GREMLIN Database
GUN - Endoglucanase
UniProt: P37651 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12258
Length: 368 (328)
Sequences: 927 (701)
Seq/√Len: 38.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_F335_V5.6281.00
129_G138_T4.7571.00
70_R74_D4.5431.00
77_L140_I4.3681.00
36_I42_V3.8071.00
61_M76_I3.5521.00
58_S121_M3.5491.00
70_R134_E3.5431.00
119_V188_A3.3531.00
61_M77_L3.2381.00
81_Q140_I3.0871.00
145_L191_F2.9391.00
120_W250_W2.9381.00
69_D72_A2.9351.00
129_G141_G2.8461.00
286_D290_G2.8181.00
58_S117_G2.8041.00
149_A197_P2.7371.00
126_L194_F2.6971.00
179_N221_W2.6961.00
212_T222_V2.6251.00
283_E295_K2.5771.00
60_G76_I2.5371.00
179_N182_Y2.4681.00
148_I152_E2.4611.00
52_T56_G2.4341.00
219_P222_V2.3181.00
113_S152_E2.2971.00
127_E190_Y2.2651.00
147_R151_E2.1920.99
253_M343_W2.1740.99
317_Q320_R2.1280.99
60_G141_G2.1030.99
180_P222_V2.0820.99
94_P121_M1.9980.99
286_D289_T1.9100.98
232_L238_L1.9010.98
320_R323_D1.8950.98
95_A108_V1.8850.98
182_Y221_W1.8720.98
79_W98_W1.8570.98
129_G134_E1.8140.98
138_T142_S1.7840.97
212_T219_P1.7770.97
186_T254_M1.7740.97
99_G109_L1.7300.97
80_T121_M1.7120.97
239_I243_D1.7090.97
101_K105_K1.6880.96
32_K72_A1.6590.96
272_A308_L1.6570.96
61_M140_I1.6450.96
28_W248_Y1.6380.96
240_S300_F1.6270.95
120_W184_P1.6180.95
153_V163_L1.6080.95
184_P250_W1.5860.95
154_V171_A1.5710.94
149_A195_G1.5400.94
17_F21_A1.5290.94
183_L205_N1.5290.94
122_A191_F1.5280.94
34_D40_G1.5260.94
153_V201_L1.5140.93
281_P301_S1.4960.93
92_R147_R1.4960.93
120_W249_M1.4940.93
54_S96_W1.4870.93
62_F120_W1.4870.93
78_D82_N1.4850.93
330_A333_N1.4710.92
53_T117_G1.4700.92
192_T199_T1.4540.92
71_A75_N1.4540.92
164_L169_G1.4350.91
116_D246_R1.4210.91
191_F198_W1.4190.91
141_G145_L1.4050.90
264_M267_R1.4000.90
16_A19_V1.3990.90
245_I299_G1.3760.89
144_L148_I1.3720.89
61_M121_M1.3700.89
74_D134_E1.3690.89
27_A341_Q1.3600.89
46_S330_A1.3590.89
336_L340_G1.3560.89
300_F303_A1.3460.88
218_S247_V1.3450.88
139_D143_A1.3360.88
28_W69_D1.3000.86
27_A31_F1.2900.86
187_L191_F1.2870.86
41_R221_W1.2780.86
162_M204_T1.2640.85
217_F240_S1.2610.85
314_Q317_Q1.2590.85
62_F66_A1.2570.85
25_W69_D1.2500.84
239_I284_K1.2480.84
305_L344_D1.2440.84
265_L269_K1.2270.83
115_S204_T1.2270.83
285_V289_T1.2240.83
283_E293_Q1.2120.82
189_Q254_M1.1970.81
134_E137_Y1.1950.81
182_Y243_D1.1930.81
123_W127_E1.1890.81
28_W64_A1.1870.81
126_L145_L1.1790.80
168_V200_T1.1730.80
267_R270_P1.1700.80
93_L118_D1.1700.80
130_R190_Y1.1640.80
57_Q80_T1.1580.79
215_K289_T1.1460.79
256_D261_K1.1360.78
155_T200_T1.1280.77
305_L320_R1.1210.77
57_Q332_Y1.1150.77
