DLGD - ECOLI - GREMLIN Contacts

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DLGD - 2,3-diketo-L-gulonate reductase

UniProt:	P37672	Sequences: MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12279
Length:	332 (321)
Sequences:	2097 (1544)
Seq/√Len:	86.2

ECOLI - DLGD ALLD YBIC
BACSU - YJMC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
313_E	317_N	4.037	1.00
68_K	82_Q	3.722	1.00
124_G	160_I	3.703	1.00
289_T	305_H	3.406	1.00
81_A	89_T	3.347	1.00
198_G	212_I	3.077	1.00
62_I	82_Q	2.979	1.00
200_D	204_N	2.956	1.00
102_A	130_K	2.760	1.00
192_Q	207_K	2.676	1.00
323_D	327_A	2.562	1.00
95_D	126_Q	2.528	1.00
9_K	31_E	2.509	1.00
110_A	241_S	2.430	1.00
94_M	127_A	2.408	1.00
208_E	211_V	2.326	1.00
192_Q	209_P	2.320	1.00
75_A	104_H	2.284	1.00
16_L	49_F	2.268	1.00
128_A	162_A	2.233	1.00
72_S	100_L	2.211	1.00
267_E	270_K	2.148	1.00
74_G	104_H	2.145	1.00
299_A	309_T	2.143	1.00
161_V	232_V	2.073	1.00
42_Y	314_N	2.053	1.00
165_S	282_Q	2.047	1.00
17_I	23_S	2.041	1.00
8_L	46_V	2.036	1.00
65_A	82_Q	2.023	1.00
99_E	103_D	2.015	1.00
312_A	316_R	2.010	1.00
296_E	299_A	2.001	1.00
38_E	314_N	1.996	1.00
37_T	42_Y	1.983	1.00
96_R	99_E	1.980	1.00
311_L	315_R	1.974	1.00
117_W	120_G	1.934	1.00
314_N	320_T	1.925	1.00
195_V	207_K	1.913	1.00
13_N	27_D	1.894	1.00
13_N	17_I	1.858	1.00
167_P	312_A	1.832	1.00
171_V	228_G	1.798	1.00
201_D	214_K	1.788	1.00
145_P	217_R	1.781	1.00
125_W	129_E	1.779	1.00
10_A	14_R	1.778	1.00
90_A	263_F	1.750	1.00
30_A	34_A	1.750	1.00
187_R	210_G	1.729	1.00
131_G	278_D	1.724	1.00
178_F	197_G	1.696	1.00
98_I	130_K	1.693	1.00
200_D	211_V	1.674	1.00
70_I	80_D	1.643	1.00
97_A	107_G	1.641	1.00
48_R	181_G	1.624	1.00
117_W	136_C	1.611	1.00
97_A	265_A	1.611	1.00
5_F	38_E	1.582	1.00
127_A	265_A	1.578	1.00
102_A	132_Y	1.567	1.00
145_P	199_F	1.563	1.00
162_A	170_M	1.556	1.00
134_G	162_A	1.537	1.00
74_G	100_L	1.531	1.00
156_T	175_M	1.525	1.00
80_D	113_N	1.512	1.00
199_F	217_R	1.508	1.00
77_E	109_V	1.506	1.00
132_Y	268_V	1.496	0.99
77_E	107_G	1.494	0.99
193_L	197_G	1.482	0.99
62_I	65_A	1.479	0.99
295_D	299_A	1.476	0.99
144_M	176_S	1.454	0.99
13_N	23_S	1.442	0.99
29_C	85_I	1.438	0.99
94_M	126_Q	1.388	0.99
289_T	299_A	1.387	0.99
39_S	311_L	1.384	0.99
179_S	182_M	1.370	0.99
65_A	84_S	1.359	0.99
91_K	126_Q	1.355	0.99
193_L	212_I	1.343	0.99
108_L	264_I	1.341	0.99
235_M	281_L	1.335	0.99
