GREMLIN Database
DLGD - 2,3-diketo-L-gulonate reductase
UniProt: P37672 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12279
Length: 332 (321)
Sequences: 2097 (1544)
Seq/√Len: 86.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
313_E317_N4.0371.00
68_K82_Q3.7221.00
124_G160_I3.7031.00
289_T305_H3.4061.00
81_A89_T3.3471.00
198_G212_I3.0771.00
62_I82_Q2.9791.00
200_D204_N2.9561.00
102_A130_K2.7601.00
192_Q207_K2.6761.00
323_D327_A2.5621.00
95_D126_Q2.5281.00
9_K31_E2.5091.00
110_A241_S2.4301.00
94_M127_A2.4081.00
208_E211_V2.3261.00
192_Q209_P2.3201.00
75_A104_H2.2841.00
16_L49_F2.2681.00
128_A162_A2.2331.00
72_S100_L2.2111.00
267_E270_K2.1481.00
74_G104_H2.1451.00
299_A309_T2.1431.00
161_V232_V2.0731.00
42_Y314_N2.0531.00
165_S282_Q2.0471.00
17_I23_S2.0411.00
8_L46_V2.0361.00
65_A82_Q2.0231.00
99_E103_D2.0151.00
312_A316_R2.0101.00
296_E299_A2.0011.00
38_E314_N1.9961.00
37_T42_Y1.9831.00
96_R99_E1.9801.00
311_L315_R1.9741.00
117_W120_G1.9341.00
314_N320_T1.9251.00
195_V207_K1.9131.00
13_N27_D1.8941.00
13_N17_I1.8581.00
167_P312_A1.8321.00
171_V228_G1.7981.00
201_D214_K1.7881.00
145_P217_R1.7811.00
125_W129_E1.7791.00
10_A14_R1.7781.00
90_A263_F1.7501.00
30_A34_A1.7501.00
187_R210_G1.7291.00
131_G278_D1.7241.00
178_F197_G1.6961.00
98_I130_K1.6931.00
200_D211_V1.6741.00
70_I80_D1.6431.00
97_A107_G1.6411.00
48_R181_G1.6241.00
117_W136_C1.6111.00
97_A265_A1.6111.00
5_F38_E1.5821.00
127_A265_A1.5781.00
102_A132_Y1.5671.00
145_P199_F1.5631.00
162_A170_M1.5561.00
134_G162_A1.5371.00
74_G100_L1.5311.00
156_T175_M1.5251.00
80_D113_N1.5121.00
199_F217_R1.5081.00
77_E109_V1.5061.00
132_Y268_V1.4960.99
77_E107_G1.4940.99
193_L197_G1.4820.99
62_I65_A1.4790.99
295_D299_A1.4760.99
144_M176_S1.4540.99
13_N23_S1.4420.99
29_C85_I1.4380.99
94_M126_Q1.3880.99
289_T299_A1.3870.99
39_S311_L1.3840.99
179_S182_M1.3700.99
65_A84_S1.3590.99
91_K126_Q1.3550.99
193_L212_I1.3430.99
108_L264_I1.3410.99
235_M281_L1.3350.99
134_G265_A1.3310.99
28_A91_K1.3290.99
243_G260_S1.3270.99
159_L233_L1.3210.99
135_I264_I1.3180.99
106_I264_I1.3180.99
69_R79_W1.3130.99
97_A109_V1.3000.99
38_E315_R1.3000.99
83_R113_N1.2990.99
77_E96_R1.2920.99
25_T88_L1.2840.98
186_N193_L1.2820.98
94_M265_A1.2790.98
15_V53_I1.2730.98
23_S27_D1.2630.98
107_G265_A1.2620.98
96_R100_L1.2610.98
244_A258_G1.2550.98
98_I132_Y1.2540.98
114_A261_Q1.2510.98
206_T212_I1.2500.98
12_F49_F1.2380.98
44_H116_H1.2270.98
73_L270_K1.2250.98
310_L314_N1.2110.98
69_R77_E1.2080.98
21_V85_I1.2040.98
108_L262_I1.2040.98
210_G214_K1.1990.98
