GREMLIN Database
YIAU - Uncharacterized HTH-type transcriptional regulator YiaU
UniProt: P37682 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12289
Length: 324 (286)
Sequences: 79324 (57258)
Seq/√Len: 3385.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
75_D79_R3.5561.00
20_S29_V3.3831.00
165_S301_L2.6671.00
101_Y148_C2.6091.00
72_Y86_F2.4231.00
16_V29_V2.2761.00
242_A249_V2.2681.00
180_Y195_H2.2591.00
169_Q278_D2.1931.00
166_F169_Q2.1771.00
116_D303_E2.1751.00
97_R127_S2.1561.00
171_A253_D2.1521.00
166_F278_D2.1191.00
25_H28_T2.0771.00
97_R125_T2.0721.00
19_A74_N2.0411.00
13_I40_Y2.0331.00
50_L65_F2.0331.00
188_R191_E2.0051.00
169_Q276_W1.9921.00
72_Y79_R1.9691.00
15_S74_N1.9591.00
239_L259_D1.9571.00
243_R264_T1.9531.00
15_S70_L1.9491.00
99_T127_S1.9441.00
116_D299_E1.9441.00
16_V19_A1.9171.00
15_S19_A1.9111.00
16_V20_S1.9071.00
198_I247_G1.8931.00
13_I37_V1.8891.00
176_A268_C1.8871.00
18_A62_L1.8861.00
173_T253_D1.8781.00
76_M80_N1.8611.00
70_L74_N1.8111.00
243_R259_D1.8111.00
23_I41_L1.7911.00
54_D61_M1.7251.00
196_S229_N1.7161.00
69_L83_L1.7151.00
173_T267_P1.7011.00
164_A280_V1.6891.00
68_A86_F1.6741.00
18_A70_L1.6191.00
117_K296_V1.5951.00
19_A29_V1.5921.00
20_S25_H1.5801.00
15_S73_I1.5711.00
163_V285_K1.5511.00
208_A212_R1.5451.00
14_I70_L1.5401.00
13_I32_I1.5301.00
10_E40_Y1.5181.00
117_K124_I1.4941.00
24_S34_Q1.4861.00
10_E47_K1.4811.00
165_S283_F1.4811.00
93_E123_D1.4761.00
33_A36_N1.4571.00
72_Y75_D1.4571.00
22_N25_H1.4561.00
64_P67_T1.4561.00
51_K54_D1.4471.00
10_E43_D1.4461.00
184_H191_E1.4271.00
153_S282_I1.4171.00
297_L301_L1.4161.00
16_V30_L1.4141.00
7_K10_E1.4061.00
15_S77_L1.3951.00
163_V283_F1.3921.00
289_Q293_V1.3851.00
76_M83_L1.3841.00
72_Y82_Q1.3831.00
107_I236_Q1.3761.00
155_A280_V1.3741.00
139_Y145_P1.3681.00
283_F297_L1.3601.00
144_F161_S1.3431.00
99_T129_K1.3351.00
95_R123_D1.3341.00
281_A297_L1.3191.00
56_T61_M1.3161.00
295_Y298_D1.3131.00
116_D120_D1.3111.00
178_Q264_T1.3111.00
131_C135_R1.3111.00
8_Y80_N1.3091.00
170_Y254_K1.2911.00
238_A249_V1.2861.00
79_R82_Q1.2851.00
176_A248_I1.2841.00
150_V293_V1.2771.00
150_V281_A1.2741.00
195_H248_I1.2711.00
120_D299_E1.2641.00
69_L84_N1.2641.00
118_I229_N1.2611.00
259_D264_T1.2571.00
47_K84_N1.2521.00
71_P75_D1.2411.00
240_E243_R1.2241.00
253_D267_P1.2231.00
72_Y83_L1.2201.00
178_Q266_V1.2161.00
253_D257_Q1.2101.00
166_F280_V1.2081.00
68_A71_P1.2021.00
209_N213_F1.2021.00
118_I196_S1.1971.00
14_I53_F1.1931.00
257_Q261_Q1.1921.00
67_T71_P1.1861.00
115_I119_K1.1751.00
42_A46_S1.1721.00
176_A180_Y1.1691.00
32_I36_N1.1671.00
164_A282_I1.1531.00
39_K43_D1.1501.00
14_I18_A1.1461.00
127_S231_V1.1411.00
14_I52_V1.1381.00
39_K42_A1.1331.00
198_I238_A1.1321.00
116_D119_K1.1281.00
115_I244_N1.1191.00
98_V296_V1.1071.00
17_I26_A1.1011.00
196_S227_K1.0971.00
38_S42_A1.0971.00
121_I295_Y1.0961.00
75_D82_Q1.0921.00
23_I60_L1.0911.00
117_K299_E1.0881.00
175_Y267_P1.0841.00
9_R12_K1.0821.00
16_V26_A1.0821.00
68_A72_Y1.0791.00
284_R287_E1.0751.00
232_C238_A1.0701.00
