GREMLIN Database
LYXK - L-xylulose/3-keto-L-gulonate kinase
UniProt: P37677 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12284
Length: 498 (472)
Sequences: 12511 (8588)
Seq/√Len: 395.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
109_I144_E3.7501.00
193_P203_E3.6651.00
21_D25_R3.4431.00
17_A58_V3.3301.00
112_R144_E3.2801.00
185_N188_L2.8611.00
381_M476_Y2.8291.00
381_M385_N2.8121.00
125_L192_D2.7991.00
420_R463_L2.7871.00
388_R419_L2.7701.00
32_L57_A2.7381.00
411_Q415_D2.7071.00
356_F368_L2.6891.00
95_L149_R2.6771.00
37_L97_N2.6771.00
184_Y211_V2.6471.00
447_N450_E2.6161.00
30_Q61_A2.6031.00
396_T422_E2.6001.00
32_L61_A2.5811.00
213_G216_E2.5601.00
446_H450_E2.5181.00
19_L62_L2.5011.00
52_W166_C2.4741.00
96_G146_E2.4561.00
407_D460_R2.4321.00
90_K154_G2.4181.00
170_V210_P2.4171.00
49_A166_C2.3981.00
89_D152_Q2.3891.00
185_N192_D2.3361.00
381_M473_Q2.2651.00
155_C171_K2.2181.00
241_L246_S2.1361.00
193_P197_D2.1101.00
164_R240_G2.1031.00
18_G431_C2.1021.00
8_L55_C2.0921.00
202_A206_H2.0911.00
335_G367_H2.0791.00
196_T203_E2.0591.00
307_N372_I1.9961.00
14_W31_R1.9881.00
222_T225_T1.9671.00
465_D468_A1.9471.00
112_R116_D1.9471.00
49_A93_K1.9241.00
330_L367_H1.9201.00
190_E203_E1.9101.00
267_A304_S1.9021.00
364_T367_H1.8901.00
418_G469_H1.8831.00
121_K124_P1.8791.00
6_L59_I1.8701.00
338_F478_R1.8631.00
388_R393_D1.8581.00
35_C50_E1.8391.00
5_W439_R1.8341.00
476_Y480_Q1.8271.00
168_T237_V1.8261.00
399_V410_M1.8241.00
425_Q457_H1.8231.00
339_F356_F1.8231.00
40_Q43_W1.8141.00
223_A233_A1.8061.00
4_Y27_A1.7941.00
10_C15_L1.7911.00
6_L17_A1.7851.00
140_R144_E1.7441.00
311_F372_I1.7361.00
212_V216_E1.7211.00
238_V441_G1.7171.00
121_K125_L1.7111.00
422_E461_T1.7041.00
61_A65_H1.7001.00
125_L194_C1.6931.00
89_D93_K1.6621.00
4_Y19_L1.6571.00
217_I220_E1.6571.00
172_G212_V1.6551.00
121_K194_C1.6491.00
92_D165_W1.6481.00
258_T396_T1.6451.00
87_L142_L1.6331.00
111_R115_E1.6191.00
415_D468_A1.6171.00
420_R461_T1.6081.00
108_E112_R1.5931.00
86_F159_T1.5891.00
114_Q119_P1.5721.00
353_T360_Q1.5721.00
469_H473_Q1.5701.00
309_E313_A1.5671.00
217_I238_V1.5661.00
415_D465_D1.5641.00
325_Q329_S1.5621.00
378_F475_K1.5521.00
87_L207_A1.5491.00
319_S322_E1.5421.00
330_L366_A1.5371.00
5_W444_V1.5291.00
148_E151_A1.4861.00
467_T470_Q1.4761.00
385_N480_Q1.4601.00
30_Q62_L1.4551.00
120_E124_P1.4521.00
52_W56_M1.4341.00
37_L50_E1.4271.00
30_Q58_V1.4221.00
47_D50_E1.4161.00
232_K235_T1.4081.00
22_R444_V1.4011.00
