GREMLIN Database
SGBU - Putative L-ribulose-5-phosphate 3-epimerase SgbU
UniProt: P37679 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12286
Length: 286 (246)
Sequences: 17084 (11967)
Seq/√Len: 763.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
98_S142_Q3.2801.00
179_T206_A3.0241.00
133_A172_M2.7871.00
24_V65_T2.7691.00
235_D238_G2.6661.00
59_V63_I2.6171.00
149_M206_A2.4421.00
199_K242_T2.4331.00
33_F251_S2.3471.00
20_P61_A2.3441.00
102_R146_S2.2941.00
60_A64_E2.2471.00
149_M179_T2.1811.00
94_R138_W2.1611.00
151_A206_A2.1041.00
105_R146_S2.0761.00
18_S21_E2.0721.00
129_R168_K2.0621.00
212_D230_G2.0571.00
102_R142_Q2.0331.00
168_K172_M2.0071.00
141_E175_S1.9131.00
111_T151_A1.9081.00
167_K200_L1.9081.00
269_I273_R1.9011.00
242_T245_K1.8711.00
167_K171_E1.8541.00
61_A65_T1.8171.00
61_A64_E1.8031.00
129_R172_M1.7431.00
52_A106_D1.7261.00
27_K65_T1.6961.00
54_Q57_S1.6811.00
193_D196_A1.6701.00
62_M69_I1.6661.00
24_V28_S1.6581.00
104_A109_I1.6491.00
130_Q172_M1.6371.00
144_A177_W1.6351.00
56_T106_D1.5851.00
142_Q145_A1.5821.00
199_K245_K1.5791.00
237_V241_K1.5741.00
91_E95_E1.5721.00
151_A181_Y1.5651.00
89_V92_R1.5511.00
101_I146_S1.5451.00
55_R106_D1.5331.00
90_R135_G1.5281.00
133_A137_A1.5251.00
25_L28_S1.5211.00
140_V178_F1.5201.00
162_S165_K1.5171.00
95_E99_K1.5111.00
111_T149_M1.4991.00
24_V61_A1.4941.00
195_P238_G1.4631.00
208_I243_L1.4501.00
124_H127_G1.4481.00
231_E270_Q1.4391.00
142_Q146_S1.4241.00
212_D232_G1.4111.00
57_S60_A1.4081.00
127_G130_Q1.4071.00
101_I143_A1.4011.00
134_E137_A1.3931.00
99_K102_R1.3841.00
242_T246_L1.3811.00
131_R134_E1.3701.00
20_P64_E1.3581.00
241_K245_K1.3541.00
161_N165_K1.3451.00
141_E145_A1.3421.00
21_E24_V1.3371.00
202_I246_L1.3341.00
179_T204_R1.3111.00
130_Q134_E1.3091.00
25_L265_V1.3071.00
196_A200_L1.2941.00
23_L65_T1.2811.00
184_V239_I1.2741.00
57_S61_A1.2651.00
168_K171_E1.2581.00
98_S138_W1.2561.00
140_V173_L1.2511.00
266_L270_Q1.2461.00
23_L61_A1.2301.00
263_E266_L1.2241.00
98_S102_R1.2041.00
25_L29_C1.2011.00
147_Q177_W1.1991.00
94_R98_S1.1941.00
29_C272_R1.1891.00
166_W180_V1.1891.00
60_A63_I1.1861.00
95_E98_S1.1801.00
20_P57_S1.1731.00
182_P187_L1.1701.00
154_I187_L1.1701.00
164_S200_L1.1641.00
238_G242_T1.1641.00
52_A56_T1.1641.00
214_Q227_V1.1611.00
86_D89_V1.1571.00
59_V106_D1.1551.00
101_I142_Q1.1541.00
33_F68_G1.1441.00
129_R133_A1.1441.00
195_P199_K1.1401.00
167_K204_R1.1311.00
26_A31_F1.1251.00
56_T60_A1.1181.00
138_W141_E1.1171.00
137_A173_L1.1141.00
27_K66_G1.1131.00
87_E91_E1.1131.00
267_E270_Q1.1011.00
97_M139_A1.0921.00
144_A175_S1.0861.00
102_R106_D1.0801.00
91_E138_W1.0771.00
144_A176_P1.0751.00
125_D165_K1.0701.00
