GREMLIN Database
BCSC - Cellulose synthase operon protein C
UniProt: P37650 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12257
Length: 1157 (1126)
Sequences: 123 (83)
Seq/√Len: 2.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
914_H968_D4.6640.76
153_W166_A4.3480.71
60_N172_R4.3330.71
245_F1121_A3.9820.64
340_D680_A3.7450.58
307_G342_W3.6560.56
58_D61_N3.6520.56
1013_D1067_Y3.5870.55
542_H1018_S3.4430.52
893_D943_R3.4090.51
200_G497_I3.3850.50
1106_V1133_V3.3550.50
57_I1018_S3.2590.47
107_L919_S3.1760.46
306_L325_N3.1210.44
963_A985_T3.0640.43
30_Q497_I2.9190.40
997_R1041_E2.8930.39
1111_F1132_Y2.8360.38
844_W847_N2.8200.38
471_L1121_A2.8160.38
952_S1124_Y2.8120.37
962_W1057_S2.7970.37
319_R990_K2.7040.35
1052_A1128_H2.6930.35
1117_D1128_H2.6340.34
565_Q684_L2.6190.33
77_D80_G2.5680.32
962_W1126_P2.5650.32
1057_S1126_P2.5650.32
40_A44_E2.4990.31
960_G988_Y2.4860.31
1055_S1110_W2.4850.31
100_S184_Q2.4590.30
40_A326_L2.4370.30
911_V963_A2.4090.29
962_W1025_Y2.4080.29
1025_Y1057_S2.4080.29
847_N851_C2.4010.29
1106_V1111_F2.3910.29
254_A832_N2.3850.29
41_T926_G2.3790.29
1106_V1144_M2.3630.28
475_G480_A2.3550.28
320_A346_L2.3270.28
276_G288_A2.2780.27
805_K882_I2.2620.27
323_V346_L2.2440.26
116_L120_R2.2330.26
367_P1018_S2.2330.26
159_I475_G2.2150.26
138_L742_G2.1860.25
762_E995_N2.1840.25
988_Y1124_Y2.1810.25
899_S910_T2.1790.25
1025_Y1126_P2.1630.25
428_I529_P2.1520.25
30_Q894_V2.1490.25
31_L34_Q2.1480.25
221_W827_D2.1380.24
436_K443_S2.1340.24
1001_I1037_V2.1230.24
626_Y642_G2.1180.24
954_D960_G2.1160.24
351_Y825_R2.1040.24
872_G946_G2.0870.24
536_G1098_A2.0840.24
795_S893_D2.0710.23
936_G1152_I2.0610.23
954_D988_Y2.0490.23
945_D999_V2.0420.23
608_T613_A2.0410.23
469_E1035_I2.0270.23
517_L770_G2.0240.23
1103_E1126_P2.0220.23
396_M824_F2.0090.22
1003_L1035_I2.0030.22
221_W270_F2.0010.22
290_P512_S1.9980.22
960_G1124_Y1.9900.22
225_I246_S1.9890.22
962_W1103_E1.9780.22
1057_S1103_E1.9780.22
784_L815_A1.9690.22
367_P542_H1.9680.22
793_W943_R1.9600.22
127_H968_D1.9590.22
157_A276_G1.9510.21
58_D898_I1.9420.21
423_R769_R1.9420.21
656_A1134_R1.9370.21
428_I550_A1.9340.21
904_I999_V1.9240.21
157_A303_S1.9200.21
401_Y431_Q1.9190.21
367_P985_T1.9100.21
276_G882_I1.9090.21
289_I1121_A1.9090.21
432_Q437_A1.9060.21
792_Y920_S1.8970.21
87_R951_L1.8900.21
634_P685_G1.8900.21
515_D538_Y1.8840.20
793_W870_A1.8770.20
633_E683_Q1.8740.20
348_V379_N1.8690.20
253_A1018_S1.8410.20
298_A308_A1.8410.20
842_G845_D1.8320.20
197_R279_A1.8280.20
498_T518_M1.8270.20
