GREMLIN Database
ALDB - Aldehyde dehydrogenase B
UniProt: P37685 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12292
Length: 512 (460)
Sequences: 36433 (21994)
Seq/√Len: 1025.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
317_E420_K5.1191.00
256_Q260_Q3.9891.00
317_E418_T3.2201.00
290_D326_R3.1831.00
320_Y418_T2.9111.00
377_R392_E2.8261.00
43_Q55_E2.8181.00
72_H238_R2.7991.00
279_A316_Q2.7741.00
399_Q402_M2.7251.00
352_H356_E2.7061.00
364_I403_R2.6101.00
294_E330_R2.5901.00
363_D367_K2.5751.00
205_L208_E2.5311.00
324_M416_V2.5291.00
279_A318_S2.4591.00
98_E132_R2.4341.00
100_N103_L2.4301.00
43_Q52_L2.3321.00
442_S448_A2.3221.00
362_I391_L2.2871.00
72_H240_A2.2521.00
60_G63_D2.2221.00
211_G216_P2.2081.00
30_G73_K2.1831.00
93_I210_V2.1521.00
101_L125_P2.1411.00
359_L363_D2.1341.00
371_D398_G2.0801.00
96_R212_D2.0781.00
159_E498_K2.0531.00
422_M447_L2.0511.00
359_L378_R2.0311.00
433_Q479_Q2.0101.00
198_L351_S1.9891.00
349_Q358_I1.9881.00
364_I368_E1.9691.00
328_I332_E1.9521.00
366_K372_V1.9341.00
450_K454_G1.9181.00
359_L391_L1.9111.00
231_E235_T1.9061.00
34_V66_L1.9051.00
322_R326_R1.9011.00
103_L205_L1.9011.00
158_H492_E1.8971.00
275_N296_F1.8881.00
373_L397_F1.8841.00
235_T257_Y1.8761.00
96_R213_L1.8391.00
89_I214_L1.8361.00
280_D447_L1.8351.00
253_Q256_Q1.8131.00
252_Q479_Q1.7981.00
102_E121_A1.7901.00
69_D238_R1.7831.00
158_H495_Q1.7701.00
456_Q478_K1.7671.00
65_D232_Y1.7501.00
422_M450_K1.7471.00
96_R99_Q1.7421.00
314_L428_L1.7391.00
100_N212_D1.7371.00
396_L404_V1.7321.00
405_F417_T1.7171.00
65_D69_D1.7071.00
331_V395_I1.6651.00
314_L425_A1.6601.00
316_Q419_F1.6561.00
424_E427_E1.6551.00
96_R209_I1.6541.00
400_N428_L1.6521.00
328_I373_L1.6511.00
371_D397_F1.6331.00
207_M221_V1.6201.00
52_L55_E1.6201.00
107_A205_L1.6191.00
137_C140_A1.6141.00
403_R407_E1.6111.00
91_F132_R1.6091.00
296_F323_F1.5931.00
320_Y324_M1.5881.00
75_K79_A1.5871.00
325_E329_R1.5841.00
420_K424_E1.5791.00
95_D99_Q1.5561.00
190_C218_V1.5521.00
131_F182_A1.5481.00
82_S85_D1.5391.00
289_F326_R1.5241.00
98_E128_I1.5171.00
321_E418_T1.5171.00
313_A414_L1.5141.00
360_N403_R1.5141.00
372_V396_L1.5071.00
301_F331_V1.4961.00
326_R329_R1.4931.00
352_H389_Y1.4871.00
65_D236_S1.4841.00
92_K95_D1.4731.00
225_A228_V1.4721.00
423_E454_G1.4721.00
85_D88_A1.4711.00
41_Y55_E1.4411.00
293_L326_R1.4401.00
208_E212_D1.4331.00
278_F447_L1.4321.00
51_Q387_D1.4281.00
