MDTF - ECOLI - GREMLIN Contacts

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MDTF - Multidrug resistance protein MdtF

UniProt:	P37637	Sequences: MANYFIDRPVFAWVLAIIMMLAGGLAIMNLPVAQYPQIAPPTITVSATYPGADAQTVEDSVTQVIEQNMNGLDGLMYMSSTSDAAGNASITLTFETGTSPDIAQVQVQNKLQLAMPSLPEAVQQQGISVDKSSSNILMVAAFISDNGSLNQYDIADYVASNIKDPLSRTAGVGSVQLFGSEYAMRIWLDPQKLNKYNLVPSDVISQIKVQNNQISGGQLGGMPQAADQQLNASIIVQTRLQTPEEFGKILLKVQQDGSQVLLRDVARVELGAEDYSTVARYNGKPAAGIAIKLAAGANALDTSRAVKEELNRLSAYFPASLKTVYPYDTTPFIEISIQEVFKTLVEAIILVFLVMYLFLQNFRATIIPTIAVPVVILGTFAILSAVGFTINTLTMFGMVLAIGLLVDDAIVVVENVERVIAEDKLPPKEATHKSMGQIQRALVGIAVVLSAVFMPMAFMSGATGEIYRQFSITLISSMLLSVFVAMSLTPALCATILKAAPEGGHKPNALFARFNTLFEKSTQHYTDSTRSLLRCTGRYMVVYLLICAGMAVLFLRTPTSFLPEEDQGVFMTTAQLPSGATMVNTTKVLQQVTDYYLTKEKDNVQSVFTVGGFGFSGQGQNNGLAFISLKPWSERVGEENSVTAIIQRAMIALSSINKAVVFPFNLPAVAELGTASGFDMELLDNGNLGHEKLTQARNELLSLAAQSPNQVTGVRPNGLEDTPMFKVNVNAAKAEAMGVALSDINQTISTAFGSSYVNDFLNQGRVKKVYVQAGTPFRMLPDNINQWYVRNASGTMAPLSAYSSTEWTYGSPRLERYNGIPSMEILGEAAAGKSTGDAMKFMADLVAKLPAGVGYSWTGLSYQEALSSNQAPALYAISLVVVFLALAALYESWSIPFSVMLVVPLGVVGALLATDLRGLSNDVYFQVGLLTTIGLSAKNAILIVEFAVEMMQKEGKTPIEAIIEAARMRLRPILMTSLAFILGVLPLVISHGAGSGAQNAVGTGVMGGMFAATVLAIYFVPVFFVVVEHLFARFKKA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12241
Length:	1037 (997)
Sequences:	15758 (10055)
Seq/√Len:	318.5

ECOLI - MDTF ACRD MDTB ACRF ACRB CUSA MDTC
BACSU - SWRC SECDF

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
957_T	960_E	4.120	1.00
244_E	247_G	4.071	1.00
62_T	88_A	3.963	1.00
309_E	312_R	3.946	1.00
311_N	314_S	3.919	1.00
247_G	263_R	3.908	1.00
47_A	88_A	3.783	1.00
728_N	806_E	3.629	1.00
913_A	1007_G	3.579	1.00
589_L	623_G	3.490	1.00
528_S	1018_Y	3.380	1.00
304_R	334_E	3.266	1.00
150_N	153_D	3.151	1.00
248_K	263_R	3.122	1.00
584_N	587_K	3.102	1.00
426_P	429_E	3.079	1.00
3_N	7_D	3.042	1.00
530_R	963_I	3.024	1.00
75_L	92_L	2.973	1.00
188_L	203_V	2.958	1.00
758_N	769_V	2.954	1.00
280_R	593_T	2.875	1.00
729_V	734_A	2.846	1.00
730_N	804_S	2.835	1.00
169_T	305_A	2.824	1.00
689_G	692_K	2.823	1.00
62_T	82_S	2.822	1.00
734_A	744_I	2.813	1.00
692_K	695_Q	2.769	1.00
58_E	821_P	2.748	1.00
193_L	198_L	2.740	1.00
165_P	309_E	2.720	1.00
142_F	158_V	2.659	1.00
307_K	328_D	2.651	1.00
247_G	268_V	2.646	1.00
76_M	93_T	2.602	1.00
262_L	268_V	2.594	1.00
282_N	606_S	2.589	1.00
895_I	948_V	2.582	1.00
740_A	743_D	2.575	1.00
345_V	349_I	2.562	1.00
251_L	265_V	2.527	1.00
703_L	706_Q	2.516	1.00
154_I	321_L	2.479	1.00
243_P	247_G	2.475	1.00
378_G	480_L	2.431	1.00
314_S	322_K	2.429	1.00
586_T	590_Q	2.417	1.00
189_D	192_K	2.396	1.00
