BCSQ - ECOLI - GREMLIN Contacts

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BCSQ - Putative cellulose biosynthesis protein BcsQ

UniProt:	P37655	Sequences: MAVLGLQGVRGGVGTTTITAALAWSLQMLGENVLVVDACPDNLLRLSFNVDFTHRQGWARAMLDGQDWRDAGLRYTSQLDLLPFGQLSIEEQENPQHWQTRLSDICSGLQQLKASGRYQWILIDLPRDASQITHQLLSLCDHSLAIVNVDANCHIRLHQQALPDGAHILINDFRIGSQVQDDIYQLWLQSQRRLLPMLIHRDEAMAECLAAKQPVGEYRSDALAAEEILTLANWCLLNYSGLKTPVGSAS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12261
Length:	250 (232)
Sequences:	16531 (10735)
Seq/√Len:	704.8

ECOLI - BCSQ MIND MRP
BACSU - SOJ YLXH MIND SALA YWQD YVEL
HALSA - Q9HHU2 Q9HHZ7 O54573 O51969 O51991 Q9HNF1 Q9HQY5 Q9HHL5 Q9HQJ7
SULSO - Q97ZW4 Q981B3 Q97VX7 Q97WA2 Q97YM8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
80_D	118_Y	3.870	1.00
200_H	227_E	3.793	1.00
19_T	122_L	3.695	1.00
29_L	233_N	3.098	1.00
31_E	120_W	3.041	1.00
5_G	140_C	2.841	1.00
26_L	120_W	2.792	1.00
18_I	228_I	2.788	1.00
214_P	217_E	2.702	1.00
34_L	118_Y	2.604	1.00
148_N	172_D	2.567	1.00
35_V	44_L	2.546	1.00
172_D	201_R	2.492	1.00
20_A	44_L	2.459	1.00
177_S	180_Q	2.375	1.00
23_A	35_V	2.229	1.00
47_S	152_N	2.147	1.00
19_T	35_V	2.038	1.00
204_A	207_E	2.033	1.00
186_L	190_S	2.032	1.00
18_I	169_L	2.018	1.00
28_M	229_L	2.004	1.00
174_R	201_R	1.968	1.00
25_S	232_A	1.955	1.00
74_R	80_D	1.940	1.00
2_A	142_H	1.924	1.00
25_S	216_G	1.922	1.00
32_N	119_Q	1.867	1.00
46_L	155_I	1.819	1.00
29_L	229_L	1.817	1.00
169_L	231_L	1.804	1.00
6_L	22_L	1.795	1.00
26_L	122_L	1.766	1.00
185_Q	189_Q	1.701	1.00
38_A	136_L	1.698	1.00
202_D	224_A	1.682	1.00
20_A	47_S	1.678	1.00
142_H	166_A	1.662	1.00
179_V	182_D	1.607	1.00
23_A	122_L	1.599	1.00
27_Q	79_L	1.578	1.00
67_D	70_D	1.577	1.00
38_A	58_W	1.540	1.00
3_V	123_I	1.535	1.00
57_G	60_R	1.516	1.00
31_E	236_L	1.513	1.00
69_R	117_R	1.503	1.00
5_G	125_L	1.503	1.00
6_L	144_L	1.480	1.00
66_Q	70_D	1.474	1.00
14_G	171_N	1.472	1.00
197_M	234_W	1.471	1.00
175_I	184_Y	1.467	1.00
197_M	231_L	1.452	1.00
170_I	184_Y	1.439	1.00
173_F	198_L	1.432	1.00
203_E	207_E	1.425	1.00
48_F	79_L	1.419	1.00
20_A	48_F	1.414	1.00
22_L	235_C	1.411	1.00
31_E	119_Q	1.397	1.00
70_D	73_L	1.395	1.00
142_H	167_H	1.388	1.00
132_I	136_L	1.373	1.00
213_Q	218_Y	1.366	1.00
38_A	123_I	1.364	1.00
43_L	156_R	1.354	1.00
