ALDB - ECOLI - GREMLIN Contacts

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ALDB - Aldehyde dehydrogenase B

UniProt:	P37685	Sequences: MTNNPPSAQIKPGEYGFPLKLKARYDNFIGGEWVAPADGEYYQNLTPVTGQLLCEVASSGKRDIDLALDAAHKVKDKWAHTSVQDRAAILFKIADRMEQNLELLATAETWDNGKPIRETSAADVPLAIDHFRYFASCIRAQEGGISEVDSETVAYHFHEPLGVVGQIIPWNFPLLMASWKMAPALAAGNCVVLKPARLTPLSVLLLMEIVGDLLPPGVVNVVNGAGGVIGEYLATSKRIAKVAFTGSTEVGQQIMQYATQNIIPVTLELGGKSPNIFFADVMDEEDAFFDKALEGFALFAFNQGEVCTCPSRALVQESIYERFMERAIRRVESIRSGNPLDSVTQMGAQVSHGQLETILNYIDIGKKEGADVLTGGRRKLLEGELKDGYYLEPTILFGQNNMRVFQEEIFGPVLAVTTFKTMEEALELANDTQYGLGAGVWSRNGNLAYKMGRGIQAGRVWTNCYHAYPAHAAFGGYKQSGIGRETHKMMLEHYQQTKCLLVSYSDKPLGLF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12292
Length:	512 (460)
Sequences:	36433 (21994)
Seq/√Len:	1025.5

ECOLI - ALDB PUUC BETB GABD ABDH FEAB ALDA ASTD EUTE SAD PUTA PAAZ PROA
BACSU - ALDH4 ROCA ROCA2 ALDH1 ALDH5 IOLA BETB ALDY GABD ALDH3 ALDH2 PROA
HALSA - Q9HQZ2 Q9HMJ6 Q9HRB5 Q9HR91
SULSO - Q97YT9 GAPN KGSDH Q97XS9 Q97XA5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
317_E	420_K	5.119	1.00
256_Q	260_Q	3.989	1.00
317_E	418_T	3.220	1.00
290_D	326_R	3.183	1.00
320_Y	418_T	2.911	1.00
377_R	392_E	2.826	1.00
43_Q	55_E	2.818	1.00
72_H	238_R	2.799	1.00
279_A	316_Q	2.774	1.00
399_Q	402_M	2.725	1.00
352_H	356_E	2.706	1.00
364_I	403_R	2.610	1.00
294_E	330_R	2.590	1.00
363_D	367_K	2.575	1.00
205_L	208_E	2.531	1.00
324_M	416_V	2.529	1.00
279_A	318_S	2.459	1.00
98_E	132_R	2.434	1.00
100_N	103_L	2.430	1.00
43_Q	52_L	2.332	1.00
442_S	448_A	2.322	1.00
362_I	391_L	2.287	1.00
72_H	240_A	2.252	1.00
60_G	63_D	2.222	1.00
211_G	216_P	2.208	1.00
30_G	73_K	2.183	1.00
93_I	210_V	2.152	1.00
101_L	125_P	2.141	1.00
359_L	363_D	2.134	1.00
371_D	398_G	2.080	1.00
96_R	212_D	2.078	1.00
159_E	498_K	2.053	1.00
422_M	447_L	2.051	1.00
359_L	378_R	2.031	1.00
433_Q	479_Q	2.010	1.00
198_L	351_S	1.989	1.00
349_Q	358_I	1.988	1.00
364_I	368_E	1.969	1.00
328_I	332_E	1.952	1.00
366_K	372_V	1.934	1.00
450_K	454_G	1.918	1.00
359_L	391_L	1.911	1.00
231_E	235_T	1.906	1.00
34_V	66_L	1.905	1.00
322_R	326_R	1.901	1.00
103_L	205_L	1.901	1.00
158_H	492_E	1.897	1.00
275_N	296_F	1.888	1.00
373_L	397_F	1.884	1.00
235_T	257_Y	1.876	1.00
96_R	213_L	1.839	1.00
89_I	214_L	1.836	1.00
280_D	447_L	1.835	1.00
253_Q	256_Q	1.813	1.00
252_Q	479_Q	1.798	1.00
102_E	121_A	1.790	1.00
69_D	238_R	1.783	1.00
158_H	495_Q	1.770	1.00
456_Q	478_K	1.767	1.00
65_D	232_Y	1.750	1.00
422_M	450_K	1.747	1.00
96_R	99_Q	1.742	1.00
