GREMLIN Database
YHJV - Inner membrane transport protein YhjV
UniProt: P37660 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12266
Length: 423 (405)
Sequences: 482 (248)
Seq/√Len: 12.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_F20_F5.1751.00
27_I255_V5.0501.00
106_I355_T4.7681.00
121_A133_D3.7480.99
252_L309_T3.4070.98
124_L131_D3.2840.98
351_F355_T3.2690.98
271_E274_S3.1850.97
170_K309_T3.1240.97
171_V251_T3.0690.96
170_K252_L3.0570.96
113_S148_L2.9180.95
106_I351_F2.8990.95
104_M373_G2.7560.94
69_L224_N2.6320.92
170_K255_V2.5790.91
271_E289_V2.5320.90
396_E399_R2.4520.89
52_T199_F2.4160.88
163_S309_T2.3690.87
124_L129_L2.3680.87
400_G403_A2.3520.86
323_K348_I2.3510.86
78_C228_R2.3380.86
149_V311_F2.3310.86
255_V309_T2.2950.85
146_A353_V2.2550.84
125_K133_D2.2430.84
386_F403_A2.2340.83
52_T412_L2.2230.83
383_L387_F2.2200.83
274_S278_Q2.1960.82
222_P316_L2.1900.82
19_D240_L2.1750.82
395_L399_R2.1660.81
207_I413_L2.0540.78
228_R240_L2.0540.78
215_V218_Q2.0460.77
327_L348_I2.0160.76
170_K178_G2.0070.76
165_P190_I1.9830.75
57_A210_C1.9730.75
156_E319_H1.9690.74
103_L373_G1.9590.74
365_S368_V1.9460.74
122_S287_A1.9440.74
404_W408_L1.9350.73
390_Y407_L1.8930.71
130_T142_V1.8630.70
367_L398_L1.8520.70
11_Q99_V1.8500.70
344_L400_G1.8300.69
252_L255_V1.7840.67
106_I266_S1.7380.65
358_I418_L1.7320.64
160_F170_K1.7220.64
44_L62_W1.7200.64
25_L173_I1.7170.64
35_T309_T1.7020.63
15_F19_D1.7000.63
64_V203_V1.6950.63
248_S255_V1.6670.61
179_F362_F1.6650.61
28_G307_V1.6640.61
348_I358_I1.6600.61
143_A307_V1.6560.61
163_S252_L1.6480.60
182_I412_L1.6470.60
240_L243_R1.6430.60
249_Y255_V1.6360.60
121_A125_K1.6180.59
86_S328_N1.6150.59
140_Y292_G1.5920.58
123_Y304_I1.5840.57
75_S84_I1.5840.57
307_V405_L1.5670.56
111_I255_V1.5620.56
35_T252_L1.5530.56
309_T312_F1.5320.55
56_I415_L1.5300.54
141_K146_A1.5270.54
213_S302_L1.5270.54
224_N406_I1.5260.54
163_S218_Q1.5090.53
368_V371_Q1.5000.53
25_L178_G1.4960.53
383_L407_L1.4880.52
347_A351_F1.4700.51
121_A139_L1.4530.51
108_G377_Y1.4460.50
311_F315_Y1.4370.50
16_T226_A1.4360.50
213_S325_I1.4170.49
323_K345_T1.4090.48
359_W373_G1.4070.48
227_Y241_A1.4070.48
109_I311_F1.4040.48
81_Y315_Y1.4030.48
200_F387_F1.4030.48
373_G399_R1.3940.48
103_L154_G1.3780.47
163_S170_K1.3770.47
210_C249_Y1.3700.46
81_Y218_Q1.3630.46
383_L411_I1.3610.46
322_I326_I1.3570.46
178_G258_F1.3550.46
99_V397_K1.3530.45
27_I309_T1.3510.45
52_T203_V1.3470.45
114_L154_G1.3390.45
219_V309_T1.3210.44
67_I116_V1.3190.44
122_S128_G1.3170.44
160_F309_T1.3160.44
95_I99_V1.3050.43
