GREMLIN Database
YIAL - Protein YiaL
UniProt: P37673 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12280
Length: 155 (149)
Sequences: 1158 (898)
Seq/√Len: 73.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_D44_N3.2031.00
44_N150_A3.1101.00
35_P51_D2.8711.00
4_G8_Q2.8391.00
51_D143_R2.6651.00
20_K41_D2.6031.00
47_T145_I2.5611.00
23_D27_A2.5101.00
29_D32_A2.4281.00
55_R60_N2.3941.00
46_Y68_Y2.3201.00
53_T141_E2.0971.00
135_I139_A2.0871.00
67_R150_A2.0241.00
39_E43_K1.9281.00
50_I146_V1.9021.00
5_H120_S1.8611.00
52_L133_G1.8531.00
82_G113_F1.8491.00
91_K106_H1.8301.00
69_I125_F1.7861.00
72_Q124_F1.7811.00
52_L142_I1.7801.00
37_V43_K1.7711.00
71_I149_V1.7451.00
131_R134_C1.6771.00
74_L118_P1.6761.00
54_T139_A1.6170.99
116_M122_A1.6150.99
40_I47_T1.6060.99
78_E117_I1.5960.99
67_R98_E1.5900.99
34_E38_V1.5580.99
62_P111_E1.5280.99
38_V49_I1.5250.99
42_G68_Y1.5240.99
81_I116_M1.4940.99
61_R94_E1.4710.99
71_I123_I1.4640.99
18_I22_L1.4440.99
64_V103_I1.4280.99
104_F132_P1.4230.99
76_W118_P1.4100.99
9_P22_L1.4090.99
80_K115_E1.4020.99
64_V105_Y1.4000.98
21_A147_V1.3820.98
66_R86_D1.3580.98
55_R59_V1.3570.98
24_F47_T1.3490.98
4_G121_Y1.3220.98
37_V46_Y1.3210.98
78_E140_S1.2920.97
39_E42_G1.2720.97
61_R104_F1.2580.97
49_I143_R1.2530.97
64_V129_V1.2480.97
56_E59_V1.2380.97
51_D141_E1.2260.96
18_I71_I1.2020.96
17_A45_I1.1970.96
4_G12_C1.1900.96
117_I120_S1.1800.96
96_L103_I1.1240.94
50_I133_G1.1180.94
81_I124_F1.1160.94
37_V48_Q1.1090.94
97_L100_R1.1030.94
24_F28_T1.0950.93
90_N129_V1.0890.93
2_I125_F1.0860.93
11_P127_Q1.0750.93
21_A71_I1.0650.93
22_L73_F1.0560.92
62_P129_V1.0550.92
13_R19_E1.0540.92
55_R133_G1.0510.92
72_Q81_I1.0500.92
66_R103_I1.0440.92
75_A145_I1.0440.92
64_V86_D1.0340.91
33_L49_I1.0340.91
81_I122_A1.0180.91
57_A113_F1.0100.90
60_N133_G1.0090.90
64_V128_D0.9790.89
94_E104_F0.9530.88
74_L77_G0.9500.87
50_I72_Q0.9460.87
15_P18_I0.9290.86
25_L73_F0.9210.86
35_P38_V0.9200.86
30_F33_L0.9140.85
19_E23_D0.9010.85
12_C121_Y0.8920.84
100_R143_R0.8780.83
72_Q132_P0.8490.81
4_G127_Q0.8400.80
114_I124_F0.8340.80
17_A118_P0.8320.80
54_T81_I0.8290.79
82_G111_E0.8290.79
66_R96_L0.8250.79
23_D26_R0.8240.79
36_G49_I0.8240.79
115_E136_M0.8180.78
47_T73_F0.8150.78
53_T139_A0.8030.77
93_S106_H0.8010.77
49_I72_Q0.7950.76
100_R104_F0.7870.76
10_N26_R0.7840.75
79_E116_M0.7750.74
54_T135_I0.7710.74
54_T142_I0.7700.74
60_N131_R0.7550.73
94_E97_L0.7540.72
133_G142_I0.7520.72
67_R106_H0.7410.71
72_Q122_A0.7360.71
