GPMI - ECOLI - GREMLIN Contacts

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GPMI - 2,3-bisphosphoglycerate-independent phosphoglycerate mutase

UniProt:	P37689	Sequences: MLVSKKPMVLVILDGYGYREEQQDNAIFSAKTPVMDALWANRPHTLIDASGLEVGLPDRQMGNSEVGHVNLGAGRIVYQDLTRLDVEIKDRAFFANPVLTGAVDKAKNAGKAVHIMGLLSAGGVHSHEDHIMAMVELAAERGAEKIYLHAFLDGRDTPPRSAESSLKKFEEKFAALGKGRVASIIGRYYAMDRDNRWDRVEKAYDLLTLAQGEFQADTAVAGLQAAYARDENDEFVKATVIRAEGQPDAAMEDGDALIFMNFRADRAREITRAFVNADFDGFARKKVVNVDFVMLTEYAADIKTAVAYPPASLVNTFGEWMAKNDKTQLRISETEKYAHVTFFFNGGVEESFKGEDRILINSPKVATYDLQPEMSSAELTEKLVAAIKSGKYDTIICNYPNGDMVGHTGVMEAAVKAVEALDHCVEEVAKAVESVGGQLLITADHGNAEQMRDPATGQAHTAHTNLPVPLIYVGDKNVKAVEGGKLSDIAPTMLSLMGMEIPQEMTGKPLFIVE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12296
Length:	514 (501)
Sequences:	2442 (1479)
Seq/√Len:	66.1

ECOLI - GPMI
BACSU - GPMI
HALSA - GPMI

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
201_E	205_D	5.054	1.00
29_S	411_M	3.563	1.00
381_E	427_E	3.520	1.00
356_D	392_Y	3.499	1.00
315_N	504_E	3.487	1.00
34_V	426_E	3.053	1.00
224_Q	228_A	3.044	1.00
200_V	269_E	2.994	1.00
380_T	399_Y	2.882	1.00
388_K	434_S	2.829	1.00
71_L	489_I	2.773	1.00
136_E	172_K	2.710	1.00
495_S	509_P	2.680	1.00
32_T	36_D	2.656	1.00
52_L	89_K	2.604	1.00
218_T	221_A	2.542	1.00
37_A	41_N	2.499	1.00
411_M	415_V	2.490	1.00
318_G	330_R	2.428	1.00
321_M	394_T	2.398	1.00
18_Y	46_L	2.398	1.00
39_W	44_H	2.373	1.00
319_E	323_K	2.357	1.00
202_K	237_K	2.350	1.00
53_E	485_K	2.344	1.00
226_A	231_E	2.327	1.00
87_E	308_Y	2.327	1.00
382_K	385_A	2.315	1.00
188_Y	366_A	2.311	1.00
131_I	260_M	2.285	1.00
167_K	171_E	2.255	1.00
216_A	239_T	2.235	1.00
48_D	53_E	2.215	1.00
170_E	174_A	2.214	1.00
320_W	324_N	2.200	1.00
152_L	236_V	2.194	1.00
160_R	232_N	2.178	1.00
104_D	141_R	2.157	1.00
112_A	147_Y	2.139	1.00
121_A	165_S	2.131	1.00
163_E	224_Q	2.092	1.00
495_S	501_I	2.062	1.00
399_Y	428_V	2.059	1.00
103_V	137_L	2.056	1.00
104_D	108_N	2.049	1.00
390_G	435_V	2.043	1.00
380_T	427_E	2.039	1.00
100_T	141_R	2.027	1.00
170_E	218_T	1.993	1.00
132_M	172_K	1.980	1.00
136_E	140_E	1.976	1.00
488_D	507_G	1.943	1.00
360_I	382_K	1.939	1.00
134_M	260_M	1.926	1.00
112_A	145_K	1.912	1.00
432_V	437_G	1.894	1.00
132_M	168_K	1.877	1.00
185_I	206_L	1.872	1.00
29_S	415_V	1.872	1.00
112_A	252_E	1.869	1.00
148_L	173_F	1.864	1.00
470_L	489_I	1.863	1.00
