GREMLIN Database
GADX - HTH-type transcriptional regulator GadX
UniProt: P37639 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12243
Length: 274 (235)
Sequences: 32914 (28853)
Seq/√Len: 1882.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
199_L232_Y3.3901.00
184_T192_E3.2721.00
152_N193_C3.0521.00
207_F215_S3.0351.00
195_M232_Y2.8881.00
150_V154_N2.8021.00
162_A172_P2.7771.00
197_R200_Q2.6871.00
154_N157_H2.6361.00
192_E231_Y2.5551.00
228_F239_Y2.5461.00
147_V175_L2.4651.00
201_L215_S2.3601.00
198_A224_F2.3551.00
179_L189_L2.1821.00
201_L216_C2.1241.00
160_T163_R2.0341.00
207_F211_R1.9891.00
19_L26_Y1.9821.00
155_I193_C1.9601.00
187_S191_T1.9301.00
234_M242_R1.9041.00
150_V167_E1.8691.00
19_L28_Y1.8661.00
147_V168_L1.8661.00
151_I190_L1.8371.00
201_L207_F1.8181.00
195_M231_Y1.7741.00
21_M26_Y1.7621.00
208_S211_R1.7511.00
221_V225_I1.7471.00
199_L239_Y1.7291.00
227_V230_N1.7011.00
161_L176_K1.6951.00
174_L178_K1.6821.00
164_I186_Y1.6581.00
9_L43_R1.6461.00
30_N33_D1.6221.00
117_L120_A1.6161.00
17_Y28_Y1.6031.00
116_A120_A1.5861.00
184_T188_Q1.5801.00
116_A123_S1.5751.00
197_R201_L1.5741.00
193_C197_R1.5681.00
152_N189_L1.5461.00
149_T153_N1.5341.00
210_K221_V1.5321.00
175_L186_Y1.5301.00
202_I209_I1.5211.00
172_P176_K1.5171.00
155_I197_R1.5101.00
150_V159_W1.5081.00
234_M238_E1.5001.00
120_A124_V1.4651.00
211_R215_S1.4541.00
186_Y190_L1.4471.00
148_C152_N1.4381.00
223_Y227_V1.4281.00
237_T241_E1.4061.00
210_K214_V1.4031.00
156_A215_S1.4031.00
174_L177_K1.4031.00
170_M174_L1.4021.00
211_R214_V1.3941.00
198_A216_C1.3931.00
141_P182_E1.3921.00
176_K186_Y1.3891.00
151_I193_C1.3861.00
173_S177_K1.3831.00
197_R216_C1.3821.00
119_F123_S1.3771.00
200_Q204_I1.3641.00
21_M44_V1.3621.00
147_V164_I1.3601.00
212_V216_C1.3561.00
163_R167_E1.3461.00
17_Y30_N1.3281.00
185_S188_Q1.3251.00
123_S127_E1.3181.00
19_L46_K1.3181.00
218_Y227_V1.3131.00
15_H48_V1.2981.00
192_E196_Q1.2921.00
23_N41_Q1.2851.00
222_S225_I1.2791.00
8_C39_A1.2721.00
193_C196_Q1.2691.00
191_T227_V1.2471.00
170_M175_L1.2291.00
14_R50_N1.2281.00
143_M170_M1.2061.00
162_A166_S1.1981.00
38_D41_Q1.1701.00
171_S174_L1.1611.00
115_R119_F1.1551.00
226_Y230_N1.1531.00
157_H163_R1.1491.00
56_R59_L1.1491.00
116_A119_F1.1391.00
95_Q99_Q1.1301.00
225_I235_T1.1291.00
225_I237_T1.1241.00
161_L186_Y1.1211.00
15_H31_G1.1201.00
94_F100_L1.1001.00
178_K182_E1.0951.00
113_R120_A1.0951.00
207_F212_V1.0941.00
205_H240_Q1.0911.00
199_L203_V1.0881.00
150_V168_L1.0781.00
158_E219_H1.0711.00
238_E241_E1.0621.00
156_A197_R1.0521.00
178_K181_E1.0511.00
