GREMLIN Database
YIAO - 2,3-diketo-L-gulonate-binding periplasmic protein YiaO
UniProt: P37676 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12283
Length: 328 (313)
Sequences: 9373 (7085)
Seq/√Len: 400.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
250_P253_Q3.6971.00
58_E252_F3.6371.00
249_S252_F3.5861.00
242_K246_D3.5301.00
280_D284_E3.2531.00
54_R258_S2.7321.00
296_K300_D2.7321.00
254_Q258_S2.6821.00
138_K242_K2.6731.00
318_A322_K2.5471.00
52_Q60_K2.5141.00
85_D244_K2.4021.00
245_F257_V2.3611.00
215_W281_G2.3571.00
27_S62_K2.3561.00
46_K49_D2.3261.00
280_D283_K2.3141.00
55_T255_A2.2701.00
31_G75_M2.2031.00
178_A181_K2.1871.00
269_K273_E2.1841.00
50_L262_E2.1681.00
138_K257_V2.1491.00
155_A166_L2.1041.00
48_N52_Q2.0881.00
49_D53_E2.0351.00
149_D230_H2.0081.00
244_K247_G2.0061.00
50_L54_R1.9831.00
27_S60_K1.9591.00
178_A309_M1.9071.00
46_K50_L1.8761.00
45_K49_D1.8581.00
281_G285_A1.8521.00
50_L53_E1.8331.00
127_D323_A1.7921.00
46_K266_Y1.7821.00
281_G284_E1.7821.00
291_T294_D1.7681.00
160_P297_A1.7551.00
250_P254_Q1.7511.00
133_E242_K1.7381.00
161_A164_K1.7241.00
273_E277_K1.7061.00
100_V131_S1.7011.00
279_I283_K1.6941.00
129_K139_V1.6371.00
54_R255_A1.6361.00
28_L244_K1.6271.00
111_R115_H1.6251.00
311_V318_A1.6131.00
26_Q252_F1.6021.00
180_F185_A1.5921.00
133_E138_K1.5891.00
55_T59_L1.5771.00
54_R259_S1.5581.00
277_K281_G1.5571.00
86_M240_I1.5511.00
50_L259_S1.5501.00
300_D304_N1.5391.00
130_A133_E1.5331.00
48_N63_L1.5261.00
47_F260_A1.4991.00
225_F288_E1.4951.00
276_Q280_D1.4841.00
18_F21_S1.4831.00
274_D277_K1.4621.00
294_D297_A1.4561.00
123_K126_D1.4521.00
49_D52_Q1.4491.00
196_Y222_V1.4451.00
296_K299_S1.4401.00
182_V305_Q1.4261.00
297_A300_D1.4211.00
270_L273_E1.4211.00
156_P288_E1.4121.00
257_V261_Q1.4121.00
121_D268_R1.4111.00
220_F285_A1.4071.00
266_Y270_L1.3961.00
15_L18_F1.3931.00
228_L279_I1.3901.00
70_G78_G1.3891.00
41_H45_K1.3841.00
295_R299_S1.3841.00
308_D311_V1.3831.00
54_R262_E1.3821.00
71_N74_A1.3801.00
30_F44_A1.3691.00
29_R64_F1.3671.00
26_Q59_L1.3601.00
51_L255_A1.3601.00
304_N308_D1.3491.00
32_Y41_H1.3401.00
25_A58_E1.3261.00
30_F61_L1.3231.00
126_D130_A1.3201.00
112_D115_H1.3201.00
245_F253_Q1.3191.00
26_Q249_S1.3151.00
230_H295_R1.3141.00
25_A60_K1.3011.00
51_L256_L1.2991.00
59_L252_F1.2951.00
138_K245_F1.2861.00
151_T207_Q1.2711.00
58_E251_E1.2711.00
28_L85_D1.2681.00
47_F51_L1.2651.00
51_L61_L1.2591.00
181_K187_P1.2521.00
117_H272_A1.2501.00
161_A297_A1.2501.00
211_I279_I1.2491.00