134_G	265_A	1.331	0.99
28_A	91_K	1.329	0.99
243_G	260_S	1.327	0.99
159_L	233_L	1.321	0.99
135_I	264_I	1.318	0.99
106_I	264_I	1.318	0.99
69_R	79_W	1.313	0.99
97_A	109_V	1.300	0.99
38_E	315_R	1.300	0.99
83_R	113_N	1.299	0.99
77_E	96_R	1.292	0.99
25_T	88_L	1.284	0.98
186_N	193_L	1.282	0.98
94_M	265_A	1.279	0.98
15_V	53_I	1.273	0.98
23_S	27_D	1.263	0.98
107_G	265_A	1.262	0.98
96_R	100_L	1.261	0.98
244_A	258_G	1.255	0.98
98_I	132_Y	1.254	0.98
114_A	261_Q	1.251	0.98
206_T	212_I	1.250	0.98
12_F	49_F	1.238	0.98
44_H	116_H	1.227	0.98
73_L	270_K	1.225	0.98
310_L	314_N	1.211	0.98
69_R	77_E	1.208	0.98
21_V	85_I	1.204	0.98
108_L	262_I	1.204	0.98
210_G	214_K	1.199	0.98
101_A	107_G	1.196	0.98
32_M	87_N	1.185	0.97
80_D	112_R	1.174	0.97
286_D	290_S	1.171	0.97
198_G	206_T	1.170	0.97
61_I	115_N	1.169	0.97
14_R	17_I	1.157	0.97
19_R	53_I	1.154	0.97
237_A	260_S	1.153	0.97
274_G	278_D	1.152	0.97
56_L	63_P	1.148	0.97
193_L	198_G	1.142	0.97
101_A	132_Y	1.139	0.97
169_T	231_I	1.125	0.96
268_V	273_D	1.124	0.96
12_F	16_L	1.121	0.96
301_R	307_F	1.108	0.96
322_D	325_V	1.101	0.96
77_E	100_L	1.100	0.96
309_T	313_E	1.096	0.96
78_Q	112_R	1.094	0.96
76_I	271_L	1.094	0.96
301_R	306_E	1.094	0.96
43_S	182_M	1.093	0.96
113_N	258_G	1.091	0.96
9_K	27_D	1.087	0.96
166_T	279_A	1.085	0.96
70_I	78_Q	1.074	0.95
138_T	261_Q	1.071	0.95
77_E	97_A	1.070	0.95
163_I	232_V	1.067	0.95
140_S	143_V	1.066	0.95
301_R	309_T	1.062	0.95
285_M	289_T	1.058	0.95
54_Q	58_N	1.057	0.95
108_L	266_I	1.056	0.95
98_I	101_A	1.049	0.95
16_L	29_C	1.044	0.95
98_I	102_A	1.042	0.94
180_Y	213_E	1.041	0.94
5_F	34_A	1.040	0.94
186_N	191_R	1.034	0.94
295_D	298_Q	1.030	0.94
187_R	209_P	1.027	0.94
124_G	136_C	1.025	0.94
166_T	282_Q	1.020	0.94
159_L	229_M	1.017	0.94
4_T	7_Q	1.016	0.94
98_I	127_A	1.002	0.93
22_D	64_D	1.002	0.93
154_I	230_S	1.001	0.93
166_T	278_D	0.996	0.93
137_W	233_L	0.991	0.93
102_A	267_E	0.991	0.93
12_F	46_V	0.990	0.93
124_G	162_A	0.987	0.93
25_T	66_Q	0.977	0.92
173_M	228_G	0.973	0.92
12_F	30_A	0.971	0.92
8_L	319_I	0.969	0.92
67_P	82_Q	0.968	0.92
321_V	326_W	0.961	0.92
192_Q	208_E	0.961	0.92
92_K	95_D	0.960	0.92
310_L	313_E	0.957	0.92
8_L	321_V	0.957	0.92
183_L	271_L	0.955	0.91
306_E	310_L	0.953	0.91
312_A	315_R	0.952	0.91
136_C	263_F	0.952	0.91
282_Q	286_D	0.951	0.91
73_L	267_E	0.941	0.91
66_Q	92_K	0.940	0.91
147_W	227_S	0.940	0.91