101_A107_G1.1960.98
32_M87_N1.1850.97
80_D112_R1.1740.97
286_D290_S1.1710.97
198_G206_T1.1700.97
61_I115_N1.1690.97
14_R17_I1.1570.97
19_R53_I1.1540.97
237_A260_S1.1530.97
274_G278_D1.1520.97
56_L63_P1.1480.97
193_L198_G1.1420.97
101_A132_Y1.1390.97
169_T231_I1.1250.96
268_V273_D1.1240.96
12_F16_L1.1210.96
301_R307_F1.1080.96
322_D325_V1.1010.96
77_E100_L1.1000.96
309_T313_E1.0960.96
78_Q112_R1.0940.96
76_I271_L1.0940.96
301_R306_E1.0940.96
43_S182_M1.0930.96
113_N258_G1.0910.96
9_K27_D1.0870.96
166_T279_A1.0850.96
70_I78_Q1.0740.95
138_T261_Q1.0710.95
77_E97_A1.0700.95
163_I232_V1.0670.95
140_S143_V1.0660.95
301_R309_T1.0620.95
285_M289_T1.0580.95
54_Q58_N1.0570.95
108_L266_I1.0560.95
98_I101_A1.0490.95
16_L29_C1.0440.95
98_I102_A1.0420.94
180_Y213_E1.0410.94
5_F34_A1.0400.94
186_N191_R1.0340.94
295_D298_Q1.0300.94
187_R209_P1.0270.94
124_G136_C1.0250.94
166_T282_Q1.0200.94
159_L229_M1.0170.94
4_T7_Q1.0160.94
98_I127_A1.0020.93
22_D64_D1.0020.93
154_I230_S1.0010.93
166_T278_D0.9960.93
137_W233_L0.9910.93
102_A267_E0.9910.93
12_F46_V0.9900.93
124_G162_A0.9870.93
25_T66_Q0.9770.92
173_M228_G0.9730.92
12_F30_A0.9710.92
8_L319_I0.9690.92
67_P82_Q0.9680.92
321_V326_W0.9610.92
192_Q208_E0.9610.92
92_K95_D0.9600.92
310_L313_E0.9570.92
8_L321_V0.9570.92
183_L271_L0.9550.91
306_E310_L0.9530.91
312_A315_R0.9520.91
136_C263_F0.9520.91
282_Q286_D0.9510.91
73_L267_E0.9410.91
66_Q92_K0.9400.91
147_W227_S0.9400.91
108_L271_L0.9360.91
143_V180_Y0.9360.91
146_P227_S0.9340.91
169_T285_M0.9320.90
125_W170_M0.9300.90
116_H181_G0.9290.90
94_M134_G0.9270.90
183_L212_I0.9220.90
93_M109_V0.9160.90
69_R96_R0.9070.89
121_G124_G0.9060.89
35_R311_L0.9030.89
69_R92_K0.9020.89
9_K13_N0.9000.89
19_R57_E0.8990.89
195_V205_L0.8950.89
231_I284_I0.8920.88
31_E122_S0.8920.88
46_V325_V0.8910.88
26_A30_A0.8900.88
11_A15_V0.8870.88
22_D25_T0.8850.88
144_M175_M0.8810.88
81_A111_L0.8710.87
178_F182_M0.8670.87
282_Q285_M0.8650.87
95_D99_E0.8640.87
300_I305_H0.8620.87
27_D31_E0.8580.86
5_F315_R0.8580.86
117_W261_Q0.8480.86
248_E287_Y0.8440.85
188_L328_K0.8410.85
6_E10_A0.8400.85
320_T323_D0.8360.85
285_M302_L0.8360.85
5_F319_I0.8340.85
206_T211_V0.8310.85
127_A134_G0.8300.85
111_L261_Q0.8260.84
154_I231_I0.8260.84
68_K80_D0.8240.84
153_R287_Y0.8200.84
140_S155_G0.8140.83
234_D238_T0.8140.83
95_D130_K0.8100.83
100_L107_G0.8060.83
165_S285_M0.8040.83
101_A265_A0.8040.83
39_S125_W0.8020.82
163_I277_R0.8010.82
268_V272_I0.7970.82
125_W311_L0.7970.82
149_A227_S0.7970.82
90_A117_W0.7970.82
