LYXK - ECOLI - GREMLIN Contacts

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LYXK - L-xylulose/3-keto-L-gulonate kinase

UniProt:	P37677	Sequences: MTQYWLGLDCGGSWLKAGLYDREGREAGVQRLPLCALSPQPGWAERDMAELWQCCMAVIRALLTHSGVSGEQIVGIGISAQGKGLFLLDKNDKPLGNAILSSDRRAMEIVRRWQEDGIPEKLYPLTRQTLWTGHPVSLLRWLKEHEPERYAQIGCVMMTHDYLRWCLTGVKGCEESNISESNLYNMSLGEYDPCLTDWLGIAEINHALPPVVGSAEICGEITAQTAALTGLKAGTPVVGGLFDVVSTALCAGIEDEFTLNAVMGTWAVTSGITRGLRDGEAHPYVYGRYVNDGEFIVHEASPTSSGNLEWFTAQWGEISFDEINQAVASLPKAGGDLFFLPFLYGSNAGLEMTSGFYGMQAIHTRAHLLQAIYEGVVFSHMTHLNRMRERFTDVHTLRVTGGPAHSDVWMQMLADVSGLRIELPQVEETGCFGAALAARVGTGVYHNFSEAQRDLRHPVRTLLPDMTAHQLYQKKYQRYQHLIAALQGFHARIKEHTL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12284
Length:	498 (472)
Sequences:	12511 (8588)
Seq/√Len:	395.3

ECOLI - LYXK ARAB LSRK XYLB GLPK RHAB FUCK YGCE
BACSU - GNTK XYLB ARAB GLPK YOAC RHAB
HALSA - GLPK
SULSO - GLPK1 GLPK2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
109_I	144_E	3.750	1.00
193_P	203_E	3.665	1.00
21_D	25_R	3.443	1.00
17_A	58_V	3.330	1.00
112_R	144_E	3.280	1.00
185_N	188_L	2.861	1.00
381_M	476_Y	2.829	1.00
381_M	385_N	2.812	1.00
125_L	192_D	2.799	1.00
420_R	463_L	2.787	1.00
388_R	419_L	2.770	1.00
32_L	57_A	2.738	1.00
411_Q	415_D	2.707	1.00
356_F	368_L	2.689	1.00
95_L	149_R	2.677	1.00
37_L	97_N	2.677	1.00
184_Y	211_V	2.647	1.00
447_N	450_E	2.616	1.00
30_Q	61_A	2.603	1.00
396_T	422_E	2.600	1.00
32_L	61_A	2.581	1.00
213_G	216_E	2.560	1.00
446_H	450_E	2.518	1.00
19_L	62_L	2.501	1.00
52_W	166_C	2.474	1.00
96_G	146_E	2.456	1.00
407_D	460_R	2.432	1.00
90_K	154_G	2.418	1.00
170_V	210_P	2.417	1.00
49_A	166_C	2.398	1.00
89_D	152_Q	2.389	1.00
185_N	192_D	2.336	1.00
381_M	473_Q	2.265	1.00
155_C	171_K	2.218	1.00
241_L	246_S	2.136	1.00
193_P	197_D	2.110	1.00
164_R	240_G	2.103	1.00
18_G	431_C	2.102	1.00
8_L	55_C	2.092	1.00
202_A	206_H	2.091	1.00
335_G	367_H	2.079	1.00
196_T	203_E	2.059	1.00
307_N	372_I	1.996	1.00
14_W	31_R	1.988	1.00
222_T	225_T	1.967	1.00
465_D	468_A	1.947	1.00
112_R	116_D	1.947	1.00
49_A	93_K	1.924	1.00
330_L	367_H	1.920	1.00
190_E	203_E	1.910	1.00
267_A	304_S	1.902	1.00
364_T	367_H	1.890	1.00
418_G	469_H	1.883	1.00
121_K	124_P	1.879	1.00
6_L	59_I	1.870	1.00
