GREMLIN Database
YIAT - Putative outer membrane protein YiaT
UniProt: P37681 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12288
Length: 246 (237)
Sequences: 1532 (1266)
Seq/√Len: 82.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
58_Y65_G5.4711.00
101_D178_E5.3861.00
217_Y234_E4.7221.00
169_D189_A3.7861.00
159_G196_Y3.6221.00
77_S112_A3.5971.00
152_L203_Y3.1201.00
79_T110_G3.0681.00
205_I211_L2.9421.00
74_N113_W2.7051.00
225_T233_N2.7011.00
120_G143_V2.6631.00
103_R170_Y2.6421.00
15_F19_A2.4241.00
152_L201_A2.3701.00
82_W105_S2.3481.00
214_S239_V2.3171.00
179_S186_S2.2221.00
15_F18_S2.2101.00
126_A137_W2.1281.00
212_M241_G2.1131.00
154_L201_A2.1081.00
100_L184_L2.0901.00
180_R183_G2.0501.00
206_G209_V1.9691.00
12_A19_A1.9651.00
89_P102_K1.9531.00
173_G189_A1.9451.00
195_P221_P1.8771.00
157_A198_S1.8551.00
217_Y236_F1.8491.00
176_E186_S1.8281.00
160_V193_W1.8231.00
32_Y42_E1.7931.00
179_S183_G1.7761.00
189_A223_E1.7351.00
109_A130_V1.7251.00
59_V64_L1.7171.00
219_E233_N1.6891.00
209_V242_V1.6511.00
8_V13_L1.6371.00
106_T131_L1.6251.00
129_D134_S1.6241.00
16_M19_A1.6141.00
175_S178_E1.6121.00
123_K142_S1.6071.00
132_D135_N1.5881.00
192_A221_P1.5861.00
83_M108_M1.5641.00
37_Y194_V1.5391.00
124_A141_L1.5130.99
12_A15_F1.4930.99
99_Q184_L1.4890.99
100_L229_M1.4830.99
192_A224_I1.4740.99
83_M167_F1.4730.99
174_I184_L1.4600.99
151_R203_Y1.4470.99
168_S224_I1.4380.99
48_P241_G1.4110.99
198_S216_G1.4010.99
74_N115_H1.3560.99
215_A236_F1.3510.99
25_S245_R1.3430.99
136_G164_D1.3360.99
97_M229_M1.3300.99
108_M134_S1.3260.99
36_P39_G1.3200.98
179_S184_L1.3120.98
169_D173_G1.2980.98
180_R184_L1.2940.98
13_L16_M1.2740.98
163_Y224_I1.2710.98
137_W164_D1.2700.98
168_S192_A1.2530.98
67_I70_Q1.2510.98
181_R184_L1.2510.98
75_E114_Y1.2460.98
117_E120_G1.2370.98
24_L52_Y1.2250.98
100_L174_I1.2190.97
149_I201_A1.2000.97
162_Y191_D1.1980.97
27_G48_P1.1940.97
30_A44_T1.1880.97
163_Y168_S1.1830.97
137_W162_Y1.1690.97
31_A239_V1.1590.97
153_S202_K1.1560.96
107_A131_L1.1420.96
168_S189_A1.1410.96
99_Q229_M1.1380.96
31_A45_K1.1370.96
128_A164_D1.1350.96
194_V224_I1.1250.96
32_Y44_T1.1050.95
12_A16_M1.1040.95
13_L19_A1.0900.95
209_V244_W1.0850.95
144_F155_T1.0800.95
49_L241_G1.0720.95
96_A184_L1.0580.94
160_V195_P1.0510.94
96_A229_M1.0380.94
146_K155_T1.0340.93
79_T127_A1.0330.93
11_F15_F1.0330.93
139_G162_Y1.0230.93
27_G49_L1.0190.93
138_V163_Y1.0120.93
126_A139_G1.0100.93
83_M138_V1.0070.93
28_A46_A1.0020.92
78_L110_G0.9990.92
122_V143_V0.9910.92
35_S43_N0.9870.92
53_E60_R0.9870.92
76_L113_W0.9770.91