330_R333_S1.4241.00
279_A447_L1.4231.00
295_G441_W1.4201.00
50_G387_D1.4191.00
438_A457_A1.4151.00
32_E216_P1.4141.00
106_T110_W1.4141.00
314_L419_F1.4131.00
91_F139_R1.4101.00
80_H454_G1.4101.00
102_E106_T1.4101.00
95_D132_R1.4021.00
320_Y397_F1.4021.00
322_R325_E1.4021.00
363_D366_K1.3981.00
63_D66_L1.3941.00
315_V323_F1.3861.00
424_E428_L1.3841.00
296_F313_A1.3771.00
109_T119_T1.3671.00
81_T85_D1.3661.00
157_F453_R1.3641.00
131_F178_S1.3591.00
166_Q191_V1.3561.00
335_R343_V1.3491.00
45_L52_L1.3481.00
361_Y409_I1.3331.00
358_I411_G1.3281.00
255_M482_I1.3271.00
94_A132_R1.3221.00
370_A396_L1.3191.00
100_N205_L1.3181.00
106_T340_L1.3111.00
419_F428_L1.3021.00
356_E360_N1.2961.00
278_F419_F1.2941.00
40_E58_S1.2941.00
355_L359_L1.2881.00
75_K190_C1.2851.00
355_L391_L1.2751.00
46_T49_T1.2741.00
329_R332_E1.2731.00
241_K266_T1.2691.00
355_L378_R1.2641.00
332_E374_T1.2591.00
278_F451_M1.2571.00
321_E325_E1.2551.00
207_M219_V1.2531.00
177_A193_L1.2481.00
368_E403_R1.2481.00
426_L451_M1.2431.00
116_I121_A1.2391.00
324_M328_I1.2341.00
421_T424_E1.2261.00
210_V219_V1.2211.00
276_I425_A1.2181.00
94_A98_E1.2171.00
316_Q421_T1.2081.00
352_H355_L1.2041.00
68_L236_S1.1981.00
104_L205_L1.1881.00
69_D73_K1.1851.00
316_Q319_I1.1841.00
401_N406_Q1.1811.00
68_L238_R1.1811.00
158_H497_T1.1771.00
489_M492_E1.1771.00
58_S225_A1.1721.00
319_I322_R1.1711.00
231_E257_Y1.1651.00
335_R345_Q1.1591.00
106_T116_I1.1571.00
81_T89_I1.1561.00
109_T339_P1.1531.00
438_A460_V1.1491.00
64_I229_I1.1491.00
400_N431_D1.1481.00
338_N341_D1.1471.00
360_N364_I1.1411.00
155_Y449_Y1.1361.00
144_G488_K1.1351.00
197_R226_G1.1291.00
231_E253_Q1.1291.00
337_G344_T1.1251.00
327_A414_L1.1231.00
488_K492_E1.1231.00
326_R330_R1.1231.00
406_Q431_D1.1221.00
324_M373_L1.1201.00
365_G396_L1.1201.00
423_E450_K1.1161.00
92_K96_R1.1151.00
93_I209_I1.1141.00
323_F327_A1.1121.00
329_R333_S1.1101.00
197_R225_A1.1081.00
324_M397_F1.1061.00
68_L239_I1.1051.00
452_G500_L1.1051.00
181_M219_V1.1041.00
250_V253_Q1.1031.00
406_Q433_Q1.0981.00
334_I346_M1.0961.00
448_A462_T1.0951.00
46_T338_N1.0931.00
253_Q257_Y1.0901.00
91_F136_S1.0811.00
101_L121_A1.0811.00
93_I131_F1.0761.00
276_I451_M1.0751.00
379_K392_E1.0751.00
42_Y58_S1.0701.00
93_I214_L1.0691.00
61_K232_Y1.0641.00
54_C201_L1.0611.00
166_Q243_A1.0611.00
161_L241_K1.0601.00
423_E427_E1.0591.00
204_L223_N1.0571.00
332_E392_E1.0551.00
249_E253_Q1.0521.00