314_L	428_L	1.739	1.00
100_N	212_D	1.737	1.00
396_L	404_V	1.732	1.00
405_F	417_T	1.717	1.00
65_D	69_D	1.707	1.00
331_V	395_I	1.665	1.00
314_L	425_A	1.660	1.00
316_Q	419_F	1.656	1.00
424_E	427_E	1.655	1.00
96_R	209_I	1.654	1.00
400_N	428_L	1.652	1.00
328_I	373_L	1.651	1.00
371_D	397_F	1.633	1.00
207_M	221_V	1.620	1.00
52_L	55_E	1.620	1.00
107_A	205_L	1.619	1.00
137_C	140_A	1.614	1.00
403_R	407_E	1.611	1.00
91_F	132_R	1.609	1.00
296_F	323_F	1.593	1.00
320_Y	324_M	1.588	1.00
75_K	79_A	1.587	1.00
325_E	329_R	1.584	1.00
420_K	424_E	1.579	1.00
95_D	99_Q	1.556	1.00
190_C	218_V	1.552	1.00
131_F	182_A	1.548	1.00
82_S	85_D	1.539	1.00
289_F	326_R	1.524	1.00
98_E	128_I	1.517	1.00
321_E	418_T	1.517	1.00
313_A	414_L	1.514	1.00
360_N	403_R	1.514	1.00
372_V	396_L	1.507	1.00
301_F	331_V	1.496	1.00
326_R	329_R	1.493	1.00
352_H	389_Y	1.487	1.00
65_D	236_S	1.484	1.00
92_K	95_D	1.473	1.00
225_A	228_V	1.472	1.00
423_E	454_G	1.472	1.00
85_D	88_A	1.471	1.00
41_Y	55_E	1.441	1.00
293_L	326_R	1.440	1.00
208_E	212_D	1.433	1.00
278_F	447_L	1.432	1.00
51_Q	387_D	1.428	1.00
330_R	333_S	1.424	1.00
279_A	447_L	1.423	1.00
295_G	441_W	1.420	1.00
50_G	387_D	1.419	1.00
438_A	457_A	1.415	1.00
32_E	216_P	1.414	1.00
106_T	110_W	1.414	1.00
314_L	419_F	1.413	1.00
91_F	139_R	1.410	1.00
80_H	454_G	1.410	1.00
102_E	106_T	1.410	1.00
95_D	132_R	1.402	1.00
320_Y	397_F	1.402	1.00
322_R	325_E	1.402	1.00
363_D	366_K	1.398	1.00
63_D	66_L	1.394	1.00
315_V	323_F	1.386	1.00
424_E	428_L	1.384	1.00
296_F	313_A	1.377	1.00
109_T	119_T	1.367	1.00
81_T	85_D	1.366	1.00
157_F	453_R	1.364	1.00
131_F	178_S	1.359	1.00
166_Q	191_V	1.356	1.00
335_R	343_V	1.349	1.00
45_L	52_L	1.348	1.00
361_Y	409_I	1.333	1.00
358_I	411_G	1.328	1.00
255_M	482_I	1.327	1.00
94_A	132_R	1.322	1.00
370_A	396_L	1.319	1.00
100_N	205_L	1.318	1.00
106_T	340_L	1.311	1.00
419_F	428_L	1.302	1.00
356_E	360_N	1.296	1.00
278_F	419_F	1.294	1.00
40_E	58_S	1.294	1.00
355_L	359_L	1.288	1.00
75_K	190_C	1.285	1.00
355_L	391_L	1.275	1.00
46_T	49_T	1.274	1.00
329_R	332_E	1.273	1.00
241_K	266_T	1.269	1.00
355_L	378_R	1.264	1.00
332_E	374_T	1.259	1.00
278_F	451_M	1.257	1.00
321_E	325_E	1.255	1.00
207_M	219_V	1.253	1.00
177_A	193_L	1.248	1.00
368_E	403_R	1.248	1.00
426_L	451_M	1.243	1.00
116_I	121_A	1.239	1.00
324_M	328_I	1.234	1.00
421_T	424_E	1.226	1.00
210_V	219_V	1.221	1.00
276_I	425_A	1.218	1.00
94_A	98_E	1.217	1.00
316_Q	421_T	1.208	1.00
352_H	355_L	1.204	1.00
68_L	236_S	1.198	1.00
104_L	205_L	1.188	1.00