338_F	478_R	1.863	1.00
388_R	393_D	1.858	1.00
35_C	50_E	1.839	1.00
5_W	439_R	1.834	1.00
476_Y	480_Q	1.827	1.00
168_T	237_V	1.826	1.00
399_V	410_M	1.824	1.00
425_Q	457_H	1.823	1.00
339_F	356_F	1.823	1.00
40_Q	43_W	1.814	1.00
223_A	233_A	1.806	1.00
4_Y	27_A	1.794	1.00
10_C	15_L	1.791	1.00
6_L	17_A	1.785	1.00
140_R	144_E	1.744	1.00
311_F	372_I	1.736	1.00
212_V	216_E	1.721	1.00
238_V	441_G	1.717	1.00
121_K	125_L	1.711	1.00
422_E	461_T	1.704	1.00
61_A	65_H	1.700	1.00
125_L	194_C	1.693	1.00
89_D	93_K	1.662	1.00
4_Y	19_L	1.657	1.00
217_I	220_E	1.657	1.00
172_G	212_V	1.655	1.00
121_K	194_C	1.649	1.00
92_D	165_W	1.648	1.00
258_T	396_T	1.645	1.00
87_L	142_L	1.633	1.00
111_R	115_E	1.619	1.00
415_D	468_A	1.617	1.00
420_R	461_T	1.608	1.00
108_E	112_R	1.593	1.00
86_F	159_T	1.589	1.00
114_Q	119_P	1.572	1.00
353_T	360_Q	1.572	1.00
469_H	473_Q	1.570	1.00
309_E	313_A	1.567	1.00
217_I	238_V	1.566	1.00
415_D	465_D	1.564	1.00
325_Q	329_S	1.562	1.00
378_F	475_K	1.552	1.00
87_L	207_A	1.549	1.00
319_S	322_E	1.542	1.00
330_L	366_A	1.537	1.00
5_W	444_V	1.529	1.00
148_E	151_A	1.486	1.00
467_T	470_Q	1.476	1.00
385_N	480_Q	1.460	1.00
30_Q	62_L	1.455	1.00
120_E	124_P	1.452	1.00
52_W	56_M	1.434	1.00
37_L	50_E	1.427	1.00
30_Q	58_V	1.422	1.00
47_D	50_E	1.416	1.00
232_K	235_T	1.408	1.00
22_R	444_V	1.401	1.00
407_D	423_L	1.400	1.00
164_R	218_C	1.396	1.00
28_G	62_L	1.393	1.00
385_N	388_R	1.389	1.00
63_L	70_G	1.388	1.00
326_A	329_S	1.363	1.00
408_V	412_M	1.358	1.00
339_F	343_L	1.356	1.00
425_Q	459_V	1.350	1.00
220_E	234_G	1.347	1.00
439_R	445_Y	1.347	1.00
141_W	145_H	1.343	1.00
370_Q	374_E	1.340	1.00
88_L	157_M	1.340	1.00
320_F	323_I	1.338	1.00
49_A	53_Q	1.332	1.00
407_D	462_L	1.330	1.00
187_S	276_L	1.324	1.00
75_G	438_A	1.320	1.00
259_L	394_V	1.315	1.00
162_Y	166_C	1.314	1.00
377_V	412_M	1.310	1.00
90_K	155_C	1.310	1.00
168_T	219_G	1.309	1.00
396_T	420_R	1.302	1.00
8_L	59_I	1.300	1.00
322_E	325_Q	1.291	1.00
69_S	72_Q	1.289	1.00
263_M	413_L	1.274	1.00
202_A	207_A	1.273	1.00
196_T	208_L	1.273	1.00
175_E	189_G	1.271	1.00
256_E	274_R	1.270	1.00
82_G	242_F	1.261	1.00
107_M	111_R	1.255	1.00
377_V	416_V	1.250	1.00
470_Q	474_K	1.247	1.00
15_L	55_C	1.243	1.00
377_V	413_L	1.242	1.00