426_L454_G1.0501.00
489_M497_T1.0491.00
48_V339_P1.0471.00
484_R496_Q1.0431.00
328_I374_T1.0391.00
232_Y236_S1.0381.00
235_T260_Q1.0381.00
255_M265_V1.0381.00
74_V190_C1.0351.00
288_F443_R1.0321.00
368_E402_M1.0301.00
475_G484_R1.0291.00
275_N310_P1.0281.00
181_M191_V1.0261.00
252_Q262_I1.0201.00
165_G239_I1.0181.00
104_L209_I1.0161.00
422_M451_M1.0161.00
375_G394_T1.0161.00
276_I429_A1.0151.00
444_N447_L1.0151.00
58_S228_V1.0101.00
217_G220_N1.0081.00
144_G489_M1.0071.00
172_F306_V1.0071.00
76_D427_E0.9971.00
165_G233_L0.9951.00
99_Q212_D0.9931.00
100_N209_I0.9921.00
157_F500_L0.9921.00
70_A220_N0.9851.00
204_L221_V0.9741.00
355_L389_Y0.9731.00
50_G389_Y0.9711.00
30_G70_A0.9681.00
375_G392_E0.9681.00
358_I413_V0.9681.00
76_D456_Q0.9621.00
127_A178_S0.9601.00
32_E66_L0.9571.00
419_F425_A0.9541.00
197_R227_G0.9521.00
208_E211_G0.9501.00
163_V190_C0.9421.00
255_M259_T0.9401.00
161_L264_P0.9381.00
272_K311_S0.9351.00
274_P438_A0.9331.00
72_H76_D0.9321.00
288_F291_K0.9321.00
321_E324_M0.9281.00
100_N208_E0.9281.00
61_K228_V0.9251.00
477_Y496_Q0.9241.00
290_D322_R0.9231.00
361_Y364_I0.9231.00
159_E453_R0.9221.00
439_G465_Y0.9191.00
427_E431_D0.9181.00
103_L106_T0.9171.00
46_T110_W0.9171.00
110_W340_L0.9061.00
154_A472_A0.9061.00
360_N363_D0.9021.00
299_F310_P0.9001.00
364_I367_K0.8961.00
76_D80_H0.8961.00
297_A330_R0.8941.00
114_K123_D0.8931.00
379_K385_L0.8921.00
163_V239_I0.8911.00
240_A456_Q0.8911.00
61_K65_D0.8901.00
291_K295_G0.8901.00
247_S250_V0.8891.00
164_V241_K0.8871.00
300_A311_S0.8851.00
79_A456_Q0.8851.00
46_T51_Q0.8851.00
366_K396_L0.8851.00
138_I186_A0.8811.00
88_A92_K0.8811.00
369_G402_M0.8781.00
97_M127_A0.8771.00
127_A174_L0.8741.00
64_I165_G0.8731.00
292_A296_F0.8721.00
289_F293_L0.8701.00
112_N199_T0.8681.00
278_F422_M0.8661.00
83_V87_A0.8661.00
361_Y403_R0.8651.00
96_R100_N0.8641.00
293_L327_A0.8641.00
320_Y416_V0.8631.00
155_Y502_V0.8631.00
159_E477_Y0.8621.00
87_A91_F0.8621.00
275_N441_W0.8601.00
91_F135_A0.8591.00
370_A402_M0.8591.00
45_L389_Y0.8561.00
417_T428_L0.8561.00
376_G394_T0.8551.00
358_I409_I0.8531.00
356_E359_L0.8531.00
293_L330_R0.8511.00
80_H453_R0.8471.00
278_F442_S0.8471.00
440_V451_M0.8441.00
252_Q256_Q0.8431.00
438_A455_I0.8421.00
137_C141_Q0.8411.00
255_M258_A0.8391.00
264_P496_Q0.8371.00
74_V218_V0.8311.00
94_A135_A0.8301.00
472_A499_C0.8261.00
449_Y453_R0.8261.00
198_L353_G0.8261.00
87_A135_A0.8231.00