112_K244_N1.0691.00
267_P270_Q1.0661.00
40_Y43_D1.0651.00
298_D301_L1.0641.00
11_L73_I1.0641.00
76_M79_R1.0571.00
239_L243_R1.0561.00
299_E303_E1.0531.00
12_K81_E1.0501.00
294_Q298_D1.0451.00
113_H300_M1.0361.00
177_S245_H1.0351.00
165_S297_L1.0331.00
144_F159_D1.0321.00
62_L66_G1.0281.00
240_E244_N1.0241.00
84_N88_A1.0201.00
189_P272_P1.0141.00
171_A276_W0.9871.00
209_N212_R0.9851.00
175_Y256_V0.9841.00
18_A53_F0.9821.00
32_I37_V0.9771.00
258_S262_D0.9761.00
78_D82_Q0.9721.00
17_I23_I0.9691.00
13_I30_L0.9681.00
117_K121_I0.9671.00
174_A248_I0.9671.00
120_D302_R0.9641.00
81_E84_N0.9621.00
81_E85_N0.9591.00
215_V224_Y0.9571.00
211_W215_V0.9561.00
299_E302_R0.9551.00
69_L73_I0.9451.00
199_L228_G0.9451.00
14_I62_L0.9421.00
43_D46_S0.9331.00
290_P293_V0.9311.00
232_C241_L0.9311.00
14_I44_F0.9291.00
26_A37_V0.9271.00
53_F60_L0.9221.00
101_Y151_L0.9171.00
113_H299_E0.9071.00
50_L87_I0.9071.00
180_Y196_S0.9061.00
176_A181_L0.9021.00
68_A90_Y0.9011.00
18_A66_G0.9001.00
104_T234_N0.8971.00
186_I266_V0.8961.00
25_H29_V0.8871.00
148_C151_L0.8801.00
155_A278_D0.8761.00
101_Y153_S0.8761.00
75_D78_D0.8751.00
71_P74_N0.8681.00
213_F217_G0.8681.00
125_T227_K0.8671.00
21_E61_M0.8631.00
24_S28_T0.8561.00
100_I150_V0.8541.00
191_E194_H0.8481.00
9_R40_Y0.8431.00
175_Y249_V0.8421.00
129_K148_C0.8421.00
56_T59_Q0.8411.00
161_S285_K0.8401.00
30_L37_V0.8401.00
124_I292_R0.8351.00
162_L282_I0.8351.00
196_S228_G0.8341.00
65_F90_Y0.8321.00
298_D302_R0.8261.00
96_G292_R0.8251.00
163_V166_F0.8231.00
65_F87_I0.8201.00
256_V259_D0.8191.00
259_D262_D0.8131.00
115_I246_L0.8121.00
21_E67_T0.8121.00
14_I69_L0.8111.00
17_I41_L0.8101.00
289_Q294_Q0.8101.00
8_Y77_L0.8081.00
34_Q38_S0.8071.00
177_S246_L0.8071.00
18_A21_E0.8051.00
42_A51_K0.8041.00
17_I53_F0.7981.00
80_N83_L0.7951.00
197_C226_V0.7951.00
80_N84_N0.7941.00
143_E151_L0.7921.00
190_D193_E0.7891.00
20_S26_A0.7871.00
79_R83_L0.7871.00
19_A70_L0.7841.00
186_I271_Q0.7831.00
188_R272_P0.7811.00
171_A269_F0.7801.00
180_Y184_H0.7771.00
291_W295_Y0.7771.00
21_E59_Q0.7761.00
94_K121_I0.7741.00
82_Q86_F0.7741.00
118_I246_L0.7721.00
113_H303_E0.7711.00
177_S180_Y0.7701.00
10_E13_I0.7701.00
96_G124_I0.7701.00
190_D222_R0.7631.00
193_E224_Y0.7621.00
65_F68_A0.7621.00
150_V296_V0.7591.00
23_I37_V0.7491.00
241_L246_L0.7481.00
175_Y251_A0.7461.00
176_A266_V0.7461.00
120_D295_Y0.7451.00
135_R139_Y0.7441.00
144_F162_L0.7421.00
116_D302_R0.7411.00
83_L87_I0.7401.00
17_I37_V0.7381.00
256_V260_L0.7381.00
12_K16_V0.7371.00
181_L184_H0.7361.00
73_I76_M0.7341.00
179_R182_E0.7311.00
171_A274_E0.7281.00
54_D63_T0.7271.00
88_A91_K0.7261.00
182_E266_V0.7231.00
175_Y260_L0.7221.00
208_A231_V0.7211.00
213_F216_A0.7191.00
54_D59_Q0.7171.00
117_K295_Y0.7151.00
74_N78_D0.7151.00
234_N237_S0.7151.00
61_M67_T0.7111.00
62_L67_T0.7111.00
260_L263_G0.7091.00
252_P255_S0.7081.00
184_H196_S0.7051.00
36_N40_Y0.7031.00
149_D293_V0.7031.00
99_T148_C0.7021.00
260_L267_P0.6981.00
287_E290_P0.6971.00
201_D231_V0.6931.00
211_W214_N0.6921.00
67_T70_L0.6911.00
