GREMLIN Database
YIAN - 2,3-diketo-L-gulonate TRAP transporter large permease protein YiaN
UniProt: P37675 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12282
Length: 425 (415)
Sequences: 8496 (5346)
Seq/√Len: 262.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
102_M182_G4.5301.00
127_R133_V4.2641.00
320_M364_N3.9521.00
229_G235_F3.4091.00
260_T263_T3.1631.00
184_T406_L2.9751.00
311_S314_L2.7671.00
397_F401_L2.6651.00
95_Y186_M2.6531.00
188_T402_V2.5521.00
160_G167_I2.4761.00
134_N391_D2.4271.00
71_A266_H2.4261.00
315_L350_A2.3661.00
150_I178_G2.3651.00
115_T381_I2.3271.00
80_D215_S2.2981.00
95_Y190_W2.2941.00
309_V314_L2.2481.00
191_W195_R2.2471.00
156_F359_V2.2331.00
67_E270_G2.2271.00
90_P194_S2.2191.00
163_S344_M2.2011.00
320_M411_V2.1951.00
25_L284_S2.1811.00
97_G140_I2.1681.00
179_M183_A2.1651.00
388_K391_D2.1181.00
98_V189_W2.0931.00
192_Q196_L2.0921.00
321_V325_I2.0781.00
348_K354_P2.0541.00
325_I329_V2.0031.00
88_H203_K1.9971.00
207_Q211_H1.9771.00
184_T402_V1.9761.00
205_T208_E1.9481.00
408_V412_F1.9241.00
162_S336_V1.9241.00
214_V218_W1.9191.00
316_F411_V1.9091.00
211_H214_V1.9041.00
81_L213_F1.8901.00
415_D419_L1.8871.00
210_W214_V1.8791.00
67_E271_A1.8741.00
88_H204_A1.8391.00
235_F243_V1.8371.00
138_G395_G1.8231.00
165_L355_I1.8111.00
76_K80_D1.8071.00
347_V357_F1.8001.00
326_V335_T1.7871.00
269_I273_K1.7861.00
116_A380_V1.7711.00
160_G170_L1.7451.00
262_A265_W1.7421.00
190_W194_S1.7371.00
83_M129_A1.7321.00
225_I247_Y1.7321.00
88_H209_I1.7071.00
125_M128_S1.6991.00
71_A263_T1.6951.00
265_W269_I1.6931.00
206_M209_I1.6751.00
317_I321_V1.6661.00
85_L209_I1.6631.00
173_A417_I1.6521.00
315_L319_I1.6491.00
415_D418_I1.6381.00
28_G287_V1.6271.00
401_L405_S1.6271.00
123_V385_A1.6221.00
315_L347_V1.5861.00
335_T365_C1.5821.00
364_N407_L1.5701.00
310_D314_L1.5651.00
94_G189_W1.5581.00
250_F254_V1.5481.00
300_M303_D1.5411.00
312_P352_I1.5411.00
187_L191_W1.5381.00
77_R258_E1.5301.00
76_K258_E1.5171.00
363_I410_F1.5101.00
391_D394_R1.5001.00
64_L268_L1.4921.00
84_K88_H1.4801.00
135_R189_W1.4651.00
320_M360_M1.4631.00
68_I245_A1.4631.00
106_S114_D1.4601.00
68_I252_A1.4541.00
204_A209_I1.4541.00
176_A416_L1.4531.00
409_V413_I1.4501.00
413_I416_L1.4461.00
313_R317_I1.4381.00
410_F417_I1.4361.00
123_V140_I1.4241.00
261_F265_W1.4241.00
317_I408_V1.4201.00
111_A377_V1.3991.00
351_G354_P1.3931.00
185_L403_L1.3801.00
86_V99_L1.3701.00
206_M210_W1.3621.00
132_P196_L1.3561.00
84_K212_S1.3561.00
137_A387_L1.3551.00
4_L8_G1.3511.00
172_M420_P1.3511.00
316_F360_M1.3511.00
112_V380_V1.3451.00
323_I361_F1.3411.00
319_I347_V1.3371.00
183_A187_L1.3301.00
