SGBU - ECOLI - GREMLIN Contacts

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SGBU - Putative L-ribulose-5-phosphate 3-epimerase SgbU

UniProt:	P37679	Sequences: MRNHQLGIYEKALAKDLSWPERLVLAKSCGFDFVEMSVDETDERLSRLDWSAAQRTSLVAAMIETGVGIPSMCLSAHRRFPFGSRDEAVRERAREIMSKAIRLARDLGIRTIQLAGYDVYYEDHDEGTRQRFAEGLAWAVEQAAASQVMLAVEIMDTAFMNSISKWKKWDEMLASPWFTVYPDVGNLSAWGNDVPAELKLGIDRIAAIHLKDTQPVTGQSPGQFRDVPFGEGCVDFVGIFKTLHKLNYRGSFLIEMWTEKAKEPVLEIIQARRWIEARMQEAGFIC	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12286
Length:	286 (246)
Sequences:	17084 (11967)
Seq/√Len:	763.0

ECOLI - SGBU ULAE FRLC YCJR HYI YGBM YIHM
BACSU - IOLI IOLH YFIH IOLE
SULSO - Q97UI8 Q97UG9 Q97UI3 Q7LX49

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
98_S	142_Q	3.280	1.00
179_T	206_A	3.024	1.00
133_A	172_M	2.787	1.00
24_V	65_T	2.769	1.00
235_D	238_G	2.666	1.00
59_V	63_I	2.617	1.00
149_M	206_A	2.442	1.00
199_K	242_T	2.433	1.00
33_F	251_S	2.347	1.00
20_P	61_A	2.344	1.00
102_R	146_S	2.294	1.00
60_A	64_E	2.247	1.00
149_M	179_T	2.181	1.00
94_R	138_W	2.161	1.00
151_A	206_A	2.104	1.00
105_R	146_S	2.076	1.00
18_S	21_E	2.072	1.00
129_R	168_K	2.062	1.00
212_D	230_G	2.057	1.00
102_R	142_Q	2.033	1.00
168_K	172_M	2.007	1.00
141_E	175_S	1.913	1.00
111_T	151_A	1.908	1.00
167_K	200_L	1.908	1.00
269_I	273_R	1.901	1.00
242_T	245_K	1.871	1.00
167_K	171_E	1.854	1.00
61_A	65_T	1.817	1.00
61_A	64_E	1.803	1.00
129_R	172_M	1.743	1.00
52_A	106_D	1.726	1.00
27_K	65_T	1.696	1.00
54_Q	57_S	1.681	1.00
193_D	196_A	1.670	1.00
62_M	69_I	1.666	1.00
24_V	28_S	1.658	1.00
104_A	109_I	1.649	1.00
130_Q	172_M	1.637	1.00
144_A	177_W	1.635	1.00
56_T	106_D	1.585	1.00
142_Q	145_A	1.582	1.00
199_K	245_K	1.579	1.00
237_V	241_K	1.574	1.00
91_E	95_E	1.572	1.00
151_A	181_Y	1.565	1.00
89_V	92_R	1.551	1.00
101_I	146_S	1.545	1.00
55_R	106_D	1.533	1.00
90_R	135_G	1.528	1.00
133_A	137_A	1.525	1.00
25_L	28_S	1.521	1.00
140_V	178_F	1.520	1.00
162_S	165_K	1.517	1.00
95_E	99_K	1.511	1.00
111_T	149_M	1.499	1.00
24_V	61_A	1.494	1.00
195_P	238_G	1.463	1.00
208_I	243_L	1.450	1.00
124_H	127_G	1.448	1.00
231_E	270_Q	1.439	1.00
142_Q	146_S	1.424	1.00
212_D	232_G	1.411	1.00
57_S	60_A	1.408	1.00
127_G	130_Q	1.407	1.00
101_I	143_A	1.401	1.00
134_E	137_A	1.393	1.00
99_K	102_R	1.384	1.00
242_T	246_L	1.381	1.00
131_R	134_E	1.370	1.00
20_P	64_E	1.358	1.00
241_K	245_K	1.354	1.00
161_N	165_K	1.345	1.00
141_E	145_A	1.342	1.00
