GREMLIN Database
YIAH - Inner membrane protein YiaH
UniProt: P37669 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12274
Length: 331 (300)
Sequences: 14258 (12712)
Seq/√Len: 733.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
269_L273_H3.8411.00
315_L319_M3.7931.00
20_V277_I3.7171.00
280_F317_L3.6241.00
66_F191_R3.3331.00
120_F124_I3.2981.00
15_A56_L3.2911.00
72_Q132_P3.2641.00
76_F80_G3.2391.00
319_M323_R3.1221.00
9_D272_R2.8301.00
273_H315_L2.8191.00
13_G271_S2.7961.00
269_L315_L2.6531.00
83_L118_L2.5741.00
310_T314_S2.5631.00
55_P186_Y2.4421.00
10_N262_R2.4201.00
269_L319_M2.3031.00
80_G84_I2.2801.00
86_Y280_F2.1861.00
316_L320_L2.1651.00
24_T285_I2.1511.00
64_L67_G2.0621.00
58_F123_A2.0541.00
67_G194_G2.0231.00
50_S53_S2.0081.00
183_Y186_Y1.9931.00
13_G274_S1.9401.00
65_F131_S1.8911.00
63_Y197_D1.8391.00
66_F131_S1.8381.00
82_C279_G1.8241.00
276_G318_S1.8241.00
86_Y279_G1.7891.00
9_D268_G1.7871.00
13_G270_I1.7651.00
22_I50_S1.7551.00
73_P77_L1.7461.00
277_I314_S1.7401.00
8_I64_L1.7201.00
8_I60_I1.7091.00
273_H314_S1.7041.00
276_G317_L1.6881.00
16_C277_I1.6711.00
64_L68_E1.6591.00
10_N263_T1.6511.00
108_N113_P1.6131.00
277_I310_T1.5811.00
140_G143_M1.5551.00
269_L272_R1.5541.00
80_G111_Q1.5531.00
264_I267_L1.5291.00
11_L56_L1.5241.00
174_L177_N1.4981.00
5_I63_Y1.4761.00
181_F185_L1.4671.00
59_M193_I1.4641.00
85_F321_V1.4531.00
89_I280_F1.4451.00
300_I304_I1.4411.00
318_S322_Q1.4381.00
107_K112_K1.4011.00
146_V149_A1.3981.00
82_C317_L1.3761.00
155_A158_N1.3701.00
210_L214_G1.3591.00
122_F126_V1.3591.00
273_H277_I1.3491.00
65_F128_Y1.3441.00
70_S74_R1.3361.00
220_R224_Y1.3361.00
281_H285_I1.3351.00
15_A53_S1.3281.00
19_V54_V1.3151.00
266_G270_I1.3051.00
119_W123_A1.2971.00
273_H276_G1.2931.00
288_L306_I1.2901.00
65_F68_E1.2661.00
104_L108_N1.2651.00
248_A251_L1.2631.00
124_I128_Y1.2611.00
268_G272_R1.2601.00
58_F124_I1.2591.00
72_Q125_A1.2531.00
247_C250_A1.2501.00
90_A283_L1.2431.00
13_G17_L1.2361.00
66_F195_M1.2361.00
129_L132_P1.2301.00
55_P183_Y1.2191.00
141_G145_L1.2161.00
86_Y118_L1.2151.00
221_G225_E1.2121.00
108_N112_K1.2001.00
80_G125_A1.1981.00
306_I310_T1.1971.00
275_L279_G1.1921.00
211_F214_G1.1921.00
16_C120_F1.1891.00
88_A109_L1.1861.00
154_I158_N1.1851.00
188_M191_R1.1671.00
61_S124_I1.1641.00
86_Y90_A1.1621.00
81_L85_F1.1591.00
145_L149_A1.1591.00
18_M53_S1.1551.00
63_Y194_G1.1441.00
70_S73_P1.1431.00
