GREMLIN Database
BCSB - Cyclic di-GMP-binding protein
UniProt: P37652 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12259
Length: 779 (707)
Sequences: 490 (357)
Seq/√Len: 13.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
368_R374_E6.2391.00
177_H183_E5.7471.00
372_F412_M5.5621.00
666_G676_S5.1941.00
320_R324_D5.0311.00
667_F677_V4.9421.00
676_S725_Y4.6071.00
114_N156_Q3.9241.00
125_P194_V3.8430.99
318_F325_L3.6490.99
120_S123_L3.4300.99
128_S191_W3.4010.99
250_V329_A3.2720.98
357_P545_M3.2270.98
142_L155_A3.2080.98
545_M550_Q3.1810.98
112_M158_P2.9570.97
355_R546_A2.8960.96
602_M678_I2.8540.96
281_A318_F2.7490.95
355_R359_D2.7470.95
182_C500_C2.7100.94
178_Y183_E2.6830.94
571_V582_A2.6710.94
231_L254_F2.6690.94
434_N480_N2.6560.94
298_A324_D2.6470.94
564_M568_L2.6400.94
232_P572_G2.6240.93
528_P726_Y2.6220.93
527_I534_A2.5630.93
278_I581_P2.5140.92
270_N288_D2.4850.91
77_F198_S2.3940.90
255_G575_G2.3870.89
59_A65_A2.3840.89
89_L682_A2.3510.89
133_Y138_L2.3280.88
251_A772_R2.3110.88
172_L194_V2.3060.88
247_S568_L2.2790.87
364_V676_S2.2620.87
120_S191_W2.2590.87
552_I599_A2.2580.87
62_P68_G2.1910.85
360_A546_A2.1800.85
298_A345_V2.1770.84
200_L572_G2.1480.84
128_S190_L2.1460.84
71_R106_E2.1190.83
178_Y187_S2.1170.83
172_L415_N2.1030.82
613_D617_I2.0920.82
543_S574_I2.0600.81
140_G157_M2.0450.80
278_I420_M2.0360.80
476_L531_D2.0310.80
749_V753_I2.0280.80
254_F517_T2.0120.79
341_G539_G2.0060.79
122_S189_T2.0000.79
427_S489_M1.9730.78
590_D593_T1.9690.78
372_F394_V1.9550.77
571_V585_L1.9410.77
159_I200_L1.9280.76
234_V277_A1.9280.76
412_M604_I1.9210.76
159_I526_F1.9180.76
211_N313_K1.9100.76
612_K616_Q1.8960.75
117_Y155_A1.8940.75
393_N481_Q1.8840.75
74_K201_D1.8820.74
183_E188_T1.8750.74
54_P57_Q1.8730.74
100_F212_D1.8640.74
710_V758_L1.8460.73
682_A703_T1.8340.72
233_M251_A1.8230.72
542_F678_I1.8100.71
174_F192_L1.7970.71
402_L525_H1.7920.71
566_T692_N1.7810.70
603_I677_V1.7740.70
313_K359_D1.7720.70
50_G60_D1.7700.70
108_V164_I1.7690.70
60_D63_V1.7640.69
418_Y443_L1.7570.69
49_V52_V1.7530.69
286_R570_T1.7530.69
364_V520_F1.7500.69
245_Q326_L1.7400.68
534_A707_S1.7390.68
74_K199_G1.7310.68
77_F531_D1.7280.68
65_A756_I1.7100.67
301_I471_I1.7090.67
301_I332_I1.7090.67
53_M555_M1.7020.67
359_D546_A1.6900.66
600_D676_S1.6880.66
115_L664_V1.6840.66
163_F408_T1.6690.65
172_L418_Y1.6660.65
64_V323_K1.6620.65
50_G55_G1.6440.64
52_V63_V1.6440.64
134_L732_W1.6410.64
198_S527_I1.6300.63
258_S370_V1.6260.63
298_A303_M1.6240.63
52_V65_A1.6210.63
512_I515_D1.6180.62
248_A567_L1.6100.62
315_L319_G1.5990.61
552_I601_I1.5890.61
540_F545_M1.5890.61
440_S761_V1.5840.61
219_P332_I1.5610.60