98_Q188_S0.9720.91
165_E190_Q0.9630.91
57_F66_F0.9450.90
121_T144_F0.9350.90
9_A16_M0.9320.89
108_M127_A0.9260.89
11_F14_P0.9250.89
144_F157_A0.9180.89
97_M100_L0.9140.88
168_S194_V0.9100.88
89_P101_D0.9020.88
138_V167_F0.8990.88
56_T66_F0.8970.87
32_Y238_F0.8920.87
163_Y192_A0.8920.87
203_Y206_G0.8880.87
220_L230_I0.8830.87
53_E67_I0.8790.86
13_L17_A0.8720.86
69_S76_L0.8690.86
8_V19_A0.8650.86
112_A123_K0.8580.85
37_Y172_Y0.8550.85
36_P40_Y0.8410.84
101_D175_S0.8400.84
10_L15_F0.8280.83
107_A130_V0.8240.83
116_H121_T0.8240.83
101_D177_S0.8230.83
157_A216_G0.8220.82
128_A137_W0.8200.82
124_A139_G0.8200.82
97_M179_S0.8090.81
57_F64_L0.8080.81
163_Y194_V0.8080.81
12_A18_S0.8070.81
168_S191_D0.8040.81
95_Y98_Q0.8010.81
87_F91_D0.7990.81
88_D100_L0.7930.80
140_E200_T0.7860.80
200_T216_G0.7850.79
9_A18_S0.7840.79
12_A17_A0.7770.79
97_M178_E0.7760.79
219_E234_E0.7750.79
39_G43_N0.7740.79
96_A100_L0.7740.79
168_S221_P0.7710.78
193_W221_P0.7680.78
134_S164_D0.7650.78
29_G239_V0.7630.78
29_G241_G0.7610.77
41_N64_L0.7590.77
167_F171_Y0.7560.77
219_E235_S0.7540.77
172_Y194_V0.7520.77
58_Y63_T0.7490.76
106_T134_S0.7470.76
40_Y43_N0.7450.76
178_E186_S0.7420.76
94_D184_L0.7370.75
88_D91_D0.7370.75
8_V11_F0.7360.75
158_L199_L0.7350.75
213_A242_V0.7350.75
76_L111_V0.7330.75
164_D217_Y0.7320.75
6_N10_L0.7310.74
75_E203_Y0.7280.74
58_Y184_L0.7260.74
169_D188_S0.7260.74
103_R224_I0.7240.74
103_R178_E0.7230.74
70_Q111_V0.7210.73
174_I228_P0.7200.73
147_M156_P0.7200.73
58_Y67_I0.7180.73
52_Y110_G0.7150.73
109_A229_M0.7140.73
94_D98_Q0.7130.73
104_D165_E0.7120.73
177_S181_R0.7100.72
29_G84_P0.7050.72
185_A188_S0.7030.72
34_E38_R0.7020.71
94_D97_M0.7000.71
165_E223_E0.6990.71
154_L199_L0.6980.71
74_N120_G0.6960.71
192_A222_E0.6920.70
95_Y162_Y0.6920.70
8_V18_S0.6920.70
35_S41_N0.6920.70
68_L134_S0.6910.70
196_Y218_S0.6900.70
60_R63_T0.6870.70
175_S179_S0.6850.70
18_S147_M0.6830.69
66_F106_T0.6780.69
162_Y193_W0.6770.69
225_T234_E0.6710.68
128_A134_S0.6710.68
33_N102_K0.6700.68
205_I209_V0.6700.68
151_R154_L0.6660.67
43_N191_D0.6650.67
11_F16_M0.6610.67
14_P18_S0.6550.66
173_G178_E0.6550.66
100_L178_E0.6500.66
34_E86_E0.6500.66
80_A109_A0.6490.65
26_I230_I0.6470.65
22_S52_Y0.6460.65
202_K210_V0.6450.65
108_M129_D0.6440.65
24_L51_S0.6440.65
34_E39_G0.6440.65
30_A240_T0.6430.65
140_E161_L0.6420.65
117_E122_V0.6410.65
216_G237_T0.6370.64
142_S159_G0.6360.64
60_R161_L0.6340.64
175_S184_L0.6340.64
16_M20_T0.6340.64
26_I84_P0.6340.64
20_T211_L0.6330.64
205_I210_V0.6320.63
49_L243_S0.6290.63
159_G218_S0.6270.63
97_M184_L0.6260.63