24_D	452_R	1.854	1.00
221_A	225_A	1.847	1.00
152_L	162_A	1.844	1.00
453_D	456_T	1.834	1.00
429_A	439_L	1.829	1.00
231_E	237_K	1.824	1.00
172_K	175_A	1.814	1.00
373_E	416_K	1.804	1.00
388_K	431_A	1.798	1.00
86_V	90_D	1.797	1.00
7_P	437_G	1.759	1.00
501_I	508_K	1.722	1.00
111_K	254_G	1.686	0.99
326_K	393_D	1.685	0.99
207_L	251_M	1.676	0.99
441_I	473_V	1.651	0.99
501_I	509_P	1.642	0.99
105_K	256_A	1.642	0.99
116_M	151_F	1.638	0.99
327_T	391_K	1.638	0.99
147_Y	182_A	1.624	0.99
180_R	243_A	1.621	0.99
170_E	219_A	1.617	0.99
206_L	240_V	1.590	0.99
321_M	326_K	1.583	0.99
160_R	230_D	1.566	0.99
148_L	169_F	1.564	0.99
394_T	493_M	1.563	0.99
251_M	274_F	1.560	0.99
170_E	220_V	1.559	0.99
97_P	101_G	1.552	0.99
317_F	394_T	1.547	0.99
35_M	425_V	1.540	0.99
34_V	37_A	1.539	0.99
384_V	431_A	1.532	0.99
70_N	77_V	1.523	0.99
440_L	496_L	1.519	0.99
251_M	257_L	1.517	0.99
106_A	256_A	1.510	0.99
102_A	256_A	1.509	0.99
253_D	289_N	1.491	0.99
432_V	439_L	1.485	0.99
205_D	211_Q	1.472	0.98
279_F	282_F	1.471	0.98
366_A	370_L	1.469	0.98
128_E	132_M	1.459	0.98
135_V	173_F	1.450	0.98
382_K	386_A	1.446	0.98
377_A	423_H	1.439	0.98
331_I	379_L	1.436	0.98
9_V	432_V	1.433	0.98
480_A	483_G	1.432	0.98
22_Q	28_F	1.419	0.98
11_V	439_L	1.410	0.98
96_N	307_A	1.403	0.98
145_K	180_R	1.402	0.98
384_V	388_K	1.398	0.98
377_A	424_C	1.390	0.98
317_F	493_M	1.388	0.98
253_D	288_V	1.387	0.98
163_E	220_V	1.386	0.98
78_Y	86_V	1.380	0.98
430_K	434_S	1.378	0.98
217_D	221_A	1.374	0.98
320_W	499_M	1.369	0.97
272_R	276_N	1.368	0.97
387_I	435_V	1.363	0.97
158_P	161_S	1.362	0.97
254_G	289_N	1.351	0.97
31_K	419_E	1.350	0.97
94_F	140_E	1.349	0.97
88_I	133_A	1.348	0.97
386_A	389_S	1.343	0.97
45_T	483_G	1.340	0.97
259_F	267_A	1.338	0.97
135_V	146_I	1.332	0.97
387_I	431_A	1.330	0.97
163_E	167_K	1.330	0.97
33_P	419_E	1.329	0.97
113_V	138_A	1.325	0.97
453_D	458_Q	1.322	0.97
331_I	397_C	1.317	0.97
185_I	190_A	1.316	0.97
13_L	425_V	1.313	0.97
146_I	178_K	1.311	0.97
297_E	310_P	1.311	0.97
106_A	113_V	1.302	0.97
115_I	260_M	1.300	0.97
88_I	93_F	1.294	0.96
383_L	397_C	1.291	0.96
377_A	420_A	1.290	0.96
414_A	451_M	1.289	0.96
426_E	430_K	1.289	0.96
13_L	35_M	1.286	0.96
77_V	313_L	1.284	0.96
121_A	128_E	1.280	0.96
420_A	424_C	1.276	0.96
440_L	470_L	1.266	0.96
85_D	129_D	1.263	0.96
190_A	203_A	1.259	0.96
431_A	434_S	1.252	0.96
