GREMLIN Database
SGBH - 3-keto-L-gulonate-6-phosphate decarboxylase SgbH
UniProt: P37678 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12285
Length: 220 (206)
Sequences: 3032 (1979)
Seq/√Len: 137.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_T53_Q3.6591.00
14_S17_A3.4361.00
199_N202_Q3.3761.00
88_C110_Q3.3561.00
51_R82_N3.2831.00
90_A94_T2.5571.00
45_G48_K2.4641.00
92_L96_E2.3501.00
201_A205_G2.2971.00
19_Q49_A2.2731.00
118_T172_I2.2621.00
150_E175_A2.2221.00
178_P210_Q2.1991.00
202_Q206_D2.1741.00
197_A203_V2.1431.00
70_E100_A2.1431.00
119_L130_V2.1261.00
157_K186_K2.1211.00
99_H103_Q2.1161.00
15_L49_A2.0351.00
93_A172_I1.9781.00
6_L190_A1.9691.00
36_T40_L1.9491.00
157_K166_L1.8921.00
178_P182_D1.8121.00
175_A183_I1.7461.00
92_L124_D1.7191.00
70_E101_M1.6911.00
119_L123_R1.6781.00
65_V76_A1.6291.00
142_Q161_D1.6291.00
156_M166_L1.6251.00
28_S205_G1.5851.00
135_Y159_L1.5721.00
185_V188_F1.5631.00
179_L182_D1.5251.00
12_H21_D1.5211.00
7_Q31_I1.5161.00
74_Q104_R1.5011.00
15_L42_E1.4911.00
129_G132_Q1.4901.00
15_L46_A1.4831.00
34_A50_L1.4621.00
118_T121_D1.4471.00
58_I82_N1.4231.00
21_D25_L1.4081.00
73_A84_M1.4051.00
6_L204_A1.4021.00
93_A96_E1.3751.00
40_L65_V1.3711.00
92_L143_A1.3661.00
92_L144_S1.3661.00
6_L211_I1.3601.00
128_I136_H1.3561.00
38_L42_E1.3421.00
113_L117_W1.3391.00
96_E100_A1.3271.00
142_Q160_S1.3051.00
18_A38_L1.3021.00
9_A191_G1.2901.00
119_L129_G1.2861.00
93_A121_D1.2741.00
41_N75_Q1.2721.00
17_A20_R1.2701.00
71_T74_Q1.2681.00
154_A183_I1.2671.00
32_V57_K1.2511.00
8_L29_V1.2491.00
20_R24_L1.2441.00
24_L200_P1.2421.00
49_A52_E1.2331.00
24_L199_N1.2291.00
168_I185_V1.2281.00
128_I132_Q1.2251.00
48_K52_E1.2231.00
22_V32_V1.2161.00
15_L19_Q1.2091.00
166_L186_K1.1750.99
139_R159_L1.1680.99
154_A158_A1.1650.99
206_D209_A1.1630.99
8_L195_A1.1600.99
85_T109_I1.1490.99
69_G94_T1.1470.99
148_W166_L1.1420.99
179_L183_I1.1400.99
123_R127_R1.1300.99
206_D210_Q1.1230.99
153_L185_V1.1210.99
38_L46_A1.1170.99
202_Q205_G1.1120.99
113_L133_A1.1110.99
107_G165_E1.0950.99
31_I58_I1.0920.99
13_S17_A1.0900.99
7_Q187_A1.0720.99
70_E74_Q1.0680.99
101_M105_C1.0560.99
155_R159_L1.0550.99
75_Q78_G1.0500.99
29_V204_A1.0450.99
205_G209_A1.0430.99
133_A137_R1.0380.99
83_W107_G1.0360.99
92_L140_D1.0350.99
165_E186_K1.0240.99
97_K100_A1.0080.98
69_G98_G1.0070.98
85_T111_I1.0040.98
120_D124_D1.0010.98
24_L201_A0.9960.98
117_W121_D0.9900.98
153_L166_L0.9800.98
71_T75_Q0.9800.98
37_I71_T0.9770.98
156_M160_S0.9690.98
42_E45_G0.9690.98
74_Q101_M0.9660.98
69_G90_A0.9590.98
89_A137_R0.9570.98
74_Q105_C0.9550.98
19_Q23_T0.9470.98
74_Q78_G0.9420.98
160_S164_L0.9410.98
84_M102_A0.9410.98
6_L208_H0.9390.98
181_K211_I0.9260.97
22_V50_L0.9250.97
78_G105_C0.9200.97
122_A126_H0.9190.97
83_W109_I0.9190.97
86_I108_E0.9140.97
19_Q22_V0.9110.97
41_N78_G0.9100.97
30_D57_K0.9100.97
73_A98_G0.9100.97
31_I83_W0.9060.97
61_A81_A0.9050.97
71_T196_G0.9000.97
93_A97_K0.8980.97
36_T72_L0.8970.97
86_I95_V0.8960.97
88_C141_A0.8950.97
89_A113_L0.8940.97
73_A102_A0.8920.97
181_K188_F0.8910.97
39_C63_W0.8910.97
65_V72_L0.8720.96
89_A133_A0.8680.96
47_V79_A0.8650.96
27_D201_A0.8600.96
28_S201_A0.8570.96
135_Y155_R0.8530.96
47_V59_I0.8490.95
203_V206_D0.8410.95
148_W156_M0.8410.95
26_K32_V0.8330.95
65_V69_G0.8310.95
92_L95_V0.8300.95
8_L25_L0.8230.95
97_K101_M0.8190.95