407_D423_L1.4001.00
164_R218_C1.3961.00
28_G62_L1.3931.00
385_N388_R1.3891.00
63_L70_G1.3881.00
326_A329_S1.3631.00
408_V412_M1.3581.00
339_F343_L1.3561.00
425_Q459_V1.3501.00
220_E234_G1.3471.00
439_R445_Y1.3471.00
141_W145_H1.3431.00
370_Q374_E1.3401.00
88_L157_M1.3401.00
320_F323_I1.3381.00
49_A53_Q1.3321.00
407_D462_L1.3301.00
187_S276_L1.3241.00
75_G438_A1.3201.00
259_L394_V1.3151.00
162_Y166_C1.3141.00
377_V412_M1.3101.00
90_K155_C1.3101.00
168_T219_G1.3091.00
396_T420_R1.3021.00
8_L59_I1.3001.00
322_E325_Q1.2911.00
69_S72_Q1.2891.00
263_M413_L1.2741.00
202_A207_A1.2731.00
196_T208_L1.2731.00
175_E189_G1.2711.00
256_E274_R1.2701.00
82_G242_F1.2611.00
107_M111_R1.2551.00
377_V416_V1.2501.00
470_Q474_K1.2471.00
15_L55_C1.2431.00
377_V413_L1.2421.00
339_F372_I1.2421.00
423_L462_L1.2411.00
121_K198_W1.2361.00
301_S379_S1.2341.00
109_I140_R1.2321.00
318_I322_E1.2321.00
143_K150_Y1.2251.00
212_V218_C1.2201.00
136_V199_L1.2171.00
261_A413_L1.2151.00
405_H427_E1.2011.00
53_Q57_A1.1991.00
382_T480_Q1.1981.00
15_L54_C1.1971.00
164_R172_G1.1911.00
170_V212_V1.1791.00
146_E149_R1.1781.00
412_M416_V1.1761.00
84_G98_A1.1721.00
385_N476_Y1.1711.00
57_A61_A1.1671.00
19_L68_V1.1591.00
122_L130_L1.1571.00
217_I236_P1.1561.00
194_C197_D1.1551.00
418_G473_Q1.1551.00
8_L17_A1.1521.00
47_D97_N1.1491.00
241_L437_A1.1491.00
20_Y26_E1.1461.00
381_M417_S1.1461.00
55_C163_L1.1451.00
28_G65_H1.1441.00
92_D171_K1.1441.00
357_Y482_L1.1291.00
148_E152_Q1.1261.00
327_V408_V1.1241.00
321_D324_N1.1231.00
315_W368_L1.1201.00
116_D198_W1.1151.00
87_L153_I1.1141.00
45_E97_N1.1121.00
473_Q477_Q1.1081.00
319_S323_I1.1001.00
410_M462_L1.1001.00
255_D258_T1.0971.00
468_A471_L1.0951.00
157_M171_K1.0871.00
322_E326_A1.0871.00
110_V130_L1.0841.00
175_E211_V1.0831.00
48_M86_F1.0821.00
255_D452_Q1.0781.00
258_T398_R1.0771.00
172_G218_C1.0761.00
153_I207_A1.0751.00
274_R292_D1.0751.00
359_M363_H1.0741.00
303_T307_N1.0691.00
150_Y153_I1.0661.00
175_E184_Y1.0641.00
118_I198_W1.0641.00
478_R481_H1.0611.00
203_E206_H1.0601.00
337_L363_H1.0591.00
217_I441_G1.0581.00
4_Y72_Q1.0581.00
274_R294_E1.0561.00
363_H367_H1.0561.00
5_W442_T1.0551.00
196_T201_I1.0551.00
436_L455_L1.0531.00
458_P461_T1.0491.00
109_I145_H1.0471.00
325_Q328_A1.0451.00
108_E111_R1.0431.00
327_V330_L1.0431.00
259_L271_G1.0401.00
326_A365_R1.0361.00
51_L159_T1.0361.00
105_R141_W1.0271.00
75_G442_T1.0261.00
87_L139_L1.0231.00
61_A64_T1.0221.00
68_V72_Q1.0211.00