69_D	73_K	1.185	1.00
316_Q	319_I	1.184	1.00
401_N	406_Q	1.181	1.00
68_L	238_R	1.181	1.00
158_H	497_T	1.177	1.00
489_M	492_E	1.177	1.00
58_S	225_A	1.172	1.00
319_I	322_R	1.171	1.00
231_E	257_Y	1.165	1.00
335_R	345_Q	1.159	1.00
106_T	116_I	1.157	1.00
81_T	89_I	1.156	1.00
109_T	339_P	1.153	1.00
438_A	460_V	1.149	1.00
64_I	229_I	1.149	1.00
400_N	431_D	1.148	1.00
338_N	341_D	1.147	1.00
360_N	364_I	1.141	1.00
155_Y	449_Y	1.136	1.00
144_G	488_K	1.135	1.00
197_R	226_G	1.129	1.00
231_E	253_Q	1.129	1.00
337_G	344_T	1.125	1.00
327_A	414_L	1.123	1.00
488_K	492_E	1.123	1.00
326_R	330_R	1.123	1.00
406_Q	431_D	1.122	1.00
324_M	373_L	1.120	1.00
365_G	396_L	1.120	1.00
423_E	450_K	1.116	1.00
92_K	96_R	1.115	1.00
93_I	209_I	1.114	1.00
323_F	327_A	1.112	1.00
329_R	333_S	1.110	1.00
197_R	225_A	1.108	1.00
324_M	397_F	1.106	1.00
68_L	239_I	1.105	1.00
452_G	500_L	1.105	1.00
181_M	219_V	1.104	1.00
250_V	253_Q	1.103	1.00
406_Q	433_Q	1.098	1.00
334_I	346_M	1.096	1.00
448_A	462_T	1.095	1.00
46_T	338_N	1.093	1.00
253_Q	257_Y	1.090	1.00
91_F	136_S	1.081	1.00
101_L	121_A	1.081	1.00
93_I	131_F	1.076	1.00
276_I	451_M	1.075	1.00
379_K	392_E	1.075	1.00
42_Y	58_S	1.070	1.00
93_I	214_L	1.069	1.00
61_K	232_Y	1.064	1.00
54_C	201_L	1.061	1.00
166_Q	243_A	1.061	1.00
161_L	241_K	1.060	1.00
423_E	427_E	1.059	1.00
204_L	223_N	1.057	1.00
332_E	392_E	1.055	1.00
249_E	253_Q	1.052	1.00
426_L	454_G	1.050	1.00
489_M	497_T	1.049	1.00
48_V	339_P	1.047	1.00
484_R	496_Q	1.043	1.00
328_I	374_T	1.039	1.00
232_Y	236_S	1.038	1.00
235_T	260_Q	1.038	1.00
255_M	265_V	1.038	1.00
74_V	190_C	1.035	1.00
288_F	443_R	1.032	1.00
368_E	402_M	1.030	1.00
475_G	484_R	1.029	1.00
275_N	310_P	1.028	1.00
181_M	191_V	1.026	1.00
252_Q	262_I	1.020	1.00
165_G	239_I	1.018	1.00
104_L	209_I	1.016	1.00
422_M	451_M	1.016	1.00
375_G	394_T	1.016	1.00
276_I	429_A	1.015	1.00
444_N	447_L	1.015	1.00
58_S	228_V	1.010	1.00
217_G	220_N	1.008	1.00
144_G	489_M	1.007	1.00
172_F	306_V	1.007	1.00
76_D	427_E	0.997	1.00
165_G	233_L	0.995	1.00
99_Q	212_D	0.993	1.00
100_N	209_I	0.992	1.00
157_F	500_L	0.992	1.00
70_A	220_N	0.985	1.00
204_L	221_V	0.974	1.00
355_L	389_Y	0.973	1.00
50_G	389_Y	0.971	1.00
30_G	70_A	0.968	1.00
375_G	392_E	0.968	1.00
358_I	413_V	0.968	1.00
76_D	456_Q	0.962	1.00
127_A	178_S	0.960	1.00
32_E	66_L	0.957	1.00
419_F	425_A	0.954	1.00
197_R	227_G	0.952	1.00
208_E	211_G	0.950	1.00
163_V	190_C	0.942	1.00
255_M	259_T	0.940	1.00
161_L	264_P	0.938	1.00
272_K	311_S	0.935	1.00
274_P	438_A	0.933	1.00
72_H	76_D	0.932	1.00
