GREMLIN Database
KDGK - 2-dehydro-3-deoxygluconokinase
UniProt: P37647 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12253
Length: 309 (270)
Sequences: 22320 (16550)
Seq/√Len: 1007.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_L272_A3.0931.00
132_Y164_I2.7251.00
64_L79_R2.6521.00
236_V284_A2.4961.00
49_H73_D2.4571.00
229_R235_L2.4531.00
6_A128_F2.4411.00
273_V278_G2.3381.00
279_S282_D2.2831.00
234_C266_F2.2121.00
154_R190_C2.1141.00
61_Q79_R2.0791.00
53_A80_M2.0101.00
37_I46_L2.0071.00
218_H237_S2.0031.00
198_L229_R1.9691.00
39_R70_E1.9531.00
273_V286_R1.9001.00
164_I271_L1.8971.00
244_V281_E1.8951.00
156_C161_G1.8931.00
7_V34_S1.8821.00
130_Y162_K1.8631.00
153_L163_V1.8461.00
265_S290_T1.8231.00
195_F267_S1.8151.00
35_V70_E1.7981.00
122_C155_E1.7891.00
211_E243_L1.7871.00
53_A116_E1.7721.00
68_H74_T1.7541.00
236_V244_V1.7481.00
278_G282_D1.7271.00
162_K192_D1.7241.00
192_D223_K1.6981.00
36_Y268_A1.6851.00
150_L186_Q1.6841.00
234_C288_H1.6841.00
214_I237_S1.6491.00
262_A295_I1.6471.00
130_Y164_I1.6311.00
64_L68_H1.6291.00
66_A69_G1.6251.00
235_L245_D1.6241.00
249_V289_L1.6111.00
229_R245_D1.6001.00
65_D69_G1.5991.00
291_A295_I1.5921.00
193_I224_E1.5861.00
150_L154_R1.5771.00
270_Y283_A1.5621.00
216_R220_A1.5551.00
269_G290_T1.5511.00
281_E285_K1.5481.00
226_V270_Y1.5111.00
5_I37_I1.5061.00
37_I272_A1.4951.00
166_D228_K1.4901.00
11_C52_T1.4851.00
155_E159_N1.4811.00
151_S154_R1.4741.00
130_Y271_L1.4621.00
202_D208_Q1.4601.00
236_V280_A1.4601.00
126_A159_N1.4561.00
24_R62_Q1.4551.00
224_E238_I1.4541.00
61_Q65_D1.4491.00
216_R219_N1.4381.00
151_S155_E1.4351.00
56_T61_Q1.4241.00
246_V284_A1.4221.00
229_R232_D1.4121.00
269_G286_R1.4021.00
209_P212_D1.3861.00
83_R111_F1.3781.00
26_F63_M1.3661.00
238_I241_E1.3541.00
162_K193_I1.3421.00
157_R192_D1.3411.00
249_V285_K1.3391.00
258_D299_G1.3381.00
167_N196_L1.3331.00
15_L22_V1.3241.00
56_T79_R1.3181.00
155_E158_A1.3181.00
64_L77_T1.3001.00
31_L67_W1.2971.00
272_A276_T1.2911.00
157_R190_C1.2791.00
207_Q216_R1.2781.00
60_S85_P1.2781.00
191_T194_A1.2761.00
211_E215_A1.2731.00
47_T73_D1.2661.00
215_A219_N1.2601.00
218_H239_A1.2601.00
251_L296_Q1.2491.00
246_V288_H1.2491.00
13_I62_Q1.2121.00
26_F66_A1.2121.00
80_M83_R1.2051.00
114_E151_S1.1941.00
224_E274_R1.1891.00
66_A70_E1.1871.00
113_L116_E1.1791.00
162_K223_K1.1731.00
234_C284_A1.1721.00
270_Y274_R1.1691.00
185_Q220_A1.1671.00
293_T297_Y1.1651.00
215_A243_L1.1641.00
237_S243_L1.1641.00
224_E280_A1.1581.00
224_E270_Y1.1551.00
269_G287_G1.1551.00
228_K266_F1.1531.00
282_D285_K1.1441.00
195_F228_K1.1421.00
215_A237_S1.1331.00
273_V283_A1.1301.00
38_A72_V1.1211.00
62_Q65_D1.1211.00
270_Y287_G1.1141.00
249_V292_S1.1101.00
229_R233_S1.1081.00
256_V295_I1.1041.00
201_E227_V1.1021.00
40_Q269_G1.1011.00
207_Q212_D1.1011.00
61_Q64_L1.0981.00
293_T296_Q1.0961.00
133_L163_V1.0891.00
249_V288_H1.0851.00
33_T132_Y1.0811.00