89_L381_S1.3030.43
37_L366_V1.3010.43
387_F407_L1.2860.42
209_F374_S1.2800.42
273_V277_E1.2780.42
156_E229_K1.2690.41
344_L421_L1.2650.41
42_I257_L1.2620.41
175_V420_K1.2610.41
126_T178_G1.2580.41
104_M305_F1.2560.41
31_I170_K1.2550.41
177_F256_I1.2400.40
27_I248_S1.2360.40
67_I154_G1.2310.39
78_C144_I1.2280.39
181_M310_A1.2210.39
302_L310_A1.2150.39
109_I222_P1.2140.39
252_L312_F1.2050.38
57_A206_T1.2020.38
176_V277_E1.2000.38
278_Q295_I1.1950.38
96_F99_V1.1950.38
249_Y252_L1.1950.38
274_S277_E1.1900.37
390_Y399_R1.1720.37
62_W398_L1.1640.36
170_K310_A1.1610.36
42_I321_A1.1600.36
152_A170_K1.1550.36
37_L117_V1.1540.36
170_K299_S1.1470.35
153_S299_S1.1450.35
113_S159_L1.1410.35
120_S143_A1.1390.35
294_I369_F1.1350.35
224_N308_L1.1330.35
81_Y215_V1.1300.35
151_I411_I1.1280.35
387_F400_G1.1270.34
122_S295_I1.1170.34
121_A134_L1.1130.34
84_I374_S1.1120.34
385_P410_G1.1040.33
81_Y370_F1.0980.33
95_I325_I1.0980.33
54_A206_T1.0980.33
20_F352_I1.0980.33
92_N195_Q1.0960.33
108_G215_V1.0930.33
136_Q169_V1.0930.33
172_G176_V1.0900.33
176_V258_F1.0890.33
170_K249_Y1.0880.33
76_D161_K1.0880.33
224_N241_A1.0870.33
271_E315_Y1.0870.33
166_M297_I1.0830.32
386_F407_L1.0780.32
114_L366_V1.0770.32
369_F374_S1.0730.32
27_I249_Y1.0720.32
27_I159_L1.0720.32
194_P199_F1.0680.32
155_G369_F1.0640.32
390_Y412_L1.0640.32
190_I366_V1.0570.31
213_S343_V1.0570.31
58_Y213_S1.0550.31
404_W407_L1.0520.31
80_D84_I1.0500.31
110_F384_I1.0440.31
14_P52_T1.0420.31
31_I255_V1.0330.30
156_E356_L1.0330.30
71_T228_R1.0320.30
325_I406_I1.0320.30
389_I407_L1.0320.30
103_L297_I1.0290.30
372_L418_L1.0240.30
229_K298_T1.0240.30
60_A119_D1.0230.30
144_I325_I1.0100.29
282_A315_Y1.0080.29
33_A38_M1.0020.29
350_A389_I1.0020.29
329_L354_I0.9990.29
51_I408_L0.9970.29
179_F230_R0.9930.29
15_F228_R0.9930.29
55_I184_H0.9900.28
164_G170_K0.9860.28
27_I170_K0.9860.28
111_I356_L0.9830.28
159_L282_A0.9820.28
123_Y300_T0.9780.28
359_W397_K0.9740.28
172_G179_F0.9710.28
369_F376_L0.9670.28
173_I302_L0.9660.27
217_I257_L0.9620.27
390_Y404_W0.9580.27
83_D344_L0.9580.27
48_W243_R0.9520.27
55_I355_T0.9520.27
27_I69_L0.9470.27
373_G414_C0.9460.27
377_Y417_P0.9450.27
144_I395_L0.9450.27
113_S248_S0.9450.27
390_Y395_L0.9390.26
42_I215_V0.9390.26
406_I411_I0.9380.26
17_R116_V0.9310.26
61_T375_P0.9300.26
37_L118_F0.9280.26
18_Y227_Y0.9270.26
378_G381_S0.9260.26
81_Y104_M0.9240.26
62_W251_T0.9240.26
51_I103_L0.9230.26
148_L292_G0.9230.26
42_I210_C0.9230.26
166_M315_Y0.9220.26
129_L151_I0.9190.26
140_Y207_I0.9100.25
88_Y395_L0.9080.25
170_K219_V0.9070.25
