GREMLIN Database
BCSA - Cellulose synthase catalytic subunit [UDP-forming]
UniProt: P37653 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12260
Length: 872 (688)
Sequences: 421 (281)
Seq/√Len: 10.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
355_F374_M9.1611.00
218_Y237_L7.6151.00
277_I299_I6.4321.00
442_P469_Y5.7291.00
250_G526_N4.9261.00
309_W329_K4.1960.99
319_F323_A4.1070.99
315_G336_H4.0710.99
465_H471_S4.0080.99
344_I449_I3.9980.99
545_L649_G3.9950.99
427_D470_T3.8320.99
351_A444_D3.7470.98
278_F351_A3.7460.98
445_E467_R3.7000.98
268_D271_L3.6740.98
323_A326_V3.5940.98
210_S569_H3.5020.98
310_I323_A3.4930.98
380_E470_T3.3780.97
368_S793_A3.3620.97
322_F326_V3.2220.96
730_G771_G3.1550.95
346_N349_K3.1200.95
368_S478_Q3.1050.95
696_R723_D3.0870.95
319_F326_V2.9760.94
332_A336_H2.8890.93
707_A731_I2.8750.92
344_I461_S2.8650.92
774_L785_F2.8310.92
707_A719_C2.8150.92
317_E321_Q2.7620.91
279_V293_I2.6630.89
319_F322_F2.5990.88
386_M471_S2.5990.88
244_W323_A2.5880.88
466_R513_G2.5790.88
274_S307_N2.5530.87
307_N329_K2.4060.83
607_V614_K2.3920.83
301_W374_M2.3850.83
643_V679_L2.3790.83
377_F383_L2.3780.83
246_V250_G2.3350.82
317_E320_R2.2830.80
647_L679_L2.2490.79
199_A579_K2.2450.79
441_K609_L2.2060.78
315_G631_V2.1820.77
297_L328_V2.1790.77
301_W599_W2.1610.76
250_G458_A2.1490.76
293_I310_I2.1210.75
252_F519_A2.0960.74
443_L446_I2.0910.74
290_K400_R2.0730.73
355_F439_R2.0550.72
288_V291_N2.0470.72
607_V610_I2.0430.72
262_P649_G2.0300.71
278_F309_W2.0250.71
357_S369_F2.0020.70
578_S587_S1.9810.69
442_P449_I1.9660.69
289_V319_F1.9600.68
385_M471_S1.9490.68
259_N421_D1.9470.68
587_S808_P1.9380.67
453_T459_H1.9350.67
235_I542_T1.9260.67
511_L811_S1.9180.67
229_S413_T1.9120.66
587_S806_D1.8880.65
465_H489_A1.8790.65
277_I810_E1.8770.65
336_H631_V1.8490.64
492_G621_A1.8440.63
293_I361_C1.8410.63
361_C391_H1.8360.63
344_I554_I1.8270.63
459_H615_G1.8240.63
334_T346_N1.8210.62
262_P760_T1.8210.62
336_H461_S1.8080.62
376_W386_M1.8020.62
281_T293_I1.7870.61
297_L783_I1.7850.61
348_L356_V1.7840.61
315_G335_T1.7780.60
190_V308_I1.7780.60
653_G672_M1.7740.60
214_I811_S1.7650.60
315_G332_A1.7640.60
156_V190_V1.7640.60
384_A438_I1.7580.60
305_K717_F1.7350.59
400_R670_V1.7130.58
386_M419_V1.7120.57
555_I605_T1.7050.57
344_I469_Y1.7000.57
235_I535_I1.6940.57
700_R723_D1.6860.56
398_F806_D1.6690.55
445_E451_V1.6600.55
226_D229_S1.6490.55
167_V731_I1.6430.54
469_Y554_I1.6430.54
320_R326_V1.6380.54
459_H508_D1.6360.54
453_T526_N1.6320.54
449_I554_I1.6250.53
359_F478_Q1.6230.53
203_I505_F1.6110.53
461_S525_V1.5880.52
161_I308_I1.5750.51
696_R728_G1.5740.51
430_F461_S1.5700.51
