GREMLIN Database
YIAV - Inner membrane protein YiaV
UniProt: P37683 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12290
Length: 378 (318)
Sequences: 18055 (14352)
Seq/√Len: 804.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
76_E93_R3.3751.00
86_K227_D3.2551.00
90_V221_I3.0751.00
295_A329_E2.7381.00
292_G328_I2.5881.00
142_A146_Q2.4871.00
107_M214_K2.4421.00
168_R172_L2.3951.00
149_A168_R2.3851.00
93_R221_I2.3831.00
277_D291_S2.3351.00
86_K89_E2.3281.00
78_T93_R2.3231.00
148_Y159_F2.3021.00
96_P100_Q2.2151.00
103_V210_L2.1701.00
148_Y167_A2.1631.00
142_A175_E2.1281.00
149_A155_K2.1241.00
90_V223_R2.1031.00
114_E207_K2.0381.00
69_Q219_Q2.0311.00
84_L229_Y2.0181.00
171_Y175_E2.0171.00
87_K227_D2.0071.00
78_T90_V1.9681.00
138_R171_Y1.9541.00
145_Y164_I1.8761.00
261_V325_I1.8741.00
161_E165_D1.8691.00
142_A171_Y1.8421.00
231_T253_I1.8411.00
293_K331_D1.8331.00
140_K144_E1.8301.00
279_E289_V1.8261.00
163_D166_V1.8211.00
277_D293_K1.8191.00
145_Y149_A1.8131.00
135_K182_A1.8081.00
103_V214_K1.8061.00
279_E291_S1.8021.00
259_Q327_T1.7921.00
293_K329_E1.7761.00
278_A328_I1.7311.00
104_D107_M1.7021.00
154_A164_I1.6991.00
110_I210_L1.6861.00
262_A347_V1.6791.00
145_Y171_Y1.6571.00
80_K83_T1.6461.00
138_R142_A1.6331.00
100_Q217_L1.6201.00
204_A207_K1.5941.00
103_V107_M1.5911.00
296_A327_T1.5841.00
262_A328_I1.5681.00
135_K178_V1.5671.00
105_R209_Q1.5321.00
211_A214_K1.5301.00
100_Q104_D1.5241.00
224_A252_F1.5201.00
40_V44_I1.5191.00
102_R105_R1.5171.00
139_D143_K1.5151.00
60_A261_V1.5111.00
164_I168_R1.5071.00
111_V114_E1.5051.00
138_R175_E1.4981.00
175_E179_K1.4891.00
72_G94_L1.4871.00
125_D128_A1.4781.00
260_I345_A1.4771.00
107_M210_L1.4761.00
145_Y168_R1.4761.00
132_Q135_K1.4731.00
92_F222_V1.4701.00
84_L255_D1.4681.00
75_I95_D1.4671.00
110_I114_E1.4541.00
172_L175_E1.4351.00
110_I207_K1.4121.00
131_T178_V1.4041.00
74_V235_I1.4021.00
118_R121_G1.3911.00
128_A189_Q1.3821.00
138_R178_V1.3761.00
166_V170_N1.3741.00
301_V324_V1.3731.00
212_E216_N1.3651.00
74_V92_F1.3641.00
179_K182_A1.3611.00
147_R165_D1.3601.00
154_A161_E1.3581.00
75_I93_R1.3571.00
39_I43_L1.3551.00
178_V182_A1.3351.00
102_R212_E1.3151.00
170_N173_A1.3091.00
146_Q150_R1.3041.00
144_E166_V1.2941.00
197_L200_H1.2911.00
110_I203_I1.2901.00
279_E350_Y1.2901.00
257_K329_E1.2891.00
207_K211_A1.2841.00
103_V217_L1.2841.00
242_A247_R1.2751.00
214_K218_E1.2711.00
141_F174_Q1.2691.00
137_T173_A1.2661.00
186_K189_Q1.2661.00
90_V93_R1.2651.00
210_L214_K1.2581.00
288_K338_A1.2571.00
128_A185_Q1.2571.00
41_S44_I1.2541.00