117_H282_A1.1381.00
152_G156_N1.1371.00
250_A253_T1.1331.00
142_K145_L1.1281.00
284_I313_A1.1271.00
79_I128_Y1.1241.00
167_F170_L1.1241.00
298_W301_L1.1151.00
10_N267_L1.1101.00
308_C312_A1.1101.00
16_C57_F1.1071.00
66_F194_G1.1031.00
76_F125_A1.1031.00
273_H319_M1.1011.00
127_I187_G1.0981.00
313_A317_L1.0941.00
131_S187_G1.0941.00
285_I306_I1.0891.00
265_R269_L1.0891.00
131_S191_R1.0851.00
179_D182_Y1.0841.00
248_A256_K1.0811.00
170_L173_N1.0801.00
75_H128_Y1.0791.00
88_A92_L1.0771.00
83_L275_L1.0701.00
117_H283_L1.0661.00
280_F283_L1.0621.00
82_C276_G1.0621.00
214_G218_I1.0601.00
241_G244_V1.0531.00
123_A183_Y1.0491.00
107_K111_Q1.0481.00
304_I308_C1.0481.00
317_L321_V1.0441.00
207_S211_F1.0411.00
13_G267_L1.0411.00
318_S323_R1.0401.00
108_N111_Q1.0311.00
209_A213_T1.0281.00
151_I155_A1.0231.00
77_L80_G1.0191.00
71_A128_Y1.0161.00
19_V53_S1.0131.00
5_I67_G1.0121.00
138_N142_K1.0121.00
212_A216_F1.0111.00
137_K140_G1.0101.00
249_I252_L1.0101.00
90_A117_H1.0091.00
54_V57_F1.0051.00
265_R268_G1.0041.00
262_R265_R1.0021.00
200_H203_L1.0001.00
20_V281_H0.9911.00
143_M146_V0.9871.00
92_L96_L0.9801.00
106_L110_L0.9731.00
108_N114_V0.9671.00
50_S54_V0.9651.00
71_A132_P0.9581.00
65_F125_A0.9561.00
104_L107_K0.9531.00
12_R60_I0.9491.00
9_D271_S0.9471.00
71_A75_H0.9471.00
312_A316_L0.9431.00
203_L206_V0.9391.00
276_G322_Q0.9361.00
22_I51_R0.9351.00
314_S318_S0.9331.00
6_Y9_D0.9251.00
290_T294_E0.9231.00
20_V307_F0.9221.00
138_N141_G0.9211.00
273_H318_S0.9211.00
12_R120_F0.9101.00
144_L147_L0.9071.00
10_N261_T0.9071.00
150_V154_I0.9061.00
249_I253_T0.9021.00
281_H310_T0.8981.00
320_L324_I0.8941.00
9_D12_R0.8941.00
280_F313_A0.8861.00
270_I311_L0.8801.00
13_G16_C0.8801.00
145_L148_M0.8771.00
208_A211_F0.8741.00
218_I221_G0.8731.00
261_T264_I0.8721.00
208_A212_A0.8691.00
246_I249_I0.8691.00
117_H278_Y0.8681.00
18_M22_I0.8631.00
179_D183_Y0.8631.00
17_L21_M0.8631.00
204_S207_S0.8581.00
177_N183_Y0.8531.00
114_V126_V0.8511.00
117_H281_H0.8471.00
165_D169_W0.8471.00
123_A127_I0.8461.00
55_P182_Y0.8441.00
152_G155_A0.8441.00
118_L279_G0.8401.00
244_V247_C0.8371.00
301_L304_I0.8361.00
221_G224_Y0.8361.00
107_K113_P0.8341.00
125_A187_G0.8331.00
105_A114_V0.8281.00
149_A152_G0.8271.00
146_V150_V0.8231.00
18_M52_V0.8221.00
157_P160_V0.8221.00
75_H124_I0.8221.00
59_M186_Y0.8211.00
251_L255_V0.8171.00
177_N180_T0.8141.00
240_C243_M0.8121.00
