GREMLIN Database
YHJB - Putative HTH-type transcriptional regulator YhjB
UniProt: P37640 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12246
Length: 200 (183)
Sequences: 80258 (57268)
Seq/√Len: 4233.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_I33_S3.2891.00
13_I31_G3.2431.00
6_F38_L2.7761.00
39_W67_K2.6011.00
36_D58_G2.5911.00
30_Q47_E2.5101.00
35_A59_E2.5021.00
34_Q58_G2.3991.00
43_E71_Q2.3741.00
59_E67_K2.3351.00
17_K31_G2.2901.00
19_S107_V2.0821.00
2_Q28_S2.0461.00
32_A41_K2.0181.00
171_G174_K1.9991.00
2_Q30_Q1.9851.00
52_L64_L1.9471.00
17_K21_Q1.8971.00
89_L109_T1.8931.00
33_S37_E1.8921.00
55_D83_D1.8771.00
79_I97_V1.7511.00
65_L77_V1.7331.00
4_V32_A1.7271.00
69_V98_L1.7131.00
79_I92_V1.7061.00
34_Q37_E1.7051.00
30_Q41_K1.6841.00
67_K71_Q1.6541.00
145_R148_E1.5991.00
25_P111_A1.5861.00
35_A64_L1.5711.00
99_A113_A1.5461.00
59_E63_W1.5451.00
41_K45_Y1.5371.00
159_N174_K1.5321.00
86_K106_T1.5261.00
66_Q95_F1.5161.00
30_Q45_Y1.5091.00
60_F63_W1.5091.00
176_H179_S1.4841.00
72_F75_V1.4821.00
20_L114_V1.4651.00
41_K44_S1.4231.00
83_D88_W1.4191.00
67_K70_V1.4011.00
65_L79_I1.4011.00
158_S161_E1.3931.00
42_L68_T1.3881.00
151_T155_A1.3841.00
146_Q183_R1.3751.00
157_E165_A1.3581.00
39_W64_L1.3481.00
36_D59_E1.3421.00
152_M165_A1.3391.00
50_V75_V1.3381.00
63_W66_Q1.3331.00
49_L114_V1.3081.00
10_S33_S1.2701.00
7_D13_I1.2681.00
41_K47_E1.2611.00
54_G62_Y1.2421.00
98_L120_G1.2291.00
78_L117_A1.2121.00
98_L117_A1.2101.00
6_F56_Q1.2091.00
52_L65_L1.1961.00
32_A38_L1.1851.00
27_V115_N1.1811.00
37_E41_K1.1811.00
39_W59_E1.1671.00
54_G79_I1.1451.00
40_Q44_S1.1451.00
8_R53_D1.1441.00
4_V38_L1.1441.00
85_N88_W1.1431.00
62_Y92_V1.1321.00
111_A115_N1.1281.00
2_Q45_Y1.1271.00
36_D40_Q1.1221.00
152_M156_G1.1191.00
37_E40_Q1.1131.00
62_Y91_E1.0981.00
91_E95_F1.0871.00
26_G115_N1.0861.00
4_V47_E1.0771.00
86_K90_Q1.0691.00
49_L118_A1.0681.00
147_R151_T1.0671.00
3_I27_V1.0501.00
161_E165_A1.0451.00
175_A178_E1.0351.00
132_P139_L1.0101.00
171_G175_A1.0011.00
94_H115_N1.0011.00
90_Q94_H0.9931.00
66_Q91_E0.9931.00
38_L64_L0.9891.00
52_L77_V0.9871.00
42_L72_F0.9831.00
160_K170_T0.9821.00
109_T112_L0.9801.00
4_V41_K0.9731.00
87_R91_E0.9641.00
152_M157_E0.9641.00
112_L116_S0.9581.00
148_E151_T0.9491.00
157_E161_E0.9491.00
10_S14_H0.9481.00
5_M16_M0.9301.00
17_K29_I0.9251.00
16_M80_T0.9211.00
54_G60_F0.9201.00
50_V68_T0.9191.00
32_A37_E0.9191.00
6_F50_V0.9181.00
39_W43_E0.9141.00
6_F32_A0.8991.00
62_Y95_F0.8961.00
38_L42_L0.8921.00
89_L102_P0.8891.00
51_M110_F0.8871.00
4_V42_L0.8821.00
27_V111_A0.8771.00
134_K139_L0.8751.00
65_L97_V0.8741.00
11_I15_G0.8741.00
172_T176_H0.8691.00
10_S13_I0.8671.00
91_E94_H0.8641.00
174_K177_L0.8611.00
177_L181_Y0.8611.00
50_V77_V0.8571.00
109_T113_A0.8571.00
40_Q43_E0.8541.00
65_L95_F0.8471.00
54_G88_W0.8371.00
63_W67_K0.8331.00
86_K89_L0.8281.00
52_L79_I0.8231.00
76_K98_L0.8181.00
170_T174_K0.8131.00
5_M29_I0.8091.00
160_K164_R0.8091.00
