GREMLIN Database
SGBE - L-ribulose-5-phosphate 4-epimerase SgbE
UniProt: P37680 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12287
Length: 231 (194)
Sequences: 6250 (3791)
Seq/√Len: 272.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
60_E65_K4.8441.00
178_K182_D3.2941.00
100_H199_F3.1671.00
195_Y199_F3.1151.00
38_W58_V2.9431.00
109_L201_R2.7501.00
5_L31_A2.7191.00
60_E63_S2.5921.00
40_V56_M2.5461.00
39_M81_L2.4681.00
8_D181_A2.4661.00
90_I176_W2.1681.00
82_A147_E2.1591.00
10_L53_A2.0871.00
99_R195_Y2.0341.00
100_H195_Y2.0241.00
103_I199_F2.0141.00
38_W67_V2.0111.00
40_V58_V1.9081.00
100_H198_L1.8901.00
165_A190_L1.8891.00
31_A180_A1.8861.00
82_A85_R1.8821.00
52_T55_D1.8811.00
141_Y147_E1.8701.00
7_A11_A1.8471.00
94_V183_A1.7651.00
199_F202_Q1.7581.00
130_R169_H1.7341.00
15_A19_H1.7021.00
110_D125_A1.6921.00
59_V77_T1.6641.00
33_D40_V1.6641.00
91_G179_N1.6631.00
179_N182_D1.6301.00
12_A184_V1.5841.00
9_V29_V1.5671.00
92_G180_A1.5471.00
10_L14_L1.4741.00
136_E148_V1.4581.00
19_H188_V1.4531.00
63_S85_R1.4471.00
177_G182_D1.4411.00
108_G169_H1.4361.00
7_A53_A1.4321.00
66_V69_G1.4261.00
127_P156_R1.4131.00
112_P197_G1.3991.00
86_R154_E1.3961.00
173_P190_L1.3931.00
33_D36_R1.3681.00
96_T187_A1.3631.00
86_R150_I1.3531.00
99_R103_I1.3461.00
9_V56_M1.3291.00
14_L18_A1.3201.00
210_M213_E1.3191.00
39_M61_I1.2981.00
87_Y90_I1.2891.00
31_A92_G1.2841.00
175_A187_A1.2841.00
140_E144_Q1.2801.00
111_L194_A1.2801.00
35_T38_W1.2781.00
82_A86_R1.2691.00
104_W201_R1.2581.00
30_S93_I1.2521.00
30_S84_Y1.2501.00
97_H171_H1.2421.00
10_L56_M1.2331.00
15_A18_A1.2191.00
81_L85_R1.1911.00
198_L203_L1.1831.00
95_H171_H1.1791.00
147_E151_E1.1681.00
101_A173_P1.1671.00
58_V68_E1.1551.00
32_V91_G1.1511.00
99_R192_E1.1511.00
130_R151_E1.1441.00
16_L29_V1.1331.00
46_V55_D1.1281.00
197_G201_R1.1271.00
12_A180_A1.1161.00
164_P186_N1.1091.00
84_Y93_I1.1011.00
168_V174_F1.0781.00
153_F176_W1.0771.00
96_T173_P1.0751.00
107_A203_L1.0731.00
16_L94_V1.0691.00
148_V151_E1.0611.00
33_D58_V1.0611.00
17_P49_D1.0551.00
41_I74_S1.0541.00
114_W197_G1.0531.00
149_I168_V1.0431.00
191_E195_Y1.0421.00
100_H191_E1.0421.00
102_T105_S1.0291.00
110_D128_C1.0071.00
46_V71_K1.0061.00
165_A175_A1.0031.00
192_E195_Y0.9981.00
144_Q147_E0.9891.00
101_A190_L0.9861.00
198_L202_Q0.9751.00
206_Q210_M0.9581.00
13_N29_V0.9541.00
87_Y176_W0.9541.00
12_A29_V0.9531.00
55_D70_S0.9521.00
129_T148_V0.9511.00
201_R205_P0.9471.00
177_G186_N0.9381.00
60_E67_V0.9381.00
19_H184_V0.9311.00
39_M77_T0.9271.00
98_S101_A0.9261.00
57_V72_K0.9191.00
207_L210_M0.9181.00
39_M59_V0.9101.00
5_L33_D0.9091.00
51_M55_D0.9091.00
8_D31_A0.9091.00
55_D71_K0.9081.00
61_I85_R0.9041.00
94_V187_A0.8971.00
153_F166_V0.8941.00
108_G206_Q0.8881.00
130_R148_V0.8841.00
16_L184_V0.8831.00
83_L90_I0.8801.00
43_P56_M0.8761.00
99_R199_F0.8751.00
83_L153_F0.8741.00
43_P46_V0.8671.00
103_I198_L0.8651.00
82_A150_I0.8541.00
33_D38_W0.8511.00
8_D11_A0.8431.00
127_P166_V0.8341.00
141_Y144_Q0.8341.00
151_E154_E0.8341.00
200_S207_L0.8280.99
98_S187_A0.8240.99
41_I76_D0.8230.99
79_T149_I0.8200.99
111_L193_C0.8070.99
137_I213_E0.8050.99
10_L51_M0.7990.99
106_Q114_W0.7870.99
