GREMLIN Database
YIAC - Uncharacterized N-acetyltransferase YiaC
UniProt: P37664 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12270
Length: 146 (128)
Sequences: 5926 (4719)
Seq/√Len: 417.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_E77_A3.2351.00
87_K118_Q3.0881.00
94_Q120_F2.6771.00
3_R54_E2.6231.00
51_W92_Y2.5771.00
112_I116_Q2.4791.00
63_V93_V2.4791.00
53_W85_I2.3881.00
60_L80_A2.3011.00
63_V71_L2.2931.00
61_G76_V2.2011.00
90_M118_Q2.1111.00
3_R9_E1.9121.00
55_E80_A1.9071.00
92_Y95_Q1.8361.00
37_I41_R1.8221.00
5_A13_I1.7711.00
15_E19_E1.7331.00
52_V59_L1.6751.00
122_I125_C1.6701.00
91_Q118_Q1.6471.00
16_L59_L1.6401.00
116_Q122_I1.6181.00
92_Y96_R1.6091.00
12_A15_E1.5351.00
113_N116_Q1.5281.00
81_V110_P1.5141.00
55_E60_L1.5041.00
60_L85_I1.4921.00
30_A34_R1.4881.00
36_C41_R1.4801.00
19_E78_P1.4731.00
80_A83_R1.4721.00
106_Q125_C1.4621.00
55_E83_R1.3931.00
66_M72_A1.3891.00
18_L22_T1.3681.00
36_C40_V1.3611.00
112_I122_I1.3491.00
23_W78_P1.2991.00
102_L115_Y1.2881.00
54_E59_L1.2861.00
54_E57_G1.2801.00
16_L20_S1.2551.00
70_F101_M1.2131.00
64_S73_A1.2041.00
29_K32_Y1.2011.00
58_K77_A1.2001.00
5_A52_V1.1941.00
100_L120_F1.1761.00
50_N64_S1.1611.00
5_A10_L1.1591.00
87_K91_Q1.1371.00
94_Q100_L1.1331.00
20_S81_V1.1321.00
32_Y35_D1.1301.00
36_C39_L1.1151.00
16_L77_A1.1111.00
19_E79_K1.1061.00
58_K79_K1.1051.00
2_I51_W1.1041.00
49_Q96_R1.1041.00
58_K80_A1.0941.00
12_A59_L1.0891.00
55_E58_K1.0881.00
12_A16_L1.0631.00
91_Q95_Q1.0591.00
77_A80_A1.0401.00
20_S75_F0.9871.00
53_W60_L0.9851.00
82_R110_P0.9681.00
37_I40_V0.9571.00
65_I93_V0.9441.00
51_W96_R0.9391.00
23_W81_V0.9361.00
39_L43_A0.9301.00
17_W62_F0.9231.00
75_F114_F0.9161.00
111_A115_Y0.8971.00
10_L14_L0.8961.00
11_P15_E0.8961.00
15_E77_A0.8961.00
12_A58_K0.8901.00
91_Q94_Q0.8891.00
76_V85_I0.8881.00
87_K117_A0.8861.00
13_I62_F0.8741.00
17_W75_F0.8691.00
71_L90_M0.8691.00
114_F117_A0.8521.00
24_G81_V0.8461.00
94_Q118_Q0.8431.00
31_N35_D0.8351.00
19_E22_T0.8231.00
38_P41_R0.8031.00
4_E51_W0.8021.00
27_F33_W0.8021.00
63_V89_L0.7911.00
78_P81_V0.7881.00
38_P42_D0.7841.00
3_R52_V0.7811.00
49_Q65_I0.7811.00
4_E96_R0.7781.00
109_Q113_N0.7741.00
27_F107_K0.7701.00
82_R117_A0.7651.00
13_I59_L0.7641.00
103_E126_A0.7571.00
104_V108_N0.7481.00
108_N115_Y0.7411.00
102_L111_A0.7401.00
36_C43_A0.7401.00
14_L18_L0.7381.00
17_W73_A0.7311.00
14_L17_W0.7281.00
61_G89_L0.7261.00
74_M90_M0.7231.00
40_V43_A0.7221.00
26_P30_A0.7171.00
48_A64_S0.7161.00
80_A85_I0.7101.00
17_W20_S0.7041.00
21_T25_H0.7031.00
4_E49_Q0.6991.00
63_V74_M0.6971.00
88_A95_Q0.6921.00
62_F73_A0.6891.00
17_W21_T0.6801.00
5_A50_N0.6761.00
108_N111_A0.6690.99
29_K33_W0.6610.99
22_T33_W0.6580.99
90_M102_L0.6570.99
27_F30_A0.6570.99
76_V89_L0.6510.99
62_F114_F0.6490.99
21_T115_Y0.6460.99
9_E54_E0.6410.99
21_T75_F0.6390.99
5_A9_E0.6340.99
3_R6_Q0.6300.99
71_L120_F0.6280.99
45_L48_A0.6230.99
109_Q112_I0.6200.99
73_A105_Y0.6170.99
33_W37_I0.6160.99
18_L37_I0.6070.99
116_Q121_H0.6000.99
28_I33_W0.5990.99
71_L115_Y0.5970.99
65_I96_R0.5960.99
61_G85_I0.5890.99
76_V86_G0.5890.99
53_W61_G0.5810.99
22_T30_A0.5800.99
12_A77_A0.5790.99
74_M115_Y0.5790.99
17_W25_H0.5790.99
19_E23_W0.5720.98
75_F105_Y0.5710.98
70_F103_E0.5640.98
53_W89_L0.5620.98
26_P33_W0.5510.98
7_R10_L0.5510.98
31_N34_R0.5480.98
39_L42_D0.5420.98
104_V111_A0.5410.98
90_M114_F0.5390.98
40_V44_Y0.5380.98
6_Q9_E0.5370.98
50_N54_E0.5340.98
104_V112_I0.5340.98
2_I6_Q0.5330.98
20_S76_V0.5320.97
20_S78_P0.5270.97
114_F118_Q0.5270.97
29_K35_D0.5260.97
45_L50_N0.5260.97
73_A103_E0.5250.97
110_P113_N0.5240.97
12_A54_E0.5220.97
126_A130_E0.5200.97
34_R37_I0.5180.97
14_L37_I0.5120.97
88_A91_Q0.5110.97
27_F32_Y0.5090.97
39_L44_Y0.5070.97
44_Y47_N0.5070.97
27_F31_N0.5040.97
70_F73_A0.5000.96
90_M115_Y0.5000.96
63_V92_Y0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kcwA 1 0.9795 99.9 0.342 Contact Map
3fncA 2 0.9795 99.8 0.376 Contact Map
2cy2A 1 1 99.8 0.389 Contact Map
3dr6A 2 1 99.8 0.398 Contact Map
3i9sA 4 0.9658 99.8 0.401 Contact Map
1cjwA 1 0.9452 99.8 0.411 Contact Map
2j8mA 2 1 99.8 0.411 Contact Map
2fiwA 2 0.9795 99.8 0.415 Contact Map
1tiqA 1 1 99.8 0.421 Contact Map
1p0hA 1 0.8836 99.8 0.421 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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