190_M204_I1.2451.00
195_V204_I1.2351.00
258_S262_E1.2341.00
308_D312_K1.2241.00
218_K221_E1.2231.00
290_I294_D1.2201.00
75_M87_E1.2171.00
29_R62_K1.2171.00
190_M198_G1.2131.00
240_I244_K1.2081.00
253_Q257_V1.1921.00
243_A246_D1.1861.00
98_S131_S1.1851.00
17_A20_T1.1671.00
254_Q257_V1.1631.00
305_Q308_D1.1591.00
79_V87_E1.1571.00
255_A259_S1.1491.00
158_K294_D1.1421.00
151_T223_Q1.1411.00
159_T162_D1.1321.00
14_G17_A1.1301.00
158_K162_D1.1211.00
114_A118_K1.1201.00
259_S262_E1.1201.00
211_I228_L1.1161.00
13_A16_A1.1141.00
168_I206_A1.1081.00
79_V241_N1.1041.00
156_P225_F1.1031.00
48_N61_L1.1021.00
64_F69_L1.0951.00
215_W278_I1.0901.00
31_G84_I1.0861.00
36_Q45_K1.0831.00
265_N269_K1.0821.00
32_Y63_L1.0811.00
125_G129_K1.0761.00
59_L256_L1.0721.00
130_A134_G1.0651.00
266_Y269_K1.0551.00
43_A267_Q1.0491.00
259_S263_A1.0481.00
143_W263_A1.0431.00
278_I281_G1.0431.00
28_L86_M1.0431.00
182_V309_M1.0431.00
50_L266_Y1.0241.00
137_L239_V1.0241.00
141_A264_G1.0221.00
127_D130_A1.0211.00
151_T214_V1.0191.00
12_I15_L1.0181.00
314_V317_G1.0091.00
319_D322_K1.0091.00
319_D323_A1.0071.00
279_I289_V1.0051.00
11_F14_G1.0041.00
297_A301_A1.0041.00
138_K246_D0.9971.00
150_V229_T0.9921.00
282_M287_V0.9871.00
101_M132_L0.9831.00
166_L206_A0.9721.00
64_F68_T0.9691.00
48_N51_L0.9641.00
36_Q66_D0.9631.00
292_D296_K0.9621.00
211_I226_L0.9531.00
140_L260_A0.9531.00
224_K288_E0.9511.00
160_P298_F0.9481.00
240_I245_F0.9441.00
150_V180_F0.9391.00
117_H121_D0.9351.00
77_S97_L0.9341.00
178_A182_V0.9291.00
196_Y221_E0.9271.00
283_K289_V0.9271.00
110_F119_T0.9251.00
130_A319_D0.9221.00
309_M313_D0.9201.00
55_T252_F0.9151.00
123_K323_A0.9141.00
262_E266_Y0.9131.00
149_D228_L0.9111.00
29_R85_D0.9071.00
115_H118_K0.9071.00
51_L59_L0.9021.00
82_G85_D0.8961.00
131_S134_G0.8951.00
277_K280_D0.8941.00
272_A276_Q0.8881.00
151_T226_L0.8841.00
136_G243_A0.8811.00
37_T41_H0.8811.00
192_F217_A0.8751.00
309_M312_K0.8721.00
58_E249_S0.8671.00
95_A102_N0.8641.00
263_A266_Y0.8631.00
307_R311_V0.8621.00
197_T201_T0.8601.00
22_S25_A0.8581.00
42_I45_K0.8531.00
129_K133_E0.8481.00
163_L185_A0.8471.00
126_D129_K0.8471.00
28_L256_L0.8461.00
77_S81_G0.8391.00
302_L305_Q0.8381.00
117_H268_R0.8371.00
30_F86_M0.8361.00
98_S101_M0.8351.00
46_K262_E0.8351.00
78_G83_T0.8331.00
23_L26_Q0.8331.00
301_A305_Q0.8311.00
207_Q223_Q0.8311.00
261_Q265_N0.8291.00
154_R224_K0.8271.00
293_L297_A0.8191.00
123_K127_D0.8181.00
45_K63_L0.8181.00
167_K186_N0.8161.00
48_N60_K0.8121.00
47_F61_L0.8051.00