99_T149_D0.6901.00
210_I214_N0.6891.00
210_I213_F0.6811.00
64_P68_A0.6801.00
65_F69_L0.6801.00
146_D284_R0.6791.00
78_D81_E0.6781.00
295_Y299_E0.6721.00
194_H227_K0.6711.00
23_I59_Q0.6701.00
69_L87_I0.6701.00
179_R245_H0.6691.00
45_E50_L0.6681.00
258_S261_Q0.6591.00
107_I240_E0.6591.00
82_Q85_N0.6591.00
230_Y241_L0.6581.00
200_I238_A0.6581.00
125_T231_V0.6571.00
12_K15_S0.6541.00
152_I300_M0.6531.00
9_R43_D0.6521.00
98_V292_R0.6521.00
45_E55_R0.6491.00
197_C248_I0.6491.00
73_I77_L0.6481.00
28_T31_G0.6451.00
17_I22_N0.6411.00
102_A110_L0.6401.00
72_Y76_M0.6361.00
174_A250_F0.6361.00
179_R266_V0.6361.00
130_T233_D0.6351.00
104_T132_N0.6321.00
201_D233_D0.6321.00
212_R216_A0.6311.00
26_A30_L0.6301.00
41_L45_E0.6291.00
174_A192_L0.6261.00
168_T279_L0.6251.00
178_Q263_G0.6111.00
291_W294_Q0.6101.00
68_A87_I0.6091.00
139_Y144_F0.6091.00
150_V297_L0.6081.00
85_N89_D0.6081.00
154_Y277_L0.6071.00
110_L113_H0.6061.00
112_K116_D0.6051.00
181_L186_I0.5991.00
170_Y277_L0.5981.00
36_N39_K0.5981.00
181_L195_H0.5981.00
174_A197_C0.5971.00
95_R125_T0.5951.00
296_V300_M0.5941.00
130_T234_N0.5921.00
98_V150_V0.5921.00
241_L247_G0.5891.00
238_A242_A0.5891.00
48_V69_L0.5871.00
12_K77_L0.5871.00
112_K115_I0.5841.00
53_F62_L0.5841.00
114_V126_L0.5811.00
101_Y131_C0.5811.00
214_N217_G0.5811.00
48_V87_I0.5801.00
33_A39_K0.5791.00
232_C237_S0.5791.00
9_R13_I0.5791.00
62_L70_L0.5781.00
50_L54_D0.5781.00
35_A39_K0.5731.00
186_I269_F0.5711.00
180_Y248_I0.5701.00
283_F294_Q0.5701.00
172_V250_F0.5691.00
217_G222_R0.5661.00
208_A211_W0.5661.00
163_V286_R0.5621.00
212_R215_V0.5611.00
48_V51_K0.5581.00
101_Y129_K0.5571.00
77_L81_E0.5561.00
14_I66_G0.5551.00
251_A256_V0.5531.00
121_I124_I0.5531.00
235_T252_P0.5511.00
207_D211_W0.5501.00
106_I109_Y0.5501.00
243_R262_D0.5491.00
193_E225_R0.5491.00
202_S231_V0.5461.00
188_R271_Q0.5421.00
96_G123_D0.5421.00
71_P86_F0.5401.00
167_I281_A0.5401.00
23_I34_Q0.5391.00
13_I41_L0.5381.00
107_I234_N0.5371.00
77_L80_N0.5371.00
96_G121_I0.5341.00
155_A164_A0.5331.00
13_I26_A0.5331.00
18_A67_T0.5311.00
293_V297_L0.5311.00
108_T111_S0.5301.00
214_N222_R0.5291.00
103_P106_I0.5271.00
270_Q273_Y0.5271.00
51_K65_F0.5241.00
85_N88_A0.5231.00
190_D224_Y0.5231.00
32_I40_Y0.5221.00
112_K240_E0.5181.00
102_A128_L0.5181.00
89_D94_K0.5181.00
21_E60_L0.5171.00
152_I281_A0.5161.00
23_I55_R0.5151.00
41_L53_F0.5141.00
76_M84_N0.5101.00
184_H187_S0.5091.00
72_Y87_I0.5081.00
144_F147_D0.5061.00
111_S115_I0.5031.00
73_I80_N0.5011.00
207_D210_I0.5011.00
90_Y94_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2esnA 3 0.9136 100 0.118 Contact Map
1uthA 2 0.6975 100 0.121 Contact Map
3fzvA 4 0.8858 100 0.139 Contact Map
3fxqA 3 0.9012 100 0.14 Contact Map
1ixcA 4 0.8981 100 0.141 Contact Map
4x6gA 4 0.9475 100 0.143 Contact Map
1al3A 1 0.6914 100 0.143 Contact Map
3szpA 3 0.8889 100 0.151 Contact Map
2h98A 2 0.6512 100 0.161 Contact Map
2h9bA 2 0.6543 100 0.168 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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