GREMLIN Database
ENVC - Murein hydrolase activator EnvC
UniProt: P37690 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12297
Length: 419 (368)
Sequences: 2718 (2257)
Seq/√Len: 117.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
369_N387_A4.2041.00
333_V369_N3.7541.00
344_A372_A3.3631.00
307_L326_G3.3591.00
248_K252_E3.1351.00
327_A389_V3.1111.00
253_R257_E3.0891.00
309_R414_Q3.0701.00
358_H364_S3.0441.00
373_L388_L2.9891.00
310_Y410_A2.9421.00
299_F382_A2.8921.00
249_A253_R2.8121.00
391_S395_Q2.7801.00
338_D381_R2.7301.00
198_Q202_T2.6911.00
253_R256_R2.6821.00
252_E256_R2.6581.00
251_A255_A2.5331.00
239_S242_R2.5321.00
249_A252_E2.5091.00
250_R254_E2.5011.00
332_E385_P2.4901.00
300_W325_I2.3991.00
120_Q159_R2.3851.00
245_A249_A2.3611.00
336_I364_S2.3471.00
246_A250_R2.2821.00
356_V386_I2.2391.00
364_S404_I2.2251.00
177_R181_E2.1601.00
329_E398_P2.1111.00
335_A356_V2.0451.00
252_E255_A2.0301.00
254_E257_E2.0291.00
374_V378_S2.0131.00
107_E111_A1.9991.00
197_Q200_K1.9571.00
103_I173_V1.9511.00
251_A254_E1.9491.00
350_Y367_G1.9451.00
340_R379_Q1.9251.00
321_K403_E1.9111.00
242_R246_A1.8881.00
248_K251_A1.8831.00
96_I180_L1.8681.00
381_R384_Q1.8331.00
98_E102_S1.8271.00
191_L195_R1.8271.00
324_V401_Y1.8171.00
369_N372_A1.7941.00
250_R253_R1.7761.00
315_Q318_L1.7721.00
171_E175_M1.6841.00
81_K197_Q1.6811.00
305_P326_G1.6781.00
33_H37_R1.6581.00
246_A249_A1.6331.00
327_A331_T1.6301.00
100_N104_A1.6161.00
110_K166_L1.6161.00
125_F128_G1.5961.00
367_G403_E1.5771.00
312_E319_R1.5531.00
47_I226_L1.5491.00
389_V400_L1.5271.00
214_G218_S1.5201.00
308_H313_Q1.5161.00
77_E81_K1.5151.00
374_V384_Q1.5131.00
183_K186_E1.5071.00
233_E237_R1.5001.00
375_S378_S1.4991.00
385_P388_L1.4971.00
27_L30_F1.4951.00
84_E88_T1.4921.00
349_G367_G1.4921.00
355_V365_L1.4841.00
121_L125_F1.4801.00
241_A245_A1.4751.00
354_V369_N1.4541.00
53_A56_Q1.4511.00
304_G325_I1.4421.00
362_D406_R1.4401.00
247_A250_R1.4401.00
164_A168_Q1.4221.00
362_D404_I1.4161.00
86_Q90_N1.4081.00
122_D126_R1.4031.00
334_K385_P1.3801.00
92_L183_K1.3731.00
209_K213_A1.3731.00
354_V386_I1.3711.00
95_Q98_E1.3691.00
412_N415_P1.3551.00
34_A37_R1.3531.00
113_Q169_T1.3381.00
228_E232_N1.3291.00
97_D100_N1.3281.00
314_L317_E1.3161.00
247_A251_A1.3121.00
324_V399_S1.3111.00
336_I402_F1.2941.00
337_A382_A1.2931.00
241_A244_E1.2911.00
342_I357_E1.2911.00
327_A330_G1.2901.00
232_N235_R1.2811.00
95_Q183_K1.2801.00
103_I106_L1.2710.99
105_K109_Q1.2650.99
219_I223_Q1.2560.99
107_E177_R1.2540.99
323_M417_L1.2530.99
333_V389_V1.2520.99
82_L194_Q1.2490.99
320_W399_S1.2400.99
141_E144_R1.2370.99
242_R245_A1.2340.99
114_E118_A1.2130.99
308_H320_W1.2110.99
320_W324_V1.2100.99
184_Q188_Q1.2070.99
108_Q112_A1.2050.99
350_Y365_L1.2000.99
175_M179_E1.1990.99
355_V363_M1.1980.99
323_M414_Q1.1870.99
61_R216_E1.1810.99
51_E55_R1.1720.99
336_I404_I1.1660.99
324_V368_Y1.1630.99
391_S396_G1.1630.99
92_L187_Q1.1620.99