696_A	853_V	2.383	1.00
526_T	967_R	2.335	1.00
704_A	842_M	2.330	1.00
76_M	95_E	2.324	1.00
833_K	841_F	2.320	1.00
424_K	433_K	2.318	1.00
701_L	705_A	2.301	1.00
157_Y	321_L	2.301	1.00
695_Q	699_E	2.301	1.00
638_E	641_S	2.295	1.00
917_R	1003_T	2.279	1.00
730_N	733_K	2.274	1.00
956_K	964_E	2.268	1.00
382_I	476_S	2.243	1.00
186_I	207_I	2.225	1.00
631_P	634_E	2.208	1.00
301_D	305_A	2.191	1.00
246_F	262_L	2.182	1.00
204_I	771_V	2.176	1.00
572_T	627_I	2.163	1.00
188_L	200_P	2.150	1.00
782_D	785_N	2.150	1.00
182_Y	270_L	2.130	1.00
600_E	649_A	2.129	1.00
729_V	744_I	2.112	1.00
187_W	269_E	2.094	1.00
419_V	437_Q	2.075	1.00
834_S	837_D	2.054	1.00
728_N	804_S	2.042	1.00
701_L	716_P	2.027	1.00
962_I	1025_V	2.022	1.00
534_R	959_I	2.021	1.00
711_V	714_V	2.016	1.00
252_K	255_Q	2.013	1.00
342_K	346_E	2.012	1.00
65_I	69_M	2.012	1.00
988_V	1006_M	2.005	1.00
798_P	801_A	2.005	1.00
144_S	148_S	2.003	1.00
684_D	700_L	1.994	1.00
727_V	803_S	1.993	1.00
713_G	828_E	1.989	1.00
576_L	580_A	1.984	1.00
739_V	789_V	1.980	1.00
418_R	422_E	1.966	1.00
726_K	808_T	1.965	1.00
785_N	800_S	1.959	1.00
65_I	90_I	1.949	1.00
700_L	846_V	1.944	1.00
429_E	433_K	1.937	1.00
707_S	841_F	1.926	1.00
601_K	645_I	1.921	1.00
603_N	637_G	1.900	1.00
280_R	586_T	1.891	1.00
242_T	245_E	1.888	1.00
525_Y	966_A	1.883	1.00
415_N	437_Q	1.876	1.00
545_L	549_G	1.865	1.00
10_V	887_A	1.865	1.00
55_Q	59_D	1.860	1.00
531_S	535_C	1.860	1.00
371_A	484_V	1.857	1.00
698_N	701_L	1.852	1.00
57_V	61_V	1.851	1.00
605_Q	630_K	1.849	1.00
520_K	524_H	1.832	1.00
305_A	308_E	1.826	1.00
596_Y	646_I	1.825	1.00
450_S	479_L	1.812	1.00
552_V	555_L	1.811	1.00
149_L	320_S	1.807	1.00
7_D	428_K	1.806	1.00
193_L	265_V	1.797	1.00
535_C	538_R	1.796	1.00
520_K	523_Q	1.796	1.00
190_P	777_F	1.795	1.00
162_I	313_L	1.785	1.00
780_L	783_N	1.779	1.00
843_A	865_A	1.779	1.00
244_E	248_K	1.777	1.00
637_G	645_I	1.773	1.00
959_I	1025_V	1.771	1.00
591_Q	594_D	1.771	1.00
183_A	770_Y	1.769	1.00
697_R	823_M	1.761	1.00
701_L	714_V	1.755	1.00
536_T	1025_V	1.749	1.00
8_R	891_E	1.748	1.00
696_A	699_E	1.745	1.00
62_T	80_S	1.741	1.00
204_I	208_K	1.732	1.00
69_M	92_L	1.730	1.00
267_R	774_G	1.725	1.00
589_L	609_T	1.710	1.00
24_G	28_M	1.706	1.00
181_E	273_E	1.705	1.00
147_G	284_K	1.696	1.00
843_A	847_A	1.694	1.00
92_L	107_V	1.694	1.00
540_M	544_L	1.691	1.00
711_V	838_A	1.691	1.00
919_L	1003_T	1.687	1.00
29_N	384_S	1.683	1.00
531_S	534_R	1.667	1.00
678_F	827_G	1.665	1.00
733_K	736_A	1.662	1.00
388_F	472_I	1.659	1.00
69_M	90_I	1.656	1.00
841_F	844_D	1.655	1.00
551_A	555_L	1.654	1.00
739_V	802_Y	1.644	1.00
65_I	114_A	1.630	1.00