129_T168_V0.7780.99
79_T174_F0.7750.99
173_P187_A0.7740.99
209_A213_E0.7720.99
126_I190_L0.7680.99
98_S191_E0.7660.99
15_A184_V0.7640.99
129_T152_T0.7640.99
208_P211_Q0.7580.99
11_A50_V0.7570.99
42_K51_M0.7450.99
44_S72_K0.7430.99
50_V181_A0.7410.99
104_W197_G0.7320.99
111_L167_L0.7300.99
86_R151_E0.7290.99
42_K84_Y0.7260.99
13_N48_Y0.7240.99
182_D186_N0.7230.99
32_V61_I0.7220.99
76_D145_T0.7210.99
6_K40_V0.7160.98
32_V37_Q0.7150.98
108_G208_P0.7150.98
85_R150_I0.7120.98
6_K68_E0.7120.98
144_Q148_V0.7030.98
91_G178_K0.6980.98
20_H195_Y0.6980.98
87_Y153_F0.6910.98
16_L21_L0.6890.98
77_T81_L0.6880.98
109_L205_P0.6880.98
130_R136_E0.6810.98
114_W201_R0.6780.98
5_L8_D0.6760.98
24_F185_H0.6760.98
190_L194_A0.6720.98
46_V51_M0.6700.98
37_Q61_I0.6670.98
125_A156_R0.6670.98
30_S41_I0.6650.98
206_Q209_A0.6640.98
182_D185_H0.6630.98
152_T166_V0.6620.97
22_V29_V0.6540.97
17_P22_V0.6510.97
28_N76_D0.6500.97
150_I153_F0.6480.97
175_A186_N0.6480.97
102_T196_M0.6450.97
27_G48_Y0.6430.97
110_D127_P0.6320.97
47_E50_V0.6310.97
44_S74_S0.6310.97
5_L40_V0.6280.97
92_G183_A0.6270.97
101_A167_L0.6220.96
107_A198_L0.6190.96
167_L173_P0.6170.96
136_E145_T0.6160.96
113_A118_H0.6140.96
25_T44_S0.6140.96
28_N74_S0.6120.96
103_I196_M0.6040.96
23_T26_W0.6040.96
23_T192_E0.6030.96
164_P178_K0.6030.96
102_T172_G0.6020.96
17_P23_T0.6010.96
78_P141_Y0.5990.95
57_V66_V0.5930.95
121_Y186_N0.5920.95
203_L207_L0.5900.95
116_T119_A0.5880.95
110_D156_R0.5880.95
98_S173_P0.5880.95
50_V55_D0.5860.95
15_A24_F0.5850.95
164_P182_D0.5830.95
101_A194_A0.5830.95
89_E178_K0.5830.95
104_W194_A0.5820.95
8_D180_A0.5800.95
126_I165_A0.5770.95
123_Y212_N0.5770.95
61_I81_L0.5750.94
107_A205_P0.5750.94
78_P140_E0.5690.94
58_V67_V0.5680.94
105_S167_L0.5660.94
6_K58_V0.5640.94
117_T189_V0.5630.94
200_S206_Q0.5630.94
13_N42_K0.5610.94
31_A56_M0.5600.94
28_N44_S0.5590.94
166_V174_F0.5580.93
78_P82_A0.5570.93
117_T121_Y0.5570.93
32_V39_M0.5560.93
19_H24_F0.5550.93
64_G81_L0.5540.93
44_S75_S0.5520.93
104_W109_L0.5510.93
131_Q168_V0.5500.93
83_L174_F0.5420.92
100_H103_I0.5410.92
104_W198_L0.5400.92
141_Y146_G0.5360.92
18_A49_D0.5340.92
94_V175_A0.5330.92
9_V40_V0.5310.92
13_N51_M0.5300.92
83_L93_I0.5280.91
17_P48_Y0.5260.91
45_G171_H0.5240.91
101_A187_A0.5240.91
148_V152_T0.5220.91
164_P176_W0.5220.91
38_W61_I0.5190.91
6_K43_P0.5190.91
107_A200_S0.5160.91
6_K56_M0.5150.90
149_I166_V0.5150.90
6_K53_A0.5140.90
28_N42_K0.5130.90
29_V180_A0.5090.90
152_T155_E0.5090.90
35_T58_V0.5070.90
9_V31_A0.5070.90
108_G207_L0.5070.90
121_Y189_V0.5060.90
170_S210_M0.5060.90
9_V13_N0.5020.89
139_G144_Q0.5000.89
11_A14_L0.5000.89
78_P146_G0.5000.89
106_Q115_G0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1k0wA 3 0.9524 100 0.134 Contact Map
4c24A 3 0.8961 100 0.15 Contact Map
1e4cP 3 0.8831 100 0.172 Contact Map
3ocrA 4 0.9264 100 0.186 Contact Map
2opiA 3 0.8745 100 0.212 Contact Map
2fk5A 4 0.8182 100 0.215 Contact Map
4xxfA 3 0.9004 100 0.217 Contact Map
2z7bA 3 0.9351 100 0.218 Contact Map
2v9lA 3 0.9394 100 0.23 Contact Map
1pvtA 3 0.8442 100 0.233 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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