108_L	271_L	0.936	0.91
143_V	180_Y	0.936	0.91
146_P	227_S	0.934	0.91
169_T	285_M	0.932	0.90
125_W	170_M	0.930	0.90
116_H	181_G	0.929	0.90
94_M	134_G	0.927	0.90
183_L	212_I	0.922	0.90
93_M	109_V	0.916	0.90
69_R	96_R	0.907	0.89
121_G	124_G	0.906	0.89
35_R	311_L	0.903	0.89
69_R	92_K	0.902	0.89
9_K	13_N	0.900	0.89
19_R	57_E	0.899	0.89
195_V	205_L	0.895	0.89
231_I	284_I	0.892	0.88
31_E	122_S	0.892	0.88
46_V	325_V	0.891	0.88
26_A	30_A	0.890	0.88
11_A	15_V	0.887	0.88
22_D	25_T	0.885	0.88
144_M	175_M	0.881	0.88
81_A	111_L	0.871	0.87
178_F	182_M	0.867	0.87
282_Q	285_M	0.865	0.87
95_D	99_E	0.864	0.87
300_I	305_H	0.862	0.87
27_D	31_E	0.858	0.86
5_F	315_R	0.858	0.86
117_W	261_Q	0.848	0.86
248_E	287_Y	0.844	0.85
188_L	328_K	0.841	0.85
6_E	10_A	0.840	0.85
320_T	323_D	0.836	0.85
285_M	302_L	0.836	0.85
5_F	319_I	0.834	0.85
206_T	211_V	0.831	0.85
127_A	134_G	0.830	0.85
111_L	261_Q	0.826	0.84
154_I	231_I	0.826	0.84
68_K	80_D	0.824	0.84
153_R	287_Y	0.820	0.84
140_S	155_G	0.814	0.83
234_D	238_T	0.814	0.83
95_D	130_K	0.810	0.83
100_L	107_G	0.806	0.83
165_S	285_M	0.804	0.83
101_A	265_A	0.804	0.83
39_S	125_W	0.802	0.82
163_I	277_R	0.801	0.82
268_V	272_I	0.797	0.82
125_W	311_L	0.797	0.82
149_A	227_S	0.797	0.82
90_A	117_W	0.797	0.82
175_M	221_M	0.797	0.82
97_A	127_A	0.795	0.82
196_D	219_L	0.791	0.82
67_P	79_W	0.790	0.82
81_A	114_A	0.788	0.81
227_S	231_I	0.787	0.81
89_T	111_L	0.781	0.81
79_W	109_V	0.778	0.81
302_L	305_H	0.776	0.80
131_G	274_G	0.774	0.80
110_A	262_I	0.774	0.80
79_W	92_K	0.774	0.80
227_S	302_L	0.771	0.80
196_D	207_K	0.771	0.80
150_K	202_E	0.768	0.80
164_P	168_I	0.767	0.80
35_R	122_S	0.763	0.79
76_I	270_K	0.761	0.79
83_R	258_G	0.759	0.79
47_N	184_E	0.756	0.79
161_V	233_L	0.753	0.78
173_M	229_M	0.752	0.78
137_W	262_I	0.751	0.78
96_R	109_V	0.750	0.78
44_H	181_G	0.748	0.78
199_F	219_L	0.747	0.78
67_P	89_T	0.745	0.78
269_D	274_G	0.731	0.76
39_S	119_R	0.730	0.76
91_K	95_D	0.727	0.76
79_W	96_R	0.726	0.76
7_Q	10_A	0.725	0.76
136_C	261_Q	0.724	0.76
48_R	116_H	0.723	0.75
40_G	304_G	0.723	0.75
204_N	295_D	0.721	0.75
67_P	92_K	0.718	0.75
94_M	98_I	0.717	0.75
144_M	220_P	0.715	0.75
28_A	88_L	0.715	0.75
15_V	49_F	0.712	0.74
177_M	223_Y	0.710	0.74
179_S	186_N	0.710	0.74
52_F	118_M	0.708	0.74
19_R	56_L	0.708	0.74
78_Q	110_A	0.708	0.74
194_P	197_G	0.706	0.74
73_L	104_H	0.706	0.74
21_V	29_C	0.703	0.73