49_I145_I0.7350.71
14_L18_I0.7300.70
61_R72_Q0.7300.70
80_K113_F0.7260.70
105_Y128_D0.7260.70
45_I149_V0.7240.69
83_I124_F0.7230.69
62_P131_R0.7010.67
54_T74_L0.6980.67
10_N19_E0.6970.66
40_I68_Y0.6970.66
72_Q146_V0.6930.66
66_R98_E0.6900.66
24_F40_I0.6890.66
41_D68_Y0.6830.65
20_K23_D0.6750.64
78_E115_E0.6740.64
66_R95_S0.6710.64
9_P71_I0.6660.63
42_G46_Y0.6650.63
18_I149_V0.6620.62
69_I126_P0.6600.62
95_S103_I0.6580.62
2_I8_Q0.6570.62
56_E135_I0.6500.61
9_P145_I0.6500.61
43_K150_A0.6490.61
61_R93_S0.6440.60
54_T79_E0.6430.60
82_G131_R0.6370.60
4_G15_P0.6360.59
36_G132_P0.6330.59
81_I92_V0.6320.59
46_Y50_I0.6300.59
26_R34_E0.6280.58
144_K148_K0.6280.58
89_N105_Y0.6240.58
116_M142_I0.6200.57
29_D33_L0.6190.57
54_T77_G0.6180.57
69_I72_Q0.6180.57
28_T33_L0.6150.57
20_K138_T0.6130.57
70_D130_H0.6110.56
13_R140_S0.6110.56
122_A128_D0.6010.55
35_P143_R0.5970.55
36_G143_R0.5970.55
37_V64_V0.5960.55
62_P104_F0.5950.54
78_E137_Q0.5920.54
52_L74_L0.5880.54
17_A44_N0.5870.53
9_P13_R0.5860.53
114_I122_A0.5860.53
25_L75_A0.5830.53
9_P12_C0.5820.53
78_E116_M0.5780.52
7_A10_N0.5770.52
40_I45_I0.5720.52
84_A105_Y0.5710.51
26_R132_P0.5680.51
21_A45_I0.5610.50
19_E44_N0.5600.50
93_S103_I0.5590.50
6_I73_F0.5570.50
2_I12_C0.5570.50
92_V106_H0.5530.49
124_F133_G0.5440.48
123_I149_V0.5430.48
58_V76_W0.5420.48
99_Q113_F0.5380.47
4_G17_A0.5380.47
77_G142_I0.5380.47
52_L64_V0.5340.47
28_T147_V0.5340.47
60_N81_I0.5330.47
43_K68_Y0.5330.47
99_Q123_I0.5330.47
71_I118_P0.5310.46
3_F16_A0.5290.46
59_V76_W0.5290.46
74_L116_M0.5270.46
74_L146_V0.5260.46
118_P142_I0.5250.46
65_H130_H0.5240.46
52_L62_P0.5220.45
42_G150_A0.5190.45
116_M124_F0.5160.45
65_H70_D0.5160.45
74_L142_I0.5150.44
63_E70_D0.5150.44
28_T31_N0.5150.44
16_A20_K0.5140.44
67_R100_R0.5120.44
72_Q133_G0.5100.44
61_R96_L0.5100.44
3_F34_E0.5090.44
3_F120_S0.5080.44
69_I151_L0.5030.43
80_K123_I0.5020.43
40_I147_V0.5010.43
135_I142_I0.5000.43
88_G91_K0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1s4cA 2 0.9871 100 0.069 Contact Map
4tsdB 2 0.9935 100 0.125 Contact Map
3gbgA 1 0.5677 40.5 0.928 Contact Map
4e2gA 2 0.6968 33 0.932 Contact Map
2gu9A 2 0.6452 32.8 0.932 Contact Map
4mv2A 2 0.7226 21.7 0.937 Contact Map
3cewA 2 0.6839 18.2 0.939 Contact Map
2arcA 2 0.6065 17.6 0.94 Contact Map
2j9iA 5 0.4387 17.6 0.94 Contact Map
3ht1A 2 0.7484 16.6 0.94 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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