99_V325_I0.9070.25
172_G404_W0.9060.25
31_I252_L0.9040.25
239_R412_L0.9030.25
57_A219_V0.9020.25
248_S309_T0.8970.25
28_G112_Y0.8920.25
369_F373_G0.8900.25
27_I252_L0.8890.24
392_V399_R0.8850.24
281_S312_F0.8820.24
143_A357_T0.8820.24
225_I253_I0.8820.24
370_F374_S0.8810.24
59_P185_W0.8810.24
52_T342_R0.8790.24
227_Y230_R0.8770.24
205_L299_S0.8760.24
96_F407_L0.8710.24
137_S361_S0.8700.24
157_R177_F0.8690.24
238_T242_L0.8660.24
280_I305_F0.8650.24
126_T288_Q0.8610.23
243_R304_I0.8600.23
178_G248_S0.8590.23
176_V301_V0.8540.23
160_F312_F0.8540.23
179_F421_L0.8530.23
81_Y321_A0.8520.23
102_F375_P0.8520.23
174_I405_L0.8510.23
269_H273_V0.8510.23
179_F277_E0.8480.23
359_W371_Q0.8460.23
257_L359_W0.8460.23
81_Y217_I0.8380.23
58_Y160_F0.8340.22
11_Q77_S0.8280.22
123_Y285_L0.8240.22
55_I161_K0.8230.22
154_G280_I0.8210.22
246_R342_R0.8140.22
248_S252_L0.8100.22
170_K302_L0.8070.22
377_Y381_S0.8050.21
156_E376_L0.8050.21
14_P342_R0.8020.21
109_I268_S0.7990.21
342_R346_L0.7990.21
164_G219_V0.7980.21
53_A85_I0.7960.21
124_L132_A0.7930.21
302_L347_A0.7920.21
194_P302_L0.7910.21
153_S170_K0.7900.21
231_E414_C0.7900.21
27_I35_T0.7890.21
150_A199_F0.7870.21
26_C381_S0.7830.21
280_I284_A0.7810.21
44_L176_V0.7800.21
249_Y309_T0.7780.21
31_I309_T0.7770.21
44_L241_A0.7760.20
150_A179_F0.7760.20
298_T316_L0.7750.20
51_I325_I0.7710.20
221_N306_A0.7680.20
266_S330_L0.7670.20
31_I47_I0.7640.20
95_I264_T0.7640.20
218_Q370_F0.7610.20
148_L312_F0.7600.20
148_L213_S0.7600.20
345_T391_K0.7600.20
112_Y185_W0.7590.20
314_I360_V0.7580.20
163_S312_F0.7570.20
124_L248_S0.7570.20
69_L384_I0.7560.20
172_G238_T0.7560.20
390_Y409_Y0.7540.20
104_M218_Q0.7540.20
84_I94_G0.7530.20
21_G58_Y0.7530.20
49_V70_K0.7510.20
400_G404_W0.7500.20
30_A101_Y0.7470.20
99_V187_F0.7460.19
267_I287_A0.7450.19
20_F247_I0.7440.19
18_Y199_F0.7420.19
209_F366_V0.7400.19
340_N347_A0.7380.19
42_I253_I0.7370.19
224_N411_I0.7360.19
16_T231_E0.7300.19
163_S305_F0.7270.19
150_A190_I0.7250.19
257_L312_F0.7250.19
113_S255_V0.7230.19
14_P92_N0.7230.19
107_H212_F0.7230.19
182_I301_V0.7220.19
68_Y220_L0.7220.19
108_G212_F0.7210.19
274_S411_I0.7210.19
21_G27_I0.7200.19
58_Y163_S0.7190.19
409_Y418_L0.7170.19
23_V302_L0.7170.19
26_C29_M0.7170.19
200_F412_L0.7170.19
354_I358_I0.7170.19
178_G255_V0.7150.19
211_F215_V0.7150.19
57_A312_F0.7130.18
228_R237_A0.7110.18
331_S399_R0.7090.18
73_S268_S0.7080.18
182_I304_I0.7070.18
303_N310_A0.7070.18
215_V321_A0.7060.18
364_V374_S0.7050.18
18_Y155_G0.7040.18
138_L188_A0.7020.18
219_V255_V0.7020.18
170_K248_S0.7010.18