46_L276_T1.0811.00
46_L275_L1.0801.00
131_L156_C1.0791.00
15_L24_R1.0681.00
251_L295_I1.0651.00
37_I48_V1.0641.00
65_D68_H1.0621.00
193_I270_Y1.0491.00
256_V259_T1.0371.00
58_S61_Q1.0361.00
224_E236_V1.0351.00
34_S48_V1.0351.00
193_I274_R1.0231.00
273_V276_T1.0201.00
132_Y271_L1.0141.00
36_Y265_S1.0121.00
212_D215_A1.0101.00
80_M111_F1.0101.00
205_W213_V1.0091.00
198_L232_D0.9981.00
35_V39_R0.9931.00
11_C63_M0.9911.00
154_R158_A0.9901.00
38_A71_N0.9841.00
49_H124_E0.9841.00
122_C159_N0.9811.00
248_A288_H0.9781.00
201_E213_V0.9741.00
11_C50_Y0.9721.00
56_T82_N0.9711.00
223_K239_A0.9701.00
131_L161_G0.9591.00
49_H128_F0.9581.00
270_Y280_A0.9571.00
214_I227_V0.9561.00
241_E244_V0.9561.00
37_I268_A0.9551.00
288_H291_A0.9531.00
55_G85_P0.9531.00
265_S294_V0.9511.00
54_L64_L0.9481.00
283_A287_G0.9471.00
285_K289_L0.9441.00
165_F191_T0.9401.00
195_F270_Y0.9371.00
123_E126_A0.9311.00
8_I131_L0.9301.00
132_Y267_S0.9261.00
251_L256_V0.9171.00
147_E151_S0.9161.00
278_G286_R0.9151.00
181_Q185_Q0.9141.00
26_F62_Q0.9141.00
272_A286_R0.9131.00
74_T77_T0.9111.00
128_F161_G0.9091.00
62_Q66_A0.9081.00
54_L60_S0.9071.00
40_Q290_T0.9061.00
64_L74_T0.9031.00
15_L87_L0.9031.00
54_L77_T0.9021.00
49_H76_L0.9001.00
6_A51_V0.8951.00
17_E89_Y0.8931.00
5_I275_L0.8871.00
57_D85_P0.8861.00
38_A47_T0.8821.00
19_G101_Y0.8781.00
16_S25_G0.8741.00
166_D195_F0.8721.00
15_L59_F0.8661.00
198_L202_D0.8641.00
241_E281_E0.8621.00
256_V296_Q0.8581.00
114_E147_E0.8571.00
197_T200_D0.8541.00
232_D245_D0.8411.00
99_T102_Y0.8381.00
125_L128_F0.8371.00
11_C31_L0.8361.00
78_Q116_E0.8351.00
235_L243_L0.8311.00
133_L153_L0.8301.00
53_A78_Q0.8301.00
196_L201_E0.8231.00
63_M85_P0.8221.00
7_V30_T0.8211.00
255_K296_Q0.8201.00
246_V285_K0.8201.00
244_V284_A0.8181.00
246_V281_E0.8171.00
279_S283_A0.8171.00
214_I225_V0.8141.00
169_Y180_T0.8121.00
233_S248_A0.8121.00
133_L149_L0.8121.00
274_R283_A0.8121.00
31_L301_I0.8091.00
54_L79_R0.8061.00
251_L292_S0.8051.00
188_L191_T0.8051.00
33_T267_S0.8011.00
150_L190_C0.7971.00
12_M86_G0.7971.00
8_I152_L0.7941.00
215_A218_H0.7941.00
265_S269_G0.7941.00
289_L293_T0.7911.00
144_T147_E0.7901.00
122_C158_A0.7891.00
154_R186_Q0.7861.00
148_K152_L0.7841.00
214_I218_H0.7841.00
266_F288_H0.7811.00
101_Y105_N0.7741.00
166_D196_L0.7701.00
125_L161_G0.7691.00
91_E99_T0.7661.00
164_I195_F0.7661.00
64_L78_Q0.7641.00
13_I24_R0.7531.00
269_G273_V0.7531.00
109_A112_W0.7521.00
265_S291_A0.7511.00
90_I100_F0.7471.00
6_A49_H0.7451.00
257_I298_R0.7431.00
186_Q189_E0.7411.00
183_V186_Q0.7401.00
38_A48_V0.7381.00
238_I280_A0.7341.00
189_E221_G0.7301.00
34_S50_Y0.7261.00
49_H75_S0.7261.00
291_A294_V0.7191.00
212_D216_R0.7191.00
211_E245_D0.7131.00
153_L190_C0.7101.00
250_K255_K0.7071.00
288_H292_S0.7041.00
13_I59_F0.7001.00
24_R59_F0.6991.00
91_E101_Y0.6951.00
110_K113_L0.6941.00
130_Y275_L0.6861.00
135_G165_F0.6851.00
5_I130_Y0.6851.00