165_D168_E0.8111.00
284_I288_L0.8111.00
238_L241_G0.8051.00
288_L302_D0.8051.00
65_F71_A0.8041.00
10_N264_I0.8031.00
78_R124_I0.8021.00
179_D186_Y0.7991.00
213_T217_I0.7971.00
112_K115_F0.7971.00
90_A94_I0.7961.00
127_I132_P0.7941.00
298_W302_D0.7941.00
75_H120_F0.7931.00
7_W10_N0.7931.00
92_L95_A0.7931.00
246_I250_A0.7921.00
288_L292_G0.7911.00
19_V120_F0.7911.00
185_L188_M0.7861.00
156_N160_V0.7841.00
105_A108_N0.7821.00
217_I221_G0.7761.00
222_T225_E0.7701.00
164_I167_F0.7591.00
265_R272_R0.7591.00
142_K146_V0.7591.00
58_F183_Y0.7581.00
263_T268_G0.7571.00
268_G271_S0.7561.00
166_G170_L0.7541.00
201_K204_S0.7531.00
75_H78_R0.7521.00
250_A254_L0.7511.00
243_M247_C0.7501.00
62_G191_R0.7431.00
155_A159_T0.7411.00
61_S65_F0.7361.00
248_A252_L0.7361.00
210_L213_T0.7331.00
51_R55_P0.7311.00
123_A126_V0.7301.00
219_S222_T0.7261.00
83_L87_S0.7231.00
211_F215_V0.7221.00
264_I268_G0.7221.00
124_I275_L0.7211.00
209_A212_A0.7211.00
187_G191_R0.7191.00
317_L320_L0.7191.00
22_I53_S0.7181.00
112_K116_Y0.7171.00
280_F310_T0.7141.00
302_D305_W0.7141.00
199_Q202_A0.7101.00
120_F275_L0.7091.00
166_G169_W0.7061.00
266_G269_L0.7061.00
98_T101_N0.6991.00
58_F120_F0.6991.00
141_G144_L0.6981.00
241_G245_F0.6971.00
259_L263_T0.6941.00
61_S187_G0.6931.00
16_C20_V0.6931.00
12_R124_I0.6921.00
16_C124_I0.6901.00
22_I55_P0.6891.00
89_I93_Y0.6871.00
145_L156_N0.6851.00
153_I157_P0.6821.00
121_F279_G0.6821.00
16_C270_I0.6821.00
243_M246_I0.6811.00
248_A255_V0.6781.00
113_P122_F0.6781.00
280_F314_S0.6761.00
214_G221_G0.6761.00
10_N13_G0.6761.00
277_I311_L0.6741.00
204_S208_A0.6731.00
189_L249_I0.6731.00
218_I222_T0.6691.00
260_D263_T0.6661.00
87_S91_L0.6661.00
205_W208_A0.6641.00
287_A290_T0.6581.00
125_A129_L0.6571.00
110_L113_P0.6561.00
19_V23_H0.6561.00
260_D264_I0.6551.00
19_V50_S0.6541.00
16_C53_S0.6521.00
244_V248_A0.6501.00
245_F248_A0.6471.00
200_H204_S0.6431.00
85_F89_I0.6431.00
263_T266_G0.6431.00
241_G253_T0.6391.00
180_T183_Y0.6381.00
156_N159_T0.6371.00
145_L152_G0.6371.00
53_S127_I0.6351.00
214_G217_I0.6321.00
282_A285_I0.6321.00
127_I183_Y0.6321.00
214_G225_E0.6301.00
56_L60_I0.6291.00
104_L116_Y0.6281.00
171_P174_L0.6281.00
20_V310_T0.6281.00
64_L276_G0.6211.00
118_L121_F0.6211.00
91_L105_A0.6201.00
65_F124_I0.6201.00
16_C19_V0.6191.00
319_M324_I0.6191.00
182_Y186_Y0.6171.00
147_L151_I0.6151.00
16_C274_S0.6121.00
64_L124_I0.6121.00
154_I157_P0.6081.00