144_M	230_S	0.701	0.73
154_I	284_I	0.700	0.73
37_T	314_N	0.699	0.73
272_I	280_K	0.698	0.73
133_I	236_I	0.696	0.73
165_S	168_I	0.696	0.73
144_M	217_R	0.694	0.72
201_D	316_R	0.694	0.72
48_R	184_E	0.693	0.72
309_T	312_A	0.692	0.72
71_T	103_D	0.692	0.72
185_V	189_A	0.689	0.72
4_T	319_I	0.684	0.71
156_T	196_D	0.684	0.71
305_H	309_T	0.682	0.71
201_D	211_V	0.682	0.71
161_V	236_I	0.680	0.71
31_E	91_K	0.677	0.71
187_R	213_E	0.677	0.71
177_M	197_G	0.676	0.70
305_H	308_T	0.675	0.70
59_G	209_P	0.675	0.70
43_S	116_H	0.668	0.70
175_M	230_S	0.668	0.70
5_F	9_K	0.665	0.69
325_V	328_K	0.663	0.69
29_C	88_L	0.663	0.69
190_G	210_G	0.656	0.68
94_M	97_A	0.654	0.68
129_E	167_P	0.653	0.68
198_G	213_E	0.653	0.68
9_K	315_R	0.652	0.68
79_W	93_M	0.652	0.68
50_P	328_K	0.651	0.68
13_N	30_A	0.649	0.67
211_V	214_K	0.649	0.67
153_R	288_V	0.647	0.67
289_T	302_L	0.646	0.67
132_Y	265_A	0.646	0.67
135_I	161_V	0.645	0.67
66_Q	82_Q	0.643	0.67
111_L	263_F	0.643	0.67
124_G	128_A	0.641	0.66
6_E	9_K	0.640	0.66
273_D	276_T	0.640	0.66
36_T	118_M	0.636	0.66
163_I	235_M	0.632	0.65
25_T	64_D	0.631	0.65
32_M	119_R	0.631	0.65
24_E	27_D	0.631	0.65
177_M	219_L	0.630	0.65
72_S	104_H	0.629	0.65
14_R	18_S	0.627	0.65
275_P	279_A	0.625	0.64
11_A	329_I	0.625	0.64
52_F	116_H	0.624	0.64
169_T	303_P	0.623	0.64
183_L	218_I	0.623	0.64
247_A	287_Y	0.622	0.64
139_N	243_G	0.621	0.64
117_W	307_F	0.619	0.64
37_T	46_V	0.618	0.64
175_M	227_S	0.616	0.63
71_T	100_L	0.615	0.63
78_Q	270_K	0.615	0.63
70_I	112_R	0.612	0.63
33_F	49_F	0.612	0.63
25_T	85_I	0.611	0.63
324_S	328_K	0.610	0.63
46_V	321_V	0.609	0.62
29_C	87_N	0.609	0.62
233_L	259_I	0.608	0.62
24_E	66_Q	0.608	0.62
83_R	257_Y	0.607	0.62
53_I	57_E	0.607	0.62
193_L	207_K	0.607	0.62
288_V	300_I	0.604	0.62
245_S	283_R	0.604	0.62
99_E	130_K	0.600	0.61
183_L	193_L	0.599	0.61
100_L	104_H	0.599	0.61
240_L	266_I	0.599	0.61
114_A	117_W	0.597	0.61
8_L	34_A	0.595	0.61
221_M	229_M	0.595	0.61
32_M	122_S	0.594	0.61
11_A	14_R	0.593	0.60
157_N	233_L	0.589	0.60
184_E	187_R	0.589	0.60
120_G	261_Q	0.589	0.60
279_A	283_R	0.588	0.60
310_L	320_T	0.587	0.60
236_I	262_I	0.585	0.59
289_T	300_I	0.583	0.59
92_K	96_R	0.583	0.59
35_R	39_S	0.583	0.59
128_A	282_Q	0.582	0.59
184_E	188_L	0.582	0.59
39_S	307_F	0.581	0.59
27_D	64_D	0.579	0.59
131_G	166_T	0.579	0.59
133_I	266_I	0.578	0.58
124_G	170_M	0.577	0.58
42_Y	46_V	0.571	0.58