133_T	136_L	1.338	1.00
27_Q	78_Q	1.315	1.00
23_A	44_L	1.312	1.00
6_L	19_T	1.301	1.00
187_W	190_S	1.231	1.00
144_L	169_L	1.230	1.00
149_V	170_I	1.229	1.00
22_L	232_A	1.229	1.00
204_A	219_R	1.193	1.00
186_L	189_Q	1.192	1.00
18_I	171_N	1.186	1.00
196_P	234_W	1.185	1.00
86_Q	159_Q	1.182	1.00
226_E	229_L	1.180	1.00
103_S	106_C	1.172	1.00
16_T	47_S	1.170	1.00
150_D	153_C	1.166	1.00
222_A	225_A	1.166	1.00
180_Q	184_Y	1.157	1.00
29_L	236_L	1.151	1.00
207_E	211_A	1.147	1.00
34_L	121_I	1.145	1.00
205_M	224_A	1.142	1.00
23_A	79_L	1.128	1.00
184_Y	198_L	1.121	1.00
26_L	33_V	1.109	1.00
227_E	230_T	1.105	1.00
25_S	29_L	1.104	1.00
80_D	116_G	1.096	1.00
43_L	152_N	1.091	1.00
184_Y	188_L	1.089	1.00
150_D	206_A	1.086	1.00
7_Q	125_L	1.083	1.00
199_I	224_A	1.083	1.00
73_L	76_T	1.083	1.00
2_A	141_D	1.082	1.00
24_W	28_M	1.080	1.00
229_L	233_N	1.080	1.00
230_T	233_N	1.075	1.00
40_P	132_I	1.069	1.00
202_D	222_A	1.065	1.00
68_W	82_L	1.062	1.00
66_Q	71_A	1.058	1.00
59_A	63_L	1.055	1.00
185_Q	188_L	1.054	1.00
100_T	103_S	1.052	1.00
108_G	111_Q	1.050	1.00
213_Q	217_E	1.048	1.00
18_I	22_L	1.044	1.00
92_Q	130_S	1.037	1.00
50_V	81_L	1.034	1.00
56_Q	60_R	1.026	1.00
120_W	236_L	1.022	1.00
36_V	121_I	1.019	1.00
36_V	123_I	1.019	1.00
98_W	102_L	1.016	1.00
66_Q	69_R	1.013	1.00
97_H	101_R	1.007	1.00
233_N	237_L	1.004	1.00
223_L	226_E	1.004	1.00
3_V	121_I	0.999	1.00
81_L	86_Q	0.990	1.00
26_L	232_A	0.985	1.00
202_D	223_L	0.984	1.00
230_T	234_W	0.982	1.00
152_N	209_L	0.979	1.00
48_F	81_L	0.973	1.00
211_A	218_Y	0.970	1.00
103_S	107_S	0.967	1.00
21_A	216_G	0.967	1.00
32_N	117_R	0.965	1.00
16_T	44_L	0.958	1.00
56_Q	66_Q	0.958	1.00
21_A	24_W	0.955	1.00
125_L	136_L	0.952	1.00
106_C	110_Q	0.947	1.00
191_Q	194_L	0.942	1.00
58_W	61_A	0.941	1.00
231_L	235_C	0.933	1.00
69_R	73_L	0.930	1.00
195_L	198_L	0.922	1.00
4_L	235_C	0.921	1.00
146_I	171_N	0.918	1.00
97_H	100_T	0.913	1.00
34_L	72_G	0.905	1.00
25_S	229_L	0.904	1.00
171_N	228_I	0.887	1.00
104_D	108_G	0.884	1.00
6_L	18_I	0.878	1.00
70_D	74_R	0.878	1.00
216_G	229_L	0.876	1.00
219_R	222_A	0.875	1.00
4_L	120_W	0.872	1.00
25_S	28_M	0.871	1.00
145_A	157_L	0.864	1.00
13_V	153_C	0.843	1.00
223_L	227_E	0.842	1.00
225_A	229_L	0.842	1.00
28_M	217_E	0.839	1.00
175_I	178_Q	0.836	1.00
224_A	227_E	0.835	1.00
