GREMLIN Database
BCSQ - Putative cellulose biosynthesis protein BcsQ
UniProt: P37655 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12261
Length: 250 (232)
Sequences: 16531 (10735)
Seq/√Len: 704.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
80_D118_Y3.8701.00
200_H227_E3.7931.00
19_T122_L3.6951.00
29_L233_N3.0981.00
31_E120_W3.0411.00
5_G140_C2.8411.00
26_L120_W2.7921.00
18_I228_I2.7881.00
214_P217_E2.7021.00
34_L118_Y2.6041.00
148_N172_D2.5671.00
35_V44_L2.5461.00
172_D201_R2.4921.00
20_A44_L2.4591.00
177_S180_Q2.3751.00
23_A35_V2.2291.00
47_S152_N2.1471.00
19_T35_V2.0381.00
204_A207_E2.0331.00
186_L190_S2.0321.00
18_I169_L2.0181.00
28_M229_L2.0041.00
174_R201_R1.9681.00
25_S232_A1.9551.00
74_R80_D1.9401.00
2_A142_H1.9241.00
25_S216_G1.9221.00
32_N119_Q1.8671.00
46_L155_I1.8191.00
29_L229_L1.8171.00
169_L231_L1.8041.00
6_L22_L1.7951.00
26_L122_L1.7661.00
185_Q189_Q1.7011.00
38_A136_L1.6981.00
202_D224_A1.6821.00
20_A47_S1.6781.00
142_H166_A1.6621.00
179_V182_D1.6071.00
23_A122_L1.5991.00
27_Q79_L1.5781.00
67_D70_D1.5771.00
38_A58_W1.5401.00
3_V123_I1.5351.00
57_G60_R1.5161.00
31_E236_L1.5131.00
69_R117_R1.5031.00
5_G125_L1.5031.00
6_L144_L1.4801.00
66_Q70_D1.4741.00
14_G171_N1.4721.00
197_M234_W1.4711.00
175_I184_Y1.4671.00
197_M231_L1.4521.00
170_I184_Y1.4391.00
173_F198_L1.4321.00
203_E207_E1.4251.00
48_F79_L1.4191.00
20_A48_F1.4141.00
22_L235_C1.4111.00
31_E119_Q1.3971.00
70_D73_L1.3951.00
142_H167_H1.3881.00
132_I136_L1.3731.00
213_Q218_Y1.3661.00
38_A123_I1.3641.00
43_L156_R1.3541.00
133_T136_L1.3381.00
27_Q78_Q1.3151.00
23_A44_L1.3121.00
6_L19_T1.3011.00
187_W190_S1.2311.00
144_L169_L1.2301.00
149_V170_I1.2291.00
22_L232_A1.2291.00
204_A219_R1.1931.00
186_L189_Q1.1921.00
18_I171_N1.1861.00
196_P234_W1.1851.00
86_Q159_Q1.1821.00
226_E229_L1.1801.00
103_S106_C1.1721.00
16_T47_S1.1701.00
150_D153_C1.1661.00
222_A225_A1.1661.00
180_Q184_Y1.1571.00
29_L236_L1.1511.00
207_E211_A1.1471.00
34_L121_I1.1451.00
205_M224_A1.1421.00
23_A79_L1.1281.00
184_Y198_L1.1211.00
26_L33_V1.1091.00
227_E230_T1.1051.00
25_S29_L1.1041.00
80_D116_G1.0961.00
43_L152_N1.0911.00
184_Y188_L1.0891.00
150_D206_A1.0861.00
7_Q125_L1.0831.00
199_I224_A1.0831.00
73_L76_T1.0831.00
2_A141_D1.0821.00
24_W28_M1.0801.00
229_L233_N1.0801.00
230_T233_N1.0751.00
40_P132_I1.0691.00
202_D222_A1.0651.00
68_W82_L1.0621.00
66_Q71_A1.0581.00
59_A63_L1.0551.00
185_Q188_L1.0541.00
100_T103_S1.0521.00
108_G111_Q1.0501.00
213_Q217_E1.0481.00
18_I22_L1.0441.00