54_P62_P1.5600.59
248_A571_V1.5560.59
182_C190_L1.5520.59
761_V765_L1.5500.59
296_V324_D1.5470.59
405_M411_D1.5430.59
160_N605_G1.5370.58
270_N552_I1.5360.58
280_F325_L1.5330.58
88_V193_D1.5270.58
128_S177_H1.5120.57
159_I481_Q1.5090.57
566_T688_Y1.5020.56
303_M569_N1.5000.56
222_D427_S1.4930.56
600_D675_R1.4850.56
49_V60_D1.4850.56
357_P544_R1.4850.56
614_D617_I1.4830.56
246_A400_P1.4830.56
58_G62_P1.4820.55
394_V435_N1.4780.55
255_G542_F1.4700.55
174_F344_V1.4650.55
321_D347_N1.4630.54
63_V66_Q1.4620.54
102_M469_V1.4610.54
130_L736_V1.4560.54
573_F577_Q1.4520.54
103_R225_D1.4510.54
287_P663_A1.4460.54
316_V752_A1.4410.53
408_T471_I1.4410.53
109_T695_V1.4410.53
51_Q54_P1.4330.53
550_Q600_D1.4330.53
553_T571_V1.4290.53
259_G362_N1.4160.52
533_R537_N1.4100.52
97_S171_R1.4000.51
280_F318_F1.3980.51
178_Y184_K1.3970.51
264_N317_V1.3930.51
536_A704_M1.3920.51
430_D437_F1.3910.51
247_S341_G1.3860.50
373_G552_I1.3840.50
600_D678_I1.3760.50
282_T679_A1.3750.50
127_Q187_S1.3740.50
262_G321_D1.3650.49
170_V345_V1.3640.49
553_T585_L1.3620.49
605_G619_L1.3550.49
166_D510_V1.3510.49
438_L478_A1.3510.49
252_S360_A1.3470.48
612_K671_Y1.3420.48
62_P74_K1.3410.48
229_N254_F1.3400.48
567_L571_V1.3400.48
275_R312_V1.3390.48
357_P546_A1.3350.48
132_V172_L1.3340.48
178_Y190_L1.3330.48
529_M534_A1.3330.48
278_I580_F1.3160.47
587_V632_M1.3150.47
725_Y728_G1.3150.47
363_W579_G1.3100.46
253_W332_I1.3070.46
125_P771_R1.2980.46
232_P266_P1.2970.46
760_W764_R1.2920.45
316_V580_F1.2900.45
209_V313_K1.2840.45
51_Q57_Q1.2830.45
49_V53_M1.2820.45
296_V317_V1.2810.45
601_I671_Y1.2790.45
443_L619_L1.2720.44
235_F246_A1.2690.44
526_F687_G1.2680.44
134_L170_V1.2670.44
190_L509_H1.2660.44
516_S602_M1.2630.44
711_I747_L1.2630.44
123_L183_E1.2630.44
604_I717_N1.2610.44
195_G374_E1.2610.44
518_I531_D1.2580.44
106_E321_D1.2570.44
76_T566_T1.2570.44
100_F280_F1.2560.44
396_L647_R1.2510.43
273_P579_G1.2500.43
387_L531_D1.2480.43
482_L582_A1.2460.43
444_S518_I1.2430.43
301_I715_G1.2410.43
105_D359_D1.2340.42
89_L108_V1.2330.42
304_I316_V1.2330.42
306_H569_N1.2330.42
52_V57_Q1.2310.42
488_Y510_V1.2280.42
263_Q332_I1.2280.42
329_A569_N1.2270.42
172_L308_Q1.2270.42
86_S196_R1.2270.42
164_I707_S1.2270.42
359_D544_R1.2260.42
518_I536_A1.2240.42
294_P332_I1.2210.42
62_P65_A1.2170.41
252_S546_A1.2170.41
324_D374_E1.2150.41
362_N399_P1.2150.41
56_V63_V1.2130.41
81_A411_D1.2120.41
102_M734_E1.2120.41
742_N752_A1.2100.41
157_M317_V1.2080.41
398_L536_A1.2030.41
121_P191_W1.1970.40
139_M174_F1.1950.40
106_E204_Y1.1940.40
280_F317_V1.1910.40
115_L198_S1.1900.40
440_S711_I1.1880.40
319_G328_A1.1880.40
233_M280_F1.1870.40
