GREMLIN Database
YIAD - Probable lipoprotein YiaD
UniProt: P37665 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12271
Length: 219 (210)
Sequences: 5871 (4889)
Seq/√Len: 337.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
117_D124_K5.2631.00
119_S160_L3.8001.00
155_T206_K3.6151.00
191_L195_N3.4391.00
151_Y195_N3.3941.00
132_T175_A3.3491.00
199_S205_G3.3251.00
149_I191_L3.2681.00
198_A205_G3.2261.00
165_S190_G3.0461.00
118_S155_T2.9061.00
200_N205_G2.8721.00
162_M166_Q2.8391.00
166_Q170_D2.7971.00
131_L175_A2.7061.00
163_R167_Q2.6061.00
132_T179_Q2.5661.00
173_A188_T2.5601.00
121_A167_Q2.4881.00
148_V173_A2.2161.00
202_T205_G2.1141.00
198_A208_Q2.0221.00
123_L175_A1.9961.00
154_S206_K1.9581.00
109_N213_E1.9561.00
85_E89_R1.9331.00
200_N206_K1.9271.00
160_L163_R1.9061.00
25_P28_G1.8781.00
201_S205_G1.6841.00
149_I215_T1.6611.00
177_I186_I1.6341.00
153_D161_N1.5691.00
135_A176_L1.5671.00
77_V81_M1.5581.00
123_L127_G1.5501.00
128_A175_A1.5441.00
175_A179_Q1.5391.00
163_R174_S1.5201.00
117_D120_S1.4991.00
170_D174_S1.4911.00
125_P128_A1.4671.00
170_D173_A1.4041.00
147_N189_Q1.3971.00
154_S200_N1.3841.00
77_V80_Y1.3821.00
173_A186_I1.3521.00
49_I53_S1.3281.00
199_S202_T1.3261.00
158_H193_P1.3241.00
177_I183_A1.3231.00
32_A36_A1.3141.00
162_M194_A1.2901.00
204_E208_Q1.2711.00
157_G160_L1.2651.00
71_A75_G1.2371.00
79_Y83_V1.2291.00
158_H194_A1.2281.00
172_V212_V1.2221.00
147_N187_R1.2141.00
182_D185_R1.2091.00
107_I213_E1.2061.00
149_I189_Q1.1691.00
72_A76_G1.1681.00
155_T203_A1.1671.00
78_G82_D1.1621.00
25_P29_E1.1581.00
166_Q190_G1.1581.00
115_T127_G1.1491.00
14_G17_A1.1451.00
181_V186_I1.1421.00
130_T133_G1.1401.00
169_A190_G1.1381.00
156_G160_L1.1251.00
107_I215_T1.1251.00
68_A72_A1.1191.00
26_Y30_R1.0981.00
81_M85_E1.0971.00
87_K90_D1.0911.00
160_L193_P1.0731.00
181_V185_R1.0711.00
136_M139_K1.0671.00
149_I195_N1.0611.00
83_V87_K1.0611.00
12_V16_L1.0591.00
66_G70_G1.0591.00
69_A72_A1.0541.00
87_K140_E1.0541.00
173_A177_I1.0481.00
70_G74_G1.0461.00
72_A75_G1.0331.00
100_T109_N0.9991.00
202_T206_K0.9921.00
167_Q170_D0.9921.00
76_G79_Y0.9911.00
156_G161_N0.9851.00
170_D188_T0.9801.00
36_A40_G0.9651.00
175_A178_T0.9621.00
24_N29_E0.9561.00
27_T30_R0.9551.00
118_S153_D0.9511.00
160_L167_Q0.9491.00
11_V15_A0.9421.00
118_S160_L0.9361.00
50_G53_S0.9351.00
45_V49_I0.9311.00
135_A179_Q0.9291.00
151_Y196_P0.9281.00
61_K64_L0.9221.00
134_V138_L0.9221.00
86_A89_R0.9211.00
13_S17_A0.9211.00
14_G18_V0.9171.00
8_I14_G0.9151.00
83_V86_A0.9121.00
174_S178_T0.9111.00
102_S105_N0.9091.00
87_K91_K0.9091.00
154_S205_G0.9081.00
123_L128_A0.8971.00
43_S46_G0.8921.00
131_L176_L0.8911.00
73_L76_G0.8891.00
155_T193_P0.8591.00
82_D86_A0.8491.00
166_Q188_T0.8481.00
36_A39_A0.8481.00
183_A194_A0.8461.00
129_N133_G0.8411.00
71_A74_G0.8411.00
62_G65_I0.8401.00
136_M140_E0.8401.00
59_R63_A0.8331.00
131_L172_V0.8311.00
153_D210_R0.8301.00
150_G212_V0.8251.00
34_K38_G0.8221.00
26_Y29_E0.8211.00
48_G51_A0.8201.00
139_K181_V0.8101.00
59_R62_G0.8091.00
19_S22_T0.8091.00
66_G69_A0.7971.00
34_K41_L0.7911.00
36_A41_L0.7901.00
151_Y194_A0.7881.00
65_I68_A0.7871.00
121_A164_L0.7821.00
203_A206_K0.7801.00
104_D107_I0.7791.00
116_F212_V0.7791.00
69_A73_L0.7781.00
44_L48_G0.7771.00
63_A67_A0.7641.00
67_A71_A0.7611.00
15_A21_C0.7601.00
156_G159_D0.7591.00
96_G99_V0.7591.00
78_G81_M0.7581.00
8_I12_V0.7561.00
24_N28_G0.7561.00
116_F172_V0.7551.00