144_A148_E0.8071.00
78_L113_A0.8071.00
56_Q64_L0.8011.00
148_E152_M0.7941.00
18_I22_Q0.7921.00
14_H17_K0.7911.00
88_W91_E0.7811.00
179_S182_R0.7781.00
84_C102_P0.7781.00
107_V111_A0.7771.00
171_G178_E0.7741.00
16_M110_F0.7721.00
146_Q149_I0.7691.00
181_Y186_V0.7681.00
93_I113_A0.7661.00
152_M162_I0.7661.00
143_S183_R0.7611.00
66_Q70_V0.7601.00
121_M125_P0.7541.00
51_M80_T0.7521.00
64_L68_T0.7521.00
54_G83_D0.7481.00
131_T148_E0.7461.00
117_A120_G0.7461.00
12_F105_S0.7441.00
161_E164_R0.7391.00
134_K137_K0.7391.00
168_I173_V0.7391.00
116_S119_M0.7361.00
51_M114_V0.7321.00
22_Q25_P0.7291.00
178_E182_R0.7261.00
35_A39_W0.7241.00
105_S110_F0.7231.00
42_L75_V0.7221.00
6_F64_L0.7191.00
25_P115_N0.7131.00
167_N170_T0.7081.00
153_L177_L0.7071.00
2_Q47_E0.7071.00
175_A179_S0.7051.00
42_L47_E0.7021.00
135_D185_E0.7021.00
90_Q108_E0.7001.00
14_H18_I0.6981.00
55_D82_T0.6961.00
118_A121_M0.6901.00
5_M17_K0.6871.00
106_T109_T0.6871.00
35_A58_G0.6871.00
59_E64_L0.6861.00
46_P72_F0.6831.00
39_W42_L0.6811.00
149_I153_L0.6761.00
159_N163_G0.6761.00
9_Q12_F0.6751.00
68_T77_V0.6681.00
158_S162_I0.6621.00
87_R108_E0.6551.00
78_L99_A0.6551.00
80_T105_S0.6511.00
113_A117_A0.6461.00
43_E72_F0.6461.00
131_T147_R0.6421.00
7_D56_Q0.6401.00
43_E67_K0.6381.00
4_V31_G0.6341.00
108_E112_L0.6301.00
76_K118_A0.6301.00
132_P135_D0.6261.00
69_V76_K0.6251.00
12_F15_G0.6241.00
68_T73_P0.6231.00
116_S121_M0.6211.00
9_Q82_T0.6191.00
35_A56_Q0.6161.00
152_M155_A0.6141.00
81_A89_L0.6111.00
15_G19_S0.6101.00
19_S111_A0.6051.00
145_R176_H0.6041.00
94_H112_L0.6021.00
62_Y88_W0.6021.00
155_A165_A0.6021.00
2_Q48_A0.5991.00
143_S146_Q0.5971.00
51_M78_L0.5941.00
92_V97_V0.5881.00
5_M31_G0.5841.00
21_Q29_I0.5831.00
142_L146_Q0.5811.00
99_A116_S0.5781.00
54_G92_V0.5771.00
42_L50_V0.5751.00
13_I17_K0.5731.00
76_K120_G0.5701.00
74_E124_L0.5691.00
52_L56_Q0.5661.00
3_I49_L0.5631.00
87_R90_Q0.5581.00
39_W71_Q0.5571.00
135_D186_V0.5521.00
89_L106_T0.5521.00
127_D130_T0.5481.00
69_V75_V0.5451.00
86_K108_E0.5431.00
105_S109_T0.5421.00
150_L153_L0.5351.00
162_I166_L0.5321.00
76_K121_M0.5301.00
76_K124_L0.5291.00
113_A116_S0.5261.00
115_N119_M0.5241.00
8_R81_A0.5201.00
159_N170_T0.5201.00
65_L69_V0.5191.00
81_A103_R0.5181.00
53_D103_R0.5171.00
31_G45_Y0.5151.00
157_E162_I0.5131.00
52_L68_T0.5121.00
20_L27_V0.5111.00
135_D138_D0.5101.00
151_T154_A0.5101.00
15_G18_I0.5061.00
133_E147_R0.5041.00
21_Q28_S0.5021.00
34_Q56_Q0.5021.00
37_E58_G0.5011.00
27_V118_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1yioA 1 0.98 100 0.162 Contact Map
3c3wA 2 0.995 100 0.166 Contact Map
4gvpA 1 0.995 100 0.17 Contact Map
1a04A 1 0.975 100 0.188 Contact Map
4ldzA 2 0.96 100 0.192 Contact Map
3kloA 2 0.995 100 0.199 Contact Map
4hyeA 2 0.98 100 0.215 Contact Map
3q9sA 1 0.965 100 0.222 Contact Map
4b09A 2 0.915 100 0.224 Contact Map
1ys7A 2 0.985 100 0.228 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0091 seconds.