36_A46_R1.0201.00
20_Y435_A1.0181.00
398_R422_E1.0181.00
78_I164_R1.0121.00
354_S359_M1.0111.00
376_V403_P1.0111.00
111_R114_Q1.0091.00
450_E453_R1.0061.00
109_I112_R1.0061.00
440_V451_A1.0041.00
255_D449_S1.0041.00
436_L451_A1.0031.00
303_T306_G0.9961.00
34_L54_C0.9941.00
118_I121_K0.9911.00
465_D469_H0.9901.00
324_N406_S0.9891.00
384_L417_S0.9881.00
255_D453_R0.9881.00
378_F416_V0.9871.00
327_V369_L0.9841.00
220_E236_P0.9831.00
4_Y68_V0.9811.00
112_R115_E0.9771.00
386_R389_E0.9751.00
76_I235_T0.9741.00
75_G238_V0.9701.00
55_C59_I0.9691.00
307_N339_F0.9681.00
165_W171_K0.9681.00
381_M416_V0.9671.00
136_V182_N0.9671.00
60_R64_T0.9661.00
445_Y451_A0.9601.00
50_E53_Q0.9601.00
79_S430_G0.9591.00
289_Y293_G0.9551.00
17_A62_L0.9541.00
255_D395_H0.9501.00
5_W75_G0.9471.00
96_G149_R0.9461.00
323_I327_V0.9461.00
370_Q408_V0.9451.00
439_R444_V0.9441.00
87_L156_V0.9401.00
139_L156_V0.9351.00
260_N400_T0.9341.00
189_G213_G0.9341.00
63_L73_I0.9301.00
153_I156_V0.9261.00
21_D27_A0.9251.00
333_A336_D0.9241.00
403_P409_W0.9231.00
184_Y188_L0.9221.00
74_V442_T0.9201.00
257_F395_H0.9171.00
6_L19_L0.9151.00
329_S366_A0.9111.00
173_C178_I0.9111.00
44_A102_S0.9091.00
93_K166_C0.9081.00
122_L182_N0.9071.00
191_Y208_L0.9041.00
20_Y432_F0.9021.00
378_F476_Y0.9011.00
326_A366_A0.9011.00
147_P151_A0.9001.00
339_F371_A0.8991.00
466_M469_H0.8991.00
396_T461_T0.8991.00
238_V442_T0.8961.00
327_V366_A0.8941.00
149_R152_Q0.8921.00
6_L73_I0.8911.00
56_M60_R0.8901.00
269_T384_L0.8881.00
324_N369_L0.8861.00
96_G142_L0.8831.00
78_I163_L0.8801.00
418_G471_L0.8801.00
154_G206_H0.8761.00
124_P187_S0.8741.00
417_S420_R0.8741.00
397_L417_S0.8721.00
71_E232_K0.8701.00
267_A380_H0.8701.00
172_G210_P0.8691.00
112_R140_R0.8681.00
331_P334_G0.8681.00
19_L73_I0.8671.00
173_C209_P0.8641.00
142_L149_R0.8631.00
359_M368_L0.8611.00
272_I294_E0.8591.00
161_D173_C0.8581.00
187_S275_G0.8551.00
73_I235_T0.8551.00
140_R143_K0.8541.00
308_L324_N0.8541.00
316_G365_R0.8481.00
278_D281_A0.8461.00
33_P309_E0.8441.00
325_Q407_D0.8431.00
220_E233_A0.8421.00
175_E213_G0.8421.00
83_K180_E0.8401.00
466_M471_L0.8371.00
326_A330_L0.8371.00
136_V183_L0.8321.00
30_Q65_H0.8311.00
85_L156_V0.8301.00
77_G238_V0.8301.00
23_E454_D0.8281.00
104_R131_W0.8251.00
176_S288_R0.8241.00
78_I167_L0.8241.00
169_G222_T0.8241.00
323_I326_A0.8231.00
445_Y454_D0.8231.00
310_W313_A0.8221.00
466_M470_Q0.8211.00
212_V239_G0.8181.00
10_C163_L0.8171.00
114_Q130_L0.8141.00
175_E289_Y0.8101.00