48_D	467_P	1.249	0.96
170_E	181_V	1.249	0.96
19_R	22_Q	1.248	0.96
164_S	167_K	1.245	0.96
143_A	146_I	1.241	0.96
27_I	448_A	1.240	0.95
313_L	316_T	1.237	0.95
107_K	141_R	1.229	0.95
226_A	237_K	1.229	0.95
205_D	209_L	1.226	0.95
377_A	381_E	1.223	0.95
348_V	352_F	1.222	0.95
87_E	92_A	1.222	0.95
183_S	206_L	1.222	0.95
166_L	223_L	1.212	0.95
495_S	511_F	1.212	0.95
16_Y	35_M	1.211	0.95
452_R	457_G	1.210	0.95
387_I	395_I	1.208	0.95
103_V	138_A	1.208	0.95
291_D	305_A	1.206	0.95
135_V	176_L	1.204	0.95
83_R	311_A	1.204	0.95
380_T	384_V	1.201	0.95
189_Y	237_K	1.198	0.95
106_A	111_K	1.195	0.94
402_G	418_V	1.191	0.94
102_A	106_A	1.189	0.94
45_T	480_A	1.189	0.94
222_G	239_T	1.186	0.94
358_I	382_K	1.183	0.94
360_I	386_A	1.183	0.94
115_I	131_I	1.182	0.94
442_T	489_I	1.180	0.94
34_V	38_L	1.168	0.94
418_V	448_A	1.163	0.94
331_I	383_L	1.163	0.94
16_Y	27_I	1.159	0.94
70_N	485_K	1.158	0.94
450_Q	454_P	1.157	0.93
101_G	305_A	1.148	0.93
321_M	324_N	1.148	0.93
317_F	321_M	1.148	0.93
222_G	241_I	1.143	0.93
415_V	419_E	1.140	0.93
356_D	391_K	1.136	0.93
332_S	400_P	1.129	0.93
425_V	441_I	1.128	0.93
226_A	229_R	1.125	0.92
19_R	28_F	1.122	0.92
376_S	420_A	1.122	0.92
275_V	302_I	1.121	0.92
8_M	497_M	1.121	0.92
431_A	435_V	1.119	0.92
195_N	272_R	1.116	0.92
478_V	481_V	1.104	0.92
220_V	224_Q	1.102	0.92
115_I	134_M	1.101	0.92
11_V	425_V	1.091	0.91
113_V	143_A	1.085	0.91
485_K	508_K	1.081	0.91
259_F	270_I	1.078	0.91
450_Q	460_H	1.070	0.90
402_G	448_A	1.061	0.90
317_F	490_A	1.058	0.90
209_L	285_K	1.057	0.90
345_N	348_V	1.056	0.90
213_E	229_R	1.055	0.90
105_K	109_A	1.054	0.90
384_V	427_E	1.053	0.90
71_L	344_F	1.051	0.90
216_A	222_G	1.049	0.90
91_R	94_F	1.048	0.90
99_L	295_L	1.047	0.90
132_M	169_F	1.046	0.89
45_T	470_L	1.046	0.89
119_L	169_F	1.046	0.89
326_K	497_M	1.040	0.89
8_M	493_M	1.038	0.89
315_N	323_K	1.035	0.89
329_L	358_I	1.027	0.89
388_K	435_V	1.027	0.89
167_K	220_V	1.020	0.88
324_N	499_M	1.019	0.88
32_T	419_E	1.017	0.88
52_L	58_D	1.015	0.88
105_K	291_D	1.014	0.88
42_R	433_E	1.013	0.88
271_T	292_F	1.013	0.88
52_L	86_V	1.011	0.88
110_G	144_E	1.009	0.88
386_A	392_Y	1.006	0.88
35_M	39_W	1.003	0.87
185_I	238_A	1.002	0.87
430_K	433_E	0.999	0.87
210_A	250_A	0.997	0.87
166_L	170_E	0.994	0.87
100_T	104_D	0.994	0.87
100_T	107_K	0.994	0.87
19_R	25_N	0.994	0.87
294_M	304_T	0.992	0.87
460_H	464_T	0.992	0.87