146_Q149_A1.2521.00
76_E237_P1.2501.00
230_V250_M1.2481.00
91_L250_M1.2461.00
135_K139_D1.2381.00
282_F345_A1.2321.00
99_Y220_T1.2301.00
162_R166_V1.2091.00
41_S45_L1.2071.00
265_R268_S1.2051.00
139_D142_A1.1981.00
149_A164_I1.1831.00
102_R216_N1.1721.00
65_P248_P1.1621.00
83_T89_E1.1591.00
40_V43_L1.1571.00
291_S331_D1.1541.00
79_D89_E1.1521.00
150_R156_V1.1511.00
215_Y219_Q1.1481.00
165_D168_R1.1381.00
59_K260_I1.1361.00
264_F272_L1.1351.00
96_P220_T1.1231.00
228_G252_F1.1191.00
130_N133_Q1.1121.00
105_R109_D1.1111.00
131_T185_Q1.1061.00
202_Q205_S1.1051.00
261_V327_T1.1031.00
107_M111_V1.1031.00
133_Q177_S1.1001.00
279_E348_A1.0961.00
294_L326_A1.0811.00
144_E162_R1.0731.00
63_S251_V1.0721.00
272_L349_V1.0691.00
185_Q189_Q1.0661.00
143_K165_D1.0651.00
281_V348_A1.0651.00
64_I226_S1.0641.00
264_F326_A1.0641.00
68_P222_V1.0631.00
272_L294_L1.0621.00
38_F42_G1.0591.00
109_D112_T1.0571.00
109_D205_S1.0491.00
65_P251_V1.0491.00
131_T135_K1.0461.00
170_N174_Q1.0401.00
134_A174_Q1.0281.00
241_A249_V1.0271.00
121_G196_V1.0261.00
81_K232_Q1.0261.00
114_E203_I1.0201.00
29_I33_A1.0151.00
37_I41_S1.0131.00
232_Q251_V1.0131.00
334_T338_A1.0121.00
200_H204_A1.0041.00
280_V330_L0.9981.00
198_G202_Q0.9961.00
104_D211_A0.9941.00
137_T140_K0.9911.00
92_F249_V0.9901.00
27_W31_T0.9891.00
281_V289_V0.9881.00
177_S180_S0.9881.00
84_L227_D0.9881.00
71_T243_S0.9861.00
131_T182_A0.9831.00
121_G200_H0.9811.00
106_L206_L0.9741.00
263_Q325_I0.9651.00
139_D172_L0.9641.00
233_V236_R0.9621.00
77_V237_P0.9621.00
224_A227_D0.9621.00
128_A132_Q0.9601.00
79_D250_M0.9521.00
150_R155_K0.9511.00
108_A208_A0.9431.00
80_K233_V0.9411.00
273_A276_D0.9381.00
144_E148_Y0.9271.00
116_K202_Q0.9261.00
69_Q73_V0.9241.00
117_Q121_G0.9221.00
298_S325_I0.9211.00
77_V92_F0.9201.00
143_K146_Q0.9171.00
62_I254_P0.9161.00
350_Y353_H0.9131.00
184_E187_Q0.9121.00
203_I207_K0.9061.00
73_V240_Y0.9031.00
112_T202_Q0.8961.00
113_A206_L0.8961.00
57_A260_I0.8951.00
124_L189_Q0.8941.00
209_Q212_E0.8931.00
254_P257_K0.8911.00
159_F163_D0.8841.00
116_K119_A0.8811.00
68_P241_A0.8811.00
264_F349_V0.8761.00
148_Y163_D0.8731.00
260_I280_V0.8711.00
137_T177_S0.8701.00
119_A195_L0.8691.00
133_Q137_T0.8671.00
101_A215_Y0.8661.00
134_A137_T0.8631.00
124_L128_A0.8611.00
92_F250_M0.8611.00
196_V200_H0.8601.00
260_I347_V0.8601.00
97_T215_Y0.8531.00
215_Y218_E0.8491.00
102_R106_L0.8471.00
140_K169_Q0.8461.00
101_A208_A0.8451.00
71_T242_A0.8431.00
233_V250_M0.8421.00
173_A177_S0.8391.00
294_L328_I0.8381.00
103_V213_A0.8381.00
85_I91_L0.8381.00
93_R96_P0.8361.00
