GREMLIN Database
ADH2 - Probable alcohol dehydrogenase
UniProt: P37686 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12293
Length: 383 (365)
Sequences: 10583 (7357)
Seq/√Len: 385.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
351_A376_V3.8991.00
355_T372_H3.8151.00
228_P333_K3.4151.00
347_E380_R3.2381.00
290_V328_R3.1431.00
82_K86_E3.1431.00
229_L236_N2.9081.00
75_E155_E2.8261.00
233_D236_N2.8211.00
80_G107_I2.7541.00
49_G53_K2.5781.00
226_N242_A2.5291.00
371_T374_E2.5181.00
346_K349_D2.4751.00
265_M379_Y2.4071.00
16_A178_S2.4021.00
181_I237_A2.3751.00
350_F376_V2.3611.00
67_G79_A2.3201.00
33_R61_F2.2931.00
21_D24_N2.2661.00
199_A219_A2.2521.00
218_K221_T2.2331.00
34_T91_S2.1871.00
175_N244_A2.1841.00
339_G342_D2.1801.00
376_V380_R2.1771.00
18_S21_D2.1311.00
17_D178_S2.0831.00
329_E333_K2.0521.00
195_A223_I2.0111.00
101_H135_A1.9961.00
213_D299_R1.9721.00
292_N366_N1.9371.00
354_A376_V1.9331.00
92_V104_A1.9291.00
196_L220_V1.9221.00
41_M45_L1.9031.00
84_L131_L1.8911.00
224_A307_M1.8771.00
188_T240_R1.8491.00
52_Q56_E1.8451.00
266_A280_C1.8441.00
190_A279_V1.8351.00
353_L379_Y1.8041.00
372_H376_V1.7971.00
78_A116_D1.7761.00
63_V87_N1.7701.00
69_Q76_N1.7611.00
326_A329_E1.7401.00
84_L111_A1.7331.00
49_G52_Q1.7161.00
290_V381_A1.7131.00
186_S279_V1.6771.00
23_M54_A1.6471.00
43_T66_D1.6381.00
354_A372_H1.6371.00
220_V303_C1.6341.00
304_A323_C1.6241.00
20_T50_D1.6221.00
185_K189_A1.6041.00
377_A381_A1.5931.00
76_N79_A1.5861.00
283_V343_L1.5681.00
16_A237_A1.5491.00
180_M240_R1.5371.00
351_A372_H1.5371.00
32_T90_D1.5261.00
232_E333_K1.5241.00
83_L87_N1.5191.00
79_A82_K1.5181.00
228_P232_E1.5181.00
94_S133_M1.5151.00
332_K338_A1.4991.00
192_G227_L1.4931.00
236_N239_A1.4821.00
63_V83_L1.4811.00
53_K57_E1.4721.00
63_V89_C1.4691.00
26_M91_S1.4671.00
377_A380_R1.4511.00
325_N329_E1.4421.00
11_V25_M1.4411.00
56_E62_S1.4391.00
77_V152_I1.4371.00
94_S104_A1.4231.00
115_G120_Y1.4171.00
238_K242_A1.4131.00
16_A241_E1.4101.00
34_T93_I1.4081.00
289_Q327_I1.4001.00
25_M28_D1.3841.00
272_F352_V1.3771.00
265_M284_L1.3761.00
180_M244_A1.3711.00
349_D352_V1.3691.00
275_L280_C1.3671.00
37_V107_I1.3651.00
217_L302_D1.3631.00
178_S237_A1.3491.00
192_G243_M1.3421.00
40_N44_K1.3421.00
352_V356_N1.3401.00
52_Q62_S1.3321.00
78_A82_K1.3301.00
77_V103_C1.3191.00
83_L86_E1.3101.00
33_R63_V1.3071.00
290_V321_E1.3031.00
108_A130_Q1.2931.00
116_D119_D1.2871.00
134_I172_L1.2811.00
81_L110_V1.2801.00
84_L89_C1.2771.00
74_T78_A1.2771.00
374_E377_A1.2611.00
69_Q73_T1.2591.00
355_T359_K1.2561.00
115_G119_D1.2521.00
25_M172_L1.2511.00
188_T234_G1.2491.00
193_M331_A1.2481.00
293_S321_E1.2471.00
91_S134_I1.2461.00
229_L233_D1.2421.00
226_N229_L1.2261.00
50_D178_S1.2251.00
37_V68_T1.2241.00
37_V104_A1.2121.00
185_K231_V1.2111.00
13_V25_M1.2021.00
12_N248_F1.1981.00
373_E376_V1.1971.00
291_F374_E1.1961.00
217_L306_A1.1921.00