68_W	71_A	0.833	1.00
188_L	191_Q	0.832	1.00
61_A	108_G	0.832	1.00
4_L	142_H	0.827	1.00
71_A	82_L	0.824	1.00
17_T	205_M	0.823	1.00
46_L	151_A	0.815	1.00
220_S	225_A	0.813	1.00
7_Q	133_T	0.809	1.00
24_W	217_E	0.800	1.00
90_E	93_E	0.794	1.00
17_T	209_L	0.792	1.00
42_N	84_F	0.789	1.00
135_Q	138_S	0.785	1.00
3_V	113_K	0.784	1.00
6_L	122_L	0.778	1.00
75_Y	81_L	0.778	1.00
42_N	45_R	0.776	1.00
118_Y	121_I	0.774	1.00
187_W	191_Q	0.773	1.00
69_R	72_G	0.770	1.00
61_A	71_A	0.769	1.00
68_W	72_G	0.769	1.00
174_R	183_I	0.766	1.00
170_I	173_F	0.765	1.00
93_E	96_Q	0.765	1.00
105_I	108_G	0.764	1.00
148_N	153_C	0.758	1.00
33_V	120_W	0.754	1.00
43_L	155_I	0.749	1.00
215_V	225_A	0.748	1.00
149_V	180_Q	0.737	1.00
59_A	94_N	0.735	1.00
199_I	227_E	0.732	1.00
176_G	183_I	0.728	1.00
167_H	195_L	0.727	1.00
57_G	85_G	0.720	1.00
181_D	185_Q	0.719	1.00
100_T	107_S	0.719	1.00
24_W	216_G	0.719	1.00
101_R	104_D	0.717	1.00
35_V	48_F	0.714	1.00
41_D	127_R	0.709	1.00
98_W	101_R	0.709	1.00
8_G	13_V	0.708	1.00
100_T	104_D	0.707	1.00
181_D	184_Y	0.702	1.00
149_V	173_F	0.694	1.00
107_S	111_Q	0.692	1.00
216_G	225_A	0.689	1.00
45_R	83_P	0.689	1.00
21_A	214_P	0.688	1.00
208_C	215_V	0.683	1.00
33_V	79_L	0.683	1.00
102_L	135_Q	0.682	1.00
142_H	165_G	0.681	1.00
226_E	230_T	0.677	1.00
101_R	132_I	0.673	1.00
125_L	133_T	0.673	1.00
108_G	112_L	0.670	1.00
170_I	198_L	0.669	1.00
234_W	237_L	0.669	1.00
15_T	127_R	0.668	1.00
136_L	140_C	0.663	1.00
182_D	185_Q	0.660	1.00
215_V	224_A	0.659	1.00
19_T	44_L	0.658	1.00
18_I	199_I	0.657	1.00
194_L	234_W	0.657	1.00
193_R	196_P	0.656	1.00
30_G	78_Q	0.656	1.00
151_A	155_I	0.652	1.00
33_V	122_L	0.651	1.00
72_G	80_D	0.650	1.00
200_H	223_L	0.646	1.00
42_N	85_G	0.643	1.00
80_D	83_P	0.642	1.00
144_L	235_C	0.637	1.00
221_D	226_E	0.636	1.00
71_A	74_R	0.635	1.00
98_W	104_D	0.634	1.00
174_R	203_E	0.631	1.00
18_I	146_I	0.630	1.00
68_W	73_L	0.630	1.00
3_V	141_D	0.630	1.00
71_A	75_Y	0.629	1.00
32_N	80_D	0.629	1.00
204_A	222_A	0.628	1.00
58_W	82_L	0.622	1.00
10_R	152_N	0.622	1.00
28_M	216_G	0.619	1.00
65_G	68_W	0.614	1.00
147_V	168_I	0.613	1.00
205_M	209_L	0.611	1.00
178_Q	182_D	0.611	1.00
61_A	82_L	0.608	1.00
24_W	79_L	0.607	1.00
24_W	214_P	0.606	1.00
41_D	45_R	0.604	1.00
20_A	35_V	0.602	1.00
10_R	13_V	0.601	1.00
