GREMLIN Database
GHRB - Glyoxylate/hydroxypyruvate reductase B
UniProt: P37666 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12272
Length: 324 (284)
Sequences: 19500 (13423)
Seq/√Len: 796.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
219_G222_Q4.3801.00
220_A248_A3.1981.00
242_D245_A3.1491.00
148_L164_A2.7151.00
147_T171_P2.4901.00
251_Q277_M2.4651.00
210_L239_P2.3971.00
195_D225_K2.3371.00
228_S254_E2.3061.00
147_T173_L2.2971.00
47_E68_R2.2911.00
149_G197_L2.1631.00
198_L222_Q2.1621.00
216_H264_E2.0461.00
199_Q225_K2.0351.00
193_D196_T2.0321.00
173_L200_E2.0231.00
153_M174_Y2.0091.00
58_A87_A2.0061.00
122_A126_K2.0001.00
108_M164_A1.9581.00
149_G201_S1.9191.00
117_R120_E1.8991.00
307_D312_K1.8811.00
115_A203_F1.8651.00
224_A254_E1.8571.00
218_F223_F1.8521.00
248_A252_K1.8491.00
159_A162_Q1.8111.00
58_A62_E1.8081.00
109_A118_V1.7891.00
232_F241_V1.7881.00
230_A255_I1.7821.00
69_A93_M1.7491.00
108_M168_F1.7481.00
171_P190_R1.7471.00
231_I257_A1.7381.00
216_H242_D1.7371.00
247_I277_M1.7201.00
111_V203_F1.7031.00
45_E66_K1.6861.00
195_D222_Q1.6841.00
277_M280_V1.6471.00
150_I157_G1.6431.00
148_L170_M1.6211.00
196_T200_E1.6111.00
220_A224_A1.6071.00
36_V59_A1.6051.00
106_T287_G1.6011.00
91_L317_C1.5881.00
246_L258_A1.5691.00
84_A87_A1.5671.00
110_L259_G1.5641.00
223_F249_A1.5631.00
202_D227_K1.5611.00
212_D215_H1.5461.00
146_K292_E1.5451.00
62_E88_R1.5441.00
113_S119_V1.5421.00
251_Q273_P1.5391.00
218_F222_Q1.5251.00
221_E225_K1.5171.00
141_T146_K1.5051.00
243_E264_E1.5051.00
198_L218_F1.5021.00
164_A170_M1.4831.00
114_T257_A1.4721.00
210_L215_H1.4451.00
36_V57_N1.4401.00
226_M230_A1.4391.00
105_D163_R1.4361.00
35_T38_Q1.4281.00
206_L240_V1.4141.00
231_I256_H1.4101.00
160_L207_I1.4071.00
173_L192_C1.4071.00
142_D296_G1.4071.00
220_A245_A1.4061.00
150_I205_C1.3961.00
306_I310_Q1.3931.00
107_L160_L1.3761.00
101_E144_H1.3711.00
207_I235_A1.3691.00
171_P200_E1.3681.00
247_I251_Q1.3621.00
159_A163_R1.3501.00
208_L240_V1.3441.00
61_L88_R1.3441.00
48_G69_A1.3411.00
307_D315_K1.3371.00
222_Q225_K1.3291.00
85_L92_L1.3281.00
43_F64_M1.3061.00
123_E126_K1.2821.00
215_H239_P1.2811.00
236_G240_V1.2781.00
197_L201_S1.2621.00
299_A303_D1.2621.00
303_D307_D1.2501.00
150_I161_A1.2431.00
206_L232_F1.2291.00
265_Q269_S1.2211.00
40_A63_K1.2151.00
101_E159_A1.2101.00
190_R200_E1.2051.00
195_D221_E1.1991.00
123_E127_A1.1921.00
47_E66_K1.1871.00
151_V208_L1.1871.00
57_N60_L1.1741.00
106_T110_L1.1741.00
99_L288_S1.1691.00
107_L235_A1.1691.00
112_L168_F1.1681.00
263_F282_A1.1631.00
114_T231_I1.1621.00
151_V218_F1.1561.00
160_L205_C1.1551.00
58_A84_A1.1491.00
308_A314_E1.1441.00
128_G276_S1.1391.00
205_C235_A1.1391.00
83_D87_A1.1371.00
84_A88_R1.1361.00
153_M158_M1.1301.00
162_Q169_N1.1291.00
151_V217_L1.1291.00
223_F232_F1.1251.00
217_L240_V1.1201.00
303_D315_K1.1161.00
109_A112_L1.1141.00
114_T281_V1.1131.00
124_R129_E1.1101.00
104_A163_R1.1081.00
69_A308_A1.1051.00
227_K230_A1.1041.00
61_L85_L1.1021.00
229_S254_E1.1001.00
114_T259_G1.0911.00
80_F85_L1.0871.00
203_F231_I1.0861.00
221_E224_A1.0841.00