159_F358_G1.3281.00
134_N395_G1.3271.00
210_W213_F1.3261.00
340_T361_F1.3251.00
222_L248_A1.3231.00
344_M348_K1.3221.00
137_A392_A1.3101.00
378_L393_V1.3091.00
73_G77_R1.3091.00
204_A208_E1.3051.00
222_L247_Y1.2981.00
94_G139_L1.2921.00
61_F242_A1.2901.00
72_G252_A1.2901.00
8_G12_G1.2881.00
119_A384_V1.2881.00
98_V143_G1.2871.00
163_S340_T1.2851.00
158_I333_T1.2801.00
387_L392_A1.2721.00
68_I249_L1.2691.00
61_F241_G1.2661.00
266_H270_G1.2661.00
211_H215_S1.2651.00
188_T192_Q1.2571.00
390_D394_R1.2521.00
176_A419_L1.2511.00
302_S306_Q1.2451.00
207_Q210_W1.2421.00
303_D307_P1.2271.00
169_K355_I1.2221.00
142_S370_I1.2211.00
296_E299_M1.2171.00
347_V352_I1.2141.00
77_R215_S1.2111.00
173_A177_P1.2101.00
79_V122_L1.2061.00
64_L68_I1.2031.00
326_V339_L1.2021.00
141_A381_I1.2001.00
299_M303_D1.1901.00
133_V391_D1.1891.00
102_M179_M1.1761.00
214_V217_I1.1741.00
148_P366_S1.1691.00
14_I17_G1.1591.00
303_D306_Q1.1531.00
118_V122_L1.1481.00
254_V259_M1.1461.00
352_I360_M1.1451.00
304_L308_L1.1321.00
323_I339_L1.1311.00
68_I267_V1.1241.00
224_V228_G1.1221.00
217_I221_F1.1071.00
181_M403_L1.1031.00
317_I320_M1.1011.00
156_F174_G1.0971.00
11_L15_A1.0961.00
132_P198_L1.0951.00
119_A123_V1.0941.00
21_A280_F1.0941.00
254_V257_R1.0931.00
76_K125_M1.0931.00
313_R320_M1.0911.00
218_W255_I1.0901.00
313_R412_F1.0871.00
304_L307_P1.0841.00
99_L186_M1.0811.00
404_Y408_V1.0801.00
144_G377_V1.0791.00
111_A366_S1.0731.00
77_R256_Y1.0731.00
356_Y417_I1.0721.00
319_I343_L1.0721.00
64_L271_A1.0711.00
262_A266_H1.0711.00
300_M304_L1.0701.00
46_T290_W1.0681.00
193_A198_L1.0671.00
409_V416_L1.0671.00
181_M406_L1.0651.00
73_G76_K1.0641.00
47_L283_A1.0631.00
309_V312_P1.0611.00
186_M190_W1.0611.00
175_I179_M1.0611.00
138_G396_V1.0611.00
135_R399_Y1.0601.00
84_K209_I1.0591.00
305_L346_L1.0561.00
227_I231_R1.0531.00
313_R352_I1.0531.00
134_N394_R1.0511.00
367_I407_L1.0481.00
124_P128_S1.0471.00
23_A27_C1.0431.00
137_A385_A1.0421.00
263_T266_H1.0371.00
125_M129_A1.0351.00
382_S389_F1.0341.00
296_E300_M1.0321.00
405_S409_V1.0321.00
252_A259_M1.0301.00
101_A143_G1.0261.00
90_P190_W1.0231.00
315_L352_I1.0191.00
101_A118_V1.0191.00
81_L216_G1.0101.00
80_D212_S1.0071.00
259_M267_V1.0071.00
364_N411_V1.0031.00
105_A147_A1.0011.00
149_I181_M1.0001.00
412_F415_D1.0001.00
104_M119_A0.9961.00
290_W294_I0.9941.00
165_L354_P0.9881.00
230_F240_A0.9871.00
322_A343_L0.9841.00
115_T144_G0.9831.00
80_D83_M0.9831.00
260_T265_W0.9821.00
340_T344_M0.9741.00
123_V136_A0.9731.00
65_A244_A0.9731.00
313_R411_V0.9721.00
156_F362_I0.9631.00
264_L268_L0.9601.00
135_R139_L0.9581.00
160_G165_L0.9581.00
196_L395_G0.9541.00