873_W1042_R1.8210.20
125_T416_S1.8160.19
815_A822_M1.8080.19
83_K101_S1.8030.19
30_Q1098_A1.7970.19
584_R589_E1.7920.19
221_W895_V1.7910.19
296_V1157_W1.7880.19
832_N1011_D1.7870.19
161_A1098_A1.7840.19
1051_G1121_A1.7830.19
288_A1010_Y1.7830.19
405_E425_L1.7770.19
305_A847_N1.7740.19
325_N328_K1.7740.19
962_W1042_R1.7680.19
1042_R1057_S1.7680.19
562_S565_Q1.7610.19
588_K591_E1.7610.19
712_M715_R1.7570.19
844_W863_S1.7400.18
1095_G1117_D1.7350.18
428_I785_N1.7320.18
441_I518_M1.7310.18
626_Y639_A1.7260.18
259_A1146_L1.7120.18
270_F1098_A1.6980.18
1040_R1097_T1.6920.18
268_P539_L1.6890.18
712_M719_K1.6870.18
374_F534_A1.6850.18
153_W781_Q1.6800.18
842_G846_D1.6800.18
580_A642_G1.6780.18
866_G886_P1.6760.18
236_S1018_S1.6750.17
92_A629_V1.6680.17
796_S1088_G1.6680.17
45_D93_P1.6620.17
53_R423_R1.6620.17
263_K281_D1.6540.17
288_A329_A1.6520.17
994_Q997_R1.6450.17
309_L532_V1.6440.17
947_V1038_M1.6430.17
385_S1000_T1.6420.17
1034_A1062_K1.6370.17
592_A921_S1.6360.17
487_R497_I1.6340.17
931_S991_V1.6220.17
166_A638_D1.6210.17
225_I1121_A1.6210.17
827_D1125_A1.6200.17
342_W391_L1.6160.17
271_R475_G1.6040.17
792_Y990_K1.5970.16
1110_W1128_H1.5950.16
329_A514_A1.5920.16
408_Y412_L1.5910.16
648_I680_A1.5910.16
174_N184_Q1.5900.16
352_W980_R1.5860.16
952_S988_Y1.5830.16
221_W920_S1.5820.16
328_K475_G1.5790.16
159_I365_N1.5770.16
94_S1003_L1.5740.16
166_A1016_G1.5710.16
629_V648_I1.5710.16
776_A1136_S1.5710.16
801_Y914_H1.5590.16
914_H928_Q1.5590.16
559_Q674_Q1.5580.16
184_Q1106_V1.5570.16
1042_R1126_P1.5560.16
87_R731_L1.5510.16
222_Y983_W1.5490.16
300_P497_I1.5480.16
536_G1157_W1.5400.16
954_D1124_Y1.5390.16
167_I171_K1.5380.16
49_Q780_R1.5380.16
766_W1103_E1.5360.16
78_I414_M1.5340.16
300_P315_Q1.5340.16
328_K536_G1.5340.16
171_K303_S1.5320.16
273_R471_L1.5320.16
1025_Y1103_E1.5300.16
920_S990_K1.5290.16
795_S943_R1.5270.16
936_G1129_F1.5250.16
972_G978_N1.5230.16
972_G986_G1.5230.16
972_G1002_G1.5230.16
972_G1022_G1.5230.16
972_G1024_Y1.5230.16
972_G1026_S1.5230.16
972_G1027_P1.5230.16
972_G1036_P1.5230.16
978_N986_G1.5230.16
978_N1002_G1.5230.16
978_N1022_G1.5230.16
978_N1024_Y1.5230.16
978_N1026_S1.5230.16
978_N1027_P1.5230.16
978_N1036_P1.5230.16
986_G1002_G1.5230.16
986_G1022_G1.5230.16
986_G1024_Y1.5230.16
986_G1026_S1.5230.16
986_G1027_P1.5230.16
986_G1036_P1.5230.16
1002_G1022_G1.5230.16
1002_G1024_Y1.5230.16
1002_G1026_S1.5230.16
1002_G1027_P1.5230.16
1002_G1036_P1.5230.16
1022_G1026_S1.5230.16
1022_G1027_P1.5230.16
1022_G1036_P1.5230.16
1024_Y1027_P1.5230.16