108_E145_H0.8081.00
336_D475_K0.8081.00
247_T400_T0.8071.00
59_I63_L0.8071.00
440_V448_F0.8051.00
178_I191_Y0.8021.00
32_L58_V0.8021.00
346_S349_G0.8001.00
110_V137_S0.7981.00
88_L92_D0.7961.00
422_E458_P0.7931.00
20_Y426_V0.7911.00
221_I235_T0.7901.00
110_V132_T0.7901.00
74_V444_V0.7881.00
158_M181_S0.7881.00
318_I324_N0.7801.00
356_F372_I0.7801.00
259_L397_L0.7791.00
190_E193_P0.7771.00
328_A408_V0.7771.00
223_A234_G0.7771.00
140_R200_G0.7761.00
384_L388_R0.7761.00
190_E210_P0.7751.00
48_M97_N0.7741.00
184_Y189_G0.7731.00
404_A427_E0.7731.00
33_P312_T0.7731.00
321_D325_Q0.7731.00
95_L152_Q0.7721.00
271_G387_M0.7711.00
50_E54_C0.7711.00
342_F346_S0.7701.00
189_G293_G0.7691.00
139_L183_L0.7671.00
345_G349_G0.7651.00
338_F357_Y0.7641.00
320_F327_V0.7581.00
450_E454_D0.7571.00
399_V413_L0.7561.00
244_V268_V0.7561.00
10_C55_C0.7561.00
474_K477_Q0.7551.00
268_V300_A0.7551.00
311_F369_L0.7531.00
399_V423_L0.7521.00
481_H484_A0.7501.00
251_A400_T0.7501.00
373_Y412_M0.7481.00
125_L185_N0.7441.00
34_L46_R0.7431.00
327_V331_P0.7411.00
323_I369_L0.7411.00
82_G177_N0.7401.00
56_M225_T0.7391.00
470_Q475_K0.7381.00
373_Y406_S0.7381.00
261_A380_H0.7381.00
475_K478_R0.7371.00
82_G298_H0.7361.00
89_D95_L0.7361.00
251_A260_N0.7351.00
194_C198_W0.7341.00
261_A267_A0.7341.00
32_L54_C0.7331.00
474_K478_R0.7321.00
382_T476_Y0.7321.00
26_E29_V0.7301.00
7_G77_G0.7291.00
331_P335_G0.7291.00
273_T277_R0.7291.00
49_A162_Y0.7281.00
39_P43_W0.7271.00
160_H240_G0.7271.00
324_N408_V0.7241.00
173_C211_V0.7221.00
101_S266_W0.7221.00
45_E105_R0.7211.00
15_L34_L0.7181.00
108_E144_E0.7181.00
29_V428_E0.7171.00
155_C207_A0.7171.00
311_F368_L0.7151.00
63_L68_V0.7151.00
377_V409_W0.7141.00
320_F324_N0.7121.00
345_G348_A0.7101.00
88_L171_K0.7101.00
75_G236_P0.7101.00
480_Q484_A0.7101.00
440_V447_N0.7081.00
247_T430_G0.7061.00
352_M355_G0.7061.00
332_K370_Q0.7061.00
76_I221_I0.7031.00
304_S376_V0.7031.00
122_L195_L0.7031.00
192_D195_L0.7011.00
111_R351_E0.7001.00
87_L95_L0.6991.00
49_A94_P0.6981.00
468_A473_Q0.6971.00
221_I232_K0.6961.00
411_Q465_D0.6961.00
185_N190_E0.6941.00
279_G283_P0.6931.00
12_G100_L0.6921.00
55_C58_V0.6901.00
225_T234_G0.6901.00
449_S452_Q0.6880.99
70_G73_I0.6850.99
88_L155_C0.6840.99
463_L466_M0.6820.99
176_S241_L0.6820.99
399_V421_I0.6810.99
404_A410_M0.6800.99
381_M480_Q0.6790.99
53_Q56_M0.6760.99
473_Q476_Y0.6750.99
89_D154_G0.6730.99
397_L419_L0.6700.99
164_R168_T0.6700.99
299_E383_H0.6690.99