79_I275_L0.6081.00
107_K116_Y0.6061.00
216_F220_R0.6041.00
140_G144_L0.6041.00
301_L305_W0.6031.00
127_I131_S0.6011.00
247_C251_L0.5981.00
6_Y263_T0.5961.00
148_M152_G0.5961.00
26_T29_V0.5931.00
24_T303_I0.5921.00
78_R81_L0.5921.00
245_F253_T0.5901.00
302_D306_I0.5901.00
14_I18_M0.5881.00
303_I307_F0.5871.00
194_G197_D0.5871.00
321_V324_I0.5871.00
11_L60_I0.5841.00
13_G273_H0.5811.00
318_S324_I0.5801.00
58_F119_W0.5781.00
188_M192_A0.5751.00
169_W172_I0.5741.00
284_I287_A0.5721.00
110_L114_V0.5721.00
284_I306_I0.5711.00
180_T184_I0.5701.00
139_V143_M0.5701.00
152_G159_T0.5691.00
75_H81_L0.5681.00
191_R194_G0.5651.00
206_V209_A0.5631.00
191_R195_M0.5611.00
220_R223_L0.5581.00
83_L111_Q0.5581.00
149_A156_N0.5571.00
7_W263_T0.5561.00
205_W209_A0.5551.00
8_I63_Y0.5541.00
54_V124_I0.5541.00
84_I125_A0.5531.00
239_Y244_V0.5511.00
107_K115_F0.5511.00
219_S223_L0.5501.00
272_R323_R0.5501.00
113_P116_Y0.5481.00
79_I125_A0.5451.00
272_R282_A0.5451.00
65_F187_G0.5441.00
286_H290_T0.5431.00
247_C253_T0.5421.00
245_F256_K0.5421.00
198_T202_A0.5421.00
111_Q114_V0.5421.00
198_T201_K0.5401.00
283_L286_H0.5381.00
79_I124_I0.5381.00
222_T226_L0.5361.00
240_C244_V0.5361.00
284_I310_T0.5351.00
24_T306_I0.5341.00
82_C321_V0.5341.00
15_A54_V0.5301.00
252_L256_K0.5291.00
115_F126_V0.5261.00
195_M199_Q0.5261.00
124_I322_Q0.5261.00
99_S103_E0.5261.00
67_G197_D0.5251.00
216_F219_S0.5241.00
68_E135_Q0.5241.00
88_A91_L0.5241.00
201_K205_W0.5211.00
53_S128_Y0.5201.00
165_D170_L0.5191.00
284_I309_A0.5181.00
241_G246_I0.5161.00
61_S120_F0.5151.00
22_I49_A0.5141.00
76_F84_I0.5141.00
305_W308_C0.5131.00
10_N268_G0.5131.00
81_L275_L0.5101.00
218_I225_E0.5091.00
120_F278_Y0.5091.00
242_P245_F0.5081.00
287_A291_R0.5071.00
297_N300_I0.5051.00
288_L291_R0.5051.00
5_I8_I0.5031.00
107_K110_L0.5010.99
18_M50_S0.5010.99
105_A111_Q0.5010.99
84_I88_A0.5000.99
53_S56_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ffvA 1 0.1813 3 0.959 Contact Map
4ev6A 3 0.1994 2.6 0.961 Contact Map
4i0uA 4 0.1934 2.2 0.962 Contact Map
3wdoA 1 0.7613 1.8 0.964 Contact Map
4p02A 1 0.3535 1.5 0.965 Contact Map
3j1zP 8 0.4139 1.5 0.965 Contact Map
4pypA 1 0.7402 1.4 0.966 Contact Map
2mv6A 1 0.148 1.2 0.968 Contact Map
3j1rA 5 0.0785 1.2 0.968 Contact Map
2gfpA 2 0.7221 1.1 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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