260_M	295_L	0.988	0.87
98_V	305_A	0.984	0.86
116_M	257_L	0.984	0.86
33_P	36_D	0.984	0.86
259_F	292_F	0.982	0.86
410_V	414_A	0.979	0.86
223_L	236_V	0.976	0.86
128_E	165_S	0.975	0.86
166_L	181_V	0.975	0.86
136_E	175_A	0.974	0.86
49_A	467_P	0.972	0.86
410_V	413_A	0.970	0.86
50_S	465_N	0.969	0.86
212_G	240_V	0.969	0.86
70_N	73_A	0.967	0.85
384_V	428_V	0.963	0.85
207_L	270_I	0.962	0.85
76_I	485_K	0.961	0.85
98_V	101_G	0.959	0.85
297_E	300_A	0.959	0.85
423_H	427_E	0.958	0.85
327_T	354_G	0.955	0.85
345_N	355_E	0.954	0.85
183_S	240_V	0.949	0.84
274_F	292_F	0.948	0.84
216_A	241_I	0.947	0.84
272_R	302_I	0.946	0.84
412_E	415_V	0.942	0.84
36_D	419_E	0.942	0.84
181_V	219_A	0.941	0.84
358_I	386_A	0.940	0.84
93_F	133_A	0.939	0.84
189_Y	202_K	0.939	0.84
16_Y	418_V	0.935	0.83
92_A	95_A	0.935	0.83
11_V	397_C	0.935	0.83
111_K	252_E	0.929	0.83
201_E	211_Q	0.928	0.83
166_L	219_A	0.927	0.83
452_R	456_T	0.926	0.83
394_T	497_M	0.925	0.83
225_A	229_R	0.919	0.82
195_N	269_E	0.919	0.82
7_P	432_V	0.916	0.82
131_I	148_L	0.915	0.82
414_A	448_A	0.914	0.82
11_V	428_V	0.913	0.82
26_A	414_A	0.912	0.82
335_E	368_Y	0.909	0.82
213_E	237_K	0.908	0.82
8_M	438_Q	0.905	0.81
277_A	287_V	0.905	0.81
84_L	295_L	0.903	0.81
380_T	424_C	0.899	0.81
440_L	472_Y	0.899	0.81
201_E	283_A	0.899	0.81
101_G	104_D	0.891	0.80
18_Y	39_W	0.890	0.80
86_V	92_A	0.886	0.80
87_E	90_D	0.886	0.80
157_T	165_S	0.884	0.80
322_A	353_K	0.884	0.80
377_A	427_E	0.883	0.80
293_V	307_A	0.881	0.80
158_P	162_A	0.879	0.79
371_Q	378_E	0.879	0.79
279_F	284_R	0.879	0.79
95_A	100_T	0.872	0.79
109_A	254_G	0.871	0.79
275_V	304_T	0.871	0.79
45_T	481_V	0.869	0.79
137_L	307_A	0.867	0.78
167_K	224_Q	0.867	0.78
243_A	248_D	0.865	0.78
324_N	500_E	0.864	0.78
7_P	435_V	0.864	0.78
215_Q	242_R	0.862	0.78
420_A	423_H	0.860	0.78
99_L	307_A	0.860	0.78
93_F	307_A	0.857	0.78
8_M	394_T	0.856	0.78
429_A	441_I	0.852	0.77
162_A	165_S	0.849	0.77
272_R	299_A	0.848	0.77
164_S	168_K	0.846	0.77
408_T	413_A	0.844	0.77
16_Y	32_T	0.844	0.77
345_N	351_S	0.843	0.77
94_F	137_L	0.842	0.76
27_I	35_M	0.842	0.76
35_M	471_I	0.841	0.76
102_A	258_I	0.840	0.76
273_A	282_F	0.840	0.76
49_A	466_L	0.839	0.76
326_K	499_M	0.839	0.76
19_R	24_D	0.837	0.76
320_W	323_K	0.835	0.76
78_Y	82_T	0.835	0.76
361_N	364_K	0.833	0.76
102_A	293_V	0.833	0.76
42_R	474_G	0.827	0.75
110_G	145_K	0.826	0.75