191_T230_N1.0511.00
142_N146_R1.0391.00
237_T240_Q1.0291.00
143_M168_L1.0151.00
196_Q199_L1.0121.00
165_A172_P1.0011.00
145_T149_T1.0011.00
13_A18_I0.9941.00
235_T238_E0.9881.00
96_E100_L0.9881.00
159_W164_I0.9841.00
113_R117_L0.9801.00
209_I212_V0.9781.00
225_I229_R0.9771.00
143_M178_K0.9761.00
188_Q191_T0.9691.00
220_S226_Y0.9691.00
173_S176_K0.9681.00
91_I95_Q0.9591.00
148_C189_L0.9571.00
164_I167_E0.9521.00
151_I186_Y0.9511.00
50_N56_R0.9491.00
161_L172_P0.9491.00
146_R167_E0.9471.00
201_L212_V0.9431.00
120_A123_S0.9351.00
22_V25_E0.9291.00
194_R216_C0.9251.00
14_R48_V0.9251.00
163_R166_S0.9161.00
150_V164_I0.9051.00
227_V231_Y0.9041.00
179_L186_Y0.8981.00
188_Q192_E0.8951.00
8_C36_F0.8921.00
21_M24_G0.8851.00
232_Y239_Y0.8811.00
168_L175_L0.8771.00
199_L228_F0.8731.00
155_I190_L0.8711.00
146_R149_T0.8691.00
187_S223_Y0.8681.00
238_E242_R0.8661.00
100_L104_K0.8581.00
145_T148_C0.8581.00
223_Y226_Y0.8531.00
202_I212_V0.8511.00
191_T231_Y0.8511.00
155_I159_W0.8471.00
144_R182_E0.8411.00
195_M227_V0.8391.00
146_R168_L0.8381.00
96_E99_Q0.8381.00
18_I29_F0.8371.00
188_Q231_Y0.8341.00
202_I240_Q0.8331.00
144_R178_K0.8331.00
144_R147_V0.8261.00
195_M224_F0.8201.00
101_S104_K0.8161.00
158_E163_R0.8161.00
154_N167_E0.8111.00
170_M178_K0.8101.00
148_C179_L0.8081.00
92_P96_E0.8051.00
189_L193_C0.8011.00
205_H212_V0.7981.00
92_P95_Q0.7981.00
144_R148_C0.7921.00
56_R60_S0.7881.00
229_R235_T0.7831.00
90_D100_L0.7821.00
50_N53_F0.7781.00
176_K180_R0.7761.00
155_I216_C0.7741.00
20_T35_V0.7731.00
113_R116_A0.7721.00
33_D83_L0.7701.00
112_L116_A0.7681.00
124_V128_D0.7641.00
140_Q181_E0.7611.00
187_S190_L0.7581.00
177_K181_E0.7581.00
176_K187_S0.7471.00
154_N163_R0.7461.00
214_V219_H0.7431.00
12_Y34_L0.7391.00
159_W163_R0.7391.00
82_L85_H0.7381.00
18_I28_Y0.7361.00
234_M239_Y0.7361.00
99_Q103_N0.7301.00
155_I194_R0.7271.00
229_R238_E0.7231.00
213_A221_V0.7231.00
203_V239_Y0.7231.00
37_A43_R0.7211.00
198_A201_L0.7171.00
52_V56_R0.7161.00
164_I175_L0.7161.00
112_L115_R0.7081.00
219_H223_Y0.7061.00
11_A37_A0.7051.00
29_F35_V0.7041.00
151_I189_L0.7041.00
143_M146_R0.7041.00
111_M115_R0.7041.00
93_V101_S0.6931.00
100_L103_N0.6921.00
147_V150_V0.6881.00
104_K108_Y0.6841.00
220_S223_Y0.6811.00
147_V186_Y0.6801.00
79_V82_L0.6761.00
60_S64_P0.6741.00
80_S83_L0.6721.00
176_K185_S0.6691.00
81_S85_H0.6561.00
221_V224_F0.6561.00
222_S226_Y0.6551.00
98_A104_K0.6541.00
184_T189_L0.6501.00
141_P178_K0.6481.00
180_R185_S0.6481.00
110_E114_K0.6471.00
191_T223_Y0.6381.00
120_A125_F0.6361.00
93_V100_L0.6341.00
13_A29_F0.6331.00