113_K	141_D	0.599	1.00
24_W	77_S	0.598	1.00
178_Q	181_D	0.597	1.00
93_E	131_Q	0.596	1.00
188_L	192_R	0.592	1.00
45_R	85_G	0.590	1.00
2_A	166_A	0.590	1.00
167_H	196_P	0.585	1.00
103_S	138_S	0.584	1.00
67_D	71_A	0.584	1.00
65_G	69_R	0.581	1.00
188_L	196_P	0.579	1.00
179_V	207_E	0.578	1.00
56_Q	71_A	0.576	1.00
97_H	104_D	0.576	1.00
21_A	228_I	0.573	1.00
147_V	157_L	0.573	1.00
203_E	206_A	0.570	1.00
9_V	128_D	0.570	1.00
66_Q	73_L	0.568	1.00
170_I	187_W	0.568	1.00
154_H	158_H	0.568	1.00
25_S	228_I	0.562	1.00
38_A	132_I	0.562	1.00
69_R	111_Q	0.556	1.00
63_L	94_N	0.553	1.00
2_A	31_E	0.552	1.00
27_Q	33_V	0.551	1.00
46_L	152_N	0.551	1.00
10_R	15_T	0.551	1.00
109_L	139_L	0.550	1.00
208_C	213_Q	0.548	1.00
75_Y	78_Q	0.548	1.00
82_L	86_Q	0.547	1.00
67_D	111_Q	0.545	1.00
32_N	118_Y	0.541	1.00
22_L	231_L	0.539	1.00
215_V	219_R	0.536	1.00
123_I	136_L	0.535	1.00
180_Q	183_I	0.534	1.00
208_C	218_Y	0.533	1.00
56_Q	70_D	0.533	1.00
91_E	95_P	0.533	1.00
177_S	203_E	0.532	1.00
188_L	198_L	0.532	1.00
47_S	209_L	0.531	1.00
130_S	133_T	0.529	1.00
5_G	143_S	0.529	1.00
77_S	80_D	0.529	1.00
184_Y	187_W	0.529	1.00
38_A	105_I	0.529	1.00
206_A	209_L	0.528	1.00
88_S	91_E	0.528	1.00
89_I	92_Q	0.527	1.00
137_L	143_S	0.524	1.00
76_T	217_E	0.524	1.00
112_L	116_G	0.523	1.00
33_V	119_Q	0.521	1.00
84_F	88_S	0.520	1.00
17_T	21_A	0.520	1.00
2_A	120_W	0.515	1.00
101_R	108_G	0.515	1.00
208_C	214_P	0.514	1.00
21_A	215_V	0.514	1.00
105_I	109_L	0.513	1.00
207_E	218_Y	0.513	1.00
150_D	201_R	0.511	0.99
220_S	226_E	0.511	0.99
8_G	156_R	0.510	0.99
166_A	195_L	0.510	0.99
97_H	102_L	0.510	0.99
228_I	231_L	0.508	0.99
4_L	144_L	0.507	0.99
9_V	129_A	0.505	0.99
64_D	70_D	0.504	0.99
122_L	235_C	0.504	0.99
145_A	165_G	0.504	0.99
151_A	210_A	0.501	0.99
44_L	81_L	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4pfsA	1	0.924	100	0.287	Contact Map
3pg5A	2	0.864	100	0.294	Contact Map
1wcv1	2	0.916	100	0.314	Contact Map
4rz3A	2	0.916	100	0.315	Contact Map
1hyqA	1	0.9	100	0.318	Contact Map
1g3qA	1	0.912	100	0.321	Contact Map
3ez2A	2	0.964	100	0.324	Contact Map
2ozeA	2	0.968	100	0.328	Contact Map
3ez9A	2	0.812	100	0.328	Contact Map
3ea0A	2	0.896	100	0.337	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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