GREMLIN Database
YHJJ - Protein YhjJ
UniProt: P37648 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12254
Length: 498 (400)
Sequences: 13802 (10601)
Seq/√Len: 530.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
202_A206_K4.2281.00
368_E372_N3.9531.00
360_K364_K3.9261.00
357_E360_K3.7711.00
153_P157_N3.2781.00
429_T432_M3.2701.00
346_K349_S3.2281.00
227_D230_S3.1061.00
90_G148_K3.0511.00
368_E430_V3.0051.00
312_A316_S2.9141.00
93_D96_Q2.9131.00
359_A363_D2.8811.00
379_K426_N2.8651.00
136_K234_Q2.8461.00
308_H370_E2.8291.00
432_M435_Q2.6861.00
46_V226_V2.6021.00
203_E207_D2.5681.00
288_E439_Q2.5681.00
177_W278_M2.4121.00
207_D211_K2.3871.00
74_Q204_K2.3071.00
430_V434_N2.2891.00
232_V236_N2.2471.00
36_G232_V2.2401.00
39_S236_N2.2131.00
353_L356_R2.2061.00
222_V231_V2.2031.00
298_A325_F2.1851.00
37_T43_Q2.1331.00
312_A317_N2.1221.00
367_P370_E2.0981.00
201_E204_K2.0631.00
35_Q43_Q2.0631.00
160_L163_Q2.0551.00
435_Q439_Q2.0541.00
63_V218_M2.0341.00
300_L366_L2.0231.00
362_R438_R2.0211.00
144_N148_K2.0151.00
115_I122_L1.9981.00
352_N356_R1.9931.00
312_A357_E1.9871.00
372_N375_V1.9801.00
91_G140_S1.9751.00
420_L423_D1.9711.00
176_G179_R1.9451.00
61_L220_L1.9331.00
34_Q228_A1.9321.00
127_L138_A1.9101.00
372_N376_A1.8901.00
434_N438_R1.8881.00
317_N353_L1.8361.00
349_S352_N1.8171.00
359_A362_R1.8121.00
99_S137_E1.8051.00
230_S233_D1.8021.00
297_R437_L1.8001.00
152_T155_T1.7951.00
365_G434_N1.7941.00
338_I354_V1.7711.00
431_E435_Q1.7661.00
348_N352_N1.7341.00
92_L99_S1.7211.00
46_V228_A1.6991.00
147_G241_E1.6931.00
43_Q219_T1.6911.00
78_S208_F1.6881.00
92_L144_N1.6831.00
91_G144_N1.6611.00
103_Q137_E1.6411.00
371_F430_V1.6241.00
136_K237_K1.6201.00
121_T213_Y1.6181.00
34_Q229_R1.6161.00
291_A436_D1.6051.00
431_E434_N1.5991.00
423_D426_N1.5901.00
206_K210_Q1.5811.00
90_G150_T1.5711.00
234_Q237_K1.5601.00
125_L138_A1.5601.00
317_N349_S1.5581.00
50_P225_N1.5531.00
288_E435_Q1.5441.00
36_G44_W1.5421.00
42_L220_L1.5351.00
73_Q204_K1.5331.00
233_D237_K1.5311.00
45_Q219_T1.5251.00
204_K207_D1.5111.00
47_L397_L1.5091.00
236_N240_G1.4891.00
48_T227_D1.4831.00
230_S234_Q1.4821.00
91_G148_K1.4801.00
163_Q167_A1.4791.00
356_R360_K1.4761.00
71_S74_Q1.4751.00
234_Q238_T1.4581.00
100_L105_I1.4441.00
207_D210_Q1.4411.00
137_E140_S1.4231.00
156_I202_A1.4011.00
99_S102_Q1.4011.00
423_D427_S1.3891.00
35_Q405_L1.3741.00
139_L234_Q1.3631.00
48_T228_A1.3591.00
77_Y200_V1.3491.00
326_D337_A1.3391.00
81_I151_I1.3341.00
161_Q198_Q1.3331.00
228_A232_V1.3311.00
42_L218_M1.3241.00