21_E	24_V	1.337	1.00
202_I	246_L	1.334	1.00
179_T	204_R	1.311	1.00
130_Q	134_E	1.309	1.00
25_L	265_V	1.307	1.00
196_A	200_L	1.294	1.00
23_L	65_T	1.281	1.00
184_V	239_I	1.274	1.00
57_S	61_A	1.265	1.00
168_K	171_E	1.258	1.00
98_S	138_W	1.256	1.00
140_V	173_L	1.251	1.00
266_L	270_Q	1.246	1.00
23_L	61_A	1.230	1.00
263_E	266_L	1.224	1.00
98_S	102_R	1.204	1.00
25_L	29_C	1.201	1.00
147_Q	177_W	1.199	1.00
94_R	98_S	1.194	1.00
29_C	272_R	1.189	1.00
166_W	180_V	1.189	1.00
60_A	63_I	1.186	1.00
95_E	98_S	1.180	1.00
20_P	57_S	1.173	1.00
182_P	187_L	1.170	1.00
154_I	187_L	1.170	1.00
164_S	200_L	1.164	1.00
238_G	242_T	1.164	1.00
52_A	56_T	1.164	1.00
214_Q	227_V	1.161	1.00
86_D	89_V	1.157	1.00
59_V	106_D	1.155	1.00
101_I	142_Q	1.154	1.00
33_F	68_G	1.144	1.00
129_R	133_A	1.144	1.00
195_P	199_K	1.140	1.00
167_K	204_R	1.131	1.00
26_A	31_F	1.125	1.00
56_T	60_A	1.118	1.00
138_W	141_E	1.117	1.00
137_A	173_L	1.114	1.00
27_K	66_G	1.113	1.00
87_E	91_E	1.113	1.00
267_E	270_Q	1.101	1.00
97_M	139_A	1.092	1.00
144_A	175_S	1.086	1.00
102_R	106_D	1.080	1.00
91_E	138_W	1.077	1.00
144_A	176_P	1.075	1.00
125_D	165_K	1.070	1.00
20_P	24_V	1.070	1.00
101_I	148_V	1.065	1.00
197_E	201_G	1.055	1.00
270_Q	273_R	1.053	1.00
133_A	173_L	1.051	1.00
98_S	145_A	1.044	1.00
171_E	204_R	1.041	1.00
23_L	62_M	1.033	1.00
228_P	231_E	1.023	1.00
199_K	246_L	1.021	1.00
92_R	95_E	1.012	1.00
167_K	201_G	1.011	1.00
94_R	135_G	1.000	1.00
33_F	70_P	0.996	1.00
98_S	146_S	0.991	1.00
102_R	105_R	0.989	1.00
143_A	150_L	0.980	1.00
62_M	67_V	0.978	1.00
31_F	272_R	0.973	1.00
111_T	206_A	0.972	1.00
188_S	233_C	0.971	1.00
36_M	69_I	0.970	1.00
134_E	138_W	0.968	1.00
137_A	175_S	0.968	1.00
137_A	141_E	0.966	1.00
137_A	174_A	0.966	1.00
127_G	131_R	0.964	1.00
31_F	254_I	0.962	1.00
141_E	144_A	0.957	1.00
72_M	104_A	0.938	1.00
126_E	130_Q	0.934	1.00
265_V	269_I	0.928	1.00
55_R	103_L	0.927	1.00
136_L	178_F	0.921	1.00
53_A	57_S	0.918	1.00
51_S	54_Q	0.918	1.00
234_V	239_I	0.917	1.00
126_E	168_K	0.916	1.00
196_A	199_K	0.913	1.00
125_D	128_T	0.913	1.00
110_R	149_M	0.913	1.00
140_V	175_S	0.912	1.00
170_D	204_R	0.911	1.00
164_S	168_K	0.903	1.00
266_L	269_I	0.902	1.00
55_R	59_V	0.902	1.00
270_Q	274_W	0.896	1.00
243_L	246_L	0.892	1.00
240_F	244_H	0.889	1.00
70_P	251_S	0.888	1.00
195_P	242_T	0.886	1.00
84_S	89_V	0.883	1.00
59_V	108_G	0.876	1.00
26_A	34_V	0.875	1.00
35_E	71_S	0.874	1.00
62_M	65_T	0.873	1.00
56_T	59_V	0.871	1.00