75_I201_L1.1610.99
61_R219_I1.1550.99
218_S221_Q1.1530.99
104_A107_E1.1440.99
195_R199_A1.1380.99
411_V416_W1.1300.99
373_L387_A1.1270.99
336_I366_Y1.1240.99
244_E247_A1.1160.99
328_S331_T1.1060.99
72_E208_R1.1020.99
234_S238_N1.1020.99
167_K171_E1.1010.98
353_V367_G1.1000.98
238_N242_R1.1000.98
47_I51_E1.0970.98
235_R239_S1.0930.98
202_T205_L1.0930.98
133_I137_L1.0880.98
391_S398_P1.0870.98
101_A105_K1.0790.98
358_H402_F1.0780.98
41_K44_Q1.0760.98
309_R412_N1.0760.98
350_Y403_E1.0740.98
25_V28_C1.0610.98
303_R334_K1.0600.98
29_A32_A1.0480.98
244_E248_K1.0380.98
364_S402_F1.0350.98
43_I47_I1.0200.98
67_Q70_K1.0190.98
40_L44_Q1.0170.97
30_F33_H1.0160.97
373_L385_P1.0150.97
170_R174_A1.0150.97
90_N93_N1.0150.97
116_S120_Q1.0080.97
108_Q111_A1.0060.97
196_A199_A1.0050.97
208_R212_L1.0030.97
32_A35_D1.0020.97
300_W417_L1.0000.97
315_Q321_K0.9950.97
196_A200_K0.9890.97
79_T83_R0.9810.97
102_S176_Q0.9800.97
181_E185_S0.9790.97
229_L233_E0.9780.97
353_V365_L0.9770.97
283_S287_R0.9730.97
81_K84_E0.9730.97
35_D38_D0.9710.97
205_L209_K0.9680.97
185_S188_Q0.9660.97
302_V327_A0.9640.97
115_R118_A0.9630.96
387_A400_L0.9600.96
36_E40_L0.9560.96
351_G390_G0.9560.96
30_F34_A0.9510.96
204_A207_E0.9500.96
310_Y409_Q0.9480.96
185_S189_T0.9480.96
28_C32_A0.9480.96
85_T194_Q0.9470.96
174_A178_A0.9450.96
343_L355_V0.9430.96
70_K74_A0.9410.96
230_R234_S0.9330.96
366_Y402_F0.9330.96
199_A202_T0.9320.96
230_R233_E0.9300.96
55_R58_Q0.9280.96
36_E39_Q0.9250.96
166_L169_T0.9210.95
78_A197_Q0.9180.95
371_S388_L0.9180.95
74_A77_E0.9160.95
189_T193_E0.9150.95
194_Q198_Q0.9150.95
120_Q124_A0.9130.95
63_S67_Q0.9110.95
368_Y393_G0.9080.95
139_G148_L0.9070.95
50_K222_G0.9020.95
42_S46_D0.9020.95
56_Q60_Q0.9010.95
350_Y405_R0.9000.95
176_Q179_E0.8990.95
85_T89_L0.8970.95
164_A167_K0.8950.95
178_A181_E0.8910.95
340_R357_E0.8910.95
34_A38_D0.8910.95
78_A81_K0.8900.95
41_K45_A0.8860.94
354_V374_V0.8850.94
88_T92_L0.8820.94
25_V29_A0.8810.94
403_E410_A0.8770.94
102_S172_E0.8770.94
210_K214_G0.8760.94
358_H366_Y0.8710.94
75_I205_L0.8700.94
369_N389_V0.8680.94
93_N97_D0.8640.94
29_A33_H0.8630.94
342_I363_M0.8620.94
243_A247_A0.8590.93
106_L110_K0.8570.93
113_Q116_S0.8570.93
298_A362_D0.8550.93
211_T214_G0.8540.93
302_V325_I0.8520.93
44_Q233_E0.8510.93
93_N184_Q0.8450.93
26_L29_A0.8430.93
48_A52_R0.8430.93
182_E186_E0.8430.93
103_I110_K0.8430.93
249_A257_E0.8400.93
207_E210_K0.8390.93
190_L193_E0.8390.93
46_D49_A0.8380.93
172_E176_Q0.8380.93
92_L95_Q0.8370.93
38_D42_S0.8370.93
36_E240_I0.8360.93
179_E183_K0.8350.92
110_K114_E0.8340.92
48_A51_E0.8330.92
69_K73_E0.8320.92
50_K226_L0.8280.92
188_Q192_Y0.8280.92
405_R410_A0.8270.92
357_E361_G0.8260.92
78_A204_A0.8260.92
109_Q169_T0.8260.92
54_V219_I0.8250.92
64_L215_L0.8250.92
28_C35_D0.8210.92
87_N91_Q0.8200.92
64_L212_L0.8190.92
50_K53_A0.8160.92
243_A246_A0.8160.92
54_V226_L0.8120.91
222_G225_Q0.8110.91
117_L166_L0.8100.91