155_P336_V0.9531.00
85_L213_F0.9491.00
110_S154_I0.9471.00
176_A180_M0.9451.00
115_T377_V0.9421.00
102_M150_I0.9411.00
26_L30_A0.9401.00
159_F344_M0.9391.00
344_M354_P0.9351.00
98_V185_L0.9331.00
14_I20_I0.9301.00
395_G398_P0.9291.00
309_V315_L0.9291.00
221_F225_I0.9291.00
18_L23_A0.9241.00
172_M175_I0.9181.00
205_T209_I0.9181.00
275_T279_M0.9171.00
184_T405_S0.9171.00
388_K393_V0.9161.00
229_G243_V0.9161.00
213_F217_I0.9131.00
323_I343_L0.9121.00
194_S197_N0.9111.00
389_F393_V0.9061.00
133_V387_L0.9051.00
320_M407_L0.9051.00
93_L129_A0.8951.00
309_V318_V0.8901.00
180_M409_V0.8891.00
94_G126_M0.8851.00
221_F224_V0.8741.00
5_I9_C0.8741.00
98_V182_G0.8731.00
76_K128_S0.8711.00
13_G23_A0.8661.00
352_I357_F0.8661.00
68_I248_A0.8641.00
81_L212_S0.8631.00
382_S386_K0.8581.00
12_G15_A0.8571.00
188_T399_Y0.8571.00
71_A270_G0.8531.00
218_W251_V0.8531.00
176_A420_P0.8531.00
9_C30_A0.8501.00
81_L85_L0.8491.00
328_M371_T0.8480.99
208_E212_S0.8450.99
343_L357_F0.8440.99
50_G286_Q0.8430.99
46_T49_N0.8390.99
51_A283_A0.8370.99
101_A104_M0.8360.99
85_L206_M0.8350.99
137_A381_I0.8340.99
413_I417_I0.8320.99
203_K208_E0.8310.99
73_G258_E0.8280.99
159_F165_L0.8280.99
416_L419_L0.8260.99
331_D334_P0.8230.99
25_L287_V0.8230.99
317_I412_F0.8220.99
219_A251_V0.8220.99
336_V340_T0.8190.99
266_H269_I0.8180.99
249_L264_L0.8170.99
9_C13_G0.8160.99
101_A114_D0.8150.99
102_M146_I0.8130.99
80_D84_K0.8130.99
10_L27_C0.8120.99
180_M416_L0.8120.99
24_L288_S0.8100.99
260_T267_V0.8090.99
316_F352_I0.8090.99
305_L315_L0.8050.99
263_T267_V0.8040.99
173_A359_V0.8000.99
28_G291_L0.7990.99
48_V52_D0.7970.99
204_A212_S0.7970.99
83_M201_Q0.7950.99
67_E70_N0.7950.99
181_M363_I0.7910.99
209_I212_S0.7910.99
129_A201_Q0.7900.99
84_K208_E0.7900.99
175_I420_P0.7890.99
90_P197_N0.7890.99
94_G135_R0.7840.99
191_W194_S0.7830.99
141_A370_I0.7810.99
80_D208_E0.7780.99
9_C27_C0.7780.99
146_I182_G0.7780.99
208_E211_H0.7760.99
178_G182_G0.7730.99
251_V255_I0.7720.99
123_V384_V0.7720.99
145_I403_L0.7720.99
100_A118_V0.7710.99
259_M263_T0.7680.99
165_L169_K0.7670.99
213_F216_G0.7620.99
352_I356_Y0.7610.99
111_A148_P0.7600.99
18_L22_W0.7590.99
13_G26_L0.7580.99
322_A326_V0.7560.99
139_L189_W0.7560.99
139_L143_G0.7560.99
111_A145_I0.7540.99
355_I418_I0.7510.99
182_G186_M0.7480.99
387_L391_D0.7470.99
84_K204_A0.7460.99
104_M118_V0.7460.99
148_P332_L0.7430.99
374_I379_N0.7390.99
165_L358_G0.7380.99
180_M406_L0.7370.99
95_Y193_A0.7340.99
21_A284_S0.7330.99
308_L311_S0.7320.99
250_F255_I0.7320.99
65_A226_I0.7300.98
135_R193_A0.7300.98
184_T409_V0.7290.98
311_S315_L0.7280.98
332_L365_C0.7260.98
70_N75_S0.7250.98