331_I346_N1.5610.50
458_A526_N1.5580.50
364_V492_G1.5570.50
571_I658_F1.5440.50
511_L525_V1.5320.49
218_Y241_T1.5270.49
534_G601_I1.5240.49
636_S683_G1.5160.48
507_L613_H1.5070.48
526_N595_T1.5070.48
599_W789_T1.5060.48
438_I562_I1.5030.48
215_W584_Y1.4990.47
393_F771_G1.4850.47
320_R323_A1.4800.47
723_D730_G1.4800.47
502_V532_L1.4800.47
423_N459_H1.4780.46
155_I186_V1.4740.46
374_M535_I1.4620.46
601_I646_N1.4580.45
238_F303_K1.4560.45
723_D728_G1.4540.45
423_N527_A1.4440.45
491_I686_V1.4420.45
729_L772_L1.4410.45
545_L687_A1.4390.45
344_I525_V1.4360.44
281_T323_A1.4300.44
485_E623_G1.4210.44
463_R489_A1.4160.44
372_M476_I1.4160.44
498_A796_W1.4140.43
354_E437_V1.4080.43
308_I512_T1.4000.43
164_L641_F1.3840.42
743_Q747_L1.3830.42
354_E439_R1.3800.42
737_A770_V1.3750.42
696_R700_R1.3750.42
677_Y790_F1.3750.42
235_I628_E1.3720.41
492_G614_K1.3690.41
484_T487_L1.3640.41
266_P378_L1.3630.41
549_L652_V1.3600.41
206_S251_Y1.3590.41
356_V547_F1.3590.41
400_R480_A1.3580.41
372_M478_Q1.3570.41
499_R615_G1.3560.41
564_L602_A1.3540.41
495_I621_A1.3370.40
416_Y473_Y1.3350.40
729_L809_L1.3340.40
472_A505_F1.3230.39
390_H430_F1.3230.39
459_H490_H1.3210.39
533_S608_A1.3200.39
536_P618_N1.3190.39
469_Y534_G1.3180.39
449_I469_Y1.3170.39
390_H501_M1.3160.39
285_D403_G1.3160.39
760_T772_L1.3160.39
320_R324_Q1.3110.39
361_C553_Y1.3070.39
281_T719_C1.3000.38
285_D532_L1.3000.38
636_S682_L1.2990.38
650_V672_M1.2980.38
229_S232_C1.2980.38
476_I793_A1.2950.38
290_K294_Y1.2900.38
307_N352_K1.2860.38
791_A795_T1.2810.37
279_V680_I1.2730.37
309_W522_L1.2710.37
449_I614_K1.2710.37
222_L354_E1.2680.37
279_V517_K1.2680.37
308_I329_K1.2670.37
627_E739_I1.2600.36
281_T328_V1.2600.36
299_I739_I1.2520.36
189_I648_V1.2510.36
554_I762_V1.2430.36
394_S466_R1.2420.36
761_Q773_K1.2400.36
184_W627_E1.2340.35
449_I601_I1.2330.35
647_L769_E1.2310.35
158_F165_I1.2310.35
461_S684_G1.2310.35
271_L305_K1.2270.35
211_C244_W1.2230.35
499_R608_A1.2230.35
262_P576_T1.2220.35
614_K668_V1.2210.35
526_N604_P1.2210.35
288_V361_C1.2210.35
531_F632_D1.2200.35
446_I745_V1.2190.35
359_F369_F1.2150.34
275_V370_L1.2140.34
321_Q325_N1.2130.34
751_R758_F1.2110.34
721_V785_F1.2050.34
358_I616_K1.2000.34
597_L604_P1.1990.34
469_Y601_I1.1920.33
346_N350_Y1.1870.33
702_E723_D1.1810.33
599_W724_F1.1810.33
281_T764_R1.1790.33
224_W230_L1.1760.33
224_W308_I1.1700.33
549_L569_H1.1700.33
338_H512_T1.1620.32
151_I189_I1.1590.32
441_K445_E1.1560.32
309_W695_V1.1540.32
704_T720_T1.1510.32
430_F591_E1.1490.32
363_H436_A1.1450.32
543_A641_F1.1450.32
324_Q627_E1.1420.31
200_L428_A1.1360.31
203_I686_V1.1320.31
386_M754_Q1.1310.31
290_K364_V1.1300.31
731_I745_V1.1300.31
