GREMLIN Database
YHJC - Uncharacterized HTH-type transcriptional regulator YhjC
UniProt: P37641 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12247
Length: 299 (284)
Sequences: 79702 (57799)
Seq/√Len: 3429.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_D75_N3.5271.00
16_L25_F3.3301.00
156_R291_A2.6561.00
97_D139_F2.4961.00
68_R82_L2.3901.00
232_G239_I2.2751.00
12_K25_F2.2351.00
160_K268_S2.1871.00
171_Y187_H2.1781.00
157_P160_K2.1761.00
162_T243_R2.1561.00
93_K124_E2.1231.00
157_P268_S2.0941.00
21_R24_D2.0691.00
93_K122_E2.0371.00
15_E70_K2.0321.00
46_T61_E2.0301.00
9_L36_Q2.0241.00
180_S183_D2.0201.00
160_K266_P1.9791.00
113_E289_W1.9611.00
68_R75_N1.9541.00
229_L249_A1.9471.00
11_I66_Y1.9371.00
11_I70_K1.9371.00
233_L254_R1.9341.00
95_R124_E1.9251.00
12_K15_E1.8891.00
11_I15_E1.8821.00
190_V237_G1.8811.00
167_A258_V1.8671.00
12_K16_L1.8671.00
164_V243_R1.8631.00
9_L33_V1.8581.00
72_V76_L1.8461.00
14_A58_L1.8411.00
233_L249_A1.8181.00
66_Y70_K1.7951.00
19_F37_I1.7611.00
50_Q57_K1.7121.00
65_Y79_L1.6881.00
188_A219_M1.6841.00
164_V257_E1.6671.00
155_A270_S1.6581.00
64_T82_L1.6581.00
133_D138_G1.5971.00
14_A66_Y1.5901.00
114_F286_F1.5891.00
176_G183_D1.5861.00
15_E25_F1.5721.00
16_L21_R1.5601.00
154_I275_Q1.5581.00
11_I69_A1.5531.00
130_R142_V1.5481.00
10_F66_Y1.5401.00
9_L28_L1.5161.00
6_A36_Q1.5161.00
6_A43_Q1.4891.00
89_S120_G1.4881.00
20_S30_K1.4791.00
132_V136_H1.4771.00
60_P63_M1.4521.00
68_R71_D1.4511.00
156_R273_Y1.4501.00
29_P32_S1.4401.00
6_A39_A1.4391.00
114_F121_I1.4341.00
18_S21_R1.4331.00
47_Q50_Q1.4291.00
12_K26_F1.4061.00
287_M291_A1.4021.00
279_L283_V1.3991.00
11_I73_L1.3921.00
154_I273_Y1.3851.00
144_R272_V1.3821.00
146_G270_S1.3811.00
68_R78_E1.3741.00
72_V79_L1.3691.00
91_S120_G1.3531.00
169_P254_R1.3431.00
104_K226_E1.3401.00
273_Y287_M1.3391.00
135_L152_G1.3381.00
271_L287_M1.3171.00
3_K6_A1.3161.00
4_I76_L1.3141.00
285_L288_Q1.3031.00
95_R126_S1.2991.00
133_D139_F1.2971.00
113_E117_L1.2941.00
141_C283_V1.2891.00
134_I142_V1.2891.00
52_T57_K1.2871.00
187_H238_I1.2771.00
141_C271_L1.2761.00
65_Y80_D1.2721.00
75_N78_E1.2711.00
161_L244_I1.2711.00
228_Y239_I1.2641.00
115_L219_M1.2591.00
167_A238_I1.2561.00
249_A254_R1.2531.00
43_Q80_D1.2471.00
117_L289_W1.2461.00
67_Q71_D1.2211.00
230_T233_L1.2211.00
199_H203_F1.2131.00
243_R247_R1.2091.00
243_R257_E1.2061.00
68_R79_L1.2011.00
247_R251_R1.1951.00
64_T67_Q1.1941.00
115_L188_A1.1921.00
157_P270_S1.1881.00
169_P256_I1.1851.00
209_N214_F1.1831.00
38_Q42_H1.1831.00
63_M67_Q1.1781.00
10_F49_L1.1761.00
112_S116_Y1.1721.00
155_A272_V1.1631.00
172_L187_H1.1501.00
177_Y256_I1.1501.00
28_L32_S1.1411.00
10_F14_A1.1391.00
35_R39_A1.1281.00
112_S234_A1.1261.00
113_E116_Y1.1191.00
10_F48_L1.1171.00
188_A217_G1.1061.00
178_P261_G1.1061.00
35_R38_Q1.1041.00
190_V228_Y1.1001.00
124_E221_T1.0991.00
94_L286_F1.0931.00
288_Q291_A1.0921.00
5_H8_Q1.0911.00
71_D78_E1.0901.00
34_S38_Q1.0901.00
19_F56_V1.0881.00
114_F289_W1.0861.00
13_V22_A1.0851.00