288_F	291_K	0.932	1.00
321_E	324_M	0.928	1.00
100_N	208_E	0.928	1.00
61_K	228_V	0.925	1.00
477_Y	496_Q	0.924	1.00
290_D	322_R	0.923	1.00
361_Y	364_I	0.923	1.00
159_E	453_R	0.922	1.00
439_G	465_Y	0.919	1.00
427_E	431_D	0.918	1.00
103_L	106_T	0.917	1.00
46_T	110_W	0.917	1.00
110_W	340_L	0.906	1.00
154_A	472_A	0.906	1.00
360_N	363_D	0.902	1.00
299_F	310_P	0.900	1.00
364_I	367_K	0.896	1.00
76_D	80_H	0.896	1.00
297_A	330_R	0.894	1.00
114_K	123_D	0.893	1.00
379_K	385_L	0.892	1.00
163_V	239_I	0.891	1.00
240_A	456_Q	0.891	1.00
61_K	65_D	0.890	1.00
291_K	295_G	0.890	1.00
247_S	250_V	0.889	1.00
164_V	241_K	0.887	1.00
300_A	311_S	0.885	1.00
79_A	456_Q	0.885	1.00
46_T	51_Q	0.885	1.00
366_K	396_L	0.885	1.00
138_I	186_A	0.881	1.00
88_A	92_K	0.881	1.00
369_G	402_M	0.878	1.00
97_M	127_A	0.877	1.00
127_A	174_L	0.874	1.00
64_I	165_G	0.873	1.00
292_A	296_F	0.872	1.00
289_F	293_L	0.870	1.00
112_N	199_T	0.868	1.00
278_F	422_M	0.866	1.00
83_V	87_A	0.866	1.00
361_Y	403_R	0.865	1.00
96_R	100_N	0.864	1.00
293_L	327_A	0.864	1.00
320_Y	416_V	0.863	1.00
155_Y	502_V	0.863	1.00
159_E	477_Y	0.862	1.00
87_A	91_F	0.862	1.00
275_N	441_W	0.860	1.00
91_F	135_A	0.859	1.00
370_A	402_M	0.859	1.00
45_L	389_Y	0.856	1.00
417_T	428_L	0.856	1.00
376_G	394_T	0.855	1.00
358_I	409_I	0.853	1.00
356_E	359_L	0.853	1.00
293_L	330_R	0.851	1.00
80_H	453_R	0.847	1.00
278_F	442_S	0.847	1.00
440_V	451_M	0.844	1.00
252_Q	256_Q	0.843	1.00
438_A	455_I	0.842	1.00
137_C	141_Q	0.841	1.00
255_M	258_A	0.839	1.00
264_P	496_Q	0.837	1.00
74_V	218_V	0.831	1.00
94_A	135_A	0.830	1.00
472_A	499_C	0.826	1.00
449_Y	453_R	0.826	1.00
198_L	353_G	0.826	1.00
87_A	135_A	0.823	1.00
66_L	70_A	0.822	1.00
30_G	216_P	0.822	1.00
277_F	323_F	0.822	1.00
161_L	496_Q	0.819	1.00
400_N	417_T	0.819	1.00
425_A	428_L	0.818	1.00
419_F	424_E	0.815	1.00
36_P	63_D	0.812	1.00
242_V	258_A	0.812	1.00
193_L	203_V	0.806	1.00
161_L	189_N	0.805	1.00
92_K	213_L	0.804	1.00
207_M	211_G	0.803	1.00
187_A	495_Q	0.803	1.00
293_L	323_F	0.802	1.00
48_V	390_Y	0.802	1.00
255_M	262_I	0.800	1.00
426_L	430_N	0.799	1.00
180_K	485_E	0.798	1.00
62_R	65_D	0.798	1.00
242_V	254_I	0.795	1.00
362_I	413_V	0.792	1.00
177_A	181_M	0.792	1.00
89_I	213_L	0.791	1.00
87_A	139_R	0.790	1.00
42_Y	225_A	0.789	1.00
70_A	217_G	0.789	1.00
183_P	490_M	0.783	1.00
184_A	191_V	0.779	1.00
97_M	128_I	0.779	1.00
66_L	69_D	0.778	1.00
71_A	220_N	0.777	1.00
445_G	448_A	0.777	1.00
62_R	66_L	0.774	1.00
33_W	211_G	0.773	1.00
397_F	418_T	0.772	1.00