66_L70_A0.8221.00
30_G216_P0.8221.00
277_F323_F0.8221.00
161_L496_Q0.8191.00
400_N417_T0.8191.00
425_A428_L0.8181.00
419_F424_E0.8151.00
36_P63_D0.8121.00
242_V258_A0.8121.00
193_L203_V0.8061.00
161_L189_N0.8051.00
92_K213_L0.8041.00
207_M211_G0.8031.00
187_A495_Q0.8031.00
293_L323_F0.8021.00
48_V390_Y0.8021.00
255_M262_I0.8001.00
426_L430_N0.7991.00
180_K485_E0.7981.00
62_R65_D0.7981.00
242_V254_I0.7951.00
362_I413_V0.7921.00
177_A181_M0.7921.00
89_I213_L0.7911.00
87_A139_R0.7901.00
42_Y225_A0.7891.00
70_A217_G0.7891.00
183_P490_M0.7831.00
184_A191_V0.7791.00
97_M128_I0.7791.00
66_L69_D0.7781.00
71_A220_N0.7771.00
445_G448_A0.7771.00
62_R66_L0.7741.00
33_W211_G0.7731.00
397_F418_T0.7721.00
36_P41_Y0.7701.00
325_E328_I0.7691.00
204_L208_E0.7691.00
90_L186_A0.7671.00
78_W218_V0.7661.00
320_Y398_G0.7631.00
292_A323_F0.7631.00
293_L297_A0.7631.00
358_I391_L0.7621.00
53_L110_W0.7621.00
73_K76_D0.7621.00
91_F95_D0.7581.00
178_S206_L0.7561.00
214_L219_V0.7561.00
109_T116_I0.7561.00
165_G242_V0.7551.00
112_N350_V0.7551.00
457_A460_V0.7541.00
34_V63_D0.7541.00
117_R345_Q0.7521.00
73_K77_K0.7501.00
195_P223_N0.7491.00
36_P57_A0.7471.00
251_G269_L0.7461.00
116_I340_L0.7461.00
336_S379_K0.7431.00
353_G356_E0.7421.00
316_Q422_M0.7391.00
59_S63_D0.7371.00
365_G409_I0.7351.00
327_A395_I0.7341.00
76_D79_A0.7341.00
334_I345_Q0.7331.00
274_P429_A0.7311.00
98_E125_P0.7291.00
258_A265_V0.7261.00
289_F319_I0.7241.00
98_E101_L0.7231.00
174_L202_S0.7231.00
46_T340_L0.7211.00
105_A121_A0.7201.00
234_A254_I0.7201.00
248_T479_Q0.7181.00
105_A116_I0.7181.00
105_A109_T0.7171.00
110_W201_L0.7151.00
443_R446_N0.7121.00
331_V374_T0.7111.00
77_K81_T0.7091.00
165_G230_G0.7081.00
251_G267_L0.7081.00
166_Q180_K0.7071.00
366_K377_R0.7031.00
341_D344_T0.7021.00
224_G229_I0.7001.00
273_S311_S0.7001.00
290_D330_R0.6981.00
297_A327_A0.6981.00
244_F250_V0.6971.00
121_A125_P0.6971.00
84_Q139_R0.6961.00
361_Y407_E0.6961.00
328_I331_V0.6951.00
315_V319_I0.6951.00
45_L50_G0.6941.00
252_Q260_Q0.6941.00
362_I396_L0.6931.00
161_L240_A0.6921.00
78_W89_I0.6891.00
177_A203_V0.6881.00
352_H378_R0.6851.00
445_G502_V0.6851.00
355_L379_K0.6831.00
137_C142_E0.6831.00
198_L350_V0.6811.00
189_N495_Q0.6801.00
278_F316_Q0.6791.00
193_L219_V0.6751.00
354_Q357_T0.6751.00
421_T427_E0.6741.00
230_G234_A0.6741.00
79_A454_G0.6721.00
462_T502_V0.6701.00
71_A190_C0.6691.00
65_D238_R0.6671.00