225_E242_A1.1911.00
35_L89_C1.1911.00
321_E325_N1.1871.00
223_I243_M1.1851.00
92_V108_A1.1761.00
140_A188_T1.1761.00
19_L136_I1.1721.00
193_M336_I1.1691.00
53_K56_E1.1651.00
261_Y370_A1.1591.00
84_L107_I1.1591.00
33_R87_N1.1571.00
82_K85_K1.1541.00
35_L84_L1.1541.00
303_C323_C1.1501.00
226_N239_A1.1431.00
73_T76_N1.1411.00
178_S181_I1.1341.00
188_T230_A1.1341.00
352_V355_T1.1281.00
183_M187_L1.1271.00
17_D20_T1.1141.00
18_S174_V1.1111.00
15_G18_S1.1071.00
217_L221_T1.1041.00
294_K368_I1.1021.00
39_D42_L1.1021.00
104_A133_M1.1011.00
22_A51_V1.1001.00
26_M134_I1.0971.00
35_L83_L1.0921.00
302_D305_A1.0901.00
27_A58_R1.0851.00
218_K222_M1.0791.00
185_K232_E1.0761.00
13_V21_D1.0751.00
358_L372_H1.0691.00
262_V285_L1.0641.00
154_D157_R1.0581.00
202_A253_A1.0571.00
255_N259_L1.0551.00
146_M248_F1.0541.00
81_L85_K1.0531.00
214_A218_K1.0521.00
287_H381_A1.0491.00
301_R319_G1.0491.00
33_R88_N1.0471.00
177_S241_E1.0441.00
41_M44_K1.0441.00
51_V95_L1.0391.00
265_M375_I1.0361.00
373_E377_A1.0331.00
16_A181_I1.0301.00
293_S320_A1.0301.00
262_V281_N1.0291.00
264_A363_G1.0261.00
40_N66_D1.0241.00
199_A250_A1.0221.00
71_N274_N1.0211.00
74_T155_E1.0201.00
230_A234_G1.0131.00
36_I62_S1.0101.00
75_E156_A1.0071.00
135_A170_P1.0051.00
149_F164_V0.9991.00
301_R320_A0.9981.00
43_T48_A0.9941.00
132_P171_L0.9931.00
42_L45_L0.9901.00
295_V368_I0.9851.00
19_L50_D0.9841.00
229_L238_K0.9821.00
146_M173_S0.9781.00
291_F368_I0.9721.00
266_A270_G0.9711.00
38_T66_D0.9711.00
189_A231_V0.9641.00
193_M282_A0.9641.00
190_A276_P0.9581.00
322_A325_N0.9561.00
36_I48_A0.9541.00
68_T103_C0.9461.00
24_N58_R0.9361.00
272_F356_N0.9351.00
17_D176_D0.9341.00
56_E61_F0.9301.00
43_T49_G0.9211.00
305_A319_G0.9191.00
94_S135_A0.9151.00
213_D216_A0.9141.00
215_C249_L0.9121.00
101_H137_N0.9081.00
203_Y302_D0.9051.00
202_A213_D0.9041.00
186_S190_A0.9031.00
338_A342_D0.9021.00
73_T155_E0.8991.00
34_T90_D0.8981.00
255_N258_S0.8971.00
231_V334_V0.8921.00
231_V335_D0.8871.00
48_A52_Q0.8831.00
219_A250_A0.8781.00
65_Y80_G0.8781.00
19_L179_L0.8771.00
221_T305_A0.8751.00
19_L178_S0.8711.00
11_V28_D0.8711.00
94_S101_H0.8711.00
350_F380_R0.8701.00
50_D54_A0.8691.00
318_E322_A0.8671.00
196_L223_I0.8661.00
351_A355_T0.8651.00
15_G21_D0.8601.00
229_L239_A0.8601.00
354_A358_L0.8601.00
108_A131_L0.8601.00
268_Q379_Y0.8591.00
43_T52_Q0.8581.00
135_A173_S0.8571.00
36_I52_Q0.8561.00
197_T285_L0.8541.00
356_N359_K0.8541.00
261_Y288_V0.8541.00
200_I220_V0.8541.00
221_T225_E0.8531.00
245_Y249_L0.8521.00
234_G240_R0.8521.00
297_A317_A0.8481.00
113_N128_K0.8471.00
42_L48_A0.8461.00
224_A326_A0.8451.00
222_M242_A0.8411.00
273_Y349_D0.8381.00
81_L107_I0.8381.00
101_H144_S0.8371.00
158_H274_N0.8361.00
140_A244_A0.8301.00
23_M57_E0.8281.00
200_I303_C0.8261.00
81_L111_A0.8221.00
196_L200_I0.8221.00
133_M171_L0.8201.00
111_A131_L0.8131.00
108_A133_M0.8131.00
222_M246_A0.8131.00