92_Q130_S1.0371.00
50_V81_L1.0341.00
56_Q60_R1.0261.00
120_W236_L1.0221.00
36_V121_I1.0191.00
36_V123_I1.0191.00
98_W102_L1.0161.00
66_Q69_R1.0131.00
97_H101_R1.0071.00
233_N237_L1.0041.00
223_L226_E1.0041.00
3_V121_I0.9991.00
81_L86_Q0.9901.00
26_L232_A0.9851.00
202_D223_L0.9841.00
230_T234_W0.9821.00
152_N209_L0.9791.00
48_F81_L0.9731.00
211_A218_Y0.9701.00
103_S107_S0.9671.00
21_A216_G0.9671.00
32_N117_R0.9651.00
16_T44_L0.9581.00
56_Q66_Q0.9581.00
21_A24_W0.9551.00
125_L136_L0.9521.00
106_C110_Q0.9471.00
191_Q194_L0.9421.00
58_W61_A0.9411.00
231_L235_C0.9331.00
69_R73_L0.9301.00
195_L198_L0.9221.00
4_L235_C0.9211.00
146_I171_N0.9181.00
97_H100_T0.9131.00
34_L72_G0.9051.00
25_S229_L0.9041.00
171_N228_I0.8871.00
104_D108_G0.8841.00
6_L18_I0.8781.00
70_D74_R0.8781.00
216_G229_L0.8761.00
219_R222_A0.8751.00
4_L120_W0.8721.00
25_S28_M0.8711.00
145_A157_L0.8641.00
13_V153_C0.8431.00
223_L227_E0.8421.00
225_A229_L0.8421.00
28_M217_E0.8391.00
175_I178_Q0.8361.00
224_A227_E0.8351.00
68_W71_A0.8331.00
188_L191_Q0.8321.00
61_A108_G0.8321.00
4_L142_H0.8271.00
71_A82_L0.8241.00
17_T205_M0.8231.00
46_L151_A0.8151.00
220_S225_A0.8131.00
7_Q133_T0.8091.00
24_W217_E0.8001.00
90_E93_E0.7941.00
17_T209_L0.7921.00
42_N84_F0.7891.00
135_Q138_S0.7851.00
3_V113_K0.7841.00
6_L122_L0.7781.00
75_Y81_L0.7781.00
42_N45_R0.7761.00
118_Y121_I0.7741.00
187_W191_Q0.7731.00
69_R72_G0.7701.00
61_A71_A0.7691.00
68_W72_G0.7691.00
174_R183_I0.7661.00
170_I173_F0.7651.00
93_E96_Q0.7651.00
105_I108_G0.7641.00
148_N153_C0.7581.00
33_V120_W0.7541.00
43_L155_I0.7491.00
215_V225_A0.7481.00
149_V180_Q0.7371.00
59_A94_N0.7351.00
199_I227_E0.7321.00
176_G183_I0.7281.00
167_H195_L0.7271.00
57_G85_G0.7201.00
181_D185_Q0.7191.00
100_T107_S0.7191.00
24_W216_G0.7191.00
101_R104_D0.7171.00
35_V48_F0.7141.00
41_D127_R0.7091.00
98_W101_R0.7091.00
8_G13_V0.7081.00
100_T104_D0.7071.00
181_D184_Y0.7021.00
149_V173_F0.6941.00
107_S111_Q0.6921.00
216_G225_A0.6891.00
45_R83_P0.6891.00
21_A214_P0.6881.00
208_C215_V0.6831.00
33_V79_L0.6831.00
102_L135_Q0.6821.00
142_H165_G0.6811.00
226_E230_T0.6771.00
101_R132_I0.6731.00
125_L133_T0.6731.00
108_G112_L0.6701.00
170_I198_L0.6691.00
234_W237_L0.6691.00
15_T127_R0.6681.00
136_L140_C0.6631.00
182_D185_Q0.6601.00
215_V224_A0.6591.00
19_T44_L0.6581.00
18_I199_I0.6571.00
194_L234_W0.6571.00
193_R196_P0.6561.00
30_G78_Q0.6561.00
151_A155_I0.6521.00
33_V122_L0.6511.00
72_G80_D0.6501.00
200_H223_L0.6461.00
42_N85_G0.6431.00