395_S572_G1.1870.40
92_I187_S1.1830.40
540_F716_I1.1820.40
177_H190_L1.1800.40
65_A598_D1.1780.39
382_L403_Y1.1740.39
251_A637_F1.1670.39
361_P546_A1.1660.39
115_L183_E1.1660.39
253_W257_R1.1650.39
55_G63_V1.1640.39
101_G276_N1.1640.39
51_Q154_L1.1610.39
103_R177_H1.1600.39
418_Y579_G1.1590.39
685_P704_M1.1550.38
157_M569_N1.1520.38
168_N182_C1.1500.38
159_I164_I1.1490.38
217_P400_P1.1490.38
326_L471_I1.1490.38
240_D322_D1.1480.38
113_L157_M1.1480.38
132_V372_F1.1480.38
272_L732_W1.1470.38
58_G64_V1.1450.38
123_L191_W1.1410.38
545_M584_N1.1390.38
95_N171_R1.1370.37
52_V64_V1.1340.37
217_P542_F1.1330.37
136_D469_V1.1320.37
298_A317_V1.1310.37
57_Q63_V1.1280.37
562_A651_T1.1260.37
333_A540_F1.1210.37
359_D540_F1.1190.37
135_N168_N1.1190.37
435_N481_Q1.1170.36
270_N572_G1.1140.36
398_L574_I1.1100.36
556_P770_S1.1090.36
396_L666_G1.1070.36
300_V318_F1.1060.36
364_V633_R1.0960.35
101_G430_D1.0940.35
410_I621_V1.0930.35
129_Q539_G1.0930.35
208_N318_F1.0930.35
239_P269_Y1.0880.35
604_I723_D1.0780.35
50_G61_A1.0780.35
639_G644_E1.0770.34
251_A578_T1.0680.34
399_P520_F1.0680.34
370_V753_I1.0670.34
280_F465_G1.0670.34
239_P273_P1.0620.34
80_I346_V1.0590.34
668_Q674_Q1.0560.33
281_A286_R1.0540.33
298_A344_V1.0520.33
193_D442_N1.0510.33
471_I553_T1.0490.33
78_A396_L1.0490.33
178_Y191_W1.0420.33
298_A320_R1.0380.33
555_M564_M1.0380.33
488_Y707_S1.0370.33
53_M60_D1.0370.33
477_G712_R1.0370.33
134_L139_M1.0350.33
566_T718_S1.0340.32
53_M59_A1.0320.32
296_V299_P1.0310.32
85_G435_N1.0300.32
329_A482_L1.0270.32
476_L665_I1.0250.32
237_G550_Q1.0250.32
660_A684_S1.0250.32
89_L183_E1.0240.32
92_I188_T1.0200.32
106_E281_A1.0180.32
160_N421_P1.0180.32
642_P647_R1.0170.32
332_I573_F1.0170.32
486_F559_P1.0170.32
226_N316_V1.0160.32
616_Q671_Y1.0140.32
549_S566_T1.0060.31
158_P233_M1.0010.31
77_F588_T1.0000.31
134_L163_F0.9980.31
223_P301_I0.9980.31
168_N530_P0.9960.31
286_R289_F0.9950.31
159_I254_F0.9930.31
157_M555_M0.9910.30
404_L691_L0.9910.30
431_I626_S0.9910.30
160_N180_D0.9900.30
571_V738_Y0.9880.30
464_D510_V0.9880.30
548_L575_G0.9850.30
362_N589_D0.9840.30
321_D324_D0.9830.30
278_I430_D0.9830.30
288_D520_F0.9820.30
161_P697_D0.9810.30
135_N182_C0.9790.30
319_G324_D0.9780.30
469_V604_I0.9780.30
373_G514_D0.9770.30
557_K590_D0.9770.30
217_P255_G0.9760.30
284_D731_P0.9760.30
214_S716_I0.9730.30
170_V754_S0.9720.30
281_A531_D0.9720.30
231_L341_G0.9710.30
415_N515_D0.9710.30
307_P361_P0.9690.30
213_L307_P0.9680.29
184_K187_S0.9680.29
382_L402_L0.9670.29
548_L551_T0.9670.29
137_E314_L0.9660.29
155_A372_F0.9660.29
438_L446_K0.9660.29
159_I194_V0.9650.29
191_W727_V0.9630.29
254_F716_I0.9620.29
316_V758_L0.9560.29