314_L317_I0.7240.98
97_G143_G0.7230.98
25_L29_A0.7220.98
105_A148_P0.7210.98
110_S113_A0.7210.98
193_A197_N0.7210.98
47_L284_S0.7210.98
289_A338_I0.7200.98
216_G219_A0.7190.98
10_L14_I0.7180.98
230_F237_P0.7180.98
249_L267_V0.7170.98
90_P200_R0.7150.98
316_F320_M0.7150.98
324_L367_I0.7150.98
219_A256_Y0.7090.98
396_V400_V0.7060.98
332_L369_L0.7050.98
148_P155_P0.7040.98
406_L410_F0.7010.98
80_D211_H0.7010.98
289_A334_P0.6990.98
31_L295_A0.6980.98
309_V350_A0.6980.98
225_I229_G0.6950.98
134_N387_L0.6940.98
408_V411_V0.6930.98
306_Q350_A0.6910.98
135_R198_L0.6910.98
203_K206_M0.6900.98
402_V405_S0.6890.98
298_P302_S0.6880.98
184_T187_L0.6870.98
156_F160_G0.6820.98
106_S231_R0.6810.98
6_F31_L0.6810.98
225_I243_V0.6800.98
63_V274_T0.6760.98
371_T400_V0.6750.97
22_W26_L0.6750.97
344_M347_V0.6740.97
134_N137_A0.6740.97
42_I290_W0.6710.97
31_L291_L0.6690.97
108_S114_D0.6680.97
363_I417_I0.6670.97
43_M47_L0.6660.97
127_R136_A0.6650.97
168_S172_M0.6640.97
324_L404_Y0.6640.97
236_T239_E0.6630.97
106_S150_I0.6620.97
331_D376_N0.6620.97
145_I369_L0.6620.97
198_L201_Q0.6610.97
292_I297_L0.6590.97
114_D147_A0.6550.97
14_I23_A0.6530.97
175_I419_L0.6520.97
360_M411_V0.6500.97
406_L409_V0.6500.97
320_M408_V0.6500.97
305_L322_A0.6440.97
302_S346_L0.6430.97
403_L406_L0.6420.97
378_L389_F0.6400.97
363_I403_L0.6390.97
269_I272_A0.6380.96
159_F340_T0.6370.96
315_L346_L0.6360.96
271_A275_T0.6350.96
13_G18_L0.6350.96
44_A47_L0.6340.96
332_L376_N0.6330.96
126_M140_I0.6320.96
45_Q49_N0.6320.96
392_A395_G0.6310.96
95_Y189_W0.6300.96
202_Q205_T0.6290.96
87_G92_G0.6270.96
169_K172_M0.6230.96
88_H202_Q0.6200.96
162_S337_L0.6200.96
382_S392_A0.6200.96
371_T374_I0.6200.96
312_P350_A0.6190.96
60_P64_L0.6180.96
132_P192_Q0.6170.96
24_L285_A0.6160.96
378_L392_A0.6140.96
82_P96_V0.6120.96
105_A178_G0.6120.96
314_L318_V0.6090.95
47_L287_V0.6090.95
363_I406_L0.6080.95
201_Q204_A0.6070.95
119_A147_A0.6060.95
29_A33_F0.6060.95
348_K352_I0.6050.95
111_A369_L0.6040.95
71_A267_V0.6040.95
59_I154_I0.6030.95
378_L396_V0.6030.95
313_R316_F0.6010.95
133_V385_A0.6000.95
228_G232_S0.6000.95
391_D395_G0.5990.95
89_K95_Y0.5970.95
84_K205_T0.5960.95
174_G362_I0.5960.95
6_F291_L0.5950.95
64_L245_A0.5930.95
289_A296_E0.5930.95
162_S334_P0.5930.95
332_L374_I0.5910.95
86_V89_K0.5910.95
139_L185_L0.5900.95
43_M287_V0.5890.95
155_P332_L0.5890.95
204_A207_Q0.5890.95
162_S340_T0.5880.95
150_I182_G0.5880.95
140_I144_G0.5880.95
170_L358_G0.5870.94
181_M185_L0.5870.94
370_I400_V0.5860.94
306_Q309_V0.5860.94
246_F250_F0.5850.94
215_S218_W0.5840.94
258_E263_T0.5810.94
146_I185_L0.5800.94
115_T141_A0.5800.94