214_A221_T0.8111.00
309_V322_A0.8101.00
50_D53_K0.8101.00
189_A336_I0.8101.00
109_L168_V0.8091.00
181_I235_S0.8091.00
37_V100_P0.8021.00
230_A239_A0.8021.00
69_Q79_A0.8001.00
180_M188_T0.7991.00
40_N67_G0.7991.00
73_T274_N0.7991.00
337_P343_L0.7981.00
103_C107_I0.7981.00
289_Q323_C0.7911.00
40_N43_T0.7911.00
291_F370_A0.7911.00
263_H277_H0.7901.00
256_N259_L0.7891.00
50_D179_L0.7881.00
148_R166_K0.7841.00
229_L232_E0.7831.00
34_T60_I0.7821.00
228_P231_V0.7811.00
223_I246_A0.7801.00
337_P342_D0.7791.00
38_T64_I0.7791.00
303_C327_I0.7781.00
204_V289_Q0.7781.00
19_L176_D0.7761.00
21_D25_M0.7761.00
287_H290_V0.7751.00
358_L375_I0.7721.00
20_T54_A0.7661.00
328_R332_K0.7651.00
65_Y79_A0.7641.00
22_A136_I0.7631.00
284_L378_I0.7631.00
202_A216_A0.7631.00
25_M29_Y0.7581.00
226_N243_M0.7581.00
77_V106_G0.7551.00
329_E332_K0.7531.00
185_K234_G0.7481.00
267_H360_D0.7471.00
46_G49_G0.7441.00
261_Y375_I0.7431.00
293_S297_A0.7411.00
226_N238_K0.7381.00
224_A228_P0.7361.00
301_R305_A0.7351.00
23_M58_R0.7341.00
225_E228_P0.7341.00
238_K241_E0.7311.00
183_M191_T0.7301.00
199_A216_A0.7291.00
34_T62_S0.7251.00
268_Q356_N0.7251.00
75_E79_A0.7221.00
32_T61_F0.7201.00
27_A32_T0.7201.00
35_L87_N0.7161.00
294_K317_A0.7121.00
203_Y217_L0.7111.00
26_M93_I0.7101.00
185_K335_D0.7071.00
289_Q300_L0.7041.00
260_G267_H0.7021.00
266_A281_N0.7011.00
94_S100_P0.6991.00
351_A354_A0.6991.00
236_N240_R0.6981.00
56_E59_N0.6981.00
221_T302_D0.6970.99
39_D45_L0.6960.99
207_A258_S0.6950.99
327_I331_A0.6930.99
13_V18_S0.6910.99
140_A180_M0.6910.99
226_N230_A0.6910.99
350_F379_Y0.6910.99
345_V350_F0.6900.99
291_F371_T0.6880.99
78_A81_L0.6870.99
279_V337_P0.6870.99
297_A320_A0.6830.99
194_D277_H0.6830.99
208_A299_R0.6830.99
33_R90_D0.6810.99
19_L51_V0.6800.99
269_L280_C0.6790.99
206_I369_Q0.6790.99
79_A83_L0.6770.99
42_L47_M0.6770.99
309_V326_A0.6730.99
286_P331_A0.6730.99
52_Q64_I0.6720.99
332_K342_D0.6710.99
330_L334_V0.6680.99
322_A326_A0.6670.99
14_I241_E0.6660.99
328_R338_A0.6660.99
221_T306_A0.6630.99
290_V324_I0.6590.99
197_T281_N0.6580.99
269_L379_Y0.6570.99
225_E229_L0.6550.99
217_L305_A0.6550.99
347_E350_F0.6500.99
303_C307_M0.6500.99
197_T262_V0.6490.99
254_F259_L0.6490.99
258_S365_T0.6480.99
220_V224_A0.6480.99
175_N248_F0.6470.99
230_A243_M0.6470.99
119_D124_D0.6470.99
208_A213_D0.6460.99
106_G150_C0.6460.99
368_I374_E0.6460.99
77_V107_I0.6440.99
54_A57_E0.6440.99
106_G152_I0.6430.99
113_N130_Q0.6420.99
290_V293_S0.6420.99
150_C163_I0.6380.99
267_H270_G0.6360.99
218_K249_L0.6350.99
146_M252_M0.6350.99
35_L63_V0.6310.99
71_N99_S0.6290.99
370_A375_I0.6280.99
19_L54_A0.6270.99
47_M95_L0.6270.99
275_L343_L0.6260.99
289_Q324_I0.6250.99
192_G334_V0.6250.99
276_P279_V0.6240.99
269_L340_L0.6220.99
24_N28_D0.6200.99
310_N319_G0.6150.99
204_V300_L0.6110.99
370_A378_I0.6110.99
20_T57_E0.6100.99
110_V114_G0.6100.99
26_M60_I0.6080.99