1024_Y1036_P1.5230.16
1026_S1036_P1.5230.16
1027_P1036_P1.5230.16
1042_R1103_E1.5220.16
288_A514_A1.5210.16
834_G896_G1.5120.15
797_G834_G1.5110.15
867_A950_S1.5080.15
801_Y968_D1.5080.15
188_A827_D1.5070.15
758_T821_R1.5060.15
428_I697_L1.5040.15
150_V926_G1.5010.15
766_W962_W1.5010.15
766_W1057_S1.5010.15
1040_R1121_A1.4990.15
307_G391_L1.4900.15
954_D1014_L1.4900.15
277_L990_K1.4890.15
1120_Q1127_S1.4840.15
497_I894_V1.4760.15
920_S1000_T1.4730.15
327_E350_R1.4720.15
758_T776_A1.4720.15
240_K893_D1.4690.15
715_R718_A1.4680.15
471_L495_V1.4660.15
535_Y559_Q1.4630.15
35_V1091_S1.4630.15
864_D963_A1.4610.15
1106_V1112_V1.4600.15
957_E1157_W1.4550.15
510_Q535_Y1.4540.15
77_D112_G1.4510.15
766_W820_G1.4510.15
663_L899_S1.4470.15
563_N566_E1.4470.15
1001_I1052_A1.4470.15
1075_T1079_E1.4460.15
562_S1107_T1.4430.15
332_L623_R1.4430.15
1018_S1107_T1.4420.15
639_A642_G1.4420.15
603_T632_R1.4390.15
975_V1030_Y1.4320.15
53_R769_R1.4310.15
124_T913_A1.4300.14
333_D535_Y1.4280.14
639_A685_G1.4270.14
94_S945_D1.4260.14
820_G1126_P1.4220.14
268_P766_W1.4210.14
501_L567_L1.4210.14
734_Y738_M1.4200.14
1055_S1123_D1.4200.14
398_R1107_T1.4160.14
109_T112_G1.4110.14
296_V305_A1.4110.14
127_H130_E1.4110.14
587_G639_A1.4100.14
956_G960_G1.4090.14
960_G1103_E1.4050.14
34_Q51_L1.4040.14
610_A642_G1.4020.14
44_E148_I1.4000.14
195_D422_V1.3950.14
363_K876_D1.3940.14
1051_G1097_T1.3920.14
433_S1013_D1.3910.14
105_M627_Q1.3890.14
173_I502_S1.3870.14
257_Q260_E1.3870.14
384_D422_V1.3870.14
150_V1048_W1.3860.14
593_E729_Q1.3840.14
711_A1156_D1.3830.14
766_W1126_P1.3830.14
221_W884_T1.3780.14
697_L1013_D1.3770.14
498_T521_L1.3740.14
505_L821_R1.3690.14
952_S960_G1.3650.14
267_D288_A1.3640.14
988_Y1103_E1.3620.14
318_D844_W1.3610.14
335_H949_L1.3590.14
238_L245_F1.3580.14
956_G988_Y1.3580.14
775_A783_D1.3570.14
884_T920_S1.3560.14
246_S416_S1.3550.14
954_D1113_G1.3550.14
831_M919_S1.3540.14
162_R184_Q1.3520.14
1004_N1031_L1.3520.14
40_A518_M1.3480.14
1025_Y1110_W1.3480.14
820_G1103_E1.3460.14
613_A618_D1.3440.14
26_T136_N1.3430.14
492_P939_W1.3420.14
43_R964_S1.3390.13
122_Q392_G1.3340.13
94_S106_L1.3330.13
300_P487_R1.3320.13
1025_Y1042_R1.3320.13
63_D109_T1.3310.13
1090_S1100_A1.3250.13
885_T895_V1.3240.13
909_Y947_V1.3230.13
782_Q1015_S1.3220.13
225_I245_F1.3210.13
964_S1122_K1.3210.13
609_L641_L1.3210.13
1025_Y1055_S1.3170.13
920_S1055_S1.3160.13
211_N909_Y1.3150.13
758_T783_D1.3130.13
183_L241_Y1.3110.13
505_L953_Y1.3100.13
580_A626_Y1.3060.13
281_D1060_R1.3040.13
1020_G1068_P1.3040.13