35_T163_S0.7000.18
203_V412_L0.6990.18
35_T255_V0.6980.18
158_L414_C0.6970.18
44_L213_S0.6960.18
349_C376_L0.6950.18
112_Y306_A0.6950.18
272_A282_A0.6940.18
209_F371_Q0.6940.18
52_T347_A0.6930.18
64_V67_I0.6890.18
215_V314_I0.6880.18
162_I296_H0.6880.18
25_L160_F0.6880.18
162_I395_L0.6870.18
57_A281_S0.6860.18
129_L166_M0.6850.18
304_I356_L0.6840.18
176_V294_I0.6840.18
123_Y311_F0.6830.18
178_G299_S0.6820.18
118_F363_R0.6810.18
59_P112_Y0.6800.17
216_F260_A0.6800.17
247_I369_F0.6800.17
56_I79_N0.6780.17
25_L243_R0.6770.17
149_V315_Y0.6770.17
172_G392_V0.6740.17
48_W51_I0.6730.17
412_L415_L0.6720.17
362_F407_L0.6720.17
115_S249_Y0.6710.17
124_L179_F0.6710.17
245_H295_I0.6700.17
79_N87_H0.6700.17
48_W359_W0.6690.17
66_D174_I0.6680.17
205_L212_F0.6670.17
79_N115_S0.6640.17
106_I340_N0.6630.17
165_P305_F0.6630.17
94_G100_I0.6620.17
173_I299_S0.6620.17
147_V347_A0.6620.17
54_A171_V0.6620.17
164_G206_T0.6620.17
137_S179_F0.6610.17
218_Q381_S0.6610.17
249_Y312_F0.6600.17
159_L255_V0.6600.17
144_I366_V0.6580.17
52_T366_V0.6570.17
152_A252_L0.6570.17
25_L170_K0.6570.17
166_M393_A0.6550.17
199_F323_K0.6540.17
97_L148_L0.6530.17
42_I81_Y0.6520.17
377_Y394_Q0.6510.17
295_I380_V0.6510.17
75_S158_L0.6510.17
161_K256_I0.6500.17
248_S253_I0.6480.17
76_D87_H0.6480.17
281_S416_S0.6470.17
160_F252_L0.6460.16
216_F317_G0.6460.16
12_K16_T0.6450.16
256_I281_S0.6440.16
250_I408_L0.6440.16
173_I261_F0.6430.16
65_Q364_V0.6420.16
23_V273_V0.6400.16
82_T114_L0.6390.16
38_M117_V0.6390.16
190_I292_G0.6380.16
358_I362_F0.6360.16
31_I178_G0.6350.16
49_V269_H0.6350.16
390_Y400_G0.6340.16
128_G287_A0.6330.16
159_L309_T0.6330.16
135_S223_M0.6330.16
318_F367_L0.6290.16
371_Q381_S0.6280.16
270_E338_K0.6280.16
199_F356_L0.6270.16
25_L309_T0.6270.16
147_V203_V0.6260.16
342_R366_V0.6250.16
294_I398_L0.6250.16
286_A310_A0.6250.16
38_M221_N0.6240.16
144_I398_L0.6230.16
150_A346_L0.6220.16
308_L421_L0.6210.16
48_W168_V0.6210.16
92_N95_I0.6200.16
75_S351_F0.6200.16
168_V219_V0.6190.16
130_T133_D0.6190.16
152_A178_G0.6170.16
291_P398_L0.6150.16
58_Y75_S0.6120.16
200_F203_V0.6100.16
180_A260_A0.6090.15
47_I150_A0.6080.15
113_S213_S0.6070.15
84_I357_T0.6060.15
382_C413_L0.6030.15
326_I341_S0.6020.15
31_I55_I0.6020.15
156_E304_I0.6000.15
63_V115_S0.6000.15
251_T277_E0.6000.15
342_R345_T0.5970.15
18_Y244_T0.5930.15
156_E323_K0.5930.15
285_L314_I0.5900.15
24_L58_Y0.5860.15
168_V174_I0.5860.15
92_N399_R0.5860.15
246_R398_L0.5850.15
174_I366_V0.5850.15
150_A406_I0.5850.15
12_K161_K0.5830.15
234_K291_P0.5820.15
294_I326_I0.5800.15
171_V233_D0.5790.15