167_A170_N0.8351.00
74_V241_A0.8321.00
99_Y213_A0.8311.00
130_N180_S0.8281.00
33_A37_I0.8231.00
57_A61_V0.8221.00
106_L213_A0.8181.00
280_V292_G0.8171.00
168_R171_Y0.8161.00
109_D113_A0.8111.00
205_S209_Q0.8061.00
174_Q177_S0.8031.00
282_F285_L0.8021.00
195_L198_G0.7981.00
285_L290_F0.7971.00
259_Q295_A0.7941.00
137_T170_N0.7941.00
263_Q323_G0.7921.00
117_Q200_H0.7921.00
213_A216_N0.7901.00
354_F357_V0.7891.00
75_I96_P0.7881.00
25_N29_I0.7881.00
140_K166_V0.7871.00
269_L324_V0.7851.00
183_A186_K0.7851.00
102_R213_A0.7851.00
75_I78_T0.7831.00
109_D209_Q0.7781.00
157_N161_E0.7761.00
134_A181_S0.7761.00
280_V345_A0.7741.00
62_I236_R0.7731.00
112_T116_K0.7721.00
68_P249_V0.7601.00
127_M130_N0.7601.00
130_N184_E0.7561.00
66_V250_M0.7521.00
218_E223_R0.7521.00
278_A292_G0.7491.00
79_D230_V0.7491.00
122_A125_D0.7481.00
123_E187_Q0.7471.00
206_L209_Q0.7471.00
199_E203_I0.7471.00
71_T240_Y0.7471.00
274_P297_I0.7461.00
87_K225_P0.7401.00
137_T141_F0.7391.00
96_P221_I0.7391.00
26_K41_S0.7381.00
111_V204_A0.7371.00
130_N134_A0.7361.00
26_K37_I0.7361.00
137_T174_Q0.7321.00
159_F164_I0.7321.00
26_K30_P0.7311.00
154_A159_F0.7291.00
277_D350_Y0.7271.00
187_Q191_Q0.7251.00
208_A211_A0.7231.00
163_D167_A0.7231.00
222_V249_V0.7221.00
148_Y162_R0.7211.00
66_V225_P0.7181.00
106_L109_D0.7151.00
134_A177_S0.7151.00
226_S252_F0.7151.00
36_G40_V0.7141.00
199_E202_Q0.7121.00
206_L210_L0.7101.00
182_A186_K0.7091.00
281_V287_G0.7081.00
113_A116_K0.7071.00
202_Q206_L0.7061.00
234_L251_V0.7061.00
186_K190_S0.6971.00
281_V346_Q0.6961.00
78_T89_E0.6951.00
126_E130_N0.6901.00
69_Q98_R0.6891.00
114_E118_R0.6881.00
180_S184_E0.6831.00
73_V95_D0.6831.00
141_F170_N0.6821.00
61_V341_D0.6811.00
284_A343_I0.6781.00
169_Q173_A0.6771.00
140_K143_K0.6761.00
70_V216_N0.6751.00
79_D83_T0.6741.00
127_M131_T0.6721.00
107_M110_I0.6711.00
174_Q178_V0.6711.00
302_P325_I0.6701.00
161_E164_I0.6641.00
28_T32_A0.6621.00
54_T346_Q0.6621.00
98_R216_N0.6561.00
324_V343_I0.6561.00
24_V27_W0.6541.00
123_E126_E0.6521.00
126_E184_E0.6521.00
301_V322_D0.6451.00
117_Q203_I0.6431.00
189_Q193_D0.6421.00
39_I42_G0.6421.00
286_P290_F0.6401.00
303_G322_D0.6371.00
266_Q344_Y0.6361.00
340_P343_I0.6361.00
332_E337_S0.6361.00
132_Q136_A0.6361.00
59_K258_R0.6351.00
96_P217_L0.6351.00
99_Y216_N0.6341.00
113_A117_Q0.6341.00
113_A199_E0.6321.00
259_Q329_E0.6311.00
46_L49_Y0.6301.00
101_A104_D0.6271.00
98_R102_R0.6271.00
160_S163_D0.6191.00
229_Y255_D0.6191.00
79_D233_V0.6181.00
127_M181_S0.6171.00
217_L220_T0.6161.00
27_W30_P0.6131.00
262_A349_V0.6131.00
