GREMLIN Database
YIAJ - HTH-type transcriptional regulator YiaJ
UniProt: P37671 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12278
Length: 282 (245)
Sequences: 12859 (9400)
Seq/√Len: 600.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_L29_G3.2351.00
114_A258_P3.1801.00
27_F69_C2.8451.00
122_S159_M2.8441.00
107_H262_T2.8281.00
203_H207_S2.6541.00
34_E86_K2.5761.00
105_A133_Y2.4251.00
173_K198_F2.4001.00
161_K200_E2.3971.00
30_L71_Y2.3481.00
161_K215_E2.2331.00
128_H151_H2.2001.00
117_E246_R2.1331.00
107_H265_A2.0991.00
167_G171_Y2.0741.00
109_E135_L2.0691.00
36_L72_V2.0531.00
31_M69_C1.9961.00
225_V259_L1.9341.00
166_F228_F1.8951.00
124_R154_L1.8861.00
225_V263_A1.8541.00
107_H269_E1.8321.00
212_D222_C1.8321.00
213_R221_S1.8171.00
221_S244_T1.7941.00
75_A78_A1.7741.00
256_L260_R1.7671.00
110_A265_A1.7601.00
32_L48_L1.7301.00
110_A114_A1.7301.00
73_T82_R1.7221.00
34_E69_C1.7161.00
35_I43_C1.6931.00
194_L198_F1.6901.00
35_I51_L1.6791.00
193_E196_A1.6751.00
63_L72_V1.6611.00
35_I52_A1.6581.00
104_A266_I1.6551.00
112_N119_I1.6511.00
214_E244_T1.6361.00
35_I48_L1.6301.00
225_V260_R1.6271.00
251_G254_N1.6271.00
242_L247_L1.6121.00
209_A256_L1.5671.00
240_I255_L1.5631.00
43_C51_L1.5541.00
42_G82_R1.5451.00
107_H110_A1.5101.00
44_P47_H1.5071.00
63_L81_Y1.5051.00
200_E203_H1.5031.00
204_I210_A1.4891.00
54_L59_V1.4841.00
115_T258_P1.4721.00
172_V198_F1.4611.00
258_P261_E1.4601.00
168_H171_Y1.4581.00
42_G80_S1.4531.00
86_K89_A1.4501.00
214_E219_G1.4491.00
129_A163_Y1.4431.00
48_L59_V1.4421.00
136_E143_R1.4311.00
187_T190_T1.4181.00
228_F267_S1.3901.00
173_K194_L1.3701.00
112_N135_L1.3581.00
67_Q72_V1.3551.00
101_I133_Y1.3511.00
129_A154_L1.3491.00
75_A82_R1.3421.00
34_E71_Y1.3391.00
104_A121_F1.3321.00
111_L258_P1.3291.00
36_L43_C1.3241.00
263_A267_S1.3161.00
67_Q74_T1.3151.00
30_L69_C1.3141.00
127_D178_S1.2781.00
36_L42_G1.2711.00
39_Y51_L1.2531.00
108_L121_F1.2471.00
201_L204_I1.2461.00
261_E265_A1.2411.00
39_Y43_C1.2411.00
169_P198_F1.2321.00
60_H64_Q1.2251.00
49_S59_V1.2161.00
111_L262_T1.2151.00
177_E194_L1.2081.00
55_N58_T1.2061.00
48_L63_L1.2061.00
105_A109_E1.2061.00
191_I200_E1.1891.00
166_F226_P1.1801.00
189_N214_E1.1621.00
228_F234_V1.1581.00
165_A204_I1.1481.00
260_R264_Q1.1371.00
122_S129_A1.1351.00
156_C190_T1.1321.00
124_R167_G1.1301.00
156_C186_L1.1251.00
169_P173_K1.1251.00
115_T255_L1.1071.00
45_L60_H1.1061.00
229_D233_R1.1031.00
124_R127_D1.0981.00
46_A50_E1.0971.00
166_F234_V1.0921.00
123_S236_Y1.0911.00
109_E113_I1.0911.00
27_F68_S1.0891.00
265_A269_E1.0821.00
176_W194_L1.0811.00
44_P80_S1.0781.00
225_V256_L1.0741.00
169_P172_V1.0731.00
121_F236_Y1.0671.00