355_A359_A1.3201.00
320_D323_L1.3161.00
89_S144_N1.3141.00
298_A336_C1.3131.00
153_P202_A1.3121.00
68_L332_L1.3121.00
163_Q166_V1.3101.00
64_N217_A1.3101.00
266_M269_A1.3101.00
296_W428_L1.3091.00
220_L235_I1.3031.00
277_I355_A1.2881.00
291_A432_M1.2821.00
80_A156_I1.2741.00
136_K230_S1.2681.00
420_L424_F1.2671.00
312_A353_L1.2631.00
140_S238_T1.2491.00
143_A239_F1.2361.00
226_V231_V1.2341.00
35_Q45_Q1.2331.00
233_D236_N1.2291.00
203_E206_K1.2201.00
36_G46_V1.2191.00
361_V366_L1.2131.00
340_I350_N1.2111.00
416_Q420_L1.1971.00
61_L218_M1.1961.00
136_K238_T1.1921.00
57_V129_N1.1921.00
59_I222_V1.1891.00
287_R432_M1.1821.00
279_W355_A1.1741.00
340_I354_V1.1731.00
62_L402_M1.1681.00
67_S192_P1.1471.00
129_N225_N1.1401.00
273_D347_L1.1401.00
281_T327_C1.1391.00
219_T405_L1.1371.00
79_H83_R1.1371.00
161_Q165_M1.1351.00
34_Q232_V1.1311.00
258_L262_A1.1291.00
435_Q438_R1.1261.00
442_S445_M1.1231.00
43_Q405_L1.1231.00
185_S188_L1.1161.00
139_L235_I1.1141.00
258_L261_E1.1141.00
46_V231_V1.1051.00
216_D247_E1.1041.00
36_G236_N1.1021.00
62_L122_L1.1011.00
161_Q164_D1.0971.00
351_L355_A1.0791.00
143_A147_G1.0761.00
96_Q99_S1.0751.00
375_V425_L1.0751.00
255_L258_L1.0741.00
320_D340_I1.0691.00
92_L140_S1.0681.00
311_Q315_A1.0611.00
216_D244_G1.0601.00
424_F427_S1.0591.00
308_H357_E1.0541.00
299_D374_L1.0501.00
72_T190_H1.0471.00
84_I205_I1.0421.00
313_L353_L1.0411.00
65_T208_F1.0391.00
45_Q405_L1.0371.00
287_R424_F1.0281.00
229_R232_V1.0251.00
58_E126_S1.0241.00
311_Q316_S1.0231.00
183_K188_L1.0201.00
79_H82_P1.0201.00
313_L320_D1.0191.00
223_V398_M1.0181.00
422_Q426_N1.0091.00
288_E291_A1.0011.00
421_R425_L0.9991.00
103_Q131_R0.9981.00
74_Q211_K0.9971.00
380_L384_K0.9941.00
181_R335_Q0.9921.00
342_S350_N0.9911.00
379_K422_Q0.9891.00
290_A424_F0.9871.00
63_V146_T0.9791.00
42_L215_P0.9781.00
47_L223_V0.9771.00
184_G188_L0.9751.00
305_L310_Q0.9711.00
375_V426_N0.9711.00
291_A428_L0.9711.00
298_A302_R0.9691.00
214_T217_A0.9611.00
369_E373_A0.9601.00
57_V224_G0.9581.00
143_A238_T0.9581.00
156_I205_I0.9551.00
297_R436_D0.9551.00
256_S259_R0.9521.00
159_A162_S0.9461.00
136_K140_S0.9441.00
300_L374_L0.9431.00
149_L209_Y0.9411.00
215_P242_L0.9371.00
99_S103_Q0.9351.00
97_A145_A0.9311.00
283_W286_I0.9301.00
353_L357_E0.9281.00
371_F375_V0.9231.00
325_F336_C0.9211.00
61_L146_T0.9191.00
252_V255_L0.9191.00
159_A163_Q0.9151.00
160_L164_D0.9151.00
115_I120_T0.9141.00
53_P225_N0.9141.00
98_R102_Q0.9121.00
437_L441_L0.9111.00
85_A149_L0.9091.00
314_S321_I0.9081.00
259_R262_A0.9041.00