301_D	304_R	1.629	1.00
570_F	627_I	1.629	1.00
198_L	202_D	1.626	1.00
726_K	806_E	1.625	1.00
526_T	530_R	1.620	1.00
304_R	308_E	1.616	1.00
199_V	202_D	1.616	1.00
211_N	758_N	1.614	1.00
241_Q	245_E	1.613	1.00
644_A	648_R	1.611	1.00
307_K	325_Y	1.607	1.00
20_M	377_L	1.601	1.00
601_K	649_A	1.600	1.00
415_N	418_R	1.598	1.00
841_F	845_L	1.594	1.00
3_N	432_H	1.591	1.00
595_Y	649_A	1.589	1.00
774_G	777_F	1.587	1.00
74_G	98_T	1.584	1.00
647_Q	713_G	1.581	1.00
338_Q	342_K	1.579	1.00
82_S	88_A	1.578	1.00
744_I	802_Y	1.573	1.00
833_K	837_D	1.573	1.00
734_A	739_V	1.567	1.00
590_Q	594_D	1.566	1.00
574_A	589_L	1.566	1.00
419_V	424_K	1.564	1.00
559_T	836_G	1.560	1.00
840_K	843_A	1.558	1.00
189_D	267_R	1.557	1.00
694_T	698_N	1.552	1.00
240_L	246_F	1.551	1.00
418_R	968_M	1.546	1.00
143_I	324_V	1.544	1.00
528_S	531_S	1.543	1.00
645_I	649_A	1.542	1.00
595_Y	652_A	1.539	1.00
902_V	940_A	1.532	1.00
585_T	623_G	1.526	1.00
883_F	896_P	1.524	1.00
386_V	476_S	1.522	1.00
547_C	551_A	1.519	1.00
26_A	381_A	1.514	1.00
248_K	261_L	1.510	1.00
479_L	483_F	1.507	1.00
757_V	771_V	1.505	1.00
574_A	592_V	1.503	1.00
596_Y	604_V	1.503	1.00
416_V	493_C	1.503	1.00
297_A	302_T	1.502	1.00
188_L	193_L	1.500	1.00
709_N	841_F	1.498	1.00
207_I	249_I	1.496	1.00
419_V	422_E	1.493	1.00
702_S	706_Q	1.480	1.00
699_E	702_S	1.479	1.00
703_L	845_L	1.477	1.00
408_D	938_K	1.477	1.00
472_I	476_S	1.474	1.00
78_M	92_L	1.473	1.00
47_A	62_T	1.470	1.00
576_L	588_V	1.467	1.00
99_S	102_I	1.466	1.00
61_V	122_V	1.465	1.00
192_K	196_Y	1.454	1.00
205_S	209_V	1.450	1.00
952_Q	1024_F	1.442	1.00
592_V	650_M	1.441	1.00
684_D	693_L	1.438	1.00
234_I	752_F	1.438	1.00
692_K	696_A	1.437	1.00
379_T	477_S	1.434	1.00
727_V	805_T	1.431	1.00
307_K	311_N	1.428	1.00
339_E	342_K	1.428	1.00
47_A	122_V	1.428	1.00
172_V	291_I	1.428	1.00
524_H	527_D	1.427	1.00
328_D	331_P	1.421	1.00
540_M	1026_V	1.418	1.00
756_Y	768_K	1.415	1.00
201_S	205_S	1.414	1.00
14_V	884_L	1.412	1.00
202_D	205_S	1.411	1.00
574_A	623_G	1.409	1.00
630_K	634_E	1.406	1.00
34_Q	567_Q	1.402	1.00
580_A	584_N	1.399	1.00
641_S	645_I	1.397	1.00
98_T	103_A	1.396	1.00
43_I	107_V	1.396	1.00
603_N	630_K	1.392	1.00
205_S	208_K	1.390	1.00
959_I	963_I	1.388	1.00
790_R	796_M	1.385	1.00
653_L	656_I	1.384	1.00
863_Q	866_L	1.384	1.00
412_V	435_M	1.381	1.00
948_V	953_K	1.378	1.00
141_A	281_Y	1.369	1.00
47_A	65_I	1.367	1.00
791_N	795_T	1.366	1.00
590_Q	593_T	1.365	1.00
699_E	703_L	1.361	1.00
163_K	167_S	1.359	1.00
240_L	249_I	1.358	1.00
199_V	790_R	1.357	1.00
789_V	802_Y	1.357	1.00
57_V	82_S	1.355	1.00
66_E	816_R	1.354	1.00
349_I	353_L	1.354	1.00