9_A18_V0.7551.00
43_S47_A0.7541.00
22_T27_T0.7541.00
139_K182_D0.7521.00
196_P209_N0.7521.00
197_I208_Q0.7511.00
87_K92_M0.7501.00
147_N215_T0.7460.99
42_G45_V0.7440.99
133_G136_M0.7390.99
160_L174_S0.7380.99
135_A181_V0.7360.99
19_S24_N0.7340.99
35_S39_A0.7310.99
44_L47_A0.7310.99
9_A12_V0.7260.99
68_A71_A0.7200.99
77_V87_K0.7200.99
154_S193_P0.7160.99
13_S19_S0.7150.99
154_S202_T0.7150.99
42_G46_G0.7140.99
126_A129_N0.7120.99
81_M87_K0.7110.99
61_K65_I0.7100.99
205_G208_Q0.7050.99
124_K127_G0.7050.99
70_G73_L0.7030.99
148_V186_I0.7030.99
15_A19_S0.7020.99
148_V188_T0.7010.99
58_D61_K0.6990.99
86_A90_D0.6980.99
33_G37_I0.6970.99
104_D149_I0.6970.99
118_S156_G0.6900.99
13_S16_L0.6890.99
118_S161_N0.6860.99
138_L146_V0.6820.99
141_Y144_T0.6810.99
145_A187_R0.6790.99
46_G50_G0.6770.99
121_A163_R0.6730.99
196_P206_K0.6700.99
21_C25_P0.6690.99
52_L55_S0.6650.99
33_G36_A0.6640.99
64_L67_A0.6640.99
52_L56_K0.6630.99
129_N132_T0.6620.99
27_T31_E0.6610.99
40_G43_S0.6600.99
80_Y92_M0.6580.99
82_D85_E0.6550.99
123_L172_V0.6540.99
60_G63_A0.6530.99
18_V21_C0.6530.99
80_Y84_Q0.6530.99
147_N217_S0.6520.99
37_I41_L0.6510.99
60_G64_L0.6470.99
85_E101_R0.6470.99
63_A66_G0.6450.99
91_K136_M0.6440.99
132_T136_M0.6440.99
162_M188_T0.6430.99
17_A20_G0.6410.98
48_G52_L0.6400.98
162_M192_G0.6390.98
62_G69_A0.6360.98
119_S157_G0.6320.98
49_I52_L0.6310.98
80_Y87_K0.6290.98
74_G78_G0.6280.98
50_G54_S0.6280.98
37_I40_G0.6220.98
16_L19_S0.6220.98
8_I19_S0.6210.98
46_G49_I0.6200.98
118_S203_A0.6190.98
128_A132_T0.6170.98
79_Y82_D0.6150.98
18_V23_T0.6140.98
163_R166_Q0.6140.98
67_A74_G0.6130.98
90_D94_G0.6110.98
198_A202_T0.6110.98
135_A139_K0.6090.98
196_P200_N0.6040.98
65_I69_A0.6010.98
149_I213_E0.5990.98
121_A171_S0.5940.98
138_L181_V0.5920.97
151_Y192_G0.5890.97
23_T30_R0.5870.97
157_G193_P0.5870.97
110_M115_T0.5860.97
14_G20_G0.5840.97
34_K37_I0.5760.97
8_I11_V0.5750.97
66_G74_G0.5740.97
10_A15_A0.5730.97
87_K93_R0.5730.97
134_V137_V0.5690.97
24_N27_T0.5680.97
54_S57_K0.5650.97
137_V141_Y0.5640.97
139_K180_G0.5640.97
146_V186_I0.5640.97
38_G41_L0.5600.96
47_A51_A0.5600.96
144_T214_I0.5600.96
47_A50_G0.5590.96
124_K129_N0.5590.96
163_R170_D0.5560.96
142_P145_A0.5550.96
27_T32_A0.5550.96
176_L181_V0.5530.96
24_N31_E0.5480.96
67_A70_G0.5480.96
11_V19_S0.5470.96
45_V48_G0.5460.96
23_T27_T0.5450.96
198_A201_S0.5450.96
119_S167_Q0.5430.96
154_S203_A0.5420.96
171_S174_S0.5410.96
151_Y209_N0.5400.96
55_S58_D0.5360.95
112_N115_T0.5360.95
35_S41_L0.5310.95
49_I54_S0.5290.95
35_S38_G0.5280.95
116_F150_G0.5270.95
187_R217_S0.5260.95
66_G71_A0.5240.95
10_A13_S0.5180.95
9_A13_S0.5170.95
139_K179_Q0.5150.94
69_A74_G0.5140.94
40_G44_L0.5120.94
78_G85_E0.5120.94
38_G46_G0.5110.94
196_P202_T0.5110.94
163_R193_P0.5100.94
43_S48_G0.5080.94
44_L50_G0.5070.94
22_T29_E0.5060.94
41_L44_L0.5060.94
46_G51_A0.5030.94
22_T28_G0.5020.94
84_Q89_R0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2k1sA 1 0.6438 100 0.344 Contact Map
3ldtA 2 0.6484 100 0.345 Contact Map
3wpwA 2 0.6575 100 0.345 Contact Map
3s0yA 4 0.7534 100 0.362 Contact Map
3khnA 2 0.6895 100 0.37 Contact Map
4b62A 1 0.6347 100 0.37 Contact Map
3s06A 3 0.6301 100 0.379 Contact Map
1r1mA 1 0.5434 100 0.382 Contact Map
2hqsH 1 0.4932 100 0.387 Contact Map
2zvyA 2 0.6986 100 0.39 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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