257_L321_A0.5780.15
141_K353_V0.5770.15
166_M376_L0.5740.15
104_M204_L0.5730.15
57_A250_I0.5720.15
20_F23_V0.5720.15
254_A354_I0.5720.15
135_S361_S0.5720.15
171_V190_I0.5700.14
124_L166_M0.5700.14
74_E380_V0.5690.14
372_L380_V0.5680.14
347_A354_I0.5680.14
358_I406_I0.5680.14
254_A379_I0.5670.14
81_Y163_S0.5640.14
31_I305_F0.5620.14
182_I277_E0.5620.14
152_A299_S0.5600.14
148_L308_L0.5600.14
196_A270_E0.5590.14
140_Y413_L0.5590.14
40_V174_I0.5580.14
57_A163_S0.5580.14
57_A409_Y0.5580.14
168_V318_F0.5560.14
105_I384_I0.5550.14
407_L416_S0.5550.14
12_K266_S0.5550.14
96_F336_T0.5520.14
35_T170_K0.5520.14
55_I239_R0.5520.14
70_K107_H0.5510.14
101_Y117_V0.5500.14
308_L350_A0.5500.14
252_L307_V0.5500.14
253_I257_L0.5490.14
27_I168_V0.5480.14
18_Y356_L0.5470.14
217_I315_Y0.5470.14
219_V252_L0.5440.14
353_V356_L0.5430.14
15_F247_I0.5420.14
69_L249_Y0.5420.14
21_G31_I0.5390.14
53_A222_P0.5390.14
26_C30_A0.5380.14
50_F177_F0.5370.14
13_L329_L0.5360.14
103_L399_R0.5340.14
287_A301_V0.5340.14
339_I362_F0.5340.14
118_F136_Q0.5320.14
65_Q313_G0.5310.14
229_K240_L0.5310.14
196_A329_L0.5310.14
41_Q50_F0.5310.14
17_R389_I0.5300.13
165_P268_S0.5280.13
168_V288_Q0.5260.13
56_I226_A0.5260.13
76_D411_I0.5260.13
14_P358_I0.5240.13
108_G220_L0.5230.13
89_L413_L0.5200.13
33_A65_Q0.5200.13
174_I286_A0.5200.13
384_I415_L0.5200.13
58_Y210_C0.5200.13
88_Y413_L0.5190.13
99_V213_S0.5190.13
292_G417_P0.5180.13
179_F224_N0.5180.13
22_W34_G0.5180.13
213_S407_L0.5170.13
364_V370_F0.5150.13
29_M65_Q0.5140.13
48_W94_G0.5130.13
69_L99_V0.5130.13
82_T102_F0.5120.13
180_A307_V0.5110.13
57_A72_L0.5110.13
176_V354_I0.5100.13
173_I278_Q0.5100.13
40_V109_I0.5100.13
160_F255_V0.5100.13
192_A391_K0.5100.13
330_L340_N0.5090.13
86_S411_I0.5080.13
129_L297_I0.5080.13
176_V350_A0.5080.13
280_I400_G0.5080.13
68_Y380_V0.5070.13
171_V328_N0.5070.13
48_W190_I0.5060.13
92_N411_I0.5060.13
104_M370_F0.5060.13
63_V161_K0.5040.13
111_I207_I0.5040.13
415_L419_L0.5040.13
63_V403_A0.5030.13
195_Q254_A0.5020.13
260_A300_T0.5010.13
51_I158_L0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.8983 99.8 0.869 Contact Map
3giaA 1 0.9078 99.7 0.885 Contact Map
4djkA 2 0.8936 99.3 0.912 Contact Map
4wgvA 2 0.8322 98.4 0.935 Contact Map
4xp4A 1 0.9054 95 0.96 Contact Map
2a65A 2 0.8889 94.5 0.961 Contact Map
4us3A 1 0.8771 94.1 0.962 Contact Map
3dh4A 3 0.8818 88 0.968 Contact Map
2xq2A 2 0.8865 83.9 0.969 Contact Map
2jlnA 1 0.8747 44.5 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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