292_L436_D0.9041.00
362_R365_G0.9031.00
277_I351_L0.9021.00
135_L234_Q0.8971.00
214_T245_K0.8941.00
264_S267_T0.8901.00
324_G339_N0.8891.00
174_K178_W0.8891.00
38_L44_W0.8831.00
357_E361_V0.8831.00
60_R122_L0.8781.00
366_L371_F0.8761.00
400_Q404_S0.8751.00
216_D245_K0.8741.00
36_G228_A0.8741.00
296_W371_F0.8681.00
278_M337_A0.8641.00
155_T158_H0.8621.00
375_V379_K0.8601.00
274_R341_E0.8601.00
135_L231_V0.8591.00
164_D167_A0.8581.00
49_T394_T0.8571.00
44_W232_V0.8561.00
349_S353_L0.8551.00
222_V226_V0.8541.00
161_Q196_L0.8541.00
131_R137_E0.8531.00
343_P346_K0.8501.00
123_F213_Y0.8481.00
82_P116_V0.8471.00
275_L340_I0.8461.00
256_S260_A0.8461.00
302_R325_F0.8451.00
363_D438_R0.8431.00
210_Q245_K0.8411.00
162_S166_V0.8391.00
118_Y178_W0.8361.00
419_K422_Q0.8341.00
379_K383_Q0.8331.00
85_A123_F0.8271.00
77_Y81_I0.8261.00
65_T69_A0.8251.00
401_R404_S0.8221.00
266_M270_V0.8211.00
43_Q64_N0.8201.00
52_R56_R0.8161.00
81_I205_I0.8161.00
83_R113_P0.8091.00
160_L198_Q0.8061.00
191_D195_P0.8061.00
409_V414_P0.8001.00
59_I125_L0.7981.00
229_R233_D0.7971.00
319_K346_K0.7961.00
64_N331_Y0.7961.00
89_S149_L0.7951.00
263_V351_L0.7941.00
235_I238_T0.7941.00
253_P256_S0.7931.00
218_M242_L0.7871.00
364_K434_N0.7871.00
169_W172_D0.7871.00
356_R359_A0.7791.00
92_L141_Y0.7781.00
143_A241_E0.7741.00
99_S141_Y0.7731.00
160_L167_A0.7721.00
374_L378_K0.7701.00
147_G242_L0.7671.00
119_D187_L0.7661.00
414_P420_L0.7661.00
176_G180_Y0.7631.00
238_T241_E0.7601.00
251_P254_T0.7591.00
366_L434_N0.7591.00
125_L142_L0.7591.00
369_E372_N0.7591.00
299_D378_K0.7571.00
139_L238_T0.7541.00
287_R290_A0.7521.00
362_R434_N0.7511.00
173_T177_W0.7501.00
175_E179_R0.7481.00
79_H116_V0.7471.00
208_F212_W0.7441.00
105_I138_A0.7411.00
300_L308_H0.7381.00
414_P417_Y0.7381.00
297_R433_L0.7351.00
173_T276_S0.7341.00
451_Q454_G0.7311.00
267_T271_R0.7301.00
65_T212_W0.7291.00
268_D271_R0.7291.00
383_Q422_Q0.7291.00
80_A205_I0.7221.00
34_Q48_T0.7211.00
366_L430_V0.7191.00
297_R361_V0.7171.00
84_I87_T0.7151.00
202_A205_I0.7071.00
92_L97_A0.7071.00
327_C330_L0.7061.00
83_R116_V0.7061.00
436_D440_Q0.7051.00
84_I156_I0.7021.00
58_E394_T0.7011.00
148_K241_E0.6991.00
289_S293_L0.6981.00
310_Q314_S0.6961.00
82_P121_T0.6961.00
76_G194_D0.6911.00
362_R442_S0.6911.00
67_S70_E0.6901.00
447_L451_Q0.6901.00
57_V135_L0.6901.00
164_D193_A0.6891.00
287_R291_A0.6871.00
347_L351_L0.6841.00
404_S409_V0.6841.00
360_K363_D0.6811.00
288_E440_Q0.6801.00
82_P114_V0.6801.00
184_G187_L0.6801.00
74_Q77_Y0.6771.00
231_V235_I0.6741.00
77_Y204_K0.6741.00