118_H285_L1.0791.00
7_M69_A1.0781.00
166_C257_E1.0681.00
229_L233_L1.0641.00
222_V228_Y1.0631.00
64_T68_R1.0611.00
12_K22_A1.0591.00
72_V75_N1.0591.00
109_P234_A1.0581.00
284_N288_Q1.0531.00
257_E260_P1.0501.00
8_Q77_S1.0461.00
36_Q39_A1.0421.00
135_L150_E1.0411.00
156_R287_M1.0371.00
110_R290_L1.0271.00
168_S235_G1.0171.00
181_P262_Y1.0151.00
230_T234_A1.0151.00
58_L62_G1.0111.00
162_T266_P1.0071.00
80_D84_Q1.0011.00
166_C246_V0.9991.00
179_Q183_D0.9951.00
248_E252_A0.9921.00
77_S80_D0.9871.00
28_L33_V0.9801.00
165_N238_I0.9761.00
114_F118_H0.9711.00
77_S81_G0.9691.00
9_L26_F0.9671.00
14_A49_L0.9651.00
133_D136_H0.9631.00
13_V19_F0.9611.00
10_F58_L0.9581.00
74_S78_E0.9521.00
167_A171_Y0.9511.00
65_Y69_A0.9501.00
171_Y174_R0.9461.00
222_V231_A0.9431.00
191_R218_G0.9421.00
280_S283_V0.9381.00
117_L292_G0.9321.00
289_W292_G0.9261.00
39_A42_H0.9241.00
10_F40_L0.9181.00
110_R289_W0.9181.00
22_A33_V0.9131.00
49_L56_V0.9071.00
46_T83_F0.9071.00
21_R25_F0.9031.00
64_T86_D0.9001.00
14_A62_G0.8951.00
122_E217_G0.8911.00
171_Y188_A0.8901.00
139_F142_V0.8881.00
126_S133_D0.8881.00
67_Q70_K0.8851.00
274_P277_R0.8781.00
171_Y175_F0.8711.00
5_H36_Q0.8711.00
97_D144_R0.8661.00
152_G275_Q0.8661.00
100_P224_S0.8631.00
189_I216_S0.8601.00
20_S24_D0.8601.00
71_D74_S0.8601.00
146_G268_S0.8591.00
97_D130_R0.8561.00
17_E57_K0.8561.00
183_D186_S0.8541.00
153_V272_V0.8521.00
175_F188_A0.8501.00
188_A218_G0.8481.00
166_C239_I0.8481.00
121_I282_R0.8471.00
167_A172_L0.8461.00
26_F33_V0.8431.00
96_I141_C0.8381.00
173_T187_H0.8381.00
246_V249_A0.8331.00
52_T55_R0.8291.00
97_D142_V0.8261.00
172_L177_Y0.8241.00
61_E86_D0.8221.00
92_G282_R0.8181.00
288_Q292_G0.8181.00
249_A252_A0.8171.00
154_I157_P0.8171.00
279_L284_N0.8131.00
4_I73_L0.8111.00
14_A17_E0.8111.00
17_E63_M0.8061.00
30_K34_S0.8021.00
10_F65_Y0.8011.00
112_S236_L0.8001.00
131_P135_L0.7991.00
38_Q47_Q0.7981.00
61_E83_F0.7961.00
168_S236_L0.7941.00
15_E66_Y0.7941.00
180_S261_G0.7901.00
75_N79_L0.7871.00
182_D185_T0.7871.00
126_S139_F0.7831.00
76_L79_L0.7831.00
76_L80_D0.7821.00
13_V37_I0.7791.00
61_E64_T0.7781.00
162_T264_A0.7751.00
13_V49_L0.7741.00
16_L22_A0.7711.00
162_T259_L0.7681.00
117_L285_L0.7671.00
185_T214_F0.7641.00
17_E55_R0.7631.00
281_R285_L0.7631.00
78_E82_L0.7611.00
6_A9_L0.7601.00
141_C286_F0.7601.00
115_L236_L0.7601.00
231_A236_L0.7541.00
170_H174_R0.7501.00
182_D212_Q0.7491.00
90_I118_H0.7491.00
166_C241_I0.7481.00
8_Q12_K0.7461.00
79_L83_F0.7421.00
135_L153_V0.7411.00
129_D132_V0.7411.00
98_I103_A0.7401.00
84_Q87_A0.7371.00
13_V33_V0.7351.00
19_F33_V0.7271.00
199_H221_T0.7261.00
168_S171_Y0.7231.00
114_F285_L0.7231.00
69_A72_V0.7221.00
57_K63_M0.7201.00
50_Q59_T0.7191.00
58_L63_M0.7171.00
70_K74_S0.7151.00
180_S262_Y0.7141.00
95_R139_F0.7131.00
174_R256_I0.7111.00
61_E65_Y0.7031.00
242_P245_A0.7001.00
167_A173_T0.6971.00
167_A256_I0.6961.00
50_Q55_R0.6961.00
140_D283_V0.6931.00
32_S36_Q0.6931.00
122_E221_T0.6911.00
186_S217_G0.6891.00
41_E46_T0.6861.00
63_M66_Y0.6851.00