231_L235_T0.6690.99
253_I258_T0.6690.99
86_F98_A0.6680.99
92_D154_G0.6640.99
80_A177_N0.6640.99
336_D374_E0.6630.99
336_D370_Q0.6630.99
126_T195_L0.6610.99
56_M166_C0.6600.99
10_C54_C0.6590.99
350_L382_T0.6560.99
162_Y165_W0.6550.99
214_S240_G0.6550.99
243_D265_T0.6550.99
318_I323_I0.6550.99
311_F315_W0.6540.99
353_T357_Y0.6530.99
221_I231_L0.6520.99
59_I62_L0.6510.99
218_C239_G0.6510.99
99_I105_R0.6490.99
231_L234_G0.6480.99
407_D411_Q0.6470.99
374_E412_M0.6450.99
395_H419_L0.6450.99
333_A367_H0.6450.99
49_A97_N0.6440.99
477_Q480_Q0.6430.99
90_K152_Q0.6420.99
113_W199_L0.6370.99
88_L165_W0.6370.99
57_A60_R0.6360.99
261_A397_L0.6360.99
85_L135_P0.6340.99
52_W225_T0.6340.99
183_L208_L0.6310.99
88_L162_Y0.6310.99
5_W74_V0.6310.99
406_S409_W0.6300.99
439_R443_G0.6290.99
155_C165_W0.6290.99
396_T419_L0.6280.99
471_L475_K0.6280.99
397_L421_I0.6270.99
448_F452_Q0.6270.99
394_V419_L0.6260.99
76_I237_V0.6250.99
130_L182_N0.6250.99
176_S214_S0.6250.99
233_A236_P0.6210.99
276_L284_Y0.6200.99
330_L335_G0.6180.99
447_N453_R0.6170.99
220_E223_A0.6160.99
20_Y431_C0.6160.99
160_H177_N0.6140.99
470_Q473_Q0.6130.99
139_L207_A0.6130.99
332_K471_L0.6120.99
455_L458_P0.6120.99
92_D155_C0.6110.99
18_G26_E0.6110.99
340_L355_G0.6090.99
38_S44_A0.6090.99
67_G70_G0.6080.99
217_I442_T0.6060.99
236_P442_T0.6060.99
140_R150_Y0.6050.99
324_N327_V0.6050.99
309_E320_F0.6040.99
330_L334_G0.6030.99
134_H180_E0.6030.99
213_G289_Y0.6020.99
56_M59_I0.6020.99
449_S453_R0.6020.99
267_A413_L0.6000.99
331_P367_H0.5980.99
370_Q412_M0.5980.99
339_F375_G0.5980.99
161_D171_K0.5980.99
451_A454_D0.5970.99
86_F94_P0.5970.99
411_Q462_L0.5970.99
48_M98_A0.5950.99
5_W445_Y0.5940.99
420_R464_P0.5930.99
334_G338_F0.5930.99
113_W137_S0.5900.98
150_Y154_G0.5890.98
423_L459_V0.5880.98
342_F345_G0.5850.98
80_A159_T0.5850.98
81_Q101_S0.5850.98
436_L440_V0.5850.98
270_S296_I0.5830.98
335_G363_H0.5820.98
150_Y200_G0.5820.98
335_G362_I0.5820.98
128_Q134_H0.5810.98
418_G466_M0.5810.98
336_D367_H0.5800.98
143_K200_G0.5790.98
242_F245_V0.5790.98
263_M399_V0.5790.98
261_A269_T0.5780.98
318_I321_D0.5760.98
334_G370_Q0.5760.98
411_Q414_A0.5760.98
244_V262_V0.5750.98
140_R199_L0.5740.98
4_Y71_E0.5730.98
49_A52_W0.5730.98
22_R74_V0.5720.98
106_A137_S0.5700.98
440_V445_Y0.5680.98
99_I142_L0.5680.98
73_I231_L0.5680.98
425_Q458_P0.5660.98
301_S383_H0.5640.98
280_E389_E0.5620.98
47_D53_Q0.5620.98
452_Q455_L0.5620.98
376_V409_W0.5600.98
26_E426_V0.5580.98