90_R	134_E	0.869	1.00
140_V	177_W	0.866	1.00
17_L	25_L	0.863	1.00
153_E	255_E	0.863	1.00
198_L	246_L	0.862	1.00
81_P	86_D	0.858	1.00
113_Q	181_Y	0.855	1.00
27_K	32_D	0.854	1.00
90_R	131_R	0.854	1.00
105_R	147_Q	0.853	1.00
135_G	138_W	0.844	1.00
238_G	241_K	0.840	1.00
163_I	200_L	0.838	1.00
198_L	242_T	0.830	1.00
226_D	229_F	0.826	1.00
96_I	99_K	0.825	1.00
104_A	112_I	0.825	1.00
81_P	85_R	0.820	1.00
28_S	265_V	0.818	1.00
214_Q	225_R	0.818	1.00
82_F	85_R	0.817	1.00
131_R	135_G	0.813	1.00
208_I	252_F	0.810	1.00
129_R	165_K	0.806	1.00
149_M	177_W	0.801	1.00
227_V	231_E	0.800	1.00
173_L	178_F	0.800	1.00
35_E	207_A	0.797	1.00
170_D	180_V	0.795	1.00
214_Q	233_C	0.792	1.00
105_R	148_V	0.790	1.00
180_V	201_G	0.790	1.00
103_L	107_L	0.787	1.00
55_R	107_L	0.785	1.00
68_G	110_R	0.782	1.00
198_L	201_G	0.775	1.00
24_V	64_E	0.774	1.00
229_F	271_A	0.768	1.00
183_D	255_E	0.756	1.00
99_K	103_L	0.753	1.00
138_W	142_Q	0.752	1.00
210_L	275_I	0.744	1.00
210_L	236_F	0.740	1.00
268_I	272_R	0.736	1.00
210_L	252_F	0.735	1.00
90_R	94_R	0.733	1.00
119_V	122_E	0.726	1.00
69_I	109_I	0.720	1.00
271_A	274_W	0.719	1.00
268_I	271_A	0.713	1.00
163_I	192_N	0.708	1.00
236_F	240_F	0.706	1.00
17_L	21_E	0.706	1.00
247_N	250_G	0.705	1.00
136_L	169_W	0.703	1.00
73_C	76_A	0.702	1.00
197_E	200_L	0.702	1.00
88_A	92_R	0.700	1.00
81_P	84_S	0.700	1.00
160_M	166_W	0.697	1.00
24_V	27_K	0.696	1.00
21_E	25_L	0.695	1.00
262_K	266_L	0.695	1.00
29_C	269_I	0.691	1.00
68_G	251_S	0.688	1.00
137_A	172_M	0.687	1.00
114_L	150_L	0.685	1.00
93_A	96_I	0.682	1.00
165_K	168_K	0.681	1.00
185_G	211_K	0.679	1.00
186_N	211_K	0.676	1.00
184_V	236_F	0.673	1.00
23_L	27_K	0.673	1.00
27_K	67_V	0.672	1.00
87_E	90_R	0.671	1.00
35_E	253_L	0.668	1.00
128_T	131_R	0.667	1.00
174_A	177_W	0.666	1.00
82_F	135_G	0.658	1.00
185_G	213_T	0.657	1.00
207_A	253_L	0.657	1.00
188_S	234_V	0.656	1.00
140_V	150_L	0.656	1.00
82_F	86_D	0.656	1.00
181_Y	207_A	0.656	1.00
254_I	271_A	0.655	1.00
112_I	143_A	0.653	1.00
154_I	166_W	0.652	1.00
100_A	112_I	0.652	1.00
22_R	26_A	0.650	1.00
267_E	271_A	0.650	1.00
92_R	96_I	0.648	1.00
139_A	150_L	0.647	1.00
72_M	75_S	0.647	1.00
87_E	131_R	0.643	1.00
32_D	68_G	0.641	1.00
10_E	13_L	0.640	1.00
133_A	169_W	0.636	1.00
170_D	178_F	0.632	1.00
198_L	205_I	0.632	1.00
202_I	242_T	0.629	1.00
28_S	269_I	0.629	1.00
104_A	148_V	0.628	1.00
141_E	177_W	0.626	1.00
111_T	207_A	0.626	1.00
202_I	205_I	0.622	1.00