47_F256_L0.8041.00
183_F302_L0.8031.00
243_A247_G0.8011.00
293_L296_K0.7991.00
32_Y65_P0.7981.00
30_F238_V0.7961.00
214_V226_L0.7961.00
75_M84_I0.7931.00
46_K263_A0.7901.00
261_Q264_G0.7891.00
111_R299_S0.7881.00
238_V260_A0.7871.00
16_A19_S0.7871.00
276_Q279_I0.7821.00
168_I185_A0.7821.00
148_R208_E0.7801.00
129_K138_K0.7791.00
65_P68_T0.7761.00
159_T294_D0.7751.00
255_A258_S0.7701.00
177_I181_K0.7671.00
78_G84_I0.7541.00
136_G242_K0.7541.00
28_L59_L0.7531.00
226_L289_V0.7521.00
37_T42_I0.7511.00
163_L298_F0.7511.00
156_P227_S0.7501.00
157_V162_D0.7451.00
178_A310_F0.7431.00
311_V321_L0.7391.00
157_V163_L0.7371.00
91_S237_L0.7361.00
52_Q55_T0.7361.00
52_Q57_G0.7351.00
86_M256_L0.7331.00
36_Q41_H0.7301.00
59_L255_A0.7301.00
122_G125_G0.7291.00
73_Q172_N0.7201.00
211_I278_I0.7181.00
227_S290_I0.7181.00
182_V306_V0.7181.00
10_L15_L0.7181.00
26_Q247_G0.7151.00
7_T10_L0.7151.00
17_A21_S0.7141.00
90_G234_S0.7131.00
183_F301_A0.7121.00
149_D226_L0.7121.00
244_K248_L0.7121.00
99_P313_D0.7091.00
28_L240_I0.7091.00
76_I137_L0.7071.00
194_E197_T0.7041.00
42_I270_L0.7031.00
164_K184_G0.6981.00
79_V137_L0.6931.00
139_V237_L0.6911.00
142_Y238_V0.6891.00
26_Q244_K0.6871.00
148_R232_A0.6861.00
199_L223_Q0.6820.99
304_N307_R0.6820.99
150_V157_V0.6790.99
220_F287_V0.6780.99
9_A12_I0.6780.99
38_D41_H0.6780.99
22_S26_Q0.6770.99
311_V322_K0.6730.99
252_F255_A0.6710.99
47_F263_A0.6700.99
18_F22_S0.6700.99
42_I274_D0.6680.99
262_E265_N0.6670.99
224_K287_V0.6660.99
299_S304_N0.6640.99
127_D319_D0.6640.99
51_L259_S0.6630.99
197_T200_E0.6590.99
242_K245_F0.6570.99
192_F213_V0.6570.99
52_Q61_L0.6560.99
36_Q65_P0.6530.99
168_I180_F0.6520.99
133_E246_D0.6510.99
70_G75_M0.6510.99
153_S206_A0.6480.99
103_L324_V0.6480.99
59_L248_L0.6460.99
31_G70_G0.6450.99
41_H65_P0.6450.99
141_A260_A0.6420.99
251_E254_Q0.6420.99
113_T272_A0.6410.99
15_L19_S0.6390.99
44_A63_L0.6370.99
170_T176_N0.6360.99
158_K291_T0.6340.99
164_K301_A0.6340.99
115_H119_T0.6330.99
310_F313_D0.6300.99
150_V163_L0.6280.99
98_S135_K0.6280.99
241_N247_G0.6270.99
24_A58_E0.6250.99
244_K256_L0.6240.99
20_T23_L0.6230.99
179_A302_L0.6230.99
47_F259_S0.6230.99
42_I266_Y0.6220.99
61_L256_L0.6220.99
114_A117_H0.6210.99
179_A306_V0.6200.99
150_V168_I0.6200.99
132_L139_V0.6200.99
300_D305_Q0.6170.99
167_K205_D0.6150.99
207_Q219_F0.6140.99
273_E276_Q0.6110.99
163_L183_F0.6090.99
146_G275_Q0.6050.99
92_N171_N0.6040.99
180_F208_E0.6040.99
170_T177_I0.6030.99
28_L61_L0.6020.99
69_L84_I0.6020.99
58_E255_A0.6020.99