170_L1112_V1.3040.13
377_A678_A1.3010.13
313_Y893_D1.2970.13
174_N964_S1.2960.13
357_Q1033_F1.2960.13
622_A639_A1.2960.13
487_R494_S1.2930.13
956_G1030_Y1.2930.13
167_I682_A1.2870.13
408_Y884_T1.2830.13
1097_T1121_A1.2810.13
218_S241_Y1.2780.13
220_I290_P1.2770.13
268_P1103_E1.2770.13
313_Y884_T1.2750.13
864_D904_I1.2730.13
207_M770_G1.2720.13
303_S493_G1.2720.13
580_A592_A1.2700.13
491_D536_G1.2690.13
623_R646_V1.2680.13
727_P734_Y1.2670.13
895_V920_S1.2660.13
40_A211_N1.2620.13
134_S1063_T1.2590.13
878_W977_D1.2590.13
1005_N1033_F1.2570.13
184_Q679_L1.2550.13
171_K963_A1.2540.13
846_D851_C1.2540.13
962_W988_Y1.2540.13
988_Y1057_S1.2540.13
38_G1008_W1.2480.13
184_Q1065_P1.2470.13
571_L992_I1.2460.13
424_G786_V1.2440.13
548_A923_L1.2410.12
268_P962_W1.2390.12
268_P1057_S1.2390.12
946_G988_Y1.2380.12
1122_K1125_A1.2370.12
88_L125_T1.2330.12
825_R923_L1.2310.12
956_G1103_E1.2300.12
999_V1007_I1.2280.12
352_W764_D1.2270.12
988_Y1042_R1.2270.12
408_Y943_R1.2270.12
594_A626_Y1.2220.12
184_Q976_E1.2210.12
302_D1156_D1.2190.12
529_P565_Q1.2190.12
993_N1118_I1.2190.12
46_L533_Y1.2180.12
268_P820_G1.2150.12
452_I456_E1.2150.12
87_R462_D1.2090.12
964_S1011_D1.2080.12
960_G1126_P1.2070.12
47_V989_Y1.2060.12
276_G854_Q1.2030.12
374_F769_R1.2000.12
45_D663_L1.1940.12
564_I894_V1.1930.12
99_K708_M1.1920.12
661_A1098_A1.1890.12
844_W894_V1.1890.12
954_D1147_P1.1890.12
767_L1047_S1.1880.12
993_N1121_A1.1870.12
322_A915_R1.1860.12
268_P878_W1.1860.12
842_G847_N1.1860.12
148_I904_I1.1850.12
388_V541_G1.1850.12
374_F774_D1.1840.12
211_N914_H1.1840.12
1133_V1144_M1.1810.12
476_K996_N1.1790.12
112_G808_T1.1780.12
280_V399_K1.1760.12
962_W1124_Y1.1740.12
1057_S1124_Y1.1740.12
595_M617_R1.1730.12
144_P921_S1.1720.12
423_R515_D1.1720.12
315_Q1039_W1.1660.12
1042_R1105_R1.1640.12
917_P989_Y1.1610.12
268_P1126_P1.1590.12
35_V64_V1.1590.12
248_G304_E1.1580.12
290_P305_A1.1580.12
167_I190_L1.1580.12
306_L332_L1.1540.12
202_A840_A1.1510.12
560_W1013_D1.1510.12
189_L1011_D1.1500.12
137_K232_D1.1480.12
484_Q487_R1.1470.12
31_L921_S1.1470.12
820_G962_W1.1450.12
820_G1057_S1.1450.12
607_L634_P1.1440.12
522_A532_V1.1430.12
1001_I1018_S1.1410.12
58_D231_S1.1390.11
35_V130_E1.1380.11
277_L1128_H1.1370.11
88_L315_Q1.1370.11
272_A424_G1.1370.11
984_M1153_P1.1370.11
163_R167_I1.1370.11
123_A280_V1.1330.11
844_W869_V1.1320.11
766_W1025_Y1.1300.11
953_Y1015_S1.1300.11
31_L51_L1.1290.11
358_G1139_G1.1290.11
300_P496_W1.1270.11
283_G678_A1.1250.11
61_N384_D1.1240.11
146_G833_V1.1240.11
60_N215_E1.1230.11