339_F	372_I	1.242	1.00
423_L	462_L	1.241	1.00
121_K	198_W	1.236	1.00
301_S	379_S	1.234	1.00
109_I	140_R	1.232	1.00
318_I	322_E	1.232	1.00
143_K	150_Y	1.225	1.00
212_V	218_C	1.220	1.00
136_V	199_L	1.217	1.00
261_A	413_L	1.215	1.00
405_H	427_E	1.201	1.00
53_Q	57_A	1.199	1.00
382_T	480_Q	1.198	1.00
15_L	54_C	1.197	1.00
164_R	172_G	1.191	1.00
170_V	212_V	1.179	1.00
146_E	149_R	1.178	1.00
412_M	416_V	1.176	1.00
84_G	98_A	1.172	1.00
385_N	476_Y	1.171	1.00
57_A	61_A	1.167	1.00
19_L	68_V	1.159	1.00
122_L	130_L	1.157	1.00
217_I	236_P	1.156	1.00
194_C	197_D	1.155	1.00
418_G	473_Q	1.155	1.00
8_L	17_A	1.152	1.00
47_D	97_N	1.149	1.00
241_L	437_A	1.149	1.00
20_Y	26_E	1.146	1.00
381_M	417_S	1.146	1.00
55_C	163_L	1.145	1.00
28_G	65_H	1.144	1.00
92_D	171_K	1.144	1.00
357_Y	482_L	1.129	1.00
148_E	152_Q	1.126	1.00
327_V	408_V	1.124	1.00
321_D	324_N	1.123	1.00
315_W	368_L	1.120	1.00
116_D	198_W	1.115	1.00
87_L	153_I	1.114	1.00
45_E	97_N	1.112	1.00
473_Q	477_Q	1.108	1.00
319_S	323_I	1.100	1.00
410_M	462_L	1.100	1.00
255_D	258_T	1.097	1.00
468_A	471_L	1.095	1.00
157_M	171_K	1.087	1.00
322_E	326_A	1.087	1.00
110_V	130_L	1.084	1.00
175_E	211_V	1.083	1.00
48_M	86_F	1.082	1.00
255_D	452_Q	1.078	1.00
258_T	398_R	1.077	1.00
172_G	218_C	1.076	1.00
153_I	207_A	1.075	1.00
274_R	292_D	1.075	1.00
359_M	363_H	1.074	1.00
303_T	307_N	1.069	1.00
150_Y	153_I	1.066	1.00
175_E	184_Y	1.064	1.00
118_I	198_W	1.064	1.00
478_R	481_H	1.061	1.00
203_E	206_H	1.060	1.00
337_L	363_H	1.059	1.00
217_I	441_G	1.058	1.00
4_Y	72_Q	1.058	1.00
274_R	294_E	1.056	1.00
363_H	367_H	1.056	1.00
5_W	442_T	1.055	1.00
196_T	201_I	1.055	1.00
436_L	455_L	1.053	1.00
458_P	461_T	1.049	1.00
109_I	145_H	1.047	1.00
325_Q	328_A	1.045	1.00
108_E	111_R	1.043	1.00
327_V	330_L	1.043	1.00
259_L	271_G	1.040	1.00
326_A	365_R	1.036	1.00
51_L	159_T	1.036	1.00
105_R	141_W	1.027	1.00
75_G	442_T	1.026	1.00
87_L	139_L	1.023	1.00
61_A	64_T	1.022	1.00
68_V	72_Q	1.021	1.00
36_A	46_R	1.020	1.00
20_Y	435_A	1.018	1.00
398_R	422_E	1.018	1.00
78_I	164_R	1.012	1.00
354_S	359_M	1.011	1.00
376_V	403_P	1.011	1.00
111_R	114_Q	1.009	1.00
450_E	453_R	1.006	1.00
109_I	112_R	1.006	1.00
440_V	451_A	1.004	1.00
255_D	449_S	1.004	1.00
436_L	451_A	1.003	1.00