83_R108_A0.6831.00
233_S245_D0.6831.00
147_E150_L0.6821.00
40_Q272_A0.6801.00
231_A250_K0.6801.00
99_T103_W0.6801.00
57_D60_S0.6791.00
66_A301_I0.6771.00
40_Q286_R0.6731.00
98_R102_Y0.6721.00
131_L152_L0.6701.00
238_I244_V0.6691.00
146_R183_V0.6681.00
189_E220_A0.6681.00
99_T105_N0.6671.00
122_C126_A0.6631.00
266_F284_A0.6631.00
182_Q185_Q0.6621.00
59_F87_L0.6601.00
226_V236_V0.6581.00
201_E217_T0.6581.00
35_V301_I0.6571.00
185_Q189_E0.6561.00
266_F287_G0.6511.00
90_I260_T0.6431.00
101_Y104_R0.6381.00
29_D168_N0.6381.00
109_A113_L0.6361.00
156_C163_V0.6351.00
124_E128_F0.6351.00
52_T77_T0.6331.00
6_A124_E0.6331.00
114_E148_K0.6331.00
278_G283_A0.6291.00
211_E235_L0.6251.00
210_V229_R0.6241.00
211_E214_I0.6161.00
34_S72_V0.6151.00
218_H238_I0.6141.00
58_S62_Q0.6051.00
47_T129_D0.6051.00
266_F291_A0.6051.00
213_V217_T0.6031.00
164_I267_S0.6031.00
76_L124_E0.6031.00
108_A116_E0.6031.00
112_W116_E0.6031.00
14_E27_G0.6011.00
164_I193_I0.5981.00
23_K298_R0.5961.00
102_Y105_N0.5931.00
226_V266_F0.5871.00
210_V214_I0.5861.00
211_E237_S0.5861.00
93_D97_E0.5851.00
37_I271_L0.5801.00
284_A288_H0.5791.00
214_I243_L0.5791.00
210_V213_V0.5721.00
152_L155_E0.5681.00
98_R101_Y0.5681.00
218_H240_G0.5671.00
218_H221_G0.5671.00
195_F226_V0.5671.00
75_S78_Q0.5671.00
268_A272_A0.5661.00
75_S124_E0.5651.00
27_G32_N0.5651.00
163_V191_T0.5641.00
146_R150_L0.5641.00
207_Q213_V0.5611.00
7_V48_V0.5581.00
234_C246_V0.5551.00
61_Q68_H0.5541.00
40_Q268_A0.5541.00
282_D286_R0.5541.00
182_Q186_Q0.5541.00
31_L50_Y0.5511.00
274_R277_G0.5501.00
205_W216_R0.5501.00
100_F104_R0.5471.00
15_L89_Y0.5451.00
47_T275_L0.5401.00
88_Y102_Y0.5401.00
129_D161_G0.5391.00
67_W72_V0.5361.00
150_L153_L0.5361.00
7_V37_I0.5351.00
33_T37_I0.5341.00
166_D264_D0.5341.00
130_Y193_I0.5301.00
218_H222_V0.5301.00
201_E210_V0.5271.00
10_E168_N0.5271.00
194_A225_V0.5251.00
260_T300_A0.5251.00
17_E22_V0.5241.00
38_A70_E0.5231.00
221_G225_V0.5231.00
30_T34_S0.5221.00
117_Q121_I0.5211.00
246_V249_V0.5201.00
51_V121_I0.5201.00
129_D162_K0.5161.00
33_T268_A0.5161.00
191_T222_V0.5121.00
231_A256_V0.5111.00
164_I274_R0.5111.00
45_A48_V0.5101.00
153_L187_M0.5101.00
5_I46_L0.5091.00
199_D203_A0.5081.00
130_Y274_R0.5081.00
33_T271_L0.5081.00
90_I98_R0.5071.00
165_F184_Y0.5061.00
156_C159_N0.5051.00
201_E237_S0.5051.00
26_F301_I0.5021.00
7_V50_Y0.5021.00
198_L230_G0.5021.00
135_G139_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ljsA 2 0.9482 100 0.179 Contact Map
3lhxA 2 0.9547 100 0.194 Contact Map
1tyyA 2 0.9223 100 0.195 Contact Map
3iq0A 2 0.945 100 0.202 Contact Map
4du5A 2 0.9094 100 0.203 Contact Map
3hj6A 2 0.8738 100 0.203 Contact Map
3pl2A 2 0.9547 100 0.206 Contact Map
4k8kA 2 0.9385 100 0.21 Contact Map
2qcvA 3 0.945 100 0.211 Contact Map
2rbcA 2 0.9061 100 0.216 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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