20_P24_V1.0701.00
101_I148_V1.0651.00
197_E201_G1.0551.00
270_Q273_R1.0531.00
133_A173_L1.0511.00
98_S145_A1.0441.00
171_E204_R1.0411.00
23_L62_M1.0331.00
228_P231_E1.0231.00
199_K246_L1.0211.00
92_R95_E1.0121.00
167_K201_G1.0111.00
94_R135_G1.0001.00
33_F70_P0.9961.00
98_S146_S0.9911.00
102_R105_R0.9891.00
143_A150_L0.9801.00
62_M67_V0.9781.00
31_F272_R0.9731.00
111_T206_A0.9721.00
188_S233_C0.9711.00
36_M69_I0.9701.00
134_E138_W0.9681.00
137_A175_S0.9681.00
137_A141_E0.9661.00
137_A174_A0.9661.00
127_G131_R0.9641.00
31_F254_I0.9621.00
141_E144_A0.9571.00
72_M104_A0.9381.00
126_E130_Q0.9341.00
265_V269_I0.9281.00
55_R103_L0.9271.00
136_L178_F0.9211.00
53_A57_S0.9181.00
51_S54_Q0.9181.00
234_V239_I0.9171.00
126_E168_K0.9161.00
196_A199_K0.9131.00
125_D128_T0.9131.00
110_R149_M0.9131.00
140_V175_S0.9121.00
170_D204_R0.9111.00
164_S168_K0.9031.00
266_L269_I0.9021.00
55_R59_V0.9021.00
270_Q274_W0.8961.00
243_L246_L0.8921.00
240_F244_H0.8891.00
70_P251_S0.8881.00
195_P242_T0.8861.00
84_S89_V0.8831.00
59_V108_G0.8761.00
26_A34_V0.8751.00
35_E71_S0.8741.00
62_M65_T0.8731.00
56_T59_V0.8711.00
90_R134_E0.8691.00
140_V177_W0.8661.00
17_L25_L0.8631.00
153_E255_E0.8631.00
198_L246_L0.8621.00
81_P86_D0.8581.00
113_Q181_Y0.8551.00
27_K32_D0.8541.00
90_R131_R0.8541.00
105_R147_Q0.8531.00
135_G138_W0.8441.00
238_G241_K0.8401.00
163_I200_L0.8381.00
198_L242_T0.8301.00
226_D229_F0.8261.00
96_I99_K0.8251.00
104_A112_I0.8251.00
81_P85_R0.8201.00
28_S265_V0.8181.00
214_Q225_R0.8181.00
82_F85_R0.8171.00
131_R135_G0.8131.00
208_I252_F0.8101.00
129_R165_K0.8061.00
149_M177_W0.8011.00
227_V231_E0.8001.00
173_L178_F0.8001.00
35_E207_A0.7971.00
170_D180_V0.7951.00
214_Q233_C0.7921.00
105_R148_V0.7901.00
180_V201_G0.7901.00
103_L107_L0.7871.00
55_R107_L0.7851.00
68_G110_R0.7821.00
198_L201_G0.7751.00
24_V64_E0.7741.00
229_F271_A0.7681.00
183_D255_E0.7561.00
99_K103_L0.7531.00
138_W142_Q0.7521.00
210_L275_I0.7441.00
210_L236_F0.7401.00
268_I272_R0.7361.00
210_L252_F0.7351.00
90_R94_R0.7331.00
119_V122_E0.7261.00
69_I109_I0.7201.00
271_A274_W0.7191.00
268_I271_A0.7131.00
163_I192_N0.7081.00
236_F240_F0.7061.00
17_L21_E0.7061.00
247_N250_G0.7051.00
136_L169_W0.7031.00
73_C76_A0.7021.00
197_E200_L0.7021.00
88_A92_R0.7001.00
81_P84_S0.7001.00
160_M166_W0.6971.00
24_V27_K0.6961.00
21_E25_L0.6951.00
262_K266_L0.6951.00
29_C269_I0.6911.00
68_G251_S0.6881.00
137_A172_M0.6871.00
114_L150_L0.6851.00
93_A96_I0.6821.00
165_K168_K0.6811.00
185_G211_K0.6791.00
186_N211_K0.6761.00
184_V236_F0.6731.00
23_L27_K0.6731.00
27_K67_V0.6721.00
87_E90_R0.6711.00
35_E253_L0.6681.00
128_T131_R0.6671.00
174_A177_W0.6661.00
82_F135_G0.6581.00