80_D83_P0.6421.00
144_L235_C0.6371.00
221_D226_E0.6361.00
71_A74_R0.6351.00
98_W104_D0.6341.00
174_R203_E0.6311.00
18_I146_I0.6301.00
68_W73_L0.6301.00
3_V141_D0.6301.00
71_A75_Y0.6291.00
32_N80_D0.6291.00
204_A222_A0.6281.00
58_W82_L0.6221.00
10_R152_N0.6221.00
28_M216_G0.6191.00
65_G68_W0.6141.00
147_V168_I0.6131.00
205_M209_L0.6111.00
178_Q182_D0.6111.00
61_A82_L0.6081.00
24_W79_L0.6071.00
24_W214_P0.6061.00
41_D45_R0.6041.00
20_A35_V0.6021.00
10_R13_V0.6011.00
113_K141_D0.5991.00
24_W77_S0.5981.00
178_Q181_D0.5971.00
93_E131_Q0.5961.00
188_L192_R0.5921.00
45_R85_G0.5901.00
2_A166_A0.5901.00
167_H196_P0.5851.00
103_S138_S0.5841.00
67_D71_A0.5841.00
65_G69_R0.5811.00
188_L196_P0.5791.00
179_V207_E0.5781.00
56_Q71_A0.5761.00
97_H104_D0.5761.00
21_A228_I0.5731.00
147_V157_L0.5731.00
203_E206_A0.5701.00
9_V128_D0.5701.00
66_Q73_L0.5681.00
170_I187_W0.5681.00
154_H158_H0.5681.00
25_S228_I0.5621.00
38_A132_I0.5621.00
69_R111_Q0.5561.00
63_L94_N0.5531.00
2_A31_E0.5521.00
27_Q33_V0.5511.00
46_L152_N0.5511.00
10_R15_T0.5511.00
109_L139_L0.5501.00
208_C213_Q0.5481.00
75_Y78_Q0.5481.00
82_L86_Q0.5471.00
67_D111_Q0.5451.00
32_N118_Y0.5411.00
22_L231_L0.5391.00
215_V219_R0.5361.00
123_I136_L0.5351.00
180_Q183_I0.5341.00
208_C218_Y0.5331.00
56_Q70_D0.5331.00
91_E95_P0.5331.00
177_S203_E0.5321.00
188_L198_L0.5321.00
47_S209_L0.5311.00
130_S133_T0.5291.00
5_G143_S0.5291.00
77_S80_D0.5291.00
184_Y187_W0.5291.00
38_A105_I0.5291.00
206_A209_L0.5281.00
88_S91_E0.5281.00
89_I92_Q0.5271.00
137_L143_S0.5241.00
76_T217_E0.5241.00
112_L116_G0.5231.00
33_V119_Q0.5211.00
84_F88_S0.5201.00
17_T21_A0.5201.00
2_A120_W0.5151.00
101_R108_G0.5151.00
208_C214_P0.5141.00
21_A215_V0.5141.00
105_I109_L0.5131.00
207_E218_Y0.5131.00
150_D201_R0.5110.99
220_S226_E0.5110.99
8_G156_R0.5100.99
166_A195_L0.5100.99
97_H102_L0.5100.99
228_I231_L0.5080.99
4_L144_L0.5070.99
9_V129_A0.5050.99
64_D70_D0.5040.99
122_L235_C0.5040.99
145_A165_G0.5040.99
151_A210_A0.5010.99
44_L81_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pfsA 1 0.924 100 0.287 Contact Map
3pg5A 2 0.864 100 0.294 Contact Map
1wcv1 2 0.916 100 0.314 Contact Map
4rz3A 2 0.916 100 0.315 Contact Map
1hyqA 1 0.9 100 0.318 Contact Map
1g3qA 1 0.912 100 0.321 Contact Map
3ez2A 2 0.964 100 0.324 Contact Map
2ozeA 2 0.968 100 0.328 Contact Map
3ez9A 2 0.812 100 0.328 Contact Map
3ea0A 2 0.896 100 0.337 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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