175_M221_M0.7970.82
97_A127_A0.7950.82
196_D219_L0.7910.82
67_P79_W0.7900.82
81_A114_A0.7880.81
227_S231_I0.7870.81
89_T111_L0.7810.81
79_W109_V0.7780.81
302_L305_H0.7760.80
131_G274_G0.7740.80
110_A262_I0.7740.80
79_W92_K0.7740.80
227_S302_L0.7710.80
196_D207_K0.7710.80
150_K202_E0.7680.80
164_P168_I0.7670.80
35_R122_S0.7630.79
76_I270_K0.7610.79
83_R258_G0.7590.79
47_N184_E0.7560.79
161_V233_L0.7530.78
173_M229_M0.7520.78
137_W262_I0.7510.78
96_R109_V0.7500.78
44_H181_G0.7480.78
199_F219_L0.7470.78
67_P89_T0.7450.78
269_D274_G0.7310.76
39_S119_R0.7300.76
91_K95_D0.7270.76
79_W96_R0.7260.76
7_Q10_A0.7250.76
136_C261_Q0.7240.76
48_R116_H0.7230.75
40_G304_G0.7230.75
204_N295_D0.7210.75
67_P92_K0.7180.75
94_M98_I0.7170.75
144_M220_P0.7150.75
28_A88_L0.7150.75
15_V49_F0.7120.74
177_M223_Y0.7100.74
179_S186_N0.7100.74
52_F118_M0.7080.74
19_R56_L0.7080.74
78_Q110_A0.7080.74
194_P197_G0.7060.74
73_L104_H0.7060.74
21_V29_C0.7030.73
144_M230_S0.7010.73
154_I284_I0.7000.73
37_T314_N0.6990.73
272_I280_K0.6980.73
133_I236_I0.6960.73
165_S168_I0.6960.73
144_M217_R0.6940.72
201_D316_R0.6940.72
48_R184_E0.6930.72
309_T312_A0.6920.72
71_T103_D0.6920.72
185_V189_A0.6890.72
4_T319_I0.6840.71
156_T196_D0.6840.71
305_H309_T0.6820.71
201_D211_V0.6820.71
161_V236_I0.6800.71
31_E91_K0.6770.71
187_R213_E0.6770.71
177_M197_G0.6760.70
305_H308_T0.6750.70
59_G209_P0.6750.70
43_S116_H0.6680.70
175_M230_S0.6680.70
5_F9_K0.6650.69
325_V328_K0.6630.69
29_C88_L0.6630.69
190_G210_G0.6560.68
94_M97_A0.6540.68
129_E167_P0.6530.68
198_G213_E0.6530.68
9_K315_R0.6520.68
79_W93_M0.6520.68
50_P328_K0.6510.68
13_N30_A0.6490.67
211_V214_K0.6490.67
153_R288_V0.6470.67
289_T302_L0.6460.67
132_Y265_A0.6460.67
135_I161_V0.6450.67
66_Q82_Q0.6430.67
111_L263_F0.6430.67
124_G128_A0.6410.66
6_E9_K0.6400.66
273_D276_T0.6400.66
36_T118_M0.6360.66
163_I235_M0.6320.65
25_T64_D0.6310.65
32_M119_R0.6310.65
24_E27_D0.6310.65
177_M219_L0.6300.65
72_S104_H0.6290.65
14_R18_S0.6270.65
275_P279_A0.6250.64
11_A329_I0.6250.64
52_F116_H0.6240.64
169_T303_P0.6230.64
183_L218_I0.6230.64
247_A287_Y0.6220.64
139_N243_G0.6210.64
117_W307_F0.6190.64
37_T46_V0.6180.64
175_M227_S0.6160.63
71_T100_L0.6150.63
78_Q270_K0.6150.63
70_I112_R0.6120.63
33_F49_F0.6120.63
25_T85_I0.6110.63
324_S328_K0.6100.63
46_V321_V0.6090.62
29_C87_N0.6090.62
233_L259_I0.6080.62
24_E66_Q0.6080.62
83_R257_Y0.6070.62
53_I57_E0.6070.62
193_L207_K0.6070.62
288_V300_I0.6040.62
245_S283_R0.6040.62
99_E130_K0.6000.61
183_L193_L0.5990.61
100_L104_H0.5990.61