146_Q164_L0.8140.94
103_Q106_G0.8030.94
39_C44_L0.8010.94
151_A175_A0.7940.94
204_A208_H0.7930.94
201_A204_A0.7910.93
95_V144_S0.7890.93
123_R128_I0.7870.93
5_L58_I0.7870.93
85_T95_V0.7830.93
44_L47_V0.7820.93
110_Q141_A0.7750.93
193_A207_F0.7730.93
10_L34_A0.7700.93
40_L76_A0.7690.92
131_R155_R0.7670.92
26_K29_V0.7660.92
109_I167_S0.7620.92
175_A179_L0.7590.92
10_L50_L0.7560.92
128_I133_A0.7500.92
203_V210_Q0.7500.92
89_A117_W0.7480.91
121_D125_W0.7470.91
135_Y160_S0.7410.91
19_Q53_Q0.7390.91
194_L204_A0.7390.91
121_D124_D0.7360.91
139_R160_S0.7310.90
190_A207_F0.7280.90
30_D204_A0.7260.90
42_E46_A0.7210.90
37_I195_A0.7160.90
4_P30_D0.7110.89
32_V50_L0.7110.89
135_Y139_R0.7110.89
27_D30_D0.7100.89
8_L194_L0.7090.89
77_F105_C0.7070.89
17_A24_L0.7000.88
77_F106_G0.6940.88
100_A104_R0.6920.88
15_L45_G0.6910.88
25_L201_A0.6900.88
4_P58_I0.6890.88
31_I82_N0.6870.88
99_H108_E0.6840.87
16_E19_Q0.6830.87
207_F210_Q0.6820.87
66_A89_A0.6680.86
34_A38_L0.6670.86
98_G101_M0.6590.85
72_L75_Q0.6590.85
59_I81_A0.6580.85
83_W187_A0.6580.85
155_R158_A0.6560.85
44_L79_A0.6550.85
139_R143_A0.6520.85
50_L57_K0.6470.84
139_R142_Q0.6440.84
12_H195_A0.6440.84
70_E97_K0.6430.84
114_F117_W0.6430.84
201_A209_A0.6400.84
26_K57_K0.6390.83
34_A46_A0.6390.83
199_N203_V0.6390.83
138_G142_Q0.6360.83
21_D24_L0.6350.83
119_L122_A0.6350.83
16_E20_R0.6300.83
29_V57_K0.6260.82
22_V54_C0.6260.82
149_G152_D0.6230.82
177_L184_R0.6190.82
45_G49_A0.6170.81
120_D123_R0.6150.81
49_A53_Q0.6150.81
46_A49_A0.6140.81
20_R23_T0.6130.81
126_H133_A0.6130.81
73_A76_A0.6130.81
177_L188_F0.6120.81
60_V85_T0.6080.80
22_V42_E0.6070.80
22_V25_L0.6060.80
27_D57_K0.6040.80
112_E146_Q0.6010.80
36_T65_V0.6000.79
146_Q156_M0.5960.79
8_L21_D0.5950.79
29_V208_H0.5870.78
34_A39_C0.5860.78
51_R80_G0.5840.78
166_L187_A0.5830.78
45_G52_E0.5790.77
203_V207_F0.5790.77
73_A86_I0.5780.77
85_T164_L0.5770.77
5_L181_K0.5760.77
25_L57_K0.5760.77
7_Q167_S0.5750.77
70_E104_R0.5750.77
40_L72_L0.5740.76
77_F84_M0.5720.76
51_R59_I0.5660.75
87_I169_T0.5660.75
12_H18_A0.5650.75
89_A126_H0.5630.75
28_S208_H0.5610.75
167_S189_I0.5590.75
188_F211_I0.5590.75
177_L207_F0.5590.75
61_A76_A0.5560.74
86_I109_I0.5500.73
64_K67_D0.5480.73
165_E187_A0.5450.73
153_L168_I0.5440.73
47_V51_R0.5440.73
113_L137_R0.5430.72
142_Q163_G0.5430.72
83_W147_Q0.5390.72
65_V73_A0.5380.72
136_H140_D0.5350.71
31_I57_K0.5350.71
50_L53_Q0.5330.71
37_I68_A0.5290.71
123_R129_G0.5290.71
66_A87_I0.5250.70
158_A209_A0.5240.70
36_T76_A0.5240.70
73_A108_E0.5230.70
101_M104_R0.5210.69
13_S75_Q0.5200.69
157_K187_A0.5200.69
77_F102_A0.5190.69
146_Q166_L0.5190.69
25_L204_A0.5190.69
133_A156_M0.5180.69
60_V115_G0.5060.67
39_C75_Q0.5060.67
96_E143_A0.5060.67
40_L63_W0.5060.67
149_G173_T0.5050.67
77_F101_M0.5040.67
152_D173_T0.5030.67
86_I98_G0.5010.66
39_C61_A0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qw4B 4 0.9727 100 0.335 Contact Map
3qw3A 2 0.95 100 0.343 Contact Map
4mjzA 2 0.9818 100 0.364 Contact Map
2ffcA 2 0.9773 100 0.371 Contact Map
3gdmA 2 0.95 100 0.372 Contact Map
3ldvA 2 0.95 100 0.382 Contact Map
3tfxA 2 0.9773 100 0.384 Contact Map
1dbtA 2 0.9591 100 0.388 Contact Map
3tr2A 2 0.9455 100 0.39 Contact Map
1eixA 2 0.9545 100 0.392 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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