261_L	264_D	1.353	1.00
202_D	790_R	1.352	1.00
604_V	627_I	1.351	1.00
250_L	259_Q	1.351	1.00
594_D	597_L	1.351	1.00
837_D	840_K	1.346	1.00
840_K	844_D	1.342	1.00
352_F	369_T	1.342	1.00
45_V	69_M	1.341	1.00
317_F	323_T	1.340	1.00
536_T	1029_H	1.339	1.00
209_V	735_E	1.338	1.00
593_T	597_L	1.334	1.00
382_I	386_V	1.333	1.00
981_I	1006_M	1.330	1.00
697_R	716_P	1.329	1.00
649_A	652_A	1.329	1.00
192_K	195_K	1.324	1.00
53_D	56_T	1.319	1.00
170_A	305_A	1.318	1.00
278_V	586_T	1.317	1.00
305_A	309_E	1.316	1.00
115_M	124_Q	1.311	1.00
279_A	288_G	1.311	1.00
587_K	591_Q	1.309	1.00
949_E	953_K	1.305	1.00
549_G	553_L	1.303	1.00
63_Q	816_R	1.302	1.00
19_M	378_G	1.302	1.00
981_I	1010_F	1.298	1.00
526_T	964_E	1.296	1.00
595_Y	601_K	1.295	1.00
22_A	381_A	1.293	1.00
69_M	107_V	1.293	1.00
702_S	705_A	1.291	1.00
611_G	623_G	1.291	1.00
77_Y	818_N	1.291	1.00
548_A	552_V	1.288	1.00
607_V	625_A	1.286	1.00
524_H	528_S	1.285	1.00
570_F	643_T	1.283	1.00
936_S	1012_A	1.282	1.00
541_V	545_L	1.281	1.00
374_V	488_L	1.279	1.00
58_E	816_R	1.279	1.00
45_V	92_L	1.279	1.00
560_S	920_S	1.277	1.00
77_Y	93_T	1.276	1.00
112_Q	115_M	1.276	1.00
597_L	607_V	1.276	1.00
739_V	792_A	1.268	1.00
245_E	248_K	1.268	1.00
144_S	147_G	1.264	1.00
202_D	252_K	1.263	1.00
960_E	964_E	1.259	1.00
686_G	853_V	1.255	1.00
4_Y	11_F	1.251	1.00
711_V	827_G	1.251	1.00
707_S	845_L	1.250	1.00
846_V	855_Y	1.250	1.00
683_L	817_Y	1.248	1.00
958_P	962_I	1.248	1.00
13_W	893_W	1.248	1.00
27_I	341_F	1.247	1.00
552_V	556_R	1.242	1.00
947_A	962_I	1.239	1.00
910_A	929_L	1.237	1.00
156_D	767_K	1.236	1.00
43_I	104_Q	1.236	1.00
914_T	925_F	1.236	1.00
193_L	203_V	1.234	1.00
74_G	95_E	1.234	1.00
6_I	432_H	1.231	1.00
165_P	316_Y	1.229	1.00
644_A	647_Q	1.228	1.00
952_Q	1028_E	1.222	1.00
601_K	642_V	1.221	1.00
142_F	162_I	1.220	1.00
645_I	648_R	1.220	1.00
637_G	642_V	1.217	1.00
309_E	313_L	1.214	1.00
69_M	78_M	1.212	1.00
3_N	436_G	1.211	1.00
6_I	491_A	1.211	1.00
419_V	433_K	1.210	1.00
149_L	153_D	1.210	1.00
724_M	810_G	1.209	1.00
556_R	915_D	1.207	1.00
433_K	436_G	1.206	1.00
26_A	384_S	1.205	1.00
783_N	786_Q	1.205	1.00
527_D	530_R	1.204	1.00
642_V	645_I	1.204	1.00
527_D	531_S	1.201	1.00
187_W	267_R	1.201	1.00
216_G	236_V	1.199	1.00
956_K	960_E	1.199	1.00
576_L	585_T	1.199	1.00
541_V	548_A	1.198	1.00
157_Y	161_N	1.197	1.00
709_N	833_K	1.197	1.00
415_N	946_F	1.196	1.00
304_R	307_K	1.195	1.00
57_V	88_A	1.192	1.00
203_V	265_V	1.191	1.00
703_L	848_K	1.191	1.00
247_G	267_R	1.189	1.00
589_L	611_G	1.186	1.00
310_L	323_T	1.186	1.00
423_D	433_K	1.183	1.00
532_L	1022_V	1.183	1.00
526_T	963_I	1.183	1.00
985_L	1006_M	1.182	1.00