185_G213_T0.6571.00
207_A253_L0.6571.00
188_S234_V0.6561.00
140_V150_L0.6561.00
82_F86_D0.6561.00
181_Y207_A0.6561.00
254_I271_A0.6551.00
112_I143_A0.6531.00
154_I166_W0.6521.00
100_A112_I0.6521.00
22_R26_A0.6501.00
267_E271_A0.6501.00
92_R96_I0.6481.00
139_A150_L0.6471.00
72_M75_S0.6471.00
87_E131_R0.6431.00
32_D68_G0.6411.00
10_E13_L0.6401.00
133_A169_W0.6361.00
170_D178_F0.6321.00
198_L205_I0.6321.00
202_I242_T0.6291.00
28_S269_I0.6291.00
104_A148_V0.6281.00
141_E177_W0.6261.00
111_T207_A0.6261.00
202_I205_I0.6221.00
132_F169_W0.6221.00
140_V144_A0.6201.00
130_Q133_A0.6201.00
163_I167_K0.6191.00
182_P198_L0.6161.00
156_D159_F0.6131.00
198_L202_I0.6121.00
23_L34_V0.6101.00
23_L58_L0.6101.00
63_I108_G0.6091.00
58_L61_A0.6031.00
143_A146_S0.6011.00
229_F274_W0.6001.00
264_P267_E0.5981.00
20_P65_T0.5971.00
90_R138_W0.5971.00
119_V123_D0.5961.00
244_H252_F0.5941.00
153_E209_H0.5921.00
94_R142_Q0.5911.00
188_S194_V0.5901.00
240_F252_F0.5901.00
211_K257_W0.5891.00
143_A148_V0.5881.00
88_A91_E0.5871.00
11_K14_A0.5851.00
94_R139_A0.5821.00
269_I272_R0.5811.00
211_K226_D0.5801.00
167_K170_D0.5801.00
23_L67_V0.5761.00
72_M109_I0.5751.00
14_A29_C0.5731.00
73_C115_A0.5721.00
160_M169_W0.5671.00
169_W173_L0.5661.00
13_L25_L0.5641.00
163_I196_A0.5641.00
182_P205_I0.5631.00
59_V62_M0.5611.00
59_V107_L0.5591.00
184_V210_L0.5581.00
175_S178_F0.5581.00
198_L239_I0.5571.00
31_F268_I0.5551.00
203_D246_L0.5541.00
129_R169_W0.5511.00
101_I112_I0.5511.00
132_F136_L0.5501.00
254_I275_I0.5451.00
140_V143_A0.5421.00
182_P197_E0.5411.00
108_G148_V0.5391.00
91_E94_R0.5391.00
132_F135_G0.5381.00
222_G225_R0.5381.00
187_L197_E0.5371.00
125_D129_R0.5361.00
110_R147_Q0.5361.00
70_P110_R0.5361.00
151_A179_T0.5341.00
170_D174_A0.5341.00
243_L248_Y0.5311.00
75_S100_A0.5311.00
180_V205_I0.5271.00
113_Q155_M0.5261.00
94_R97_M0.5241.00
71_S113_Q0.5211.00
71_S253_L0.5191.00
115_A118_D0.5171.00
74_L100_A0.5161.00
224_F229_F0.5161.00
263_E267_E0.5161.00
9_Y12_A0.5151.00
123_D131_R0.5111.00
133_A168_K0.5091.00
143_A147_Q0.5091.00
244_H247_N0.5081.00
19_W22_R0.5071.00
158_A161_N0.5041.00
70_P253_L0.5041.00
22_R25_L0.5041.00
52_A55_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cqjA 2 0.965 100 0.198 Contact Map
1i60A 1 0.9545 100 0.238 Contact Map
2zdsA 5 0.979 100 0.243 Contact Map
3wqoA 2 0.9161 100 0.248 Contact Map
2qulA 2 0.9091 100 0.253 Contact Map
3vniA 4 0.9126 100 0.258 Contact Map
3qc0A 2 0.9161 100 0.258 Contact Map
2qw5A 3 0.9231 100 0.259 Contact Map
3kwsA 2 0.8916 100 0.26 Contact Map
3dx5A 2 0.9161 100 0.262 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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