303_T	306_G	0.996	1.00
34_L	54_C	0.994	1.00
118_I	121_K	0.991	1.00
465_D	469_H	0.990	1.00
324_N	406_S	0.989	1.00
384_L	417_S	0.988	1.00
255_D	453_R	0.988	1.00
378_F	416_V	0.987	1.00
327_V	369_L	0.984	1.00
220_E	236_P	0.983	1.00
4_Y	68_V	0.981	1.00
112_R	115_E	0.977	1.00
386_R	389_E	0.975	1.00
76_I	235_T	0.974	1.00
75_G	238_V	0.970	1.00
55_C	59_I	0.969	1.00
307_N	339_F	0.968	1.00
165_W	171_K	0.968	1.00
381_M	416_V	0.967	1.00
136_V	182_N	0.967	1.00
60_R	64_T	0.966	1.00
445_Y	451_A	0.960	1.00
50_E	53_Q	0.960	1.00
79_S	430_G	0.959	1.00
289_Y	293_G	0.955	1.00
17_A	62_L	0.954	1.00
255_D	395_H	0.950	1.00
5_W	75_G	0.947	1.00
96_G	149_R	0.946	1.00
323_I	327_V	0.946	1.00
370_Q	408_V	0.945	1.00
439_R	444_V	0.944	1.00
87_L	156_V	0.940	1.00
139_L	156_V	0.935	1.00
260_N	400_T	0.934	1.00
189_G	213_G	0.934	1.00
63_L	73_I	0.930	1.00
153_I	156_V	0.926	1.00
21_D	27_A	0.925	1.00
333_A	336_D	0.924	1.00
403_P	409_W	0.923	1.00
184_Y	188_L	0.922	1.00
74_V	442_T	0.920	1.00
257_F	395_H	0.917	1.00
6_L	19_L	0.915	1.00
329_S	366_A	0.911	1.00
173_C	178_I	0.911	1.00
44_A	102_S	0.909	1.00
93_K	166_C	0.908	1.00
122_L	182_N	0.907	1.00
191_Y	208_L	0.904	1.00
20_Y	432_F	0.902	1.00
378_F	476_Y	0.901	1.00
326_A	366_A	0.901	1.00
147_P	151_A	0.900	1.00
339_F	371_A	0.899	1.00
466_M	469_H	0.899	1.00
396_T	461_T	0.899	1.00
238_V	442_T	0.896	1.00
327_V	366_A	0.894	1.00
149_R	152_Q	0.892	1.00
6_L	73_I	0.891	1.00
56_M	60_R	0.890	1.00
269_T	384_L	0.888	1.00
324_N	369_L	0.886	1.00
96_G	142_L	0.883	1.00
78_I	163_L	0.880	1.00
418_G	471_L	0.880	1.00
154_G	206_H	0.876	1.00
124_P	187_S	0.874	1.00
417_S	420_R	0.874	1.00
397_L	417_S	0.872	1.00
71_E	232_K	0.870	1.00
267_A	380_H	0.870	1.00
172_G	210_P	0.869	1.00
112_R	140_R	0.868	1.00
331_P	334_G	0.868	1.00
19_L	73_I	0.867	1.00
173_C	209_P	0.864	1.00
142_L	149_R	0.863	1.00
359_M	368_L	0.861	1.00
272_I	294_E	0.859	1.00
161_D	173_C	0.858	1.00
187_S	275_G	0.855	1.00
73_I	235_T	0.855	1.00
140_R	143_K	0.854	1.00
308_L	324_N	0.854	1.00
316_G	365_R	0.848	1.00
278_D	281_A	0.846	1.00
33_P	309_E	0.844	1.00
325_Q	407_D	0.843	1.00
220_E	233_A	0.842	1.00
175_E	213_G	0.842	1.00
83_K	180_E	0.840	1.00
466_M	471_L	0.837	1.00
326_A	330_L	0.837	1.00
