GREMLIN Database
YHJH - Cyclic di-GMP phosphodiesterase YhjH
UniProt: P37646 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12252
Length: 255 (237)
Sequences: 24491 (19140)
Seq/√Len: 1243.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_T234_A3.8071.00
47_V248_L3.5551.00
131_R177_Y2.8471.00
121_L152_F2.8471.00
182_R186_V2.6501.00
150_C176_D2.5561.00
225_D229_S2.5531.00
31_A54_T2.5421.00
92_A129_W2.4021.00
240_S243_A2.3071.00
156_W177_Y2.2661.00
13_E67_R2.2641.00
223_W239_L2.2301.00
206_N232_F2.1601.00
220_P224_R2.1231.00
82_K126_R2.1061.00
20_Q55_H2.1041.00
199_S207_R2.0711.00
37_I233_A2.0501.00
195_R225_D1.9591.00
131_R156_W1.9511.00
89_A93_D1.9231.00
34_W87_L1.9061.00
54_T62_R1.8961.00
55_H61_Q1.8721.00
219_T222_E1.8431.00
199_S229_S1.8361.00
79_E83_E1.8361.00
223_W234_A1.8181.00
171_S194_G1.8001.00
23_R27_Q1.7781.00
37_I177_Y1.7661.00
87_L245_I1.7641.00
177_Y213_I1.7281.00
182_R216_G1.7081.00
223_W227_Q1.7011.00
31_A62_R1.6821.00
101_L131_R1.6761.00
33_T244_P1.6611.00
244_P247_T1.6601.00
57_L61_Q1.6241.00
217_V234_A1.6201.00
83_E87_L1.6001.00
55_H60_S1.5991.00
154_P176_D1.5991.00
223_W238_F1.5721.00
178_I205_M1.5701.00
101_L154_P1.5681.00
14_A74_V1.5671.00
45_M233_A1.5591.00
199_S203_H1.5581.00
189_R195_R1.5221.00
37_I131_R1.5141.00
38_Y239_L1.5041.00
33_T62_R1.4801.00
211_G233_A1.4741.00
202_L231_A1.4571.00
220_P238_F1.4511.00
87_L90_Q1.4391.00
146_F155_L1.4251.00
30_R51_T1.4201.00
57_L60_S1.4161.00
83_E86_D1.4081.00
203_H207_R1.3971.00
177_Y211_G1.3791.00
87_L91_K1.3781.00
202_L229_S1.3761.00
211_G232_F1.3681.00
234_A239_L1.3661.00
106_I116_Q1.3631.00
189_R221_E1.3601.00
123_Q127_L1.3591.00
214_V231_A1.3451.00
85_I123_Q1.3301.00
88_L92_A1.3161.00
28_C83_E1.3151.00
237_W242_P1.3061.00
94_F249_N1.2931.00
51_T80_V1.2761.00
80_V84_Q1.2751.00
119_K123_Q1.2681.00
189_R222_E1.2531.00
82_K123_Q1.2281.00
205_M212_V1.2241.00
39_Q45_M1.2221.00
196_T207_R1.2041.00
29_E55_H1.2041.00
189_R219_T1.2031.00
188_L225_D1.2021.00
131_R154_P1.2001.00
82_K127_L1.1961.00
121_L125_E1.1921.00
37_I46_A1.1901.00
99_G129_W1.1901.00
32_Y80_V1.1891.00
171_S187_M1.1861.00
103_S131_R1.1801.00
22_R77_R1.1711.00
189_R225_D1.1681.00
106_I132_F1.1671.00
46_A101_L1.1581.00
122_R126_R1.1411.00
117_Q148_S1.1241.00
90_Q94_F1.1231.00
191_S194_G1.1231.00
202_L212_V1.1181.00
220_P223_W1.1121.00
224_R227_Q1.1101.00
42_G227_Q1.1021.00
91_K245_I1.1011.00
37_I103_S1.0981.00
157_L175_Y1.0961.00
39_Q43_R1.0961.00
13_E60_S1.0891.00
225_D228_N1.0851.00
34_W47_V1.0751.00
188_L198_F1.0691.00
200_Q207_R1.0681.00