302_D306_A0.6080.99
270_G280_C0.6060.99
33_R89_C0.6020.99
237_A241_E0.6020.99
200_I285_L0.6010.99
23_M27_A0.6010.99
39_D44_K0.6000.98
200_I323_C0.5990.98
193_M334_V0.5990.98
84_L92_V0.5970.98
147_T251_G0.5960.98
370_A374_E0.5960.98
114_G120_Y0.5950.98
14_I245_Y0.5940.98
319_G322_A0.5940.98
264_A362_C0.5920.98
304_A309_V0.5910.98
222_M249_L0.5900.98
68_T71_N0.5890.98
49_G56_E0.5890.98
265_M357_A0.5890.98
134_I174_V0.5890.98
137_N175_N0.5870.98
78_A110_V0.5870.98
109_L126_S0.5840.98
29_Y134_I0.5840.98
198_H277_H0.5830.98
205_S365_T0.5820.98
197_T260_G0.5820.98
37_V80_G0.5820.98
194_D263_H0.5820.98
206_I365_T0.5820.98
241_E245_Y0.5770.98
20_T178_S0.5760.98
317_A321_E0.5740.98
290_V325_N0.5740.98
160_K277_H0.5740.98
12_N173_S0.5730.98
130_Q171_L0.5730.98
282_A331_A0.5730.98
151_I194_D0.5720.98
137_N247_Q0.5710.98
22_A54_A0.5700.98
261_Y264_A0.5700.98
38_T100_P0.5680.98
129_P167_H0.5680.98
51_V54_A0.5660.98
200_I289_Q0.5660.98
13_V172_L0.5660.98
24_N27_A0.5650.98
325_N328_R0.5650.98
281_N284_L0.5620.98
148_R255_N0.5610.98
192_G223_I0.5610.98
118_R154_D0.5580.98
122_G125_R0.5570.98
177_S237_A0.5570.98
198_H250_A0.5570.98
149_F162_A0.5560.98
297_A300_L0.5560.98
16_A238_K0.5550.98
203_Y299_R0.5540.97
47_M179_L0.5510.97
83_L89_C0.5480.97
26_M55_L0.5470.97
177_S244_A0.5460.97
78_A117_I0.5460.97
93_I134_I0.5450.97
92_V107_I0.5440.97
71_N270_G0.5440.97
261_Y366_N0.5430.97
259_L362_C0.5430.97
35_L65_Y0.5430.97
106_G163_I0.5360.97
13_V174_V0.5360.97
23_M26_M0.5360.97
226_N246_A0.5340.97
76_N103_C0.5330.97
69_Q274_N0.5320.97
354_A375_I0.5320.97
269_L275_L0.5310.97
272_F353_L0.5300.97
45_L48_A0.5290.97
300_L304_A0.5280.97
102_D277_H0.5280.97
162_A362_C0.5270.97
317_A320_A0.5270.97
181_I240_R0.5260.97
220_V306_A0.5220.96
331_A336_I0.5220.96
279_V336_I0.5220.96
20_T53_K0.5220.96
22_A174_V0.5220.96
260_G365_T0.5200.96
259_L267_H0.5180.96
77_V81_L0.5180.96
279_V343_L0.5170.96
48_A95_L0.5170.96
91_S132_P0.5160.96
9_P169_T0.5160.96
356_N360_D0.5140.96
305_A308_G0.5140.96
320_A323_C0.5130.96
36_I95_L0.5130.96
357_A379_Y0.5120.96
37_V103_C0.5110.96
130_Q167_H0.5110.96
118_R156_A0.5090.96
331_A334_V0.5080.96
286_P328_R0.5080.96
227_L330_L0.5080.96
75_E78_A0.5080.96
300_L323_C0.5080.96
43_T64_I0.5080.96
84_L87_N0.5070.96
92_V131_L0.5050.96
265_M268_Q0.5050.96
204_V288_V0.5020.96
102_D278_G0.5010.95
187_L191_T0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ox4A 2 0.9974 100 0.079 Contact Map
3bfjA 5 0.9948 100 0.08 Contact Map
1rrmA 2 0.9922 100 0.104 Contact Map
1vljA 2 0.9922 100 0.105 Contact Map
4fr2A 2 0.9948 100 0.105 Contact Map
4qgsA 2 0.9661 100 0.141 Contact Map
3zdrA 2 0.9817 100 0.141 Contact Map
1o2dA 1 0.9321 100 0.167 Contact Map
3w5sA 2 0.8956 100 0.193 Contact Map
3iv7A 2 0.893 100 0.194 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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