226_K229_G1.1130.76
136_R139_D1.1100.76
41_R178_F1.1090.76
36_I40_G1.1010.76
240_S248_Y1.0970.75
165_P221_W1.0950.75
334_Y337_T1.0870.75
238_L286_D1.0820.74
101_K107_E1.0790.74
123_W187_L1.0600.73
236_K243_D1.0580.73
71_A291_K1.0550.73
60_G280_Y1.0450.72
189_Q202_R1.0450.72
49_R274_F1.0420.72
74_D136_R1.0390.71
114_A182_Y1.0390.71
310_N313_A1.0370.71
62_F339_F1.0320.71
37_S43_I1.0310.71
177_R233_K1.0290.71
117_G184_P1.0260.70
132_W198_W1.0170.70
190_Y194_F1.0140.69
77_L85_A1.0130.69
73_F124_S1.0080.69
51_I97_L1.0080.69
66_A127_E1.0020.69
47_D51_I0.9960.68
112_N170_F0.9950.68
65_L127_E0.9950.68
65_L68_N0.9840.67
64_A69_D0.9770.67
55_E116_D0.9740.66
98_W182_Y0.9730.66
101_K235_E0.9670.66
274_F278_N0.9620.65
236_K239_I0.9600.65
297_P333_N0.9600.65
31_F35_Y0.9570.65
314_Q318_R0.9570.65
53_T58_S0.9560.65
63_S338_L0.9530.65
93_L96_W0.9480.64
94_P120_W0.9450.64
165_P169_G0.9430.64
44_D170_F0.9430.64
95_A98_W0.9400.64
217_F274_F0.9400.64
179_N243_D0.9390.63
120_W339_F0.9380.63
86_Q95_A0.9380.63
126_L129_G0.9360.63
69_D182_Y0.9340.63
33_K71_A0.9310.63
262_A266_N0.9290.63
142_S145_L0.9290.63
216_G219_P0.9270.62
40_G112_N0.9240.62
198_W217_F0.9200.62
329_D334_Y0.9170.62
50_K155_T0.9110.61
233_K236_K0.9070.61
186_T253_M0.9030.60
318_R321_V0.9020.60
112_N242_Y0.8970.60
303_A307_F0.8960.60
264_M268_F0.8930.60
77_L121_M0.8910.59
145_L194_F0.8900.59
291_K311_R0.8860.59
49_R97_L0.8860.59
93_L169_G0.8840.59
165_P179_N0.8830.59
162_M178_F0.8810.58
332_Y340_G0.8810.58
74_D137_Y0.8800.58
96_W116_D0.8720.58
115_S153_V0.8700.57
143_A203_E0.8630.57
278_N285_V0.8610.57
76_I166_G0.8590.57
114_A246_R0.8580.56
59_Y172_E0.8510.56
68_N132_W0.8460.55
149_A153_V0.8460.55
157_P176_W0.8440.55
21_A25_W0.8420.55
112_N336_L0.8410.55
129_G145_L0.8400.55
249_M343_W0.8380.55
87_G305_L0.8360.54
318_R322_A0.8360.54
83_N98_W0.8350.54
91_E151_E0.8310.54
45_P97_L0.8250.53
180_P188_A0.8240.53
247_V276_E0.8200.53
130_R162_M0.8190.53
241_S284_K0.8170.53
60_G276_E0.8150.53
311_R314_Q0.8140.52
192_T205_N0.8080.52
54_S110_D0.8040.52
164_L170_F0.8030.52
165_P182_Y0.8010.51
35_Y334_Y0.8010.51
42_V60_G0.8000.51
44_D84_L0.7970.51
61_M219_P0.7960.51
272_A307_F0.7950.51
289_T292_A0.7880.50
85_A300_F0.7860.50
51_I80_T0.7860.50
70_R211_E0.7830.50
54_S94_P0.7810.50
141_G254_M0.7790.49
45_P330_A0.7780.49
113_S167_K0.7780.49
61_M80_T0.7750.49
282_P285_V0.7740.49
53_T120_W0.7660.48
59_Y116_D0.7660.48
116_D182_Y0.7620.48
63_S335_V0.7620.48
58_S333_N0.7600.48
28_W299_G0.7600.48
201_L204_T0.7570.47
271_M275_T0.7530.47
325_F344_D0.7530.47
187_L250_W0.7520.47
145_L185_P0.7500.47