151_I209_Y0.6721.00
377_Q381_E0.6721.00
151_I156_I0.6711.00
98_R101_W0.6711.00
309_V323_L0.6711.00
365_G430_V0.6711.00
81_I208_F0.6681.00
312_A360_K0.6681.00
75_S190_H0.6671.00
60_R124_N0.6671.00
348_N351_L0.6661.00
33_W45_Q0.6631.00
257_P261_E0.6611.00
91_G150_T0.6611.00
89_S150_T0.6611.00
178_W182_L0.6601.00
382_L421_R0.6601.00
128_P131_R0.6601.00
61_L239_F0.6591.00
142_L145_A0.6591.00
307_W310_Q0.6581.00
397_L401_R0.6581.00
83_R86_L0.6571.00
71_S211_K0.6531.00
60_R398_M0.6531.00
154_E158_H0.6521.00
313_L323_L0.6511.00
388_A396_I0.6511.00
299_D377_Q0.6501.00
78_S81_I0.6501.00
282_P440_Q0.6491.00
67_S118_Y0.6481.00
180_Y183_K0.6431.00
222_V235_I0.6421.00
216_D246_R0.6411.00
282_P286_I0.6411.00
82_P86_L0.6401.00
319_K349_S0.6401.00
212_W217_A0.6401.00
265_I268_D0.6391.00
367_P430_V0.6391.00
64_N219_T0.6391.00
394_T397_L0.6381.00
292_L440_Q0.6381.00
221_L398_M0.6371.00
280_D333_R0.6351.00
50_P227_D0.6341.00
57_V226_V0.6341.00
118_Y192_P0.6321.00
251_P255_L0.6301.00
254_T257_P0.6291.00
74_Q200_V0.6281.00
256_S262_A0.6271.00
57_V222_V0.6261.00
61_L142_L0.6251.00
62_L221_L0.6231.00
79_H159_A0.6231.00
44_W235_I0.6201.00
80_A84_I0.6201.00
323_L338_I0.6201.00
212_W215_P0.6191.00
219_T406_Q0.6191.00
318_S321_I0.6191.00
263_V266_M0.6181.00
105_I127_L0.6181.00
114_V123_F0.6141.00
40_N215_P0.6141.00
180_Y264_S0.6131.00
203_E210_Q0.6131.00
40_N240_G0.6111.00
70_E76_G0.6101.00
361_V437_L0.6101.00
267_T270_V0.6091.00
85_A145_A0.6071.00
49_T223_V0.6061.00
370_E373_A0.6051.00
183_K187_L0.6051.00
255_L259_R0.6051.00
398_M402_M0.6041.00
296_W374_L0.6031.00
362_R441_L0.6031.00
419_K423_D0.6021.00
354_V357_E0.6021.00
272_Q341_E0.6011.00
42_L239_F0.6001.00
274_R339_N0.6001.00
436_D439_Q0.6001.00
289_S292_L0.5991.00
38_L236_N0.5991.00
156_I200_V0.5971.00
65_T121_T0.5971.00
47_L401_R0.5941.00
301_A358_L0.5931.00
300_L370_E0.5931.00
276_S337_A0.5931.00
45_Q221_L0.5931.00
263_V267_T0.5931.00
151_I202_A0.5920.99
365_G431_E0.5910.99
139_L231_V0.5910.99
46_V235_I0.5900.99
97_A141_Y0.5890.99
277_I354_V0.5860.99
177_W276_S0.5860.99
221_L401_R0.5850.99
310_Q315_A0.5840.99
137_E141_Y0.5840.99
273_D452_P0.5840.99
438_R442_S0.5830.99
437_L440_Q0.5820.99
36_G235_I0.5810.99
95_A98_R0.5810.99
89_S148_K0.5790.99
57_V127_L0.5770.99
417_Y420_L0.5770.99
162_S165_M0.5760.99
80_A160_L0.5750.99
70_E74_Q0.5740.99
140_S237_K0.5740.99
161_Q166_V0.5740.99
92_L96_Q0.5720.99
59_I138_A0.5720.99
83_R114_V0.5700.99
275_L351_L0.5700.99
317_N320_D0.5690.99
89_S92_L0.5690.99
308_H312_A0.5680.99
116_V121_T0.5670.99