379_K740_L1.1290.31
153_G157_T1.1260.31
435_C484_T1.1260.31
221_T786_V1.1220.31
536_P689_S1.1170.30
250_G577_N1.1170.30
430_F524_Y1.1170.30
453_T615_G1.1150.30
278_F348_L1.1110.30
382_Q469_Y1.1100.30
361_C632_D1.1090.30
599_W642_L1.1080.30
484_T490_H1.1050.30
395_P405_F1.1020.30
526_N535_I1.0970.30
301_W624_G1.0930.29
416_Y591_E1.0930.29
246_V526_N1.0920.29
704_T732_K1.0900.29
321_Q324_Q1.0900.29
490_H597_L1.0880.29
352_K654_I1.0870.29
356_V443_L1.0840.29
301_W355_F1.0780.29
412_G435_C1.0780.29
396_D674_W1.0730.29
635_I683_G1.0710.29
366_T522_L1.0650.28
713_D739_I1.0630.28
349_K770_V1.0600.28
406_R645_L1.0590.28
232_C310_I1.0570.28
311_L420_Q1.0570.28
492_G668_V1.0550.28
246_V530_H1.0520.28
224_W621_A1.0500.28
747_L809_L1.0460.28
478_Q486_S1.0460.28
430_F436_A1.0450.28
336_H449_I1.0380.27
277_I306_L1.0360.27
290_K293_I1.0360.27
649_G701_V1.0330.27
570_M675_V1.0320.27
368_S486_S1.0310.27
164_L657_Y1.0300.27
555_I682_L1.0300.27
253_Q531_F1.0280.27
431_F691_E1.0270.27
642_L646_N1.0250.27
189_I366_T1.0240.27
551_H823_Y1.0210.27
772_L821_R1.0200.27
650_V676_F1.0190.27
307_N353_G1.0170.27
577_N608_A1.0170.27
382_Q467_R1.0150.26
391_H799_W1.0090.26
678_N789_T1.0080.26
253_Q632_D1.0030.26
157_T733_I1.0000.26
592_I826_L0.9980.26
216_W411_E0.9970.26
246_V453_T0.9970.26
293_I322_F0.9960.26
363_H431_F0.9940.26
533_S671_S0.9910.26
608_A615_G0.9900.26
231_V809_L0.9890.26
364_V777_L0.9870.25
278_F308_I0.9870.25
158_F753_Q0.9860.25
323_A606_L0.9810.25
408_T805_E0.9800.25
427_D543_A0.9790.25
347_A351_A0.9770.25
155_I518_F0.9730.25
241_T774_L0.9720.25
309_W707_A0.9710.25
646_N822_G0.9690.25
299_I565_F0.9690.25
473_Y524_Y0.9680.25
249_L474_M0.9650.25
431_F434_S0.9650.25
182_L761_Q0.9640.25
423_N531_F0.9630.25
385_M590_S0.9620.25
330_Y443_L0.9550.24
165_I356_V0.9540.24
299_I578_S0.9540.24
383_L472_A0.9530.24
294_Y779_T0.9510.24
489_A678_N0.9510.24
298_G602_A0.9500.24
159_S773_K0.9460.24
255_V522_L0.9460.24
429_T465_H0.9450.24
366_T381_K0.9440.24
739_I767_G0.9430.24
419_V580_I0.9400.24
237_L552_A0.9380.24
324_Q739_I0.9380.24
265_L306_L0.9340.24
459_H531_F0.9340.24
423_N632_D0.9320.24
463_R508_D0.9300.23
383_L477_P0.9290.23
157_T245_I0.9260.23
323_A391_H0.9250.23
248_V560_L0.9240.23
330_Y515_G0.9240.23
377_F685_A0.9220.23
394_S484_T0.9220.23
479_A484_T0.9210.23
435_C479_A0.9200.23
356_V663_T0.9200.23
724_F789_T0.9160.23
399_E410_N0.9150.23
344_I358_I0.9120.23
423_N499_R0.9120.23
540_F638_P0.9110.23
238_F769_E0.9100.23
608_A636_S0.9080.23
209_V572_H0.9080.23
257_P524_Y0.9080.23
459_H597_L0.9070.23
155_I770_V0.9070.23
315_G671_S0.9060.23
253_Q423_N0.9060.23
469_Y543_A0.9040.23
533_S577_N0.9040.23