36_P	41_Y	0.770	1.00
325_E	328_I	0.769	1.00
204_L	208_E	0.769	1.00
90_L	186_A	0.767	1.00
78_W	218_V	0.766	1.00
320_Y	398_G	0.763	1.00
292_A	323_F	0.763	1.00
293_L	297_A	0.763	1.00
358_I	391_L	0.762	1.00
53_L	110_W	0.762	1.00
73_K	76_D	0.762	1.00
91_F	95_D	0.758	1.00
178_S	206_L	0.756	1.00
214_L	219_V	0.756	1.00
109_T	116_I	0.756	1.00
165_G	242_V	0.755	1.00
112_N	350_V	0.755	1.00
457_A	460_V	0.754	1.00
34_V	63_D	0.754	1.00
117_R	345_Q	0.752	1.00
73_K	77_K	0.750	1.00
195_P	223_N	0.749	1.00
36_P	57_A	0.747	1.00
251_G	269_L	0.746	1.00
116_I	340_L	0.746	1.00
336_S	379_K	0.743	1.00
353_G	356_E	0.742	1.00
316_Q	422_M	0.739	1.00
59_S	63_D	0.737	1.00
365_G	409_I	0.735	1.00
327_A	395_I	0.734	1.00
76_D	79_A	0.734	1.00
334_I	345_Q	0.733	1.00
274_P	429_A	0.731	1.00
98_E	125_P	0.729	1.00
258_A	265_V	0.726	1.00
289_F	319_I	0.724	1.00
98_E	101_L	0.723	1.00
174_L	202_S	0.723	1.00
46_T	340_L	0.721	1.00
105_A	121_A	0.720	1.00
234_A	254_I	0.720	1.00
248_T	479_Q	0.718	1.00
105_A	116_I	0.718	1.00
105_A	109_T	0.717	1.00
110_W	201_L	0.715	1.00
443_R	446_N	0.712	1.00
331_V	374_T	0.711	1.00
77_K	81_T	0.709	1.00
165_G	230_G	0.708	1.00
251_G	267_L	0.708	1.00
166_Q	180_K	0.707	1.00
366_K	377_R	0.703	1.00
341_D	344_T	0.702	1.00
224_G	229_I	0.700	1.00
273_S	311_S	0.700	1.00
290_D	330_R	0.698	1.00
297_A	327_A	0.698	1.00
244_F	250_V	0.697	1.00
121_A	125_P	0.697	1.00
84_Q	139_R	0.696	1.00
361_Y	407_E	0.696	1.00
328_I	331_V	0.695	1.00
315_V	319_I	0.695	1.00
45_L	50_G	0.694	1.00
252_Q	260_Q	0.694	1.00
362_I	396_L	0.693	1.00
161_L	240_A	0.692	1.00
78_W	89_I	0.689	1.00
177_A	203_V	0.688	1.00
352_H	378_R	0.685	1.00
445_G	502_V	0.685	1.00
355_L	379_K	0.683	1.00
137_C	142_E	0.683	1.00
198_L	350_V	0.681	1.00
189_N	495_Q	0.680	1.00
278_F	316_Q	0.679	1.00
193_L	219_V	0.675	1.00
354_Q	357_T	0.675	1.00
421_T	427_E	0.674	1.00
230_G	234_A	0.674	1.00
79_A	454_G	0.672	1.00
462_T	502_V	0.670	1.00
71_A	190_C	0.669	1.00
65_D	238_R	0.667	1.00
331_V	334_I	0.667	1.00
313_A	323_F	0.667	1.00
40_E	228_V	0.666	1.00
64_I	232_Y	0.665	1.00
64_I	68_L	0.665	1.00
234_A	257_Y	0.664	1.00
107_A	201_L	0.663	1.00
338_N	344_T	0.662	1.00
374_T	395_I	0.661	1.00
146_S	149_D	0.660	1.00
314_L	405_F	0.659	1.00
357_T	360_N	0.658	1.00
83_V	138_I	0.658	1.00
59_S	67_A	0.658	1.00
391_L	394_T	0.657	1.00
102_E	116_I	0.657	1.00
154_A	499_C	0.656	1.00
256_Q	259_T	0.656	1.00
400_N	405_F	0.655	1.00
303_Q	346_M	0.655	1.00
422_M	426_L	0.654	1.00
229_I	232_Y	0.653	1.00
280_D	442_S	0.653	1.00
168_I	177_A	0.652	1.00