132_F	169_W	0.622	1.00
140_V	144_A	0.620	1.00
130_Q	133_A	0.620	1.00
163_I	167_K	0.619	1.00
182_P	198_L	0.616	1.00
156_D	159_F	0.613	1.00
198_L	202_I	0.612	1.00
23_L	34_V	0.610	1.00
23_L	58_L	0.610	1.00
63_I	108_G	0.609	1.00
58_L	61_A	0.603	1.00
143_A	146_S	0.601	1.00
229_F	274_W	0.600	1.00
264_P	267_E	0.598	1.00
20_P	65_T	0.597	1.00
90_R	138_W	0.597	1.00
119_V	123_D	0.596	1.00
244_H	252_F	0.594	1.00
153_E	209_H	0.592	1.00
94_R	142_Q	0.591	1.00
188_S	194_V	0.590	1.00
240_F	252_F	0.590	1.00
211_K	257_W	0.589	1.00
143_A	148_V	0.588	1.00
88_A	91_E	0.587	1.00
11_K	14_A	0.585	1.00
94_R	139_A	0.582	1.00
269_I	272_R	0.581	1.00
211_K	226_D	0.580	1.00
167_K	170_D	0.580	1.00
23_L	67_V	0.576	1.00
72_M	109_I	0.575	1.00
14_A	29_C	0.573	1.00
73_C	115_A	0.572	1.00
160_M	169_W	0.567	1.00
169_W	173_L	0.566	1.00
13_L	25_L	0.564	1.00
163_I	196_A	0.564	1.00
182_P	205_I	0.563	1.00
59_V	62_M	0.561	1.00
59_V	107_L	0.559	1.00
184_V	210_L	0.558	1.00
175_S	178_F	0.558	1.00
198_L	239_I	0.557	1.00
31_F	268_I	0.555	1.00
203_D	246_L	0.554	1.00
129_R	169_W	0.551	1.00
101_I	112_I	0.551	1.00
132_F	136_L	0.550	1.00
254_I	275_I	0.545	1.00
140_V	143_A	0.542	1.00
182_P	197_E	0.541	1.00
108_G	148_V	0.539	1.00
91_E	94_R	0.539	1.00
132_F	135_G	0.538	1.00
222_G	225_R	0.538	1.00
187_L	197_E	0.537	1.00
125_D	129_R	0.536	1.00
110_R	147_Q	0.536	1.00
70_P	110_R	0.536	1.00
151_A	179_T	0.534	1.00
170_D	174_A	0.534	1.00
243_L	248_Y	0.531	1.00
75_S	100_A	0.531	1.00
180_V	205_I	0.527	1.00
113_Q	155_M	0.526	1.00
94_R	97_M	0.524	1.00
71_S	113_Q	0.521	1.00
71_S	253_L	0.519	1.00
115_A	118_D	0.517	1.00
74_L	100_A	0.516	1.00
224_F	229_F	0.516	1.00
263_E	267_E	0.516	1.00
9_Y	12_A	0.515	1.00
123_D	131_R	0.511	1.00
133_A	168_K	0.509	1.00
143_A	147_Q	0.509	1.00
244_H	247_N	0.508	1.00
19_W	22_R	0.507	1.00
158_A	161_N	0.504	1.00
70_P	253_L	0.504	1.00
22_R	25_L	0.504	1.00
52_A	55_R	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3cqjA	2	0.965	100	0.198	Contact Map
1i60A	1	0.9545	100	0.238	Contact Map
2zdsA	5	0.979	100	0.243	Contact Map
3wqoA	2	0.9161	100	0.248	Contact Map
2qulA	2	0.9091	100	0.253	Contact Map
3vniA	4	0.9126	100	0.258	Contact Map
3qc0A	2	0.9161	100	0.258	Contact Map
2qw5A	3	0.9231	100	0.259	Contact Map
3kwsA	2	0.8916	100	0.26	Contact Map
3dx5A	2	0.9161	100	0.262	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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