351_S	356_D	0.824	0.75
438_Q	496_L	0.824	0.75
317_F	344_F	0.824	0.75
30_A	419_E	0.824	0.75
429_A	433_E	0.822	0.75
103_V	141_R	0.821	0.75
202_K	238_A	0.820	0.75
27_I	449_E	0.817	0.74
433_E	473_V	0.814	0.74
327_T	393_D	0.814	0.74
132_M	136_E	0.814	0.74
163_E	223_L	0.813	0.74
356_D	386_A	0.812	0.74
323_K	353_K	0.811	0.74
172_K	176_L	0.810	0.74
101_G	291_D	0.807	0.73
46_L	467_P	0.807	0.73
132_M	135_V	0.806	0.73
80_D	83_R	0.806	0.73
5_K	393_D	0.806	0.73
161_S	165_S	0.805	0.73
38_L	471_I	0.803	0.73
93_F	137_L	0.801	0.73
488_D	506_T	0.799	0.73
184_I	223_L	0.799	0.73
119_L	260_M	0.797	0.72
275_V	303_K	0.797	0.72
221_A	224_Q	0.797	0.72
106_A	143_A	0.797	0.72
198_D	202_K	0.796	0.72
376_S	424_C	0.793	0.72
44_H	471_I	0.793	0.72
106_A	109_A	0.792	0.72
135_V	148_L	0.790	0.72
16_Y	402_G	0.789	0.72
322_A	325_D	0.789	0.72
208_T	274_F	0.788	0.72
449_E	465_N	0.788	0.72
320_W	497_M	0.787	0.71
450_Q	466_L	0.786	0.71
294_M	306_V	0.782	0.71
482_E	508_K	0.781	0.71
383_L	395_I	0.781	0.71
272_R	301_D	0.781	0.71
129_D	168_K	0.779	0.71
29_S	412_E	0.779	0.71
173_F	179_G	0.779	0.71
152_L	223_L	0.777	0.70
9_V	397_C	0.777	0.70
34_V	425_V	0.773	0.70
9_V	439_L	0.772	0.70
171_E	175_A	0.770	0.70
273_A	279_F	0.768	0.70
107_K	144_E	0.765	0.69
139_A	178_K	0.765	0.69
83_R	296_T	0.765	0.69
50_S	53_E	0.762	0.69
402_G	421_L	0.760	0.69
39_W	471_I	0.760	0.69
121_A	164_S	0.759	0.69
267_A	292_F	0.758	0.69
416_K	419_E	0.757	0.68
376_S	400_P	0.757	0.68
429_A	473_V	0.754	0.68
242_R	248_D	0.754	0.68
442_T	470_L	0.753	0.68
119_L	128_E	0.753	0.68
58_D	89_K	0.753	0.68
104_D	107_K	0.752	0.68
162_A	223_L	0.751	0.68
168_K	171_E	0.750	0.68
73_A	77_V	0.749	0.68
424_C	427_E	0.749	0.68
11_V	376_S	0.746	0.67
219_A	241_I	0.743	0.67
31_K	415_V	0.743	0.67
86_V	89_K	0.742	0.67
16_Y	421_L	0.742	0.67
242_R	249_A	0.741	0.67
376_S	399_Y	0.741	0.67
258_I	307_A	0.740	0.67
229_R	237_K	0.740	0.67
294_M	299_A	0.739	0.67
209_L	286_K	0.739	0.67
107_K	143_A	0.738	0.67
20_E	28_F	0.737	0.66
432_V	435_V	0.736	0.66
35_M	402_G	0.735	0.66
100_T	137_L	0.735	0.66
32_T	35_M	0.735	0.66
331_I	360_I	0.734	0.66
9_V	383_L	0.732	0.66
135_V	172_K	0.731	0.66
38_L	439_L	0.726	0.65
196_R	335_E	0.725	0.65
438_Q	475_D	0.724	0.65
216_A	225_A	0.723	0.65
316_T	352_F	0.721	0.65
157_T	162_A	0.721	0.65
213_E	225_A	0.720	0.65
80_D	264_A	0.720	0.65
116_M	207_L	0.719	0.64