200_T292_A0.7490.47
238_L287_V0.7480.47
205_N305_L0.7460.46
14_L20_Q0.7450.46
41_R52_T0.7440.46
126_L141_G0.7440.46
84_L182_Y0.7430.46
232_L237_T0.7430.46
44_D47_D0.7430.46
211_E277_K0.7430.46
183_L243_D0.7410.46
171_A224_Y0.7380.46
20_Q345_Q0.7380.46
200_T203_E0.7360.45
192_T202_R0.7350.45
69_D165_P0.7320.45
22_A262_A0.7300.45
50_K68_N0.7300.45
115_S299_G0.7290.45
69_D221_W0.7290.45
60_G195_G0.7280.45
85_A94_P0.7280.45
55_E114_A0.7240.44
300_F304_M0.7240.44
34_D37_S0.7200.44
67_A243_D0.7190.44
206_Q254_M0.7190.44
113_S148_I0.7160.44
39_E262_A0.7150.44
239_I286_D0.7150.44
288_A292_A0.7120.43
121_M243_D0.7110.43
60_G335_V0.7080.43
53_T250_W0.7080.43
58_S243_D0.7050.43
193_R311_R0.7030.43
37_S40_G0.7020.42
305_L343_W0.7000.42
86_Q91_E0.6990.42
130_R194_F0.6960.42
15_A201_L0.6940.42
192_T196_A0.6930.42
163_L188_A0.6930.42
118_D148_I0.6910.41
31_F106_W0.6910.41
44_D56_G0.6910.41
80_T154_V0.6900.41
251_V254_M0.6890.41
226_K279_G0.6890.41
29_E146_K0.6860.41
119_V248_Y0.6850.41
196_A269_K0.6830.41
240_S271_M0.6830.41
63_S342_G0.6790.40
73_F125_L0.6790.40
277_K319_Q0.6790.40
56_G80_T0.6770.40
110_D170_F0.6750.40
44_D51_I0.6750.40
209_L212_T0.6710.40
170_F336_L0.6690.40
247_V330_A0.6680.39
113_S248_Y0.6670.39
202_R206_Q0.6650.39
72_A76_I0.6640.39
84_L179_N0.6630.39
93_L198_W0.6610.39
186_T250_W0.6600.39
155_T292_A0.6580.39
94_P248_Y0.6570.39
191_F205_N0.6570.39
129_G149_A0.6560.38
296_G301_S0.6560.38
149_A196_A0.6540.38
44_D53_T0.6540.38
141_G149_A0.6530.38
71_A203_E0.6530.38
143_A147_R0.6520.38
116_D331_Y0.6510.38
113_S124_S0.6480.38
123_W220_D0.6480.38
139_D150_R0.6470.38
196_A200_T0.6470.38
203_E206_Q0.6460.38
64_A71_A0.6460.38
35_Y40_G0.6460.38
92_R273_T0.6460.38
79_W343_W0.6450.38
180_P216_G0.6450.38
217_F252_G0.6440.37
209_L251_V0.6420.37
57_Q76_I0.6420.37
274_F301_S0.6340.37
178_F321_V0.6340.37
245_I303_A0.6320.36
94_P98_W0.6280.36
185_P201_L0.6280.36
52_T96_W0.6240.36
66_A123_W0.6230.36
58_S120_W0.6210.36
117_G339_F0.6210.36
134_E189_Q0.6200.35
36_I72_A0.6140.35
238_L285_V0.6120.35
33_K210_L0.6110.35
138_T141_G0.6110.35
17_F20_Q0.6110.35
14_L19_V0.6100.35
59_Y98_W0.6090.35
164_L167_K0.6080.34
294_G304_M0.6060.34
252_G303_A0.6060.34
99_G342_G0.6050.34
193_R200_T0.6030.34
219_P234_A0.6030.34
200_T273_T0.6030.34
42_V76_I0.6020.34
55_E246_R0.6020.34
135_Q143_A0.6000.34
64_A182_Y0.5990.34
53_T187_L0.5980.34
184_P221_W0.5950.33
150_R195_G0.5930.33
165_P249_M0.5930.33
77_L81_Q0.5920.33
191_F209_L0.5900.33
130_R342_G0.5900.33
94_P300_F0.5890.33
37_S118_D0.5890.33
149_A219_P0.5890.33
128_A137_Y0.5880.33
169_G179_N0.5870.33