331_V334_I0.6671.00
313_A323_F0.6671.00
40_E228_V0.6661.00
64_I232_Y0.6651.00
64_I68_L0.6651.00
234_A257_Y0.6641.00
107_A201_L0.6631.00
338_N344_T0.6621.00
374_T395_I0.6611.00
146_S149_D0.6601.00
314_L405_F0.6591.00
357_T360_N0.6581.00
83_V138_I0.6581.00
59_S67_A0.6581.00
391_L394_T0.6571.00
102_E116_I0.6571.00
154_A499_C0.6561.00
256_Q259_T0.6561.00
400_N405_F0.6551.00
303_Q346_M0.6551.00
422_M426_L0.6541.00
229_I232_Y0.6531.00
280_D442_S0.6531.00
168_I177_A0.6521.00
50_G352_H0.6521.00
31_G211_G0.6511.00
351_S354_Q0.6511.00
108_E111_D0.6481.00
95_D98_E0.6471.00
104_L174_L0.6461.00
228_V231_E0.6451.00
336_S346_M0.6451.00
33_W208_E0.6451.00
297_A334_I0.6421.00
72_H75_K0.6421.00
428_L431_D0.6401.00
79_A159_E0.6401.00
452_G462_T0.6391.00
79_A160_P0.6391.00
30_G66_L0.6381.00
264_P493_H0.6381.00
442_S447_L0.6381.00
314_L400_N0.6361.00
210_V214_L0.6361.00
103_L208_E0.6351.00
448_A452_G0.6341.00
142_E145_I0.6331.00
154_A501_L0.6331.00
30_G220_N0.6321.00
177_A206_L0.6321.00
29_I67_A0.6311.00
277_F292_A0.6311.00
449_Y502_V0.6311.00
157_F498_K0.6311.00
287_A292_A0.6301.00
456_Q477_Y0.6291.00
77_K80_H0.6291.00
296_F327_A0.6281.00
257_Y260_Q0.6251.00
359_L362_I0.6241.00
192_V220_N0.6221.00
376_G392_E0.6221.00
76_D454_G0.6211.00
197_R357_T0.6201.00
327_A416_V0.6201.00
289_F322_R0.6191.00
353_G357_T0.6191.00
109_T340_L0.6181.00
69_D72_H0.6171.00
445_G449_Y0.6171.00
492_E495_Q0.6161.00
41_Y57_A0.6151.00
280_D444_N0.6121.00
114_K118_E0.6121.00
155_Y500_L0.6121.00
153_V449_Y0.6111.00
59_S222_V0.6101.00
266_T493_H0.6101.00
56_V200_P0.6091.00
138_I141_Q0.6091.00
78_W185_L0.6081.00
368_E401_N0.6081.00
85_D89_I0.6071.00
205_L209_I0.6061.00
372_V394_T0.6061.00
426_L450_K0.6041.00
291_K443_R0.6041.00
57_A223_N0.6041.00
234_A242_V0.6041.00
492_E497_T0.6041.00
255_M267_L0.6031.00
141_Q495_Q0.6021.00
114_K172_F0.6011.00
44_N54_C0.5991.00
94_A128_I0.5961.00
224_G230_G0.5961.00
174_L206_L0.5961.00
349_Q354_Q0.5951.00
181_M193_L0.5951.00
108_E202_S0.5941.00
97_M206_L0.5921.00
74_V77_K0.5911.00
197_R253_Q0.5911.00
106_T109_T0.5901.00
379_K386_K0.5891.00
124_V128_I0.5861.00
121_A342_S0.5851.00
440_V448_A0.5851.00
101_L105_A0.5841.00
97_M131_F0.5831.00
299_F465_Y0.5831.00
275_N313_A0.5831.00
83_V186_A0.5821.00
180_K243_A0.5821.00
190_C220_N0.5801.00
97_M174_L0.5791.00
291_K294_E0.5791.00
44_N111_D0.5781.00
409_I413_V0.5771.00
164_V189_N0.5771.00
67_A222_V0.5751.00