202_T206_N0.8080.91
142_S148_L0.8070.91
226_L230_R0.8050.91
85_T88_T0.8050.91
96_I103_I0.8040.91
248_K256_R0.8040.91
97_D101_A0.8030.91
368_Y399_S0.8030.91
99_M103_I0.8020.91
155_L159_R0.7970.91
346_W352_L0.7960.91
90_N94_K0.7930.90
365_L405_R0.7930.90
295_R337_A0.7920.90
345_D372_A0.7910.90
355_V405_R0.7900.90
298_A416_W0.7900.90
310_Y411_V0.7900.90
38_D41_K0.7890.90
120_Q125_F0.7880.90
325_I417_L0.7850.90
307_L399_S0.7820.90
159_R162_T0.7800.90
195_R198_Q0.7800.90
121_L128_G0.7790.90
67_Q208_R0.7790.90
368_Y395_Q0.7790.90
283_S286_S0.7780.90
320_W401_Y0.7730.89
66_A69_K0.7720.89
370_Q388_L0.7710.89
139_G142_S0.7670.89
291_L295_R0.7670.89
68_L72_E0.7660.89
113_Q125_F0.7650.89
74_A204_A0.7640.89
74_A78_A0.7630.89
91_Q95_Q0.7610.89
357_E405_R0.7600.88
307_L320_W0.7600.88
192_Y195_R0.7590.88
78_A82_L0.7590.88
81_K85_T0.7570.88
92_L96_I0.7560.88
192_Y196_A0.7500.88
144_R148_L0.7500.88
35_D39_Q0.7490.88
347_L353_V0.7460.88
288_T291_L0.7460.88
110_K169_T0.7430.87
291_L416_W0.7420.87
238_N241_A0.7410.87
227_S231_A0.7390.87
206_N209_K0.7370.87
219_I222_G0.7350.87
369_N400_L0.7350.87
30_F35_D0.7320.87
189_T192_Y0.7310.86
225_Q228_E0.7240.86
68_L211_T0.7210.86
306_T414_Q0.7200.86
343_L353_V0.7180.85
298_A337_A0.7180.85
367_G405_R0.7170.85
31_S34_A0.7140.85
61_R215_L0.7140.85
28_C31_S0.7140.85
291_L362_D0.7130.85
45_A48_A0.7130.85
168_Q172_E0.7120.85
332_E388_L0.7110.85
354_V371_S0.7090.85
300_W303_R0.7040.84
227_S230_R0.7020.84
356_V380_V0.7020.84
329_E370_Q0.7000.84
101_A104_A0.6990.84
239_S243_A0.6980.84
57_K61_R0.6980.84
295_R416_W0.6970.84
357_E363_M0.6960.84
320_W397_R0.6950.84
324_V397_R0.6950.84
237_R241_A0.6930.83
236_L240_I0.6890.83
362_D416_W0.6870.83
324_V393_G0.6870.83
245_A248_K0.6860.83
224_Q228_E0.6850.83
165_Q169_T0.6830.83
389_V398_P0.6820.82
313_Q319_R0.6800.82
291_L298_A0.6780.82
110_K170_R0.6780.82
72_E76_S0.6760.82
80_R84_E0.6760.82
294_P297_Q0.6750.82
397_R401_Y0.6740.82
44_Q48_A0.6730.82
338_D379_Q0.6730.82
85_T190_L0.6710.81
53_A57_K0.6700.81
318_L325_I0.6690.81
100_N177_R0.6670.81
343_L405_R0.6670.81
395_Q399_S0.6660.81
103_I107_E0.6660.81
291_L297_Q0.6630.81
252_E257_E0.6620.81
139_G159_R0.6620.81
368_Y397_R0.6590.80
249_A256_R0.6580.80
49_A53_A0.6530.80
123_A128_G0.6510.79
299_F336_I0.6500.79
89_L187_Q0.6450.79
231_A234_S0.6450.79
60_Q63_S0.6450.79
36_E236_L0.6450.79
161_E164_A0.6440.79
172_E175_M0.6440.79
42_S45_A0.6430.79
190_L194_Q0.6420.78
111_A114_E0.6410.78
322_G359_G0.6410.78
57_K222_G0.6380.78
343_L347_L0.6380.78
203_Q206_N0.6350.78
350_Y355_V0.6350.78
396_G399_S0.6350.78
61_R212_L0.6340.78
188_Q191_L0.6340.78
308_H324_V0.6340.78
357_E372_A0.6320.77
390_G399_S0.6320.77
365_L403_E0.6320.77
67_Q71_Q0.6310.77
291_L294_P0.6290.77
315_Q319_R0.6280.77
368_Y392_S0.6280.77
320_W390_G0.6250.77
99_M102_S0.6250.77
294_P337_A0.6240.77
306_T309_R0.6220.76
215_L219_I0.6190.76
94_K98_E0.6160.76
223_Q227_S0.6140.75
58_Q223_Q0.6140.75