137_D274_P0.6841.00
95_R140_D0.6841.00
143_I290_L0.6831.00
113_E292_G0.6831.00
60_P64_T0.6821.00
224_S227_N0.6791.00
92_G121_I0.6781.00
285_L289_W0.6771.00
192_Y228_Y0.6771.00
5_H39_A0.6731.00
74_S77_S0.6701.00
189_I238_I0.6631.00
178_P259_L0.6611.00
98_I107_L0.6611.00
220_L231_A0.6601.00
41_E51_R0.6581.00
78_E81_G0.6571.00
8_Q11_I0.6571.00
37_I41_E0.6571.00
248_E251_R0.6561.00
170_H235_G0.6561.00
19_F55_R0.6561.00
24_D27_A0.6551.00
69_A73_L0.6551.00
65_Y83_F0.6521.00
170_H173_T0.6501.00
172_L175_F0.6491.00
169_P253_G0.6461.00
94_L282_R0.6451.00
170_H256_I0.6391.00
104_K230_T0.6381.00
193_T221_T0.6351.00
68_R72_V0.6341.00
165_N184_L0.6331.00
281_R284_N0.6281.00
22_A26_F0.6271.00
13_V18_S0.6261.00
277_R280_S0.6221.00
107_L110_R0.6191.00
141_C287_M0.6161.00
134_I272_V0.6141.00
129_D133_D0.6121.00
103_A127_S0.6121.00
165_N240_Q0.6091.00
286_F290_L0.6091.00
159_G269_L0.6061.00
64_T83_F0.6051.00
94_L141_C0.6011.00
193_T223_N0.6011.00
81_G85_Q0.5991.00
109_P112_S0.5981.00
5_H9_L0.5981.00
176_G179_Q0.5961.00
44_L65_Y0.5931.00
228_Y232_G0.5931.00
145_T267_L0.5931.00
165_N189_I0.5901.00
231_A237_G0.5881.00
44_L83_F0.5871.00
58_L66_Y0.5861.00
222_V227_N0.5861.00
31_G35_R0.5861.00
49_L58_L0.5821.00
8_Q73_L0.5791.00
273_Y284_N0.5781.00
154_I276_R0.5771.00
32_S35_R0.5771.00
161_L267_L0.5761.00
46_T50_Q0.5741.00
91_S122_E0.5741.00
134_I153_V0.5741.00
29_P35_R0.5741.00
173_T176_G0.5701.00
173_T179_Q0.5701.00
130_R137_D0.5701.00
163_M240_Q0.5671.00
92_G118_H0.5651.00
209_N216_S0.5631.00
109_P113_E0.5631.00
158_L271_L0.5611.00
225_S242_P0.5601.00
73_L77_S0.5601.00
102_I106_L0.5591.00
3_K39_A0.5591.00
171_Y238_I0.5571.00
172_L176_G0.5531.00
194_P221_T0.5511.00
10_F62_G0.5511.00
9_L37_I0.5491.00
146_G155_A0.5491.00
44_L47_Q0.5481.00
241_I246_V0.5451.00
143_I271_L0.5441.00
132_V138_G0.5421.00
67_Q82_L0.5411.00
73_L76_L0.5401.00
19_F30_K0.5371.00
9_L22_A0.5361.00
37_I49_L0.5321.00
167_A174_R0.5311.00
111_L123_L0.5311.00
185_T215_K0.5281.00
233_L252_A0.5281.00
28_L36_Q0.5281.00
85_Q90_I0.5261.00
92_G120_G0.5261.00
249_A253_G0.5261.00
283_V287_M0.5231.00
47_Q61_E0.5221.00
68_R83_F0.5201.00
19_F51_R0.5201.00
81_G84_Q0.5191.00
14_A63_M0.5191.00
175_F178_P0.5181.00
118_H121_I0.5161.00
210_G213_W0.5161.00
99_P102_I0.5141.00
109_P230_T0.5131.00
17_E56_V0.5121.00
178_P183_D0.5121.00
273_Y279_L0.5111.00
116_Y174_R0.5101.00
97_D126_S0.5081.00
199_H202_G0.5081.00
209_N212_Q0.5061.00
104_K224_S0.5041.00
96_I286_F0.5001.00
192_Y225_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fxqA 3 0.9699 100 0.084 Contact Map
2esnA 3 0.9732 100 0.087 Contact Map
1ixcA 4 0.9666 100 0.094 Contact Map
3fzvA 4 0.9532 100 0.097 Contact Map
3szpA 3 0.9699 100 0.097 Contact Map
3hhgA 3 0.9799 100 0.099 Contact Map
1uthA 2 0.7458 100 0.102 Contact Map
4x6gA 4 0.9967 100 0.103 Contact Map
1al3A 1 0.699 100 0.103 Contact Map
2h98A 2 0.6789 100 0.106 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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