126_M139_L0.5790.94
306_Q346_L0.5780.94
383_G386_K0.5770.94
193_A199_P0.5770.94
267_V271_A0.5770.94
114_D144_G0.5710.94
67_E71_A0.5710.94
366_S377_V0.5710.94
22_W280_F0.5680.93
184_T188_T0.5670.93
42_I45_Q0.5660.93
327_G371_T0.5660.93
331_D368_G0.5650.93
366_S370_I0.5630.93
352_I411_V0.5610.93
347_V351_G0.5600.93
291_L295_A0.5590.93
89_K190_W0.5590.93
180_M410_F0.5570.93
50_G283_A0.5570.93
342_V345_P0.5520.92
261_F264_L0.5520.92
323_I335_T0.5510.92
405_S413_I0.5510.92
277_V383_G0.5500.92
157_I171_F0.5490.92
99_L102_M0.5490.92
192_Q198_L0.5480.92
268_L271_A0.5470.92
142_S145_I0.5460.92
307_P310_D0.5460.92
192_Q195_R0.5460.92
166_S169_K0.5460.92
79_V124_P0.5460.92
218_W256_Y0.5440.92
169_K353_D0.5440.92
68_I264_L0.5430.92
318_V322_A0.5430.92
209_I213_F0.5420.92
223_P227_I0.5410.92
226_I244_A0.5400.92
101_A140_I0.5390.92
314_L412_F0.5380.91
292_I298_P0.5380.91
66_G75_S0.5380.91
310_D315_L0.5370.91
88_H206_M0.5360.91
12_G16_I0.5340.91
85_L88_H0.5330.91
63_V275_T0.5330.91
122_L143_G0.5320.91
27_C30_A0.5320.91
276_S279_M0.5320.91
161_V167_I0.5320.91
115_T384_V0.5310.91
394_R398_P0.5310.91
405_S408_V0.5310.91
205_T210_W0.5300.91
82_P86_V0.5300.91
394_R397_F0.5280.91
66_G117_A0.5280.91
159_F170_L0.5280.91
92_G96_V0.5280.91
105_A366_S0.5260.91
257_R260_T0.5260.91
191_W196_L0.5230.90
279_M282_V0.5230.90
101_A105_A0.5230.90
65_A222_L0.5230.90
28_G284_S0.5230.90
302_S349_E0.5220.90
331_D369_L0.5220.90
164_G169_K0.5200.90
136_A140_I0.5200.90
147_A231_R0.5190.90
119_A381_I0.5180.90
132_P197_N0.5180.90
115_T380_V0.5170.90
119_A385_A0.5170.90
148_P331_D0.5170.90
101_A159_F0.5160.90
79_V83_M0.5160.90
306_Q349_E0.5160.90
316_F364_N0.5150.90
359_V417_I0.5150.90
114_D140_I0.5150.90
57_L279_M0.5130.89
142_S396_V0.5130.89
35_L295_A0.5120.89
370_I396_V0.5120.89
24_L284_S0.5110.89
101_A144_G0.5110.89
381_I387_L0.5100.89
82_P103_I0.5090.89
232_S240_A0.5090.89
35_L38_F0.5090.89
139_L399_Y0.5070.89
6_F27_C0.5060.89
187_L190_W0.5050.89
251_V256_Y0.5050.89
381_I392_A0.5030.89
142_S185_L0.5020.88
268_L272_A0.5020.88
155_P362_I0.5010.88
112_V115_T0.5010.88
103_I227_I0.5010.88
5_I35_L0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r1iA 2 0.9624 100 0.661 Contact Map
4f35D 2 0.9106 100 0.691 Contact Map
4r0cA 3 0.9718 100 0.694 Contact Map
2l2tA 2 0.1035 7.8 0.978 Contact Map
2k1kA 2 0.0894 6.5 0.979 Contact Map
2ks1B 1 0.1035 5.9 0.979 Contact Map
2jwaA 2 0.0965 5.2 0.98 Contact Map
2m20A 2 0.1412 4.8 0.98 Contact Map
2l9uA 2 0.0941 4.2 0.98 Contact Map
4w6vA 1 0.4188 3.4 0.981 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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