172_V205_R1.0581.00
27_F65_G1.0531.00
37_S40_P1.0451.00
115_T240_I1.0451.00
159_M237_A1.0381.00
121_F227_V1.0341.00
108_L119_I1.0251.00
169_P202_A1.0231.00
238_V266_I1.0201.00
155_Y190_T1.0181.00
125_E151_H1.0161.00
45_L49_S1.0151.00
23_S65_G1.0141.00
87_F94_A1.0101.00
105_A135_L1.0061.00
173_K177_E1.0021.00
157_S160_G0.9981.00
71_Y90_V0.9961.00
47_H50_E0.9901.00
110_A262_T0.9851.00
257_K261_E0.9801.00
188_R218_L0.9751.00
264_Q268_N0.9681.00
158_A222_C0.9621.00
114_A261_E0.9581.00
226_P234_V0.9481.00
171_Y174_S0.9481.00
185_P192_T0.9471.00
42_G75_A0.9451.00
122_S131_L0.9441.00
186_L190_T0.9391.00
100_I236_Y0.9351.00
22_G68_S0.9271.00
24_Q28_R0.9251.00
248_K251_G0.9241.00
204_I207_S0.9191.00
130_I151_H0.9181.00
162_I166_F0.9161.00
46_A56_K0.9161.00
199_D202_A0.9051.00
223_I256_L0.8991.00
196_A200_E0.8951.00
253_K257_K0.8951.00
103_I269_E0.8951.00
199_D203_H0.8861.00
172_V201_L0.8851.00
108_L133_Y0.8841.00
174_S178_S0.8831.00
119_I240_I0.8791.00
38_N51_L0.8791.00
33_I87_F0.8781.00
207_S256_L0.8741.00
202_A206_E0.8691.00
47_H51_L0.8621.00
164_M197_M0.8601.00
120_N241_S0.8571.00
198_F202_A0.8551.00
101_I105_A0.8501.00
67_Q81_Y0.8441.00
171_Y175_Y0.8421.00
57_S60_H0.8401.00
32_L52_A0.8401.00
162_I234_V0.8371.00
229_D235_P0.8311.00
159_M239_S0.8291.00
224_A239_S0.8231.00
214_E218_L0.8221.00
162_I204_I0.8161.00
186_L216_N0.8161.00
125_E130_I0.8161.00
108_L238_V0.8151.00
32_L62_L0.8141.00
259_L263_A0.8141.00
28_R58_T0.8081.00
196_A199_D0.7971.00
213_R252_E0.7941.00
213_R244_T0.7931.00
203_H206_E0.7921.00
158_A224_A0.7861.00
107_H266_I0.7821.00
22_G27_F0.7801.00
124_R171_Y0.7761.00
36_L39_Y0.7711.00
45_L63_L0.7701.00
262_T265_A0.7691.00
165_A201_L0.7681.00
243_S246_R0.7641.00
36_L41_N0.7611.00
200_E207_S0.7561.00
100_I104_A0.7561.00
52_A59_V0.7501.00
200_E204_I0.7481.00
222_C241_S0.7481.00
54_L58_T0.7471.00
163_Y237_A0.7451.00
73_T84_T0.7441.00
83_L87_F0.7441.00
191_I196_A0.7411.00
25_S29_G0.7401.00
120_N134_K0.7261.00
254_N257_K0.7231.00
33_I71_Y0.7221.00
223_I252_E0.7191.00
252_E256_L0.7181.00
87_F90_V0.7161.00
156_C216_N0.7131.00
254_N258_P0.7131.00
211_M252_E0.7121.00
257_K260_R0.7101.00
43_C48_L0.7071.00
64_Q68_S0.7071.00
228_F235_P0.7071.00
64_Q67_Q0.7041.00
74_T78_A0.7031.00
222_C239_S0.7001.00
74_T79_G0.6981.00
87_F91_G0.6971.00
108_L135_L0.6911.00
161_K204_I0.6891.00
127_D175_Y0.6881.00
191_I197_M0.6871.00
120_N146_A0.6871.00
172_V175_Y0.6861.00
252_E257_K0.6831.00
124_R163_Y0.6801.00
45_L59_V0.6801.00
26_L62_L0.6751.00
32_L59_V0.6741.00
213_R249_Q0.6711.00
251_G255_L0.6681.00
45_L81_Y0.6681.00
261_E264_Q0.6671.00
49_S52_A0.6631.00
112_N137_P0.6601.00
262_T266_I0.6601.00