136_V	183_L	0.832	1.00
30_Q	65_H	0.831	1.00
85_L	156_V	0.830	1.00
77_G	238_V	0.830	1.00
23_E	454_D	0.828	1.00
104_R	131_W	0.825	1.00
176_S	288_R	0.824	1.00
78_I	167_L	0.824	1.00
169_G	222_T	0.824	1.00
323_I	326_A	0.823	1.00
445_Y	454_D	0.823	1.00
310_W	313_A	0.822	1.00
466_M	470_Q	0.821	1.00
212_V	239_G	0.818	1.00
10_C	163_L	0.817	1.00
114_Q	130_L	0.814	1.00
175_E	289_Y	0.810	1.00
108_E	145_H	0.808	1.00
336_D	475_K	0.808	1.00
247_T	400_T	0.807	1.00
59_I	63_L	0.807	1.00
440_V	448_F	0.805	1.00
178_I	191_Y	0.802	1.00
32_L	58_V	0.802	1.00
346_S	349_G	0.800	1.00
110_V	137_S	0.798	1.00
88_L	92_D	0.796	1.00
422_E	458_P	0.793	1.00
20_Y	426_V	0.791	1.00
221_I	235_T	0.790	1.00
110_V	132_T	0.790	1.00
74_V	444_V	0.788	1.00
158_M	181_S	0.788	1.00
318_I	324_N	0.780	1.00
356_F	372_I	0.780	1.00
259_L	397_L	0.779	1.00
190_E	193_P	0.777	1.00
328_A	408_V	0.777	1.00
223_A	234_G	0.777	1.00
140_R	200_G	0.776	1.00
384_L	388_R	0.776	1.00
190_E	210_P	0.775	1.00
48_M	97_N	0.774	1.00
184_Y	189_G	0.773	1.00
404_A	427_E	0.773	1.00
33_P	312_T	0.773	1.00
321_D	325_Q	0.773	1.00
95_L	152_Q	0.772	1.00
271_G	387_M	0.771	1.00
50_E	54_C	0.771	1.00
342_F	346_S	0.770	1.00
189_G	293_G	0.769	1.00
139_L	183_L	0.767	1.00
345_G	349_G	0.765	1.00
338_F	357_Y	0.764	1.00
320_F	327_V	0.758	1.00
450_E	454_D	0.757	1.00
399_V	413_L	0.756	1.00
244_V	268_V	0.756	1.00
10_C	55_C	0.756	1.00
474_K	477_Q	0.755	1.00
268_V	300_A	0.755	1.00
311_F	369_L	0.753	1.00
399_V	423_L	0.752	1.00
481_H	484_A	0.750	1.00
251_A	400_T	0.750	1.00
373_Y	412_M	0.748	1.00
125_L	185_N	0.744	1.00
34_L	46_R	0.743	1.00
327_V	331_P	0.741	1.00
323_I	369_L	0.741	1.00
82_G	177_N	0.740	1.00
56_M	225_T	0.739	1.00
470_Q	475_K	0.738	1.00
373_Y	406_S	0.738	1.00
261_A	380_H	0.738	1.00
475_K	478_R	0.737	1.00
82_G	298_H	0.736	1.00
89_D	95_L	0.736	1.00
251_A	260_N	0.735	1.00
194_C	198_W	0.734	1.00
261_A	267_A	0.734	1.00
32_L	54_C	0.733	1.00
474_K	478_R	0.732	1.00
382_T	476_Y	0.732	1.00
26_E	29_V	0.730	1.00
7_G	77_G	0.729	1.00
331_P	335_G	0.729	1.00
273_T	277_R	0.729	1.00
49_A	162_Y	0.728	1.00
39_P	43_W	0.727	1.00
160_H	240_G	0.727	1.00
324_N	408_V	0.724	1.00
173_C	211_V	0.722	1.00
101_S	266_W	0.722	1.00
45_E	105_R	0.721	1.00
15_L	34_L	0.718	1.00