69_S164_D0.6250.63
151_R206_G0.6230.62
77_S114_Y0.6230.62
58_Y181_R0.6220.62
152_L204_P0.6220.62
13_L98_Q0.6210.62
220_L235_S0.6190.62
212_M216_G0.6170.62
13_L20_T0.6160.61
101_D181_R0.6130.61
230_I244_W0.6110.61
94_D99_Q0.6090.61
25_S210_V0.6090.61
9_A12_A0.6060.60
76_L147_M0.6050.60
104_D233_N0.6050.60
81_S108_M0.6030.60
67_I77_S0.6020.60
187_Y240_T0.6000.59
220_L231_D0.5990.59
64_L158_L0.5960.59
36_P86_E0.5950.59
73_K117_E0.5940.59
100_L103_R0.5930.59
20_T41_N0.5900.58
159_G195_P0.5870.58
37_Y41_N0.5870.58
39_G42_E0.5860.58
38_R192_A0.5830.57
205_I208_H0.5800.57
95_Y183_G0.5760.56
190_Q223_E0.5740.56
218_S221_P0.5740.56
165_E185_A0.5720.56
37_Y171_Y0.5720.56
113_W117_E0.5720.56
94_D237_T0.5710.56
163_Y172_Y0.5690.55
7_I10_L0.5690.55
94_D100_L0.5680.55
103_R171_Y0.5640.55
216_G240_T0.5630.55
104_D107_A0.5630.55
109_A113_W0.5590.54
13_L66_F0.5590.54
78_L83_M0.5570.54
175_S183_G0.5560.54
13_L18_S0.5560.54
138_V159_G0.5560.54
9_A20_T0.5550.54
175_S181_R0.5540.53
111_V126_A0.5530.53
14_P17_A0.5520.53
220_L225_T0.5510.53
226_D232_R0.5480.53
168_S190_Q0.5470.53
164_D234_E0.5460.52
148_Q153_S0.5450.52
141_L185_A0.5450.52
149_I152_L0.5420.52
37_Y40_Y0.5420.52
9_A19_A0.5410.52
109_A131_L0.5390.52
65_G111_V0.5370.51
41_N124_A0.5360.51
8_V16_M0.5340.51
46_A145_H0.5330.51
106_T171_Y0.5330.51
6_N9_A0.5320.51
9_A102_K0.5310.50
37_Y156_P0.5310.50
103_R163_Y0.5300.50
127_A138_V0.5300.50
35_S100_L0.5290.50
22_S54_G0.5290.50
174_I186_S0.5270.50
136_G143_V0.5250.50
80_A165_E0.5240.50
136_G246_F0.5210.49
118_R156_P0.5200.49
7_I16_M0.5200.49
27_G163_Y0.5200.49
20_T230_I0.5190.49
48_P56_T0.5190.49
227_S230_I0.5190.49
112_A132_D0.5160.48
25_S172_Y0.5160.48
175_S186_S0.5150.48
219_E225_T0.5150.48
135_N232_R0.5140.48
65_G192_A0.5140.48
26_I30_A0.5120.48
150_G179_S0.5100.48
36_P103_R0.5100.48
224_I230_I0.5100.48
11_F226_D0.5090.48
150_G188_S0.5070.47
51_S62_T0.5060.47
156_P197_V0.5050.47
85_L105_S0.5050.47
81_S171_Y0.5040.47
169_D245_R0.5020.47
65_G74_N0.5020.47
140_E196_Y0.5010.47
14_P199_L0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3nb3A 2 0.5528 98.7 0.811 Contact Map
2x27X 1 0.7683 98.5 0.823 Contact Map
2k0lA 1 0.7764 98 0.848 Contact Map
1qjpA 1 0.5244 97.4 0.863 Contact Map
2f1vA 4 0.6423 97.4 0.864 Contact Map
1p4tA 2 0.6057 97.4 0.865 Contact Map
2lhfA 1 0.6545 97.3 0.868 Contact Map
2jmmA 1 0.5772 97 0.873 Contact Map
3qraA 1 0.5772 96.6 0.879 Contact Map
2mafA 1 0.7358 96.3 0.883 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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