124_V174_L0.5711.00
426_L455_I0.5701.00
328_I395_I0.5701.00
108_E119_T0.5691.00
280_D287_A0.5671.00
361_Y365_G0.5661.00
53_L201_L0.5621.00
378_R392_E0.5601.00
398_G418_T0.5591.00
61_K235_T0.5581.00
446_N450_K0.5581.00
279_A419_F0.5581.00
206_L210_V0.5581.00
460_V498_K0.5581.00
315_V416_V0.5561.00
315_V320_Y0.5551.00
275_N439_G0.5551.00
359_L366_K0.5541.00
108_E123_D0.5521.00
446_N449_Y0.5511.00
93_I96_R0.5481.00
61_K231_E0.5471.00
141_Q145_I0.5441.00
241_K493_H0.5441.00
373_L398_G0.5441.00
300_A414_L0.5431.00
280_D443_R0.5421.00
248_T252_Q0.5411.00
308_T467_A0.5411.00
94_A131_F0.5401.00
89_I93_I0.5401.00
273_S437_G0.5401.00
187_A491_L0.5401.00
337_G341_D0.5391.00
306_V309_C0.5391.00
104_L124_V0.5381.00
105_A124_V0.5381.00
404_V409_I0.5371.00
440_V462_T0.5371.00
44_N200_P0.5361.00
336_S345_Q0.5341.00
141_Q491_L0.5341.00
185_L214_L0.5341.00
97_M104_L0.5331.00
349_Q391_L0.5311.00
362_I394_T0.5301.00
72_H163_V0.5291.00
422_M454_G0.5291.00
234_A261_N0.5291.00
164_V191_V0.5281.00
166_Q181_M0.5281.00
405_F428_L0.5271.00
455_I460_V0.5271.00
317_E320_Y0.5271.00
70_A216_P0.5271.00
40_E60_G0.5261.00
313_A416_V0.5261.00
400_N427_E0.5231.00
226_G230_G0.5221.00
429_A455_I0.5221.00
425_A429_A0.5211.00
461_W464_C0.5201.00
372_V375_G0.5201.00
265_V482_I0.5191.00
71_A192_V0.5191.00
29_I34_V0.5191.00
112_N302_N0.5191.00
456_Q496_Q0.5181.00
249_E353_G0.5181.00
175_L179_W0.5171.00
71_A163_V0.5151.00
137_C488_K0.5141.00
125_P128_I0.5141.00
368_E399_Q0.5131.00
185_L219_V0.5121.00
67_A192_V0.5121.00
163_V240_A0.5121.00
289_F292_A0.5111.00
179_W486_T0.5111.00
84_Q88_A0.5111.00
56_V201_L0.5111.00
290_D329_R0.5111.00
361_Y404_V0.5091.00
231_E234_A0.5091.00
138_I142_E0.5091.00
44_N53_L0.5091.00
243_A494_Y0.5081.00
70_A74_V0.5071.00
289_F323_F0.5061.00
274_P457_A0.5051.00
325_E332_E0.5051.00
310_P439_G0.5051.00
228_V232_Y0.5041.00
354_Q358_I0.5011.00
327_A331_V0.5001.00
105_A119_T0.5001.00
134_F183_P0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4yweA 5 0.9199 100 0.088 Contact Map
4qf6A 4 0.9473 100 0.089 Contact Map
4o5hA 4 0.9629 100 0.09 Contact Map
4pz2A 4 0.9355 100 0.092 Contact Map
2d4eA 4 0.9805 100 0.093 Contact Map
4pxlA 4 0.9355 100 0.093 Contact Map
4lihA 5 0.9531 100 0.094 Contact Map
4wj9A 4 0.9492 100 0.095 Contact Map
1wndA 4 0.918 100 0.095 Contact Map
1a4sA 4 0.9688 100 0.096 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0145 seconds.