0.89
94_A	117_L	0.508	0.89
289_P	313_K	0.508	0.89
66_I	70_R	0.508	0.89
200_Y	204_E	0.507	0.88
197_W	331_T	0.505	0.88
35_V	90_S	0.505	0.88
88_P	92_K	0.504	0.88
198_P	268_N	0.503	0.88
9_S	190_E	0.500	0.88
25_Q	29_P	0.500	0.88

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1pswA	1	0.9511	100	0.213	Contact Map
3tovA	1	0.9655	100	0.243	Contact Map
2gt1A	1	0.8937	100	0.313	Contact Map
4rapA	3	0.7816	100	0.474	Contact Map
3ot5A	2	0.8793	99.4	0.802	Contact Map
4nesA	2	0.8879	99.2	0.818	Contact Map
4rifA	2	0.8621	99.1	0.823	Contact Map
1vgvA	2	0.8994	99	0.832	Contact Map
2yjnA	2	0.8649	99	0.836	Contact Map
3dzcA	2	0.8879	99	0.836	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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