438_Q	472_Y	0.719	0.64
150_A	181_V	0.717	0.64
235_F	367_T	0.715	0.64
319_E	348_V	0.712	0.64
38_L	473_V	0.711	0.64
384_V	387_I	0.711	0.64
87_E	93_F	0.709	0.63
137_L	141_R	0.708	0.63
21_E	25_N	0.706	0.63
151_F	190_A	0.706	0.63
38_L	429_A	0.704	0.63
383_L	428_V	0.704	0.63
94_F	133_A	0.703	0.63
321_M	497_M	0.703	0.63
150_A	184_I	0.702	0.63
371_Q	377_A	0.701	0.63
169_F	173_F	0.701	0.63
264_A	302_I	0.701	0.63
128_E	176_L	0.700	0.62
48_D	485_K	0.700	0.62
19_R	450_Q	0.700	0.62
89_K	129_D	0.699	0.62
93_F	134_M	0.699	0.62
9_V	395_I	0.699	0.62
438_Q	474_G	0.698	0.62
42_R	473_V	0.698	0.62
198_D	364_K	0.696	0.62
452_R	464_T	0.694	0.62
449_E	464_T	0.693	0.62
384_V	435_V	0.692	0.62
389_S	392_Y	0.692	0.62
101_G	105_K	0.691	0.61
271_T	304_T	0.690	0.61
116_M	267_A	0.689	0.61
151_F	207_L	0.688	0.61
316_T	319_E	0.687	0.61
185_I	203_A	0.683	0.61
32_T	418_V	0.683	0.61
225_A	228_A	0.681	0.60
391_K	395_I	0.681	0.60
145_K	252_E	0.681	0.60
448_A	462_A	0.679	0.60
299_A	302_I	0.678	0.60
42_R	471_I	0.677	0.60
322_A	345_N	0.677	0.60
116_M	292_F	0.677	0.60
324_N	497_M	0.676	0.60
47_I	470_L	0.676	0.60
129_D	132_M	0.675	0.60
338_A	359_L	0.675	0.60
128_E	168_K	0.674	0.60
273_A	284_R	0.674	0.60
105_K	111_K	0.674	0.60
440_L	489_I	0.672	0.59
477_N	481_V	0.670	0.59
319_E	352_F	0.669	0.59
280_D	283_A	0.669	0.59
37_A	433_E	0.668	0.59
201_E	282_F	0.668	0.59
345_N	356_D	0.666	0.59
269_E	292_F	0.666	0.59
222_G	226_A	0.664	0.58
139_A	179_G	0.663	0.58
219_A	222_G	0.663	0.58
329_L	392_Y	0.663	0.58
321_M	325_D	0.662	0.58
257_L	274_F	0.662	0.58
126_S	260_M	0.659	0.58
19_R	449_E	0.658	0.58
226_A	239_T	0.658	0.58
380_T	428_V	0.657	0.58
195_N	200_V	0.657	0.58
416_K	420_A	0.656	0.57
99_L	258_I	0.656	0.57
16_Y	39_W	0.655	0.57
23_Q	452_R	0.654	0.57
344_F	396_I	0.654	0.57
52_L	85_D	0.654	0.57
51_G	58_D	0.651	0.57
91_R	95_A	0.651	0.57
88_I	94_F	0.650	0.57
134_M	258_I	0.650	0.57
399_Y	427_E	0.649	0.57
436_G	475_D	0.649	0.57
53_E	487_S	0.648	0.57
163_E	228_A	0.646	0.56
381_E	384_V	0.646	0.56
119_L	152_L	0.646	0.56
18_Y	47_I	0.645	0.56
331_I	358_I	0.645	0.56
71_L	442_T	0.645	0.56
243_A	249_A	0.645	0.56
61_M	77_V	0.644	0.56
500_E	503_Q	0.644	0.56
118_L	126_S	0.644	0.56
441_I	471_I	0.644	0.56
165_S	168_K	0.644	0.56
274_F	290_V	0.640	0.56
363_P	371_Q	0.638	0.55
6_K	393_D	0.637	0.55
408_T	414_A	0.637	0.55
98_V	293_V	0.637	0.55