316_V429_M0.9550.29
279_V670_P0.9540.29
277_A314_L0.9530.29
402_L529_M0.9530.29
117_Y399_P0.9520.29
49_V62_P0.9510.29
189_T376_K0.9510.29
555_M709_A0.9510.29
542_F575_G0.9490.29
55_G65_A0.9480.29
392_I520_F0.9480.29
296_V318_F0.9470.29
180_D605_G0.9460.28
193_D663_A0.9440.28
177_H187_S0.9430.28
735_R739_A0.9430.28
644_E647_R0.9430.28
398_L433_L0.9420.28
132_V535_F0.9380.28
160_N681_L0.9370.28
682_A710_V0.9360.28
197_S233_M0.9360.28
77_F695_V0.9350.28
166_D478_A0.9350.28
548_L582_A0.9340.28
396_L536_A0.9330.28
730_L767_R0.9320.28
214_S671_Y0.9300.28
177_H191_W0.9250.28
741_A769_I0.9240.28
54_P604_I0.9230.28
566_T592_S0.9230.28
276_N422_P0.9170.27
63_V673_D0.9170.27
113_L434_N0.9160.27
384_S510_V0.9150.27
192_L684_S0.9140.27
68_G270_N0.9130.27
362_N579_G0.9110.27
112_M605_G0.9100.27
128_S182_C0.9080.27
554_V588_T0.9070.27
248_A553_T0.9060.27
225_D666_G0.9050.27
360_A579_G0.9050.27
120_S128_S0.9040.27
49_V67_N0.9040.27
643_D646_D0.9040.27
477_G699_G0.9030.27
668_Q672_N0.9020.27
542_F578_T0.9010.27
355_R548_L0.9000.27
437_F440_S0.8970.26
434_N478_A0.8960.26
51_Q356_K0.8950.26
244_Q568_L0.8950.26
604_I749_V0.8940.26
267_V563_Q0.8930.26
82_P469_V0.8920.26
346_V522_K0.8910.26
500_C541_P0.8900.26
52_V55_G0.8880.26
215_H257_R0.8880.26
255_G669_S0.8860.26
195_G698_S0.8830.26
58_G67_N0.8830.26
419_T769_I0.8820.26
212_D290_L0.8810.26
144_V707_S0.8790.26
144_V512_I0.8770.26
389_P509_H0.8750.26
144_V173_E0.8740.25
255_G416_Y0.8740.25
289_F293_H0.8740.25
438_L736_V0.8730.25
136_D523_Y0.8730.25
555_M567_L0.8710.25
742_N749_V0.8700.25
85_G372_F0.8690.25
306_H314_L0.8670.25
309_N769_I0.8650.25
601_I770_S0.8650.25
223_P711_I0.8610.25
547_D551_T0.8600.25
53_M63_V0.8570.25
518_I731_P0.8560.25
100_F164_I0.8540.25
560_N637_F0.8540.25
558_A746_L0.8530.25
105_D540_F0.8530.25
130_L322_D0.8510.25
540_F600_D0.8500.25
68_G749_V0.8480.24
251_A265_F0.8480.24
247_S252_S0.8470.24
241_V589_D0.8460.24
131_K173_E0.8460.24
363_W678_I0.8460.24
92_I178_Y0.8440.24
92_I179_Q0.8440.24
122_S418_Y0.8440.24
464_D604_I0.8430.24
237_G271_Q0.8420.24
281_A534_A0.8410.24
56_V518_I0.8390.24
401_D525_H0.8380.24
56_V65_A0.8370.24
76_T558_A0.8360.24
390_A393_N0.8360.24
753_I760_W0.8350.24
182_C401_D0.8310.24
557_K595_Q0.8310.24
414_I616_Q0.8310.24
157_M554_V0.8290.24
76_T290_L0.8280.24
605_G722_G0.8250.24
214_S259_G0.8240.24
87_M96_G0.8240.24
404_L407_S0.8190.23
56_V704_M0.8190.23
75_L664_V0.8180.23
109_T435_N0.8170.23
214_S565_E0.8170.23
161_P695_V0.8160.23
540_F767_R0.8160.23
604_I633_R0.8160.23
178_Y188_T0.8140.23
100_F168_N0.8130.23
75_L575_G0.8110.23
56_V639_G0.8100.23
435_N623_A0.8100.23
172_L757_L0.8090.23