162_T165_Q0.6110.75
346_W392_S0.6100.75
44_Q47_I0.6070.75
368_Y404_I0.6060.74
321_K410_A0.6050.74
240_I244_E0.6050.74
320_W368_Y0.6050.74
193_E197_Q0.6030.74
82_L86_Q0.6030.74
154_Y158_A0.6030.74
124_A159_R0.5950.73
333_V400_L0.5950.73
47_I54_V0.5930.73
43_I46_D0.5910.73
168_Q171_E0.5900.72
79_T205_L0.5900.72
322_G401_Y0.5880.72
248_K254_E0.5870.72
368_Y401_Y0.5860.72
411_V415_P0.5860.72
195_R202_T0.5860.72
357_E407_Q0.5860.72
47_I50_K0.5850.72
330_G388_L0.5840.72
58_Q62_A0.5840.72
83_R86_Q0.5790.71
136_I139_G0.5790.71
346_W369_N0.5780.71
151_Y166_L0.5760.71
406_R411_V0.5750.71
172_E179_E0.5740.70
83_R87_N0.5730.70
193_E196_A0.5720.70
103_I180_L0.5710.70
26_L30_F0.5700.70
320_W396_G0.5700.70
120_Q139_G0.5680.70
45_A49_A0.5670.69
51_E226_L0.5670.69
352_L392_S0.5660.69
100_N184_Q0.5650.69
131_T136_I0.5650.69
86_Q198_Q0.5650.69
68_L212_L0.5640.69
91_Q101_A0.5640.69
26_L31_S0.5630.69
132_G142_S0.5610.69
46_D225_Q0.5610.69
57_K219_I0.5600.69
296_G359_G0.5600.69
57_K215_L0.5580.68
182_E185_S0.5570.68
306_T323_M0.5550.68
233_E240_I0.5540.68
350_Y353_V0.5530.68
207_E211_T0.5520.67
200_K203_Q0.5510.67
86_Q191_L0.5510.67
312_E315_Q0.5480.67
201_L204_A0.5480.67
206_N210_K0.5480.67
203_Q250_R0.5460.67
61_R65_L0.5450.66
312_E318_L0.5450.66
103_I177_R0.5450.66
298_A364_S0.5440.66
120_Q128_G0.5430.66
229_L343_L0.5430.66
43_I50_K0.5410.66
113_Q117_L0.5400.66
157_Q161_E0.5380.65
147_R150_A0.5380.65
284_L288_T0.5370.65
89_L191_L0.5360.65
88_T91_Q0.5350.65
78_A194_Q0.5350.65
92_L190_L0.5350.65
87_N90_N0.5350.65
290_G293_A0.5350.65
334_K383_G0.5330.65
151_Y155_L0.5310.64
392_S395_Q0.5290.64
138_S141_E0.5280.64
284_L287_R0.5270.64
320_W395_Q0.5260.64
125_F133_I0.5260.64
116_S119_A0.5260.64
106_L109_Q0.5250.64
95_Q179_E0.5240.63
390_G408_G0.5240.63
104_A108_Q0.5230.63
369_N373_L0.5210.63
147_R151_Y0.5210.63
186_E190_L0.5200.63
61_R64_L0.5200.63
99_M176_Q0.5190.63
169_T172_E0.5190.63
237_R240_I0.5170.62
139_G145_G0.5170.62
311_G315_Q0.5160.62
115_R119_A0.5160.62
222_G226_L0.5140.62
150_A154_Y0.5120.62
200_K204_A0.5120.62
110_K113_Q0.5100.61
236_L239_S0.5080.61
286_S289_G0.5080.61
122_D125_F0.5080.61
39_Q43_I0.5070.61
162_T166_L0.5070.61
180_L184_Q0.5030.60
55_R59_Q0.5030.60
102_S105_K0.5020.60
135_L142_S0.5020.60
84_E87_N0.5020.60
393_G399_S0.5020.60
321_K405_R0.5020.60
158_A208_R0.5010.60
338_D382_A0.5010.60
186_E189_T0.5000.60
331_T389_V0.5000.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4bh5A 4 0.3103 100 0.525 Contact Map
2hsiA 1 0.5227 100 0.551 Contact Map
3tufB 1 0.3007 100 0.552 Contact Map
4rnzA 1 0.7112 100 0.566 Contact Map
1qwyA 1 0.5418 100 0.574 Contact Map
2gu1A 1 0.6802 100 0.579 Contact Map
3sluA 1 0.6921 100 0.583 Contact Map
4qp5A 1 0.3007 100 0.592 Contact Map
3nyyA 2 0.4869 100 0.596 Contact Map
4lxcA 4 0.3031 100 0.598 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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