108_E	144_E	0.718	1.00
29_V	428_E	0.717	1.00
155_C	207_A	0.717	1.00
311_F	368_L	0.715	1.00
63_L	68_V	0.715	1.00
377_V	409_W	0.714	1.00
320_F	324_N	0.712	1.00
345_G	348_A	0.710	1.00
88_L	171_K	0.710	1.00
75_G	236_P	0.710	1.00
480_Q	484_A	0.710	1.00
440_V	447_N	0.708	1.00
247_T	430_G	0.706	1.00
352_M	355_G	0.706	1.00
332_K	370_Q	0.706	1.00
76_I	221_I	0.703	1.00
304_S	376_V	0.703	1.00
122_L	195_L	0.703	1.00
192_D	195_L	0.701	1.00
111_R	351_E	0.700	1.00
87_L	95_L	0.699	1.00
49_A	94_P	0.698	1.00
468_A	473_Q	0.697	1.00
221_I	232_K	0.696	1.00
411_Q	465_D	0.696	1.00
185_N	190_E	0.694	1.00
279_G	283_P	0.693	1.00
12_G	100_L	0.692	1.00
55_C	58_V	0.690	1.00
225_T	234_G	0.690	1.00
449_S	452_Q	0.688	0.99
70_G	73_I	0.685	0.99
88_L	155_C	0.684	0.99
463_L	466_M	0.682	0.99
176_S	241_L	0.682	0.99
399_V	421_I	0.681	0.99
404_A	410_M	0.680	0.99
381_M	480_Q	0.679	0.99
53_Q	56_M	0.676	0.99
473_Q	476_Y	0.675	0.99
89_D	154_G	0.673	0.99
397_L	419_L	0.670	0.99
164_R	168_T	0.670	0.99
299_E	383_H	0.669	0.99
231_L	235_T	0.669	0.99
253_I	258_T	0.669	0.99
86_F	98_A	0.668	0.99
92_D	154_G	0.664	0.99
80_A	177_N	0.664	0.99
336_D	374_E	0.663	0.99
336_D	370_Q	0.663	0.99
126_T	195_L	0.661	0.99
56_M	166_C	0.660	0.99
10_C	54_C	0.659	0.99
350_L	382_T	0.656	0.99
162_Y	165_W	0.655	0.99
214_S	240_G	0.655	0.99
243_D	265_T	0.655	0.99
318_I	323_I	0.655	0.99
311_F	315_W	0.654	0.99
353_T	357_Y	0.653	0.99
221_I	231_L	0.652	0.99
59_I	62_L	0.651	0.99
218_C	239_G	0.651	0.99
99_I	105_R	0.649	0.99
231_L	234_G	0.648	0.99
407_D	411_Q	0.647	0.99
374_E	412_M	0.645	0.99
395_H	419_L	0.645	0.99
333_A	367_H	0.645	0.99
49_A	97_N	0.644	0.99
477_Q	480_Q	0.643	0.99
90_K	152_Q	0.642	0.99
113_W	199_L	0.637	0.99
88_L	165_W	0.637	0.99
57_A	60_R	0.636	0.99
261_A	397_L	0.636	0.99
85_L	135_P	0.634	0.99
52_W	225_T	0.634	0.99
183_L	208_L	0.631	0.99
88_L	162_Y	0.631	0.99
5_W	74_V	0.631	0.99
406_S	409_W	0.630	0.99
439_R	443_G	0.629	0.99
155_C	165_W	0.629	0.99
396_T	419_L	0.628	0.99
471_L	475_K	0.628	0.99
397_L	421_I	0.627	0.99
448_F	452_Q	0.627	0.99
394_V	419_L	0.626	0.99
76_I	237_V	0.625	0.99
130_L	182_N	0.625	0.99
176_S	214_S	0.625	0.99
233_A	236_P	0.621	0.99
276_L	284_Y	0.620	0.99
330_L	335_G	0.618	0.99