172_V202_A0.6601.00
264_Q267_S0.6571.00
176_W182_E0.6571.00
26_L30_L0.6561.00
123_S132_I0.6521.00
192_T196_A0.6491.00
260_R263_A0.6481.00
167_G172_V0.6471.00
238_V263_A0.6471.00
172_V176_W0.6461.00
202_A205_R0.6431.00
110_A113_I0.6411.00
111_L115_T0.6371.00
34_E89_A0.6371.00
45_L56_K0.6331.00
111_L240_I0.6301.00
99_N102_H0.6271.00
163_Y167_G0.6271.00
28_R54_L0.6251.00
73_T85_T0.6221.00
225_V267_S0.6221.00
187_T191_I0.6201.00
103_I106_P0.6201.00
25_S62_L0.6151.00
117_E242_L0.6141.00
157_S222_C0.6131.00
113_I138_T0.6121.00
169_P205_R0.6091.00
106_P269_E0.6061.00
164_M201_L0.6041.00
155_Y183_I0.6031.00
75_A80_S0.6021.00
265_A268_N0.6011.00
153_P156_C0.6001.00
74_T81_Y0.5991.00
47_H80_S0.5971.00
91_G94_A0.5971.00
31_M34_E0.5961.00
120_N222_C0.5951.00
109_E133_Y0.5911.00
64_Q74_T0.5911.00
31_M35_I0.5901.00
37_S90_V0.5881.00
238_V259_L0.5871.00
111_L119_I0.5851.00
238_V262_T0.5851.00
164_M172_V0.5841.00
190_T193_E0.5821.00
40_P51_L0.5821.00
117_E240_I0.5781.00
162_I224_A0.5781.00
214_E221_S0.5781.00
134_K146_A0.5751.00
147_Y150_Q0.5701.00
189_N218_L0.5691.00
37_S83_L0.5691.00
71_Y86_K0.5691.00
195_P198_F0.5671.00
36_L40_P0.5651.00
49_S56_K0.5641.00
129_A152_M0.5621.00
209_A260_R0.5611.00
258_P262_T0.5591.00
70_G86_K0.5571.00
131_L146_A0.5571.00
26_L65_G0.5571.00
162_I226_P0.5571.00
208_G228_F0.5540.99
133_Y148_I0.5530.99
104_A108_L0.5520.99
42_G78_A0.5500.99
119_I135_L0.5490.99
33_I90_V0.5490.99
116_G138_T0.5490.99
34_E90_V0.5490.99
134_K148_I0.5490.99
29_G62_L0.5480.99
255_L258_P0.5480.99
161_K212_D0.5470.99
225_V238_V0.5460.99
227_V267_S0.5440.99
162_I210_A0.5430.99
23_S62_L0.5420.99
185_P188_R0.5410.99
227_V236_Y0.5410.99
129_A159_M0.5400.99
195_P199_D0.5390.99
136_E147_Y0.5350.99
88_I95_L0.5350.99
131_L159_M0.5330.99
120_N239_S0.5320.99
166_F205_R0.5230.99
163_Y236_Y0.5220.99
197_M201_L0.5210.99
92_Q95_L0.5200.99
35_I39_Y0.5180.99
146_A150_Q0.5170.99
29_G66_L0.5150.99
28_R62_L0.5140.99
129_A157_S0.5110.99
44_P56_K0.5110.99
142_L245_S0.5100.99
122_S157_S0.5090.99
155_Y175_Y0.5080.99
183_I187_T0.5070.99
118_T134_K0.5040.99
35_I38_N0.5040.99
227_V266_I0.5030.99
24_Q65_G0.5010.99
27_F31_M0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mq0A 2 0.8901 100 0.15 Contact Map
2ia2A 4 0.883 100 0.159 Contact Map
2g7uA 6 0.8901 100 0.164 Contact Map
3r4kA 2 0.9043 100 0.171 Contact Map
1mkmA 4 0.8759 100 0.174 Contact Map
2xrnA 3 0.8546 100 0.186 Contact Map
2o0yA 4 0.9043 100 0.21 Contact Map
1ysqA 1 0.6277 100 0.435 Contact Map
1tf1A 1 0.6525 100 0.454 Contact Map
1yspA 1 0.5816 100 0.457 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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