50_G	352_H	0.652	1.00
31_G	211_G	0.651	1.00
351_S	354_Q	0.651	1.00
108_E	111_D	0.648	1.00
95_D	98_E	0.647	1.00
104_L	174_L	0.646	1.00
228_V	231_E	0.645	1.00
336_S	346_M	0.645	1.00
33_W	208_E	0.645	1.00
297_A	334_I	0.642	1.00
72_H	75_K	0.642	1.00
428_L	431_D	0.640	1.00
79_A	159_E	0.640	1.00
452_G	462_T	0.639	1.00
79_A	160_P	0.639	1.00
30_G	66_L	0.638	1.00
264_P	493_H	0.638	1.00
442_S	447_L	0.638	1.00
314_L	400_N	0.636	1.00
210_V	214_L	0.636	1.00
103_L	208_E	0.635	1.00
448_A	452_G	0.634	1.00
142_E	145_I	0.633	1.00
154_A	501_L	0.633	1.00
30_G	220_N	0.632	1.00
177_A	206_L	0.632	1.00
29_I	67_A	0.631	1.00
277_F	292_A	0.631	1.00
449_Y	502_V	0.631	1.00
157_F	498_K	0.631	1.00
287_A	292_A	0.630	1.00
456_Q	477_Y	0.629	1.00
77_K	80_H	0.629	1.00
296_F	327_A	0.628	1.00
257_Y	260_Q	0.625	1.00
359_L	362_I	0.624	1.00
192_V	220_N	0.622	1.00
376_G	392_E	0.622	1.00
76_D	454_G	0.621	1.00
197_R	357_T	0.620	1.00
327_A	416_V	0.620	1.00
289_F	322_R	0.619	1.00
353_G	357_T	0.619	1.00
109_T	340_L	0.618	1.00
69_D	72_H	0.617	1.00
445_G	449_Y	0.617	1.00
492_E	495_Q	0.616	1.00
41_Y	57_A	0.615	1.00
280_D	444_N	0.612	1.00
114_K	118_E	0.612	1.00
155_Y	500_L	0.612	1.00
153_V	449_Y	0.611	1.00
59_S	222_V	0.610	1.00
266_T	493_H	0.610	1.00
56_V	200_P	0.609	1.00
138_I	141_Q	0.609	1.00
78_W	185_L	0.608	1.00
368_E	401_N	0.608	1.00
85_D	89_I	0.607	1.00
205_L	209_I	0.606	1.00
372_V	394_T	0.606	1.00
426_L	450_K	0.604	1.00
291_K	443_R	0.604	1.00
57_A	223_N	0.604	1.00
234_A	242_V	0.604	1.00
492_E	497_T	0.604	1.00
255_M	267_L	0.603	1.00
141_Q	495_Q	0.602	1.00
114_K	172_F	0.601	1.00
44_N	54_C	0.599	1.00
94_A	128_I	0.596	1.00
224_G	230_G	0.596	1.00
174_L	206_L	0.596	1.00
349_Q	354_Q	0.595	1.00
181_M	193_L	0.595	1.00
108_E	202_S	0.594	1.00
97_M	206_L	0.592	1.00
74_V	77_K	0.591	1.00
197_R	253_Q	0.591	1.00
106_T	109_T	0.590	1.00
379_K	386_K	0.589	1.00
124_V	128_I	0.586	1.00
121_A	342_S	0.585	1.00
440_V	448_A	0.585	1.00
101_L	105_A	0.584	1.00
97_M	131_F	0.583	1.00
299_F	465_Y	0.583	1.00
275_N	313_A	0.583	1.00
83_V	186_A	0.582	1.00
180_K	243_A	0.582	1.00
190_C	220_N	0.580	1.00
97_M	174_L	0.579	1.00
291_K	294_E	0.579	1.00
44_N	111_D	0.578	1.00
409_I	413_V	0.577	1.00
164_V	189_N	0.577	1.00
67_A	222_V	0.575	1.00
124_V	174_L	0.571	1.00
426_L	455_I	0.570	1.00
328_I	395_I	0.570	1.00
108_E	119_T	0.569	1.00
280_D	287_A	0.567	1.00
361_Y	365_G	0.566	1.00
53_L	201_L	0.562	1.00
378_R	392_E	0.560	1.00
398_G	418_T	0.559	1.00
61_K	235_T	0.558	1.00
446_N	450_K	0.558	1.00