447_N	453_R	0.617	0.99
220_E	223_A	0.616	0.99
20_Y	431_C	0.616	0.99
160_H	177_N	0.614	0.99
470_Q	473_Q	0.613	0.99
139_L	207_A	0.613	0.99
332_K	471_L	0.612	0.99
455_L	458_P	0.612	0.99
92_D	155_C	0.611	0.99
18_G	26_E	0.611	0.99
340_L	355_G	0.609	0.99
38_S	44_A	0.609	0.99
67_G	70_G	0.608	0.99
217_I	442_T	0.606	0.99
236_P	442_T	0.606	0.99
140_R	150_Y	0.605	0.99
324_N	327_V	0.605	0.99
309_E	320_F	0.604	0.99
330_L	334_G	0.603	0.99
134_H	180_E	0.603	0.99
213_G	289_Y	0.602	0.99
56_M	59_I	0.602	0.99
449_S	453_R	0.602	0.99
267_A	413_L	0.600	0.99
331_P	367_H	0.598	0.99
370_Q	412_M	0.598	0.99
339_F	375_G	0.598	0.99
161_D	171_K	0.598	0.99
451_A	454_D	0.597	0.99
86_F	94_P	0.597	0.99
411_Q	462_L	0.597	0.99
48_M	98_A	0.595	0.99
5_W	445_Y	0.594	0.99
420_R	464_P	0.593	0.99
334_G	338_F	0.593	0.99
113_W	137_S	0.590	0.98
150_Y	154_G	0.589	0.98
423_L	459_V	0.588	0.98
342_F	345_G	0.585	0.98
80_A	159_T	0.585	0.98
81_Q	101_S	0.585	0.98
436_L	440_V	0.585	0.98
270_S	296_I	0.583	0.98
335_G	363_H	0.582	0.98
150_Y	200_G	0.582	0.98
335_G	362_I	0.582	0.98
128_Q	134_H	0.581	0.98
418_G	466_M	0.581	0.98
336_D	367_H	0.580	0.98
143_K	200_G	0.579	0.98
242_F	245_V	0.579	0.98
263_M	399_V	0.579	0.98
261_A	269_T	0.578	0.98
318_I	321_D	0.576	0.98
334_G	370_Q	0.576	0.98
411_Q	414_A	0.576	0.98
244_V	262_V	0.575	0.98
140_R	199_L	0.574	0.98
4_Y	71_E	0.573	0.98
49_A	52_W	0.573	0.98
22_R	74_V	0.572	0.98
106_A	137_S	0.570	0.98
440_V	445_Y	0.568	0.98
99_I	142_L	0.568	0.98
73_I	231_L	0.568	0.98
425_Q	458_P	0.566	0.98
301_S	383_H	0.564	0.98
280_E	389_E	0.562	0.98
47_D	53_Q	0.562	0.98
452_Q	455_L	0.562	0.98
376_V	409_W	0.560	0.98
26_E	426_V	0.558	0.98
201_I	208_L	0.558	0.98
122_L	199_L	0.556	0.98
248_A	270_S	0.556	0.98
181_S	191_Y	0.553	0.98
120_E	123_Y	0.553	0.98
137_S	182_N	0.552	0.98
107_M	132_T	0.551	0.98
324_N	373_Y	0.551	0.98
84_G	100_L	0.549	0.98
314_Q	364_T	0.547	0.97
436_L	454_D	0.547	0.97
350_L	483_I	0.547	0.97
63_L	69_S	0.547	0.97
340_L	483_I	0.547	0.97
197_D	200_G	0.546	0.97
334_G	367_H	0.546	0.97
170_V	220_E	0.544	0.97
5_W	22_R	0.543	0.97
410_M	423_L	0.541	0.97
105_R	145_H	0.540	0.97
215_A	441_G	0.540	0.97
282_H	285_V	0.540	0.97
347_N	350_L	0.540	0.97
22_R	439_R	0.540	0.97
82_G	180_E	0.538	0.97