201_I208_L0.5580.98
122_L199_L0.5560.98
248_A270_S0.5560.98
181_S191_Y0.5530.98
120_E123_Y0.5530.98
137_S182_N0.5520.98
107_M132_T0.5510.98
324_N373_Y0.5510.98
84_G100_L0.5490.98
314_Q364_T0.5470.97
436_L454_D0.5470.97
350_L483_I0.5470.97
63_L69_S0.5470.97
340_L483_I0.5470.97
197_D200_G0.5460.97
334_G367_H0.5460.97
170_V220_E0.5440.97
5_W22_R0.5430.97
410_M423_L0.5410.97
105_R145_H0.5400.97
215_A441_G0.5400.97
282_H285_V0.5400.97
347_N350_L0.5400.97
22_R439_R0.5400.97
82_G180_E0.5380.97
344_Y361_A0.5380.97
258_T452_Q0.5380.97
340_L346_S0.5380.97
249_L436_L0.5360.97
197_D202_A0.5360.97
374_E378_F0.5360.97
337_L371_A0.5350.97
252_G452_Q0.5340.97
269_T383_H0.5340.97
273_T297_V0.5330.97
426_V432_F0.5320.97
175_E214_S0.5320.97
250_C429_T0.5310.97
432_F436_L0.5310.97
249_L448_F0.5310.97
214_S241_L0.5300.97
404_A423_L0.5300.97
195_L199_L0.5300.97
267_A301_S0.5300.97
431_C434_A0.5290.97
285_V296_I0.5290.97
13_S16_K0.5280.97
222_T234_G0.5280.97
341_P344_Y0.5270.97
195_L198_W0.5260.97
344_Y348_A0.5250.97
309_E312_T0.5240.97
294_E448_F0.5240.97
330_L370_Q0.5240.97
83_K266_W0.5240.97
157_M165_W0.5240.97
412_M475_K0.5210.97
414_A421_I0.5200.97
281_A298_H0.5190.97
342_F348_A0.5180.97
25_R425_Q0.5180.97
327_V332_K0.5170.96
473_Q480_Q0.5170.96
413_L417_S0.5160.96
176_S245_V0.5160.96
225_T231_L0.5150.96
215_A440_V0.5150.96
337_L359_M0.5150.96
83_K101_S0.5150.96
445_Y455_L0.5150.96
333_A475_K0.5150.96
262_V400_T0.5140.96
221_I230_G0.5130.96
94_P97_N0.5130.96
395_H420_R0.5110.96
440_V443_G0.5110.96
93_K152_Q0.5110.96
43_W99_I0.5090.96
301_S380_H0.5090.96
258_T395_H0.5090.96
87_L96_G0.5090.96
12_G101_S0.5080.96
239_G246_S0.5070.96
116_D140_R0.5060.96
341_P375_G0.5050.96
79_S434_A0.5050.96
169_G224_Q0.5050.96
262_V268_V0.5040.96
259_L384_L0.5040.96
340_L482_L0.5020.96
31_R428_E0.5020.96
343_L346_S0.5020.96
243_D402_G0.5020.96
58_V62_L0.5020.96
25_R457_H0.5010.96
380_H413_L0.5000.96
451_A455_L0.5000.96
95_L153_I0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ll3A 2 0.9759 100 0.106 Contact Map
3qdkA 2 0.99 100 0.123 Contact Map
3ifrA 2 0.9679 100 0.13 Contact Map
2itmA 2 0.9498 100 0.131 Contact Map
3hz6A 1 0.9618 100 0.134 Contact Map
3l0qA 2 0.9819 100 0.144 Contact Map
3wxlA 2 0.9739 100 0.147 Contact Map
3g25A 3 0.9679 100 0.156 Contact Map
3ezwA 3 0.9719 100 0.156 Contact Map
2zf5O 3 0.9719 100 0.158 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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