48_E105_N1.0661.00
117_Q121_L1.0641.00
47_V100_L1.0641.00
40_T223_W1.0471.00
243_A247_T1.0431.00
34_W49_L1.0411.00
117_Q145_T1.0381.00
112_I141_P1.0371.00
89_A92_A1.0371.00
21_E72_I1.0341.00
145_T148_S1.0341.00
18_S75_S1.0321.00
20_Q60_S1.0311.00
177_Y233_A1.0301.00
29_E53_V1.0291.00
60_S67_R1.0271.00
88_L102_A1.0201.00
49_L102_A1.0111.00
18_S22_R0.9981.00
37_I101_L0.9931.00
121_L148_S0.9891.00
86_D127_L0.9871.00
245_I249_N0.9841.00
23_R29_E0.9831.00
196_T199_S0.9791.00
97_E100_L0.9771.00
148_S151_E0.9701.00
175_Y210_R0.9681.00
16_I20_Q0.9631.00
91_K249_N0.9601.00
147_A151_E0.9531.00
120_I132_F0.9381.00
120_I149_M0.9351.00
36_P240_S0.9231.00
56_P61_Q0.9191.00
32_Y49_L0.9191.00
187_M194_G0.9191.00
31_A244_P0.9151.00
82_K86_D0.9091.00
86_D90_Q0.9091.00
32_Y79_E0.9071.00
123_Q126_R0.9001.00
214_V226_V0.9001.00
84_Q102_A0.8991.00
17_E71_E0.8971.00
224_R228_N0.8961.00
34_W245_I0.8961.00
79_E84_Q0.8851.00
140_L169_A0.8841.00
213_I233_A0.8781.00
143_D173_V0.8611.00
29_E56_P0.8581.00
217_V223_W0.8501.00
24_F29_E0.8481.00
101_L129_W0.8461.00
147_A174_R0.8321.00
202_L206_N0.8321.00
203_H206_N0.8271.00
42_G223_W0.8271.00
89_A127_L0.8241.00
39_Q232_F0.8161.00
186_V222_E0.8151.00
23_R26_L0.8151.00
20_Q57_L0.8041.00
69_F78_M0.8001.00
237_W241_R0.7971.00
115_R119_K0.7951.00
119_K122_R0.7931.00
87_L249_N0.7921.00
133_E179_K0.7851.00
38_Y44_L0.7811.00
66_D182_R0.7781.00
217_V226_V0.7781.00
154_P211_G0.7761.00
159_D215_E0.7701.00
118_P122_R0.7681.00
32_Y51_T0.7661.00
37_I213_I0.7651.00
73_T78_M0.7611.00
72_I78_M0.7601.00
60_S63_L0.7541.00
194_G222_E0.7521.00
55_H63_L0.7471.00
90_Q245_I0.7461.00
192_P195_R0.7431.00
118_P148_S0.7431.00
36_P243_A0.7421.00
160_F201_L0.7421.00
36_P44_L0.7411.00
66_D70_T0.7371.00
64_P67_R0.7331.00
148_S152_F0.7321.00
195_R199_S0.7211.00
185_F188_L0.7181.00
116_Q120_I0.7171.00
226_V234_A0.7151.00
226_V231_A0.7111.00
145_T149_M0.7101.00
24_F30_R0.7091.00
187_M191_S0.7081.00
171_S197_L0.7071.00
51_T79_E0.7061.00
118_P121_L0.7061.00
187_M190_Q0.7051.00
80_V85_I0.7051.00
154_P177_Y0.7021.00
124_I127_L0.7021.00
85_I130_L0.7001.00
9_I13_E0.6901.00
192_P196_T0.6861.00
15_S19_L0.6831.00
21_E30_R0.6821.00
180_I231_A0.6801.00
185_F214_V0.6771.00
33_T242_P0.6741.00
100_L129_W0.6681.00
46_A103_S0.6671.00
90_Q93_D0.6661.00
196_T200_Q0.6661.00
51_T68_Y0.6651.00
188_L226_V0.6631.00
243_A248_L0.6581.00
108_G137_H0.6571.00
65_P68_Y0.6571.00
92_A99_G0.6571.00
30_R53_V0.6571.00
21_E24_F0.6541.00
200_Q203_H0.6501.00
206_N212_V0.6461.00
11_N15_S0.6461.00
30_R79_E0.6441.00
81_V85_I0.6441.00
143_D172_E0.6371.00