344_Y	361_A	0.538	0.97
258_T	452_Q	0.538	0.97
340_L	346_S	0.538	0.97
249_L	436_L	0.536	0.97
197_D	202_A	0.536	0.97
374_E	378_F	0.536	0.97
337_L	371_A	0.535	0.97
252_G	452_Q	0.534	0.97
269_T	383_H	0.534	0.97
273_T	297_V	0.533	0.97
426_V	432_F	0.532	0.97
175_E	214_S	0.532	0.97
250_C	429_T	0.531	0.97
432_F	436_L	0.531	0.97
249_L	448_F	0.531	0.97
214_S	241_L	0.530	0.97
404_A	423_L	0.530	0.97
195_L	199_L	0.530	0.97
267_A	301_S	0.530	0.97
431_C	434_A	0.529	0.97
285_V	296_I	0.529	0.97
13_S	16_K	0.528	0.97
222_T	234_G	0.528	0.97
341_P	344_Y	0.527	0.97
195_L	198_W	0.526	0.97
344_Y	348_A	0.525	0.97
309_E	312_T	0.524	0.97
294_E	448_F	0.524	0.97
330_L	370_Q	0.524	0.97
83_K	266_W	0.524	0.97
157_M	165_W	0.524	0.97
412_M	475_K	0.521	0.97
414_A	421_I	0.520	0.97
281_A	298_H	0.519	0.97
342_F	348_A	0.518	0.97
25_R	425_Q	0.518	0.97
327_V	332_K	0.517	0.96
473_Q	480_Q	0.517	0.96
413_L	417_S	0.516	0.96
176_S	245_V	0.516	0.96
225_T	231_L	0.515	0.96
215_A	440_V	0.515	0.96
337_L	359_M	0.515	0.96
83_K	101_S	0.515	0.96
445_Y	455_L	0.515	0.96
333_A	475_K	0.515	0.96
262_V	400_T	0.514	0.96
221_I	230_G	0.513	0.96
94_P	97_N	0.513	0.96
395_H	420_R	0.511	0.96
440_V	443_G	0.511	0.96
93_K	152_Q	0.511	0.96
43_W	99_I	0.509	0.96
301_S	380_H	0.509	0.96
258_T	395_H	0.509	0.96
87_L	96_G	0.509	0.96
12_G	101_S	0.508	0.96
239_G	246_S	0.507	0.96
116_D	140_R	0.506	0.96
341_P	375_G	0.505	0.96
79_S	434_A	0.505	0.96
169_G	224_Q	0.505	0.96
262_V	268_V	0.504	0.96
259_L	384_L	0.504	0.96
340_L	482_L	0.502	0.96
31_R	428_E	0.502	0.96
343_L	346_S	0.502	0.96
243_D	402_G	0.502	0.96
58_V	62_L	0.502	0.96
25_R	457_H	0.501	0.96
380_H	413_L	0.500	0.96
451_A	455_L	0.500	0.96
95_L	153_I	0.500	0.96

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3ll3A	2	0.9759	100	0.106	Contact Map
3qdkA	2	0.99	100	0.123	Contact Map
3ifrA	2	0.9679	100	0.13	Contact Map
2itmA	2	0.9498	100	0.131	Contact Map
3hz6A	1	0.9618	100	0.134	Contact Map
3l0qA	2	0.9819	100	0.144	Contact Map
3wxlA	2	0.9739	100	0.147	Contact Map
3g25A	3	0.9679	100	0.156	Contact Map
3ezwA	3	0.9719	100	0.156	Contact Map
2zf5O	3	0.9719	100	0.158	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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