524_Y591_E0.9040.23
533_S614_K0.9040.23
576_T681_V0.9000.22
183_L298_G0.8960.22
239_A523_C0.8940.22
780_Q783_I0.8900.22
285_D288_V0.8900.22
207_L248_V0.8900.22
492_G536_P0.8890.22
232_C562_I0.8870.22
167_V185_G0.8850.22
408_T586_H0.8850.22
344_I601_I0.8850.22
308_I444_D0.8850.22
314_G434_S0.8840.22
411_E593_Y0.8820.22
697_R773_K0.8780.22
611_N614_K0.8770.22
391_H555_I0.8770.22
363_H691_E0.8770.22
316_R322_F0.8740.22
385_M638_P0.8710.21
385_M586_H0.8710.21
357_S589_W0.8710.21
631_V811_S0.8700.21
279_V491_I0.8700.21
188_L779_T0.8680.21
394_S472_A0.8680.21
776_P835_K0.8680.21
436_A501_M0.8640.21
159_S238_F0.8640.21
621_A635_I0.8610.21
291_N636_S0.8610.21
554_I719_C0.8610.21
569_H811_S0.8610.21
355_F626_V0.8570.21
459_H632_D0.8570.21
270_S761_Q0.8570.21
214_I244_W0.8560.21
475_R799_W0.8550.21
508_D615_G0.8540.21
376_W569_H0.8520.21
588_F689_S0.8520.21
275_V464_L0.8510.21
374_M449_I0.8510.21
375_G509_N0.8500.21
403_G709_I0.8470.21
157_T190_V0.8460.21
461_S592_I0.8430.21
363_H422_G0.8420.21
209_V675_V0.8420.21
310_I606_L0.8420.21
454_V531_F0.8420.21
308_I684_G0.8380.20
416_Y524_Y0.8380.20
320_R505_F0.8380.20
434_S691_E0.8360.20
464_L561_M0.8350.20
203_I580_I0.8350.20
461_S558_P0.8340.20
641_F733_I0.8320.20
350_Y703_M0.8310.20
371_Q793_A0.8300.20
272_W531_F0.8300.20
324_Q539_I0.8300.20
458_A595_T0.8280.20
506_R615_G0.8280.20
512_T517_K0.8260.20
156_V278_F0.8260.20
154_I828_E0.8250.20
443_L540_F0.8250.20
731_I772_L0.8250.20
631_V786_V0.8240.20
392_F401_N0.8230.20
473_Y611_N0.8230.20
335_T563_A0.8230.20
251_Y576_T0.8220.20
350_Y356_V0.8220.20
586_H806_D0.8220.20
308_I352_K0.8210.20
390_H431_F0.8210.20
505_F525_V0.8210.20
187_A701_V0.8200.20
363_H434_S0.8190.20
289_V361_C0.8170.20
150_L158_F0.8170.20
179_F645_L0.8140.20
390_H436_A0.8130.20
473_Y591_E0.8120.20
332_A346_N0.8100.20
723_D771_G0.8100.20
265_L305_K0.8090.20
373_T385_M0.8090.20
274_S648_V0.8080.20
486_S532_L0.8040.19
299_I812_L0.8040.19
412_G598_A0.8040.19
171_F815_I0.8020.19
761_Q775_M0.8020.19
310_I328_V0.8010.19
365_P473_Y0.8000.19
506_R608_A0.8000.19
245_I444_D0.8000.19
274_S306_L0.7990.19
406_R491_I0.7990.19
671_S721_V0.7950.19
376_W379_K0.7940.19
636_S639_Y0.7940.19
304_D655_W0.7930.19
677_Y785_F0.7930.19
335_T346_N0.7920.19
828_E832_S0.7910.19
480_A591_E0.7880.19
435_C478_Q0.7870.19
158_F767_G0.7860.19
547_F564_L0.7840.19
602_A684_G0.7830.19
487_L689_S0.7820.19
518_F659_Y0.7820.19
628_E676_F0.7820.19
157_T172_N0.7820.19
383_L470_T0.7810.19
299_I408_T0.7780.19
491_I688_V0.7760.19
300_D371_Q0.7760.19
423_N451_V0.7750.19
230_L237_L0.7750.19
331_I669_V0.7750.19
359_F506_R0.7750.19
344_I787_Q0.7730.19
532_L647_L0.7730.19