202_E	316_R	0.570	0.57
42_Y	320_T	0.568	0.57
62_I	84_S	0.567	0.57
27_D	204_N	0.567	0.57
180_Y	198_G	0.567	0.57
140_S	156_T	0.566	0.57
48_R	180_Y	0.562	0.56
201_D	206_T	0.561	0.56
14_R	316_R	0.558	0.56
99_E	192_Q	0.558	0.56
72_S	76_I	0.557	0.56
32_M	123_Y	0.556	0.56
9_K	34_A	0.556	0.56
301_R	305_H	0.556	0.56
72_S	96_R	0.555	0.55
43_S	138_T	0.555	0.55
24_E	92_K	0.553	0.55
232_V	262_I	0.552	0.55
32_M	36_T	0.552	0.55
290_S	309_T	0.552	0.55
235_M	277_R	0.552	0.55
124_G	134_G	0.552	0.55
188_L	325_V	0.551	0.55
93_M	111_L	0.550	0.55
4_T	135_I	0.548	0.54
86_G	123_Y	0.547	0.54
72_S	77_E	0.547	0.54
144_M	156_T	0.547	0.54
9_K	30_A	0.544	0.54
323_D	326_W	0.542	0.54
84_S	87_N	0.541	0.54
15_V	19_R	0.540	0.53
47_N	188_L	0.540	0.53
114_A	139_N	0.539	0.53
20_G	101_A	0.539	0.53
231_I	288_V	0.537	0.53
303_P	306_E	0.536	0.53
10_A	24_E	0.536	0.53
119_R	139_N	0.536	0.53
171_V	232_V	0.536	0.53
23_S	316_R	0.535	0.53
43_S	185_V	0.534	0.53
144_M	180_Y	0.534	0.53
101_A	105_G	0.533	0.52
147_W	224_W	0.531	0.52
51_R	54_Q	0.531	0.52
74_G	103_D	0.530	0.52
70_I	100_L	0.529	0.52
71_T	76_I	0.528	0.52
62_I	83_R	0.527	0.52
281_L	285_M	0.527	0.52
163_I	169_T	0.526	0.52
98_I	126_Q	0.521	0.51
269_D	273_D	0.520	0.51
143_V	177_M	0.520	0.51
55_Q	115_N	0.519	0.51
250_T	263_F	0.518	0.50
288_V	302_L	0.517	0.50
88_L	92_K	0.516	0.50
141_I	176_S	0.512	0.50
90_A	111_L	0.512	0.50
248_E	283_R	0.511	0.50
268_V	274_G	0.510	0.49
38_E	318_G	0.509	0.49
17_I	26_A	0.507	0.49
192_Q	195_V	0.507	0.49
141_I	180_Y	0.507	0.49
190_G	195_V	0.507	0.49
173_M	221_M	0.506	0.49
36_T	119_R	0.506	0.49
239_L	247_A	0.505	0.49
81_A	227_S	0.505	0.49
44_H	48_R	0.504	0.49
276_T	279_A	0.504	0.49
137_W	144_M	0.504	0.49
42_Y	319_I	0.503	0.48
36_T	181_G	0.502	0.48
236_I	239_L	0.502	0.48
116_H	222_G	0.502	0.48
49_F	159_L	0.501	0.48
84_S	89_T	0.501	0.48
201_D	216_R	0.500	0.48

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1nxuA	2	1	100	0.031	Contact Map
1v9nA	2	0.9639	100	0.04	Contact Map
2x06A	2	0.988	100	0.044	Contact Map
1vbiA	2	0.988	100	0.045	Contact Map
3i0pA	2	1	100	0.046	Contact Map
3uoeA	2	0.9849	100	0.047	Contact Map
4h8aA	2	0.991	100	0.049	Contact Map
1z2iA	2	0.988	100	0.056	Contact Map
1wtjA	2	0.9789	100	0.059	Contact Map
2g8yA	2	0.991	100	0.06	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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