274_D278_I0.6010.99
16_A20_T0.6000.99
192_F195_V0.6000.99
79_V239_V0.5990.99
170_T180_F0.5980.99
161_A301_A0.5970.99
215_W220_F0.5970.99
122_G126_D0.5970.99
61_L86_M0.5960.99
73_Q97_L0.5950.99
176_N232_A0.5940.99
28_L248_L0.5940.99
194_E203_T0.5940.99
195_V207_Q0.5930.99
302_L307_R0.5930.99
208_E231_H0.5910.99
113_T117_H0.5870.98
19_S23_L0.5850.98
8_Y14_G0.5830.98
30_F88_M0.5820.98
248_L256_L0.5810.98
248_L252_F0.5800.98
198_G203_T0.5800.98
223_Q287_V0.5790.98
8_Y13_A0.5780.98
100_V317_G0.5780.98
112_D118_K0.5770.98
198_G204_I0.5760.98
46_K270_L0.5750.98
9_A14_G0.5740.98
122_G127_D0.5740.98
177_I187_P0.5730.98
182_V301_A0.5720.98
290_I295_R0.5720.98
159_T297_A0.5710.98
55_T58_E0.5710.98
228_L289_V0.5700.98
33_E89_S0.5700.98
215_W285_A0.5660.98
86_M238_V0.5650.98
106_V307_R0.5630.98
197_T203_T0.5620.98
252_F256_L0.5620.98
10_L13_A0.5620.98
26_Q58_E0.5610.98
15_L20_T0.5610.98
117_H144_E0.5590.98
42_I46_K0.5570.98
143_W264_G0.5540.98
174_P178_A0.5540.98
258_S261_Q0.5540.98
290_I293_L0.5520.98
190_M195_V0.5500.98
176_N179_A0.5500.98
209_H214_V0.5490.98
138_K253_Q0.5490.98
154_R205_D0.5470.98
188_I204_I0.5420.97
41_H63_L0.5410.97
79_V86_M0.5410.97
215_W282_M0.5400.97
114_A272_A0.5390.97
150_V290_I0.5380.97
153_S223_Q0.5380.97
306_V309_M0.5380.97
80_R136_G0.5370.97
269_K272_A0.5370.97
53_E56_K0.5320.97
147_W233_Y0.5320.97
25_A62_K0.5310.97
43_A263_A0.5310.97
56_K251_E0.5300.97
73_Q77_S0.5290.97
245_F256_L0.5280.97
14_G18_F0.5270.97
270_L274_D0.5270.97
196_Y200_E0.5270.97
227_S293_L0.5250.97
144_E233_Y0.5250.97
11_F15_L0.5250.97
214_V287_V0.5250.97
192_F219_F0.5240.97
149_D211_I0.5240.97
317_G320_L0.5220.97
144_E268_R0.5220.97
200_E222_V0.5190.97
45_K65_P0.5170.97
110_F116_A0.5160.97
182_V302_L0.5130.96
103_L320_L0.5130.96
43_A46_K0.5120.96
11_F16_A0.5110.96
294_D298_F0.5090.96
67_S71_N0.5090.96
124_V127_D0.5070.96
108_F229_T0.5070.96
121_D261_Q0.5060.96
320_L324_V0.5050.96
19_S22_S0.5020.96
127_D131_S0.5020.96
174_P313_D0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3u65B 1 0.9116 100 0.172 Contact Map
2xwvA 1 0.9146 100 0.196 Contact Map
4xeqA 1 0.9146 100 0.199 Contact Map
4nguA 1 0.9207 100 0.199 Contact Map
4ovsA 1 0.9207 100 0.2 Contact Map
4ovqA 1 0.9207 100 0.202 Contact Map
4pddA 1 0.9146 100 0.203 Contact Map
4pakA 1 0.9238 100 0.204 Contact Map
4o94A 1 0.9177 100 0.205 Contact Map
4ovrA 1 0.9116 100 0.205 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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