240_L266_I0.5990.61
114_A117_W0.5970.61
8_L34_A0.5950.61
221_M229_M0.5950.61
32_M122_S0.5940.61
11_A14_R0.5930.60
157_N233_L0.5890.60
184_E187_R0.5890.60
120_G261_Q0.5890.60
279_A283_R0.5880.60
310_L320_T0.5870.60
236_I262_I0.5850.59
289_T300_I0.5830.59
92_K96_R0.5830.59
35_R39_S0.5830.59
128_A282_Q0.5820.59
184_E188_L0.5820.59
39_S307_F0.5810.59
27_D64_D0.5790.59
131_G166_T0.5790.59
133_I266_I0.5780.58
124_G170_M0.5770.58
42_Y46_V0.5710.58
202_E316_R0.5700.57
42_Y320_T0.5680.57
62_I84_S0.5670.57
27_D204_N0.5670.57
180_Y198_G0.5670.57
140_S156_T0.5660.57
48_R180_Y0.5620.56
201_D206_T0.5610.56
14_R316_R0.5580.56
99_E192_Q0.5580.56
72_S76_I0.5570.56
32_M123_Y0.5560.56
9_K34_A0.5560.56
301_R305_H0.5560.56
72_S96_R0.5550.55
43_S138_T0.5550.55
24_E92_K0.5530.55
232_V262_I0.5520.55
32_M36_T0.5520.55
290_S309_T0.5520.55
235_M277_R0.5520.55
124_G134_G0.5520.55
188_L325_V0.5510.55
93_M111_L0.5500.55
4_T135_I0.5480.54
86_G123_Y0.5470.54
72_S77_E0.5470.54
144_M156_T0.5470.54
9_K30_A0.5440.54
323_D326_W0.5420.54
84_S87_N0.5410.54
15_V19_R0.5400.53
47_N188_L0.5400.53
114_A139_N0.5390.53
20_G101_A0.5390.53
231_I288_V0.5370.53
303_P306_E0.5360.53
10_A24_E0.5360.53
119_R139_N0.5360.53
171_V232_V0.5360.53
23_S316_R0.5350.53
43_S185_V0.5340.53
144_M180_Y0.5340.53
101_A105_G0.5330.52
147_W224_W0.5310.52
51_R54_Q0.5310.52
74_G103_D0.5300.52
70_I100_L0.5290.52
71_T76_I0.5280.52
62_I83_R0.5270.52
281_L285_M0.5270.52
163_I169_T0.5260.52
98_I126_Q0.5210.51
269_D273_D0.5200.51
143_V177_M0.5200.51
55_Q115_N0.5190.51
250_T263_F0.5180.50
288_V302_L0.5170.50
88_L92_K0.5160.50
141_I176_S0.5120.50
90_A111_L0.5120.50
248_E283_R0.5110.50
268_V274_G0.5100.49
38_E318_G0.5090.49
17_I26_A0.5070.49
192_Q195_V0.5070.49
141_I180_Y0.5070.49
190_G195_V0.5070.49
173_M221_M0.5060.49
36_T119_R0.5060.49
239_L247_A0.5050.49
81_A227_S0.5050.49
44_H48_R0.5040.49
276_T279_A0.5040.49
137_W144_M0.5040.49
42_Y319_I0.5030.48
36_T181_G0.5020.48
236_I239_L0.5020.48
116_H222_G0.5020.48
49_F159_L0.5010.48
84_S89_T0.5010.48
201_D216_R0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nxuA 2 1 100 0.031 Contact Map
1v9nA 2 0.9639 100 0.04 Contact Map
2x06A 2 0.988 100 0.044 Contact Map
1vbiA 2 0.988 100 0.045 Contact Map
3i0pA 2 1 100 0.046 Contact Map
3uoeA 2 0.9849 100 0.047 Contact Map
4h8aA 2 0.991 100 0.049 Contact Map
1z2iA 2 0.988 100 0.056 Contact Map
1wtjA 2 0.9789 100 0.059 Contact Map
2g8yA 2 0.991 100 0.06 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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