11_A20_T0.6321.00
140_Q143_M0.6321.00
206_G212_V0.6291.00
93_V96_E0.6271.00
147_V179_L0.6271.00
61_L64_P0.6271.00
79_V84_V0.6261.00
222_S235_T0.6251.00
112_L123_S0.6241.00
195_M218_Y0.6241.00
113_R123_S0.6241.00
61_L65_M0.6211.00
104_K107_R0.6171.00
212_V240_Q0.6151.00
74_H77_K0.6151.00
116_A124_V0.6151.00
93_V98_A0.6121.00
9_L53_F0.6121.00
198_A212_V0.6121.00
83_L86_H0.6111.00
228_F234_M0.6101.00
11_A35_V0.6101.00
94_F97_V0.6091.00
110_E127_E0.6081.00
161_L187_S0.6081.00
224_F236_P0.6071.00
95_Q98_A0.6071.00
22_V37_A0.6061.00
196_Q232_Y0.6051.00
49_E53_F0.6021.00
50_N55_S0.6011.00
93_V97_V0.5991.00
11_A51_F0.5991.00
165_A168_L0.5981.00
159_W194_R0.5971.00
224_F228_F0.5951.00
150_V163_R0.5931.00
21_M46_K0.5931.00
58_T61_L0.5931.00
98_A102_Q0.5911.00
113_R127_E0.5901.00
141_P145_T0.5901.00
59_L66_L0.5891.00
112_L119_F0.5851.00
124_V127_E0.5801.00
164_I168_L0.5801.00
94_F98_A0.5771.00
147_V151_I0.5751.00
140_Q182_E0.5731.00
105_N108_Y0.5721.00
114_K118_I0.5721.00
191_T195_M0.5711.00
92_P99_Q0.5711.00
105_N109_A0.5661.00
159_W190_L0.5641.00
142_N182_E0.5631.00
190_L194_R0.5631.00
90_D104_K0.5621.00
208_S212_V0.5611.00
147_V167_E0.5591.00
196_Q231_Y0.5571.00
33_D85_H0.5571.00
20_T37_A0.5551.00
218_Y223_Y0.5541.00
144_R175_L0.5531.00
209_I237_T0.5511.00
82_L86_H0.5511.00
107_R110_E0.5501.00
122_L125_F0.5501.00
149_T152_N0.5501.00
138_V141_P0.5491.00
81_S84_V0.5481.00
114_K117_L0.5481.00
166_S169_L0.5471.00
13_A16_K0.5411.00
114_K125_F0.5411.00
51_F55_S0.5371.00
116_A125_F0.5361.00
144_R168_L0.5311.00
97_V100_L0.5301.00
80_S84_V0.5291.00
78_K81_S0.5281.00
220_S230_N0.5271.00
227_V232_Y0.5261.00
191_T218_Y0.5261.00
161_L173_S0.5241.00
55_S59_L0.5241.00
228_F232_Y0.5211.00
147_V178_K0.5211.00
202_I239_Y0.5191.00
152_N197_R0.5171.00
168_L172_P0.5161.00
118_I122_L0.5161.00
97_V101_S0.5141.00
90_D93_V0.5131.00
98_A101_S0.5131.00
79_V86_H0.5121.00
22_V27_R0.5111.00
218_Y224_F0.5111.00
200_Q203_V0.5071.00
23_N42_I0.5071.00
57_D60_S0.5061.00
20_T43_R0.5051.00
151_I159_W0.5041.00
196_Q200_Q0.5011.00
110_E113_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gbgA 1 0.8431 100 0.27 Contact Map
3mklA 1 0.4051 100 0.491 Contact Map
3oioA 1 0.4051 100 0.501 Contact Map
3oouA 1 0.3796 100 0.502 Contact Map
1bl0A 1 0.4197 100 0.502 Contact Map
3mn2A 1 0.3832 100 0.508 Contact Map
3w6vA 1 0.4015 100 0.508 Contact Map
2k9sA 1 0.3832 99.9 0.513 Contact Map
3lsgA 2 0.3686 99.9 0.52 Contact Map
4fe7A 2 0.8066 99.9 0.533 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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