903_D1152_I1.1230.11
962_W984_M1.1230.11
984_M1057_S1.1230.11
81_A139_F1.1220.11
812_Q923_L1.1220.11
150_V1072_L1.1210.11
113_R221_W1.1200.11
644_T1146_L1.1200.11
248_G958_A1.1170.11
343_N554_S1.1140.11
738_M809_T1.1140.11
608_T618_D1.1120.11
868_S943_R1.1120.11
889_F925_F1.1120.11
221_W1148_P1.1100.11
825_R1055_S1.1100.11
314_S793_W1.1100.11
218_S683_Q1.1080.11
821_R1139_G1.1080.11
909_Y1157_W1.1070.11
208_A1090_S1.1060.11
65_V784_L1.1050.11
764_D872_G1.1040.11
379_N428_I1.1030.11
365_N882_I1.1020.11
982_R1008_W1.1020.11
150_V813_V1.0990.11
170_L1052_A1.0980.11
767_L1032_S1.0980.11
924_A938_K1.0970.11
80_G303_S1.0960.11
424_G529_P1.0960.11
188_A310_G1.0920.11
464_L779_Y1.0920.11
480_A1096_Y1.0910.11
43_R316_K1.0900.11
452_I455_I1.0890.11
588_K662_K1.0870.11
960_G1057_S1.0870.11
171_K190_L1.0870.11
973_K1088_G1.0870.11
592_A656_A1.0840.11
791_D1095_G1.0840.11
640_I1016_G1.0810.11
580_A596_L1.0800.11
316_K1031_L1.0790.11
975_V988_Y1.0760.11
960_G1132_Y1.0750.11
351_Y1117_D1.0750.11
963_A1035_I1.0750.11
352_W872_G1.0740.11
194_S449_R1.0720.11
38_G46_L1.0710.11
984_M1134_R1.0680.11
221_W412_L1.0670.11
90_Q259_A1.0660.11
391_L1017_Y1.0650.11
87_R428_I1.0640.11
318_D1111_F1.0630.11
30_Q957_E1.0610.11
988_Y1126_P1.0590.11
523_Q683_Q1.0590.11
946_G960_G1.0580.11
471_L476_K1.0580.11
135_Y157_A1.0560.11
884_T1117_D1.0560.11
771_V890_N1.0550.11
36_R72_L1.0500.11
540_S1096_Y1.0490.11
310_G1054_G1.0490.11
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78_I561_N0.5080.07
875_N930_D0.5080.07
61_N93_P0.5080.07
124_T523_Q0.5080.07
230_V477_W0.5080.07
532_V1102_L0.5070.07
122_Q926_G0.5060.07
145_E591_E0.5050.07
356_Q1157_W0.5050.07
393_D953_Y0.5050.07
220_I280_V0.5050.07
962_W1014_L0.5050.07
1014_L1057_S0.5050.07
792_Y1128_H0.5040.07
43_R207_M0.5030.07
160_P413_R0.5030.07
539_L962_W0.5030.07
539_L1057_S0.5030.07
926_G991_V0.5030.07
539_L988_Y0.5030.07
495_V826_S0.5030.07
98_Y943_R0.5020.07
224_Q770_G0.5010.07
97_A1109_N0.5010.07
190_L871_V0.5010.07
269_A930_D0.5000.07
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4kvmA 3 0.5411 100 0.906 Contact Map
4bujB 1 0.6646 100 0.909 Contact Map
4rg9A 2 0.3959 100 0.912 Contact Map
4ui9J 2 0.4226 100 0.913 Contact Map
4hnyA 1 0.5609 100 0.914 Contact Map
4ui9X 2 0.4183 100 0.914 Contact Map
1w3bA 2 0.3345 100 0.915 Contact Map
2xpiA 2 0.4391 100 0.919 Contact Map
4ui9C 2 0.4373 100 0.92 Contact Map
4uzyA 1 0.5004 100 0.925 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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