72_T80_F1.0831.00
119_V122_A1.0811.00
151_V204_V1.0701.00
101_E163_R1.0631.00
173_L201_S1.0601.00
300_C316_N1.0591.00
204_V226_M1.0441.00
147_T200_E1.0341.00
62_E84_A1.0341.00
268_L272_S1.0321.00
243_E265_Q1.0311.00
106_T283_V1.0281.00
194_L222_Q1.0271.00
83_D86_T1.0221.00
71_S304_N1.0211.00
251_Q276_S1.0191.00
250_L280_V1.0181.00
111_V148_L1.0141.00
219_G245_A1.0131.00
151_V194_L0.9921.00
243_E272_S0.9881.00
244_N273_P0.9861.00
177_R213_E0.9821.00
106_T259_G0.9791.00
36_V40_A0.9781.00
192_C197_L0.9741.00
249_A254_E0.9731.00
91_L314_E0.9671.00
209_P214_T0.9671.00
38_Q41_A0.9631.00
192_C196_T0.9591.00
295_Y299_A0.9561.00
82_V86_T0.9551.00
41_A44_A0.9521.00
162_Q165_H0.9521.00
194_L198_L0.9441.00
179_H191_Y0.9391.00
110_L281_V0.9381.00
179_H184_E0.9331.00
72_T79_N0.9331.00
71_S301_A0.9311.00
111_V164_A0.9301.00
165_H188_N0.9251.00
108_M163_R0.9251.00
249_A255_I0.9241.00
48_G305_L0.9201.00
208_L217_L0.9191.00
219_G242_D0.9141.00
218_F232_F0.9121.00
223_F254_E0.9071.00
71_S93_M0.9071.00
81_D84_A0.9021.00
151_V206_L0.9001.00
201_S204_V0.8971.00
176_A180_H0.8941.00
115_A141_T0.8901.00
61_L70_T0.8731.00
247_I273_P0.8721.00
80_F92_L0.8701.00
113_S118_V0.8671.00
158_M180_H0.8651.00
102_T142_D0.8631.00
192_C200_E0.8631.00
148_L205_C0.8591.00
40_A60_L0.8531.00
103_V287_G0.8521.00
223_F226_M0.8501.00
174_Y189_A0.8491.00
74_S79_N0.8461.00
160_L164_A0.8421.00
229_S256_H0.8411.00
115_A146_K0.8391.00
144_H169_N0.8381.00
143_V170_M0.8381.00
113_S281_V0.8361.00
304_N307_D0.8361.00
150_I160_L0.8331.00
123_E278_A0.8331.00
204_V230_A0.8311.00
198_L204_V0.8301.00
142_D290_T0.8291.00
108_M160_L0.8281.00
100_T159_A0.8271.00
158_M183_A0.8261.00
70_T85_L0.8241.00
115_A231_I0.8241.00
206_L218_F0.8231.00
246_L255_I0.8221.00
48_G309_L0.8211.00
101_E105_D0.8181.00
244_N248_A0.8171.00
248_A251_Q0.8161.00
241_V246_L0.8101.00
257_A281_V0.8021.00
268_L271_D0.8021.00
243_E274_L0.8011.00
224_A252_K0.8001.00
59_A62_E0.7991.00
44_A63_K0.7971.00
153_M161_A0.7911.00
69_A305_L0.7901.00
170_M203_F0.7901.00
263_F268_L0.7891.00
43_F49_L0.7841.00
119_V123_E0.7831.00
141_T292_E0.7771.00
174_Y191_Y0.7721.00
229_S255_I0.7671.00
147_T201_S0.7671.00
161_A172_I0.7651.00
50_L301_A0.7641.00
38_Q42_I0.7641.00
210_L214_T0.7621.00
108_M111_V0.7611.00
250_L279_N0.7591.00
49_L56_V0.7531.00
163_R168_F0.7461.00
109_A113_S0.7451.00
244_N264_E0.7441.00
260_L280_V0.7431.00
258_A280_V0.7381.00
107_L205_C0.7371.00
100_T155_R0.7311.00
101_E142_D0.7311.00
180_H183_A0.7251.00
181_K184_E0.7241.00
107_L207_I0.7231.00
125_V275_L0.7221.00
246_L260_L0.7221.00
121_V286_I0.7151.00
198_L225_K0.7131.00
141_T291_H0.7131.00
111_V160_L0.7131.00
231_I259_G0.7091.00
105_D116_R0.7081.00
204_V227_K0.7081.00
195_D199_Q0.7071.00
141_T229_S0.7051.00
176_A179_H0.7021.00
220_A254_E0.6991.00
115_A119_V0.6971.00
97_T155_R0.6961.00
58_A81_D0.6951.00
184_E191_Y0.6911.00
241_V258_A0.6881.00
175_N194_L0.6861.00
296_G299_A0.6831.00
107_L110_L0.6831.00
58_A88_R0.6811.00
196_T199_Q0.6811.00
102_T293_T0.6811.00
111_V143_V0.6761.00
208_L236_G0.6741.00
215_H264_E0.6731.00