470_L	510_L	0.636	0.55
135_V	178_K	0.635	0.55
13_L	418_V	0.635	0.55
150_A	166_L	0.633	0.55
248_D	251_M	0.631	0.55
322_A	354_G	0.629	0.54
196_R	368_Y	0.629	0.54
330_R	394_T	0.628	0.54
99_L	137_L	0.627	0.54
170_E	173_F	0.627	0.54
80_D	296_T	0.626	0.54
211_Q	215_Q	0.623	0.54
47_I	510_L	0.621	0.53
19_R	23_Q	0.620	0.53
8_M	496_L	0.619	0.53
235_F	461_T	0.618	0.53
100_T	143_A	0.616	0.53
481_V	508_K	0.616	0.53
190_A	270_I	0.616	0.53
61_M	462_A	0.613	0.52
81_L	85_D	0.612	0.52
204_Y	208_T	0.612	0.52
29_S	448_A	0.612	0.52
416_K	423_H	0.611	0.52
385_A	388_K	0.611	0.52
24_D	411_M	0.610	0.52
367_T	370_L	0.609	0.52
95_A	140_E	0.608	0.52
436_G	439_L	0.607	0.52
147_Y	249_A	0.606	0.52
103_V	143_A	0.606	0.52
9_V	437_G	0.605	0.51
334_T	359_L	0.605	0.51
188_Y	269_E	0.604	0.51
459_A	464_T	0.603	0.51
379_L	400_P	0.603	0.51
219_A	239_T	0.602	0.51
402_G	425_V	0.601	0.51
210_A	248_D	0.600	0.51
11_V	432_V	0.599	0.51
314_V	319_E	0.598	0.51
185_I	237_K	0.598	0.51
218_T	241_I	0.596	0.50
138_A	143_A	0.596	0.50
332_S	376_S	0.595	0.50
116_M	251_M	0.593	0.50
462_A	466_L	0.593	0.50
364_K	371_Q	0.592	0.50
139_A	177_G	0.590	0.50
450_Q	464_T	0.590	0.50
226_A	236_V	0.589	0.50
270_I	292_F	0.589	0.50
276_N	302_I	0.587	0.49
40_A	44_H	0.583	0.49
37_A	426_E	0.583	0.49
360_I	378_E	0.583	0.49
277_A	303_K	0.582	0.49
52_L	82_T	0.581	0.49
433_E	475_D	0.578	0.48
173_F	181_V	0.578	0.48
317_F	494_L	0.577	0.48
327_T	353_K	0.577	0.48
166_L	184_I	0.576	0.48
425_V	429_A	0.576	0.48
53_E	58_D	0.576	0.48
25_N	28_F	0.575	0.48
196_R	296_T	0.575	0.48
20_E	39_W	0.574	0.48
376_S	397_C	0.573	0.48
363_P	379_L	0.572	0.48
47_I	442_T	0.572	0.48
215_Q	243_A	0.572	0.48
78_Y	342_F	0.571	0.47
96_N	99_L	0.569	0.47
385_A	389_S	0.568	0.47
35_M	441_I	0.567	0.47
103_V	111_K	0.567	0.47
117_G	260_M	0.566	0.47
183_S	248_D	0.565	0.47
175_A	178_K	0.562	0.46
70_N	487_S	0.561	0.46
268_R	349_E	0.559	0.46
452_R	458_Q	0.559	0.46
409_G	451_M	0.559	0.46
423_H	426_E	0.558	0.46
305_A	309_P	0.557	0.46
128_E	172_K	0.557	0.46
439_L	473_V	0.556	0.46
49_A	449_E	0.556	0.46
169_F	181_V	0.556	0.46
425_V	432_V	0.555	0.46
120_S	126_S	0.553	0.45
493_M	496_L	0.551	0.45
119_L	150_A	0.550	0.45
184_I	219_A	0.550	0.45
91_R	136_E	0.547	0.45
375_S	378_E	0.547	0.45
388_K	427_E	0.547	0.45
69_V	346_G	0.547	0.45
27_I	418_V	0.546	0.45
28_F	448_A	0.545	0.44
475_D	496_L	0.544	0.44