21_E77_R0.6361.00
54_T60_S0.6361.00
16_I60_S0.6351.00
54_T61_Q0.6331.00
111_L145_T0.6321.00
73_T137_H0.6311.00
20_Q23_R0.6301.00
32_Y84_Q0.6281.00
18_S71_E0.6281.00
44_L240_S0.6271.00
200_Q204_L0.6261.00
135_V159_D0.6251.00
78_M109_P0.6251.00
218_E237_W0.6241.00
76_H109_P0.6221.00
113_A119_K0.6221.00
10_S14_A0.6211.00
103_S177_Y0.6171.00
40_T227_Q0.6131.00
172_E193_E0.6121.00
218_E222_E0.6111.00
12_P16_I0.6101.00
212_V232_F0.6101.00
195_R229_S0.6101.00
125_E152_F0.6091.00
75_S78_M0.6081.00
109_P138_I0.6061.00
34_W91_K0.6061.00
204_L208_Y0.6041.00
9_I12_P0.6021.00
105_N158_D0.6021.00
168_S172_E0.6001.00
22_R26_L0.5991.00
108_G138_I0.5971.00
84_Q87_L0.5921.00
48_E179_K0.5911.00
107_D110_T0.5911.00
205_M210_R0.5901.00
28_C82_K0.5881.00
120_I123_Q0.5881.00
50_L105_N0.5881.00
171_S193_E0.5811.00
162_T183_E0.5801.00
41_C234_A0.5801.00
105_N179_K0.5791.00
81_V123_Q0.5791.00
21_E53_V0.5771.00
88_L99_G0.5761.00
90_Q249_N0.5761.00
45_M101_L0.5741.00
48_E158_D0.5731.00
28_C86_D0.5691.00
109_P112_I0.5661.00
24_F53_V0.5651.00
33_T54_T0.5651.00
28_C79_E0.5621.00
168_S183_E0.5611.00
38_Y240_S0.5581.00
108_G140_L0.5571.00
116_Q119_K0.5541.00
185_F226_V0.5531.00
72_I76_H0.5521.00
16_I19_L0.5511.00
221_E224_R0.5511.00
140_L143_D0.5491.00
33_T52_V0.5461.00
38_Y42_G0.5461.00
42_G220_P0.5461.00
132_F155_L0.5441.00
201_L205_M0.5391.00
162_T184_L0.5381.00
13_E16_I0.5381.00
122_R125_E0.5361.00
227_Q234_A0.5361.00
147_A150_C0.5361.00
117_Q152_F0.5301.00
155_L176_D0.5271.00
85_I127_L0.5271.00
180_I198_F0.5261.00
73_T138_I0.5251.00
19_L23_R0.5251.00
108_G169_A0.5251.00
202_L226_V0.5231.00
47_V102_A0.5221.00
160_F167_F0.5211.00
56_P60_S0.5201.00
111_L138_I0.5181.00
185_F198_F0.5171.00
195_R228_N0.5161.00
84_Q104_V0.5161.00
81_V120_I0.5151.00
104_V130_L0.5131.00
180_I201_L0.5121.00
106_I110_T0.5111.00
136_E161_G0.5111.00
80_V83_E0.5101.00
174_R193_E0.5071.00
178_I210_R0.5051.00
53_V68_Y0.5051.00
17_E20_Q0.5051.00
114_L145_T0.5041.00
73_T107_D0.5031.00
157_L169_A0.5021.00
50_L237_W0.5021.00
199_S225_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hjfA 1 0.9529 100 0.102 Contact Map
4rnhA 2 0.9804 100 0.116 Contact Map
4kieA 1 0.9647 100 0.132 Contact Map
4rniA 2 0.9373 100 0.141 Contact Map
4hu4A 1 0.8941 100 0.142 Contact Map
2r6oA 2 0.9412 100 0.148 Contact Map
4j40A 2 0.9255 100 0.167 Contact Map
3pjxA 1 0.9216 100 0.171 Contact Map
3sy8A 6 0.9843 100 0.175 Contact Map
3hv8A 1 0.8863 100 0.176 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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