279_A	419_F	0.558	1.00
206_L	210_V	0.558	1.00
460_V	498_K	0.558	1.00
315_V	416_V	0.556	1.00
315_V	320_Y	0.555	1.00
275_N	439_G	0.555	1.00
359_L	366_K	0.554	1.00
108_E	123_D	0.552	1.00
446_N	449_Y	0.551	1.00
93_I	96_R	0.548	1.00
61_K	231_E	0.547	1.00
141_Q	145_I	0.544	1.00
241_K	493_H	0.544	1.00
373_L	398_G	0.544	1.00
300_A	414_L	0.543	1.00
280_D	443_R	0.542	1.00
248_T	252_Q	0.541	1.00
308_T	467_A	0.541	1.00
94_A	131_F	0.540	1.00
89_I	93_I	0.540	1.00
273_S	437_G	0.540	1.00
187_A	491_L	0.540	1.00
337_G	341_D	0.539	1.00
306_V	309_C	0.539	1.00
104_L	124_V	0.538	1.00
105_A	124_V	0.538	1.00
404_V	409_I	0.537	1.00
440_V	462_T	0.537	1.00
44_N	200_P	0.536	1.00
336_S	345_Q	0.534	1.00
141_Q	491_L	0.534	1.00
185_L	214_L	0.534	1.00
97_M	104_L	0.533	1.00
349_Q	391_L	0.531	1.00
362_I	394_T	0.530	1.00
72_H	163_V	0.529	1.00
422_M	454_G	0.529	1.00
234_A	261_N	0.529	1.00
164_V	191_V	0.528	1.00
166_Q	181_M	0.528	1.00
405_F	428_L	0.527	1.00
455_I	460_V	0.527	1.00
317_E	320_Y	0.527	1.00
70_A	216_P	0.527	1.00
40_E	60_G	0.526	1.00
313_A	416_V	0.526	1.00
400_N	427_E	0.523	1.00
226_G	230_G	0.522	1.00
429_A	455_I	0.522	1.00
425_A	429_A	0.521	1.00
461_W	464_C	0.520	1.00
372_V	375_G	0.520	1.00
265_V	482_I	0.519	1.00
71_A	192_V	0.519	1.00
29_I	34_V	0.519	1.00
112_N	302_N	0.519	1.00
456_Q	496_Q	0.518	1.00
249_E	353_G	0.518	1.00
175_L	179_W	0.517	1.00
71_A	163_V	0.515	1.00
137_C	488_K	0.514	1.00
125_P	128_I	0.514	1.00
368_E	399_Q	0.513	1.00
185_L	219_V	0.512	1.00
67_A	192_V	0.512	1.00
163_V	240_A	0.512	1.00
289_F	292_A	0.511	1.00
179_W	486_T	0.511	1.00
84_Q	88_A	0.511	1.00
56_V	201_L	0.511	1.00
290_D	329_R	0.511	1.00
361_Y	404_V	0.509	1.00
231_E	234_A	0.509	1.00
138_I	142_E	0.509	1.00
44_N	53_L	0.509	1.00
243_A	494_Y	0.508	1.00
70_A	74_V	0.507	1.00
289_F	323_F	0.506	1.00
274_P	457_A	0.505	1.00
325_E	332_E	0.505	1.00
310_P	439_G	0.505	1.00
228_V	232_Y	0.504	1.00
354_Q	358_I	0.501	1.00
327_A	331_V	0.500	1.00
105_A	119_T	0.500	1.00
134_F	183_P	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4yweA	5	0.9199	100	0.088	Contact Map
4qf6A	4	0.9473	100	0.089	Contact Map
4o5hA	4	0.9629	100	0.09	Contact Map
4pz2A	4	0.9355	100	0.092	Contact Map
2d4eA	4	0.9805	100	0.093	Contact Map
4pxlA	4	0.9355	100	0.093	Contact Map
4lihA	5	0.9531	100	0.094	Contact Map
4wj9A	4	0.9492	100	0.095	Contact Map
1wndA	4	0.918	100	0.095	Contact Map
1a4sA	4	0.9688	100	0.096	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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