356_V627_E0.7720.18
465_H486_S0.7710.18
671_S689_S0.7710.18
279_V386_M0.7690.18
356_V785_F0.7690.18
235_I238_F0.7670.18
290_K631_V0.7670.18
268_D356_V0.7660.18
436_A691_E0.7660.18
319_F435_C0.7650.18
545_L569_H0.7640.18
418_L453_T0.7620.18
293_I790_F0.7610.18
577_N604_P0.7610.18
254_V808_P0.7610.18
608_A635_I0.7610.18
355_F717_F0.7610.18
180_L205_L0.7600.18
278_F329_K0.7600.18
344_I406_R0.7600.18
551_H564_L0.7590.18
569_H636_S0.7580.18
357_S683_G0.7570.18
382_Q717_F0.7570.18
305_K328_V0.7560.18
157_T564_L0.7560.18
525_V648_V0.7560.18
551_H727_G0.7560.18
301_W502_V0.7550.18
432_C594_E0.7550.18
572_H576_T0.7550.18
296_S512_T0.7550.18
553_Y556_Y0.7540.18
405_F639_Y0.7540.18
531_F589_W0.7540.18
216_W494_R0.7510.18
551_H756_Y0.7510.18
185_G613_H0.7510.18
530_H608_A0.7510.18
224_W564_L0.7500.18
466_R472_A0.7500.18
278_F684_G0.7490.18
393_F469_Y0.7480.18
186_V491_I0.7480.18
447_G656_R0.7470.18
595_T609_L0.7430.18
229_S631_V0.7430.18
746_N773_K0.7430.18
277_I464_L0.7430.18
235_I539_I0.7430.18
289_V806_D0.7430.18
609_L628_E0.7420.18
405_F608_A0.7410.18
423_N454_V0.7410.18
359_F479_A0.7400.18
295_A507_L0.7390.18
230_L489_A0.7380.18
186_V761_Q0.7380.18
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328_V529_F0.5200.12
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222_L381_K0.5170.12
430_F435_C0.5160.12
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168_T181_M0.5160.12
150_L767_G0.5160.12
178_I238_F0.5160.12
359_F521_R0.5130.12
227_P243_A0.5130.12
393_F534_G0.5120.12
592_I782_H0.5120.12
486_S552_A0.5110.12
250_G604_P0.5110.12
575_L592_I0.5110.12
707_A823_Y0.5090.12
499_R530_H0.5090.12
216_W593_Y0.5090.12
681_V729_L0.5080.12
435_C794_D0.5080.12
832_S835_K0.5080.12
208_T690_V0.5080.12
251_Y550_L0.5070.12
347_A568_P0.5070.12
427_D582_G0.5070.12
605_T618_N0.5070.12
627_E783_I0.5060.12
384_A423_N0.5060.12
641_F832_S0.5060.12
153_G185_G0.5040.12
430_F462_L0.5040.12
168_T171_F0.5040.12
186_V651_A0.5030.12
157_T709_I0.5030.12
431_F455_T0.5030.12
196_R714_G0.5020.12
308_I378_L0.5020.12
222_L353_G0.5020.12
247_L483_A0.5010.12
184_W551_H0.5010.12
323_A329_K0.5000.12
566_V645_L0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4p02A 1 0.7913 100 0.619 Contact Map
2z86A 2 0.5975 100 0.907 Contact Map
1qg8A 1 0.2397 99.9 0.928 Contact Map
5ajoA 1 0.5229 99.9 0.928 Contact Map
3bcvA 2 0.203 99.9 0.932 Contact Map
1xhbA 1 0.4461 99.9 0.932 Contact Map
2fy7A 1 0.2867 99.9 0.936 Contact Map
3ckjA 2 0.3154 99.9 0.937 Contact Map
3f1yA 2 0.3417 99.9 0.937 Contact Map
2nxvA 4 0.2787 99.9 0.938 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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