274_P295_A0.6131.00
181_S184_E0.6121.00
285_L288_K0.6121.00
295_A327_T0.6121.00
31_T38_F0.6121.00
262_A326_A0.6061.00
184_E188_I0.6061.00
176_A179_K0.6061.00
43_L357_V0.6041.00
181_S185_Q0.6031.00
141_F167_A0.6011.00
134_A178_V0.5991.00
100_Q103_V0.5991.00
81_K233_V0.5981.00
106_L110_I0.5971.00
123_E191_Q0.5971.00
68_P71_T0.5961.00
258_R341_D0.5961.00
216_N219_Q0.5951.00
92_F233_V0.5941.00
49_Y52_P0.5941.00
67_V240_Y0.5931.00
280_V347_V0.5931.00
25_N28_T0.5921.00
207_K210_L0.5881.00
68_P92_F0.5871.00
61_V253_I0.5871.00
131_T181_S0.5851.00
280_V328_I0.5841.00
283_N346_Q0.5831.00
129_A132_Q0.5821.00
106_L210_L0.5821.00
42_G46_L0.5821.00
122_A190_S0.5821.00
38_F41_S0.5801.00
59_K339_L0.5801.00
58_Q261_V0.5801.00
26_K29_I0.5791.00
123_E127_M0.5771.00
276_D351_S0.5771.00
105_R212_E0.5771.00
124_L185_Q0.5761.00
190_S193_D0.5761.00
141_F144_E0.5731.00
144_E167_A0.5731.00
97_T218_E0.5731.00
218_E221_I0.5661.00
195_L199_E0.5651.00
248_P251_V0.5621.00
88_G223_R0.5601.00
47_M50_N0.5601.00
136_A139_D0.5591.00
177_S181_S0.5571.00
275_G293_K0.5571.00
54_T348_A0.5551.00
140_K165_D0.5541.00
328_I347_V0.5481.00
110_I206_L0.5471.00
161_E168_R0.5461.00
201_S204_A0.5461.00
138_R174_Q0.5461.00
242_A246_L0.5451.00
285_L343_I0.5421.00
253_I341_D0.5421.00
175_E178_V0.5411.00
98_R215_Y0.5401.00
143_K161_E0.5401.00
99_Y217_L0.5381.00
213_A217_L0.5371.00
99_Y103_V0.5371.00
109_D202_Q0.5361.00
112_T115_H0.5361.00
85_I224_A0.5341.00
70_V219_Q0.5341.00
194_S198_G0.5331.00
81_K327_T0.5321.00
111_V115_H0.5311.00
124_L188_I0.5301.00
64_I252_F0.5301.00
45_L48_N0.5281.00
135_K138_R0.5281.00
65_P239_T0.5271.00
146_Q171_Y0.5271.00
234_L248_P0.5271.00
136_A140_K0.5251.00
179_K183_A0.5251.00
282_F339_L0.5251.00
24_V28_T0.5221.00
109_D206_L0.5211.00
197_L201_S0.5201.00
147_R162_R0.5171.00
55_F59_K0.5171.00
200_H203_I0.5161.00
120_L196_V0.5141.00
264_F347_V0.5121.00
162_R165_D0.5121.00
108_A201_S0.5081.00
57_A345_A0.5071.00
188_I191_Q0.5071.00
260_I330_L0.5061.00
165_D169_Q0.5051.00
30_P34_L0.5031.00
64_I68_P0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tkoB 1 0.7407 100 0.365 Contact Map
4dk0A 5 0.7593 100 0.379 Contact Map
3fppA 3 0.6958 100 0.39 Contact Map
2f1mA 2 0.6138 100 0.426 Contact Map
3lnnA 6 0.7831 100 0.432 Contact Map
1vf7A 5 0.5952 100 0.456 Contact Map
4l8jA 2 0.7011 100 0.459 Contact Map
3ne5B 3 0.6296 100 0.481 Contact Map
4kkuA 1 0.537 100 0.525 Contact Map
2k32A 1 0.3042 99.8 0.701 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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