286_D291_K0.5860.33
261_K274_F0.5840.33
112_N169_G0.5830.32
93_L166_G0.5810.32
79_W83_N0.5810.32
96_W179_N0.5810.32
108_V290_G0.5790.32
246_R331_Y0.5780.32
214_P278_N0.5770.32
146_K150_R0.5770.32
26_P70_R0.5770.32
242_Y348_F0.5760.32
301_S320_R0.5740.32
115_S192_T0.5740.32
65_L131_L0.5730.32
69_D179_N0.5730.32
145_L195_G0.5730.32
249_M340_G0.5720.32
65_L133_K0.5710.31
53_T253_M0.5710.31
28_W63_S0.5680.31
54_S163_L0.5680.31
162_M224_Y0.5680.31
94_P216_G0.5660.31
240_S245_I0.5650.31
189_Q203_E0.5620.31
80_T244_A0.5620.31
77_L94_P0.5610.31
169_G221_W0.5590.31
65_L124_S0.5580.30
120_W187_L0.5570.30
157_P213_A0.5570.30
181_S332_Y0.5560.30
325_F341_Q0.5550.30
83_N107_E0.5550.30
237_T307_F0.5550.30
77_L98_W0.5540.30
44_D117_G0.5530.30
67_A338_L0.5530.30
53_T186_T0.5510.30
64_A79_W0.5510.30
124_S144_L0.5480.30
41_R179_N0.5480.30
26_P29_E0.5470.30
28_W165_P0.5460.30
90_K115_S0.5460.30
60_G136_R0.5440.29
64_A72_A0.5430.29
184_P187_L0.5410.29
97_L334_Y0.5390.29
119_V220_D0.5390.29
79_W186_T0.5390.29
240_S287_V0.5370.29
66_A342_G0.5360.29
247_V296_G0.5350.29
322_A338_L0.5350.29
16_A20_Q0.5330.29
167_K284_K0.5310.28
61_M327_G0.5300.28
22_A286_D0.5300.28
183_L309_Q0.5290.28
127_E130_R0.5290.28
82_N167_K0.5290.28
145_L149_A0.5280.28
150_R242_Y0.5270.28
44_D336_L0.5270.28
79_W253_M0.5240.28
32_K36_I0.5230.28
82_N286_D0.5230.28
96_W118_D0.5230.28
69_D110_D0.5220.28
68_N131_L0.5220.28
52_T250_W0.5220.28
16_A322_A0.5220.28
210_L262_A0.5190.28
265_L292_A0.5180.28
30_Q327_G0.5180.28
175_S223_R0.5180.28
243_D284_K0.5170.27
99_G106_W0.5170.27
217_F271_M0.5170.27
75_N178_F0.5170.27
29_E32_K0.5160.27
254_M289_T0.5160.27
277_K328_S0.5150.27
142_S194_F0.5140.27
113_S166_G0.5140.27
79_W182_Y0.5140.27
72_A129_G0.5120.27
36_I276_E0.5110.27
113_S258_D0.5100.27
139_D142_S0.5090.27
126_L138_T0.5080.27
15_A19_V0.5080.27
100_K104_S0.5080.27
81_Q341_Q0.5060.27
283_E294_G0.5060.27
57_Q64_A0.5050.27
208_L230_W0.5050.27
232_L287_V0.5050.27
312_D332_Y0.5030.26
22_A207_R0.5030.26
270_P275_T0.5030.26
194_F266_N0.5030.26
331_Y336_L0.5010.26
303_A306_P0.5000.26
210_L270_P0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qxfA 1 0.9158 100 0.195 Contact Map
5cd2A 1 0.9158 100 0.206 Contact Map
4q2bA 4 0.9212 100 0.208 Contact Map
1v5dA 1 0.9266 100 0.28 Contact Map
1wzzA 1 0.8451 100 0.284 Contact Map
1kwfA 1 0.913 100 0.285 Contact Map
1wu4A 1 0.9103 100 0.289 Contact Map
1h12A 1 0.9103 100 0.324 Contact Map
3renA 1 0.8098 100 0.424 Contact Map
2gz6A 2 0.8505 93.2 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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