147_T227_K0.6711.00
302_V306_I0.6711.00
303_D306_I0.6701.00
77_Y82_V0.6671.00
206_L236_G0.6661.00
149_G175_N0.6581.00
95_T300_C0.6581.00
72_T77_Y0.6581.00
194_L217_L0.6551.00
174_Y184_E0.6531.00
40_A59_A0.6521.00
146_K203_F0.6501.00
102_T105_D0.6481.00
275_L282_A0.6481.00
71_S305_L0.6461.00
198_L226_M0.6441.00
122_A125_V0.6411.00
144_H296_G0.6411.00
97_T300_C0.6401.00
259_G281_V0.6391.00
269_S272_S0.6391.00
248_A254_E0.6371.00
95_T297_M0.6361.00
64_M67_L0.6351.00
102_T290_T0.6341.00
111_V233_I0.6331.00
307_D313_V0.6301.00
37_E41_A0.6291.00
158_M162_Q0.6271.00
153_M191_Y0.6271.00
268_L275_L0.6261.00
44_A65_P0.6221.00
68_R308_A0.6221.00
45_E65_P0.6201.00
307_D314_E0.6181.00
98_V288_S0.6171.00
25_V28_V0.6171.00
216_H219_G0.6151.00
106_T109_A0.6141.00
216_H239_P0.6141.00
104_A159_A0.6141.00
313_V317_C0.6131.00
220_A252_K0.6121.00
291_H295_Y0.6081.00
173_L197_L0.6081.00
61_L90_I0.6041.00
122_A282_A0.6041.00
211_T214_T0.6031.00
165_H172_I0.6011.00
250_L258_A0.6001.00
182_E186_R0.6001.00
147_T202_D0.5991.00
115_A170_M0.5981.00
124_R127_A0.5971.00
65_P88_R0.5971.00
143_V168_F0.5971.00
77_Y94_H0.5961.00
229_S252_K0.5951.00
78_D210_L0.5931.00
148_L160_L0.5931.00
71_S95_T0.5881.00
51_G56_V0.5861.00
163_R167_G0.5861.00
48_G71_S0.5831.00
289_A294_R0.5821.00
40_A64_M0.5821.00
56_V61_L0.5811.00
106_T116_R0.5811.00
101_E169_N0.5801.00
24_T28_V0.5781.00
251_Q278_A0.5771.00
110_L113_S0.5771.00
314_E317_C0.5761.00
110_L114_T0.5731.00
146_K170_M0.5701.00
220_A249_A0.5661.00
239_P264_E0.5611.00
99_L102_T0.5601.00
73_I297_M0.5591.00
121_V284_P0.5591.00
111_V205_C0.5561.00
204_V218_F0.5561.00
95_T98_V0.5551.00
103_V107_L0.5541.00
42_I46_A0.5521.00
97_T100_T0.5501.00
299_A302_V0.5491.00
189_A192_C0.5481.00
59_A63_K0.5481.00
98_V297_M0.5481.00
249_A252_K0.5471.00
162_Q167_G0.5441.00
204_V232_F0.5431.00
125_V263_F0.5411.00
243_E247_I0.5411.00
208_L214_T0.5391.00
198_L217_L0.5391.00
52_S73_I0.5381.00
153_M176_A0.5371.00
167_G170_M0.5371.00
265_Q272_S0.5361.00
204_V222_Q0.5351.00
251_Q279_N0.5331.00
272_S276_S0.5331.00
37_E59_A0.5331.00
126_K276_S0.5311.00
98_V300_C0.5281.00
119_V281_V0.5281.00
230_A254_E0.5261.00
48_G51_G0.5221.00
125_V282_A0.5221.00
228_S249_A0.5201.00
113_S122_A0.5191.00
180_H184_E0.5171.00
237_R285_H0.5161.00
244_N272_S0.5151.00
151_V197_L0.5121.00
88_R91_L0.5121.00
247_I280_V0.5101.00
194_L218_F0.5091.00
120_E124_R0.5081.00
69_A91_L0.5071.00
108_M148_L0.5071.00
124_R131_T0.5061.00
300_C304_N0.5021.00
173_L190_R0.5021.00
146_K202_D0.5021.00
161_A174_Y0.5011.00
93_M304_N0.5011.00
217_L222_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2d0iA 2 0.9815 100 0.199 Contact Map
1ygyA 4 0.9753 100 0.201 Contact Map
1sc6A 4 0.9383 100 0.203 Contact Map
2g76A 2 0.929 100 0.206 Contact Map
4g2nA 3 0.9753 100 0.207 Contact Map
3ba1A 2 0.9599 100 0.209 Contact Map
3k5pA 3 0.963 100 0.211 Contact Map
4lswA 2 0.966 100 0.214 Contact Map
2dbqA 2 0.9938 100 0.215 Contact Map
2gcgA 2 0.9846 100 0.218 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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