366_T370_V0.8080.23
89_L723_D0.8060.23
440_S549_S0.8060.23
310_P369_P0.8060.23
139_M475_K0.8060.23
564_M758_L0.8050.23
478_A499_N0.8010.23
156_Q321_D0.8000.23
142_L586_T0.8000.23
76_T703_T0.7980.23
246_A402_L0.7970.23
302_E318_F0.7970.23
421_P480_N0.7960.22
123_L177_H0.7960.22
57_Q62_P0.7960.22
112_M194_V0.7960.22
111_A200_L0.7960.22
179_Q756_I0.7960.22
254_F422_P0.7950.22
421_P605_G0.7950.22
473_A477_G0.7940.22
128_S178_Y0.7940.22
248_A733_F0.7930.22
261_R675_R0.7930.22
68_G750_L0.7930.22
235_F280_F0.7930.22
179_Q492_M0.7920.22
750_L762_L0.7910.22
136_D700_K0.7910.22
586_T606_G0.7900.22
543_S664_V0.7880.22
152_K462_L0.7880.22
217_P551_T0.7850.22
571_V581_P0.7850.22
177_H188_T0.7850.22
53_M58_G0.7840.22
86_S195_G0.7840.22
539_G574_I0.7830.22
296_V300_V0.7820.22
50_G56_V0.7810.22
111_A222_D0.7810.22
179_Q188_T0.7800.22
79_Q278_I0.7800.22
405_M738_Y0.7780.22
707_S720_R0.7780.22
125_P483_R0.7760.22
482_L515_D0.7750.22
731_P748_A0.7750.22
194_V755_V0.7740.22
82_P440_S0.7740.22
325_L403_Y0.7730.22
198_S408_T0.7730.22
358_Y401_D0.7730.22
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643_D771_R0.5210.14
280_F324_D0.5200.14
192_L433_L0.5200.14
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66_Q759_A0.5170.14
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354_P357_P0.5140.14
333_A572_G0.5140.14
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382_L744_P0.5130.14
399_P421_P0.5120.14
213_L579_G0.5120.14
321_D612_K0.5110.14
394_V488_Y0.5100.14
637_F767_R0.5100.14
255_G313_K0.5100.14
217_P486_F0.5090.14
321_D608_P0.5090.14
139_M312_V0.5080.14
229_N263_Q0.5080.14
306_H405_M0.5080.14
564_M611_L0.5070.14
75_L175_V0.5060.14
299_P327_Q0.5060.14
231_L469_V0.5060.14
682_A709_A0.5050.14
156_Q346_V0.5050.14
62_P646_D0.5040.13
67_N512_I0.5040.13
319_G579_G0.5040.13
254_F353_L0.5040.13
158_P317_V0.5040.13
61_A540_F0.5030.13
445_S518_I0.5030.13
284_D294_P0.5030.13
579_G716_I0.5030.13
543_S693_D0.5030.13
219_P547_D0.5020.13
301_I709_A0.5020.13
554_V758_L0.5020.13
122_S319_G0.5010.13
297_K625_E0.5010.13
135_N401_D0.5010.13
557_K566_T0.5010.13
522_K766_L0.5000.13
510_V738_Y0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4p02B 1 0.7561 100 0.447 Contact Map
2w87A 1 0.154 76.4 0.978 Contact Map
2vzpA 1 0.154 59.8 0.981 Contact Map
4aw7A 1 0.2311 55.4 0.981 Contact Map
2w47A 1 0.163 53.5 0.981 Contact Map
2kluA 1 0.0578 44.9 0.982 Contact Map
2wz8A 1 0.1669 43.2 0.983 Contact Map
2bgoA 1 0.1476 35.8 0.983 Contact Map
2kncA 1 0.0603 33.3 0.984 Contact Map
2w3jA 1 0.1694 31.5 0.984 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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