271_T	338_A	0.543	0.44
19_R	466_L	0.543	0.44
194_D	235_F	0.543	0.44
217_D	242_R	0.542	0.44
113_V	135_V	0.541	0.44
271_T	294_M	0.541	0.44
26_A	451_M	0.541	0.44
49_A	402_G	0.540	0.44
194_D	367_T	0.540	0.44
82_T	307_A	0.540	0.44
19_R	46_L	0.539	0.44
88_I	137_L	0.536	0.43
278_D	284_R	0.536	0.43
135_V	179_G	0.536	0.43
105_K	289_N	0.536	0.43
284_R	287_V	0.535	0.43
184_I	239_T	0.535	0.43
35_M	397_C	0.534	0.43
321_M	493_M	0.534	0.43
358_I	378_E	0.534	0.43
243_A	250_A	0.532	0.43
327_T	392_Y	0.532	0.43
322_A	352_F	0.532	0.43
160_R	166_L	0.531	0.43
60_Q	81_L	0.531	0.43
34_V	429_A	0.531	0.43
361_N	378_E	0.530	0.43
119_L	131_I	0.530	0.43
37_A	429_A	0.529	0.43
258_I	293_V	0.529	0.43
102_A	292_F	0.529	0.43
331_I	382_K	0.526	0.42
316_T	320_W	0.526	0.42
332_S	379_L	0.525	0.42
121_A	168_K	0.525	0.42
453_D	460_H	0.524	0.42
216_A	219_A	0.524	0.42
204_Y	274_F	0.523	0.42
180_R	242_R	0.522	0.42
184_I	241_I	0.522	0.42
13_L	469_P	0.522	0.42
61_M	66_V	0.520	0.42
299_A	304_T	0.519	0.41
257_L	292_F	0.518	0.41
276_N	280_D	0.518	0.41
370_L	410_V	0.517	0.41
136_E	176_L	0.516	0.41
8_M	470_L	0.516	0.41
85_D	133_A	0.515	0.41
66_V	343_F	0.515	0.41
209_L	283_A	0.514	0.41
479_K	483_G	0.514	0.41
257_L	270_I	0.514	0.41
449_E	453_D	0.513	0.41
325_D	353_K	0.512	0.41
185_I	207_L	0.512	0.41
158_P	453_D	0.511	0.41
268_R	271_T	0.511	0.41
380_T	383_L	0.511	0.41
85_D	264_A	0.511	0.41
229_R	239_T	0.511	0.41
35_M	426_E	0.510	0.40
275_V	300_A	0.510	0.40
77_V	462_A	0.509	0.40
271_T	302_I	0.509	0.40
45_T	482_E	0.508	0.40
162_A	226_A	0.508	0.40
217_D	225_A	0.507	0.40
83_R	309_P	0.507	0.40
188_Y	370_L	0.506	0.40
171_E	174_A	0.506	0.40
181_V	241_I	0.506	0.40
98_V	309_P	0.505	0.40
210_A	240_V	0.505	0.40
474_G	477_N	0.504	0.40
414_A	464_T	0.502	0.40
92_A	308_Y	0.501	0.39
175_A	179_G	0.501	0.39
18_Y	27_I	0.500	0.39

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1o98A	1	0.9844	100	0.204	Contact Map
4my4A	1	0.9786	100	0.237	Contact Map
3igzB	1	0.9903	100	0.237	Contact Map
2zktA	3	0.6537	100	0.833	Contact Map
3kd8A	1	0.6537	100	0.838	Contact Map
1zedA	2	0.7062	100	0.876	Contact Map
3m7vA	1	0.7062	99.9	0.898	Contact Map
3ot9A	1	0.6926	99.9	0.899	Contact Map
3tg0A	2	0.6946	99.9	0.9	Contact Map
3nkqA	1	0.5039	99.9	0.903	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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