280_D445_M0.5660.99
223_V394_T0.5660.99
62_L406_Q0.5650.99
205_I209_Y0.5650.99
171_A274_R0.5650.99
314_S320_D0.5650.99
355_A446_A0.5640.99
424_F428_L0.5600.99
94_A155_T0.5600.99
160_L166_V0.5590.99
221_L402_M0.5590.99
401_R405_L0.5590.99
255_L261_E0.5580.99
279_W358_L0.5570.99
227_D231_V0.5560.99
87_T155_T0.5550.99
415_E419_K0.5550.99
97_A100_L0.5540.99
290_A428_L0.5540.99
273_D276_S0.5540.99
434_N437_L0.5530.99
159_A164_D0.5530.99
115_I124_N0.5520.99
33_W401_R0.5500.99
404_S408_Q0.5490.99
206_K209_Y0.5490.99
360_K365_G0.5480.99
287_R427_S0.5470.99
277_I448_I0.5460.99
266_M271_R0.5450.99
45_Q401_R0.5450.99
115_I399_G0.5450.99
313_L354_V0.5450.99
402_M406_Q0.5430.99
141_Y144_N0.5420.99
299_D303_E0.5420.99
173_T176_G0.5400.99
290_A293_L0.5400.99
298_A303_E0.5390.99
293_L421_R0.5390.99
368_E375_V0.5380.99
403_R407_N0.5380.99
74_Q78_S0.5360.99
81_I85_A0.5350.99
181_R278_M0.5340.99
215_P243_K0.5340.99
114_V145_A0.5330.99
88_Q152_T0.5330.99
285_P288_E0.5320.99
220_L239_F0.5300.99
123_F142_L0.5280.99
35_Q415_E0.5270.99
418_Q421_R0.5260.99
178_W335_Q0.5260.99
146_T209_Y0.5260.99
46_V222_V0.5250.99
167_A175_E0.5250.99
165_M196_L0.5240.99
322_G341_E0.5240.99
63_V121_T0.5230.99
395_D399_G0.5230.99
46_V227_D0.5230.99
191_D194_D0.5220.99
82_P213_Y0.5210.99
319_K353_L0.5190.99
428_L432_M0.5190.99
297_R441_L0.5180.99
81_I209_Y0.5180.99
117_S120_T0.5180.99
42_L63_V0.5170.99
231_V234_Q0.5160.99
309_V354_V0.5150.99
430_V433_L0.5150.99
432_M436_D0.5130.99
182_L335_Q0.5120.99
396_I400_Q0.5120.99
297_R301_A0.5120.99
273_D344_N0.5110.99
209_Y213_Y0.5110.99
323_L354_V0.5110.99
151_I206_K0.5110.99
313_L319_K0.5100.99
244_G248_T0.5100.99
305_L308_H0.5090.98
178_W183_K0.5090.98
310_Q313_L0.5090.98
103_Q141_Y0.5070.98
79_H113_P0.5070.98
286_I289_S0.5060.98
90_G144_N0.5050.98
208_F213_Y0.5040.98
309_V357_E0.5040.98
114_V121_T0.5040.98
161_Q167_A0.5030.98
377_Q380_L0.5030.98
325_F338_I0.5010.98
53_P56_R0.5010.98
176_G264_S0.5000.98
438_R443_N0.5000.98
366_L433_L0.5000.98
164_D196_L0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3amiA 2 0.8153 100 0.305 Contact Map
3eoqA 2 0.7972 100 0.305 Contact Map
1hr6B 1 0.8434 100 0.311 Contact Map
4nnzA 2 0.7671 100 0.319 Contact Map
1pp9A 1 0.8494 100 0.322 Contact Map
3hdiA 2 0.8153 100 0.325 Contact Map
3go9A 1 0.8976 100 0.336 Contact Map
1q2lA 1 0.9177 100 0.343 Contact Map
3amjB 1 0.8052 100 0.349 Contact Map
1hr6A 1 0.8434 100 0.35 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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