65_I	111_L	1.180	1.00
308_E	312_R	1.179	1.00
685_N	822_S	1.174	1.00
142_F	323_T	1.174	1.00
140_A	325_Y	1.170	1.00
685_N	856_S	1.168	1.00
218_Q	231_N	1.166	1.00
172_V	302_T	1.164	1.00
684_D	696_A	1.161	1.00
532_L	539_Y	1.161	1.00
647_Q	651_I	1.160	1.00
75_L	78_M	1.159	1.00
591_Q	595_Y	1.158	1.00
974_L	978_L	1.157	1.00
603_N	642_V	1.151	1.00
58_E	814_L	1.149	1.00
311_N	315_A	1.148	1.00
388_F	394_T	1.148	1.00
700_L	825_I	1.145	1.00
68_N	114_A	1.144	1.00
919_L	999_N	1.139	1.00
339_E	998_Q	1.139	1.00
76_M	866_L	1.139	1.00
110_K	113_L	1.138	1.00
143_I	322_K	1.138	1.00
820_I	854_G	1.137	1.00
250_L	261_L	1.137	1.00
588_V	591_Q	1.136	1.00
605_Q	628_S	1.136	1.00
149_L	321_L	1.134	1.00
379_T	476_S	1.133	1.00
656_I	659_A	1.133	1.00
570_F	646_I	1.130	1.00
594_D	600_E	1.130	1.00
166_L	175_V	1.129	1.00
20_M	24_G	1.126	1.00
858_T	862_Y	1.125	1.00
196_Y	260_V	1.124	1.00
446_A	482_V	1.124	1.00
165_P	313_L	1.121	1.00
817_Y	858_T	1.121	1.00
49_Y	52_A	1.118	1.00
964_E	967_R	1.116	1.00
206_Q	249_I	1.116	1.00
303_S	330_T	1.114	1.00
707_S	844_D	1.114	1.00
704_A	711_V	1.110	1.00
529_T	533_L	1.110	1.00
370_I	492_L	1.108	1.00
749_S	755_S	1.108	1.00
538_R	541_V	1.106	1.00
16_A	488_L	1.105	1.00
523_Q	527_D	1.103	1.00
948_V	952_Q	1.103	1.00
447_V	885_A	1.095	1.00
298_N	301_D	1.095	1.00
759_D	768_K	1.095	1.00
5_F	12_A	1.093	1.00
248_K	732_A	1.093	1.00
648_R	651_I	1.092	1.00
449_L	938_K	1.091	1.00
742_S	746_Q	1.089	1.00
905_L	1015_L	1.088	1.00
262_L	266_A	1.085	1.00
829_A	838_A	1.083	1.00
596_Y	625_A	1.082	1.00
11_F	888_A	1.082	1.00
334_E	338_Q	1.081	1.00
593_T	609_T	1.080	1.00
869_N	872_P	1.079	1.00
750_T	755_S	1.079	1.00
560_S	922_D	1.074	1.00
772_Q	778_R	1.073	1.00
692_K	853_V	1.073	1.00
862_Y	866_L	1.071	1.00
698_N	702_S	1.071	1.00
493_C	497_L	1.070	1.00
235_I	724_M	1.068	1.00
175_V	289_I	1.062	1.00
519_E	523_Q	1.061	1.00
731_A	741_L	1.061	1.00
81_T	91_T	1.060	1.00
415_N	419_V	1.060	1.00
79_S	93_T	1.060	1.00
922_D	925_F	1.057	1.00
788_Y	796_M	1.056	1.00
445_I	482_V	1.053	1.00
308_E	311_N	1.053	1.00
428_K	432_H	1.052	1.00
155_A	180_S	1.052	1.00
115_M	123_Q	1.051	1.00
185_R	772_Q	1.050	1.00
201_S	743_D	1.050	1.00
314_S	323_T	1.048	1.00
66_E	80_S	1.048	1.00
312_R	315_A	1.047	1.00
78_M	819_G	1.045	1.00
186_I	757_V	1.045	1.00
842_M	857_W	1.044	1.00
587_K	590_Q	1.044	1.00
140_A	323_T	1.044	1.00
978_L	982_L	1.043	1.00
183_A	273_E	1.042	1.00
954_E	964_E	1.042	1.00
949_E	954_E	1.039	1.00
68_N	113_L	1.039	1.00
138_M	306_V	1.035	1.00
45_V	65_I	1.035	1.00
261_L	732_A	1.034	1.00
80_S	816_R	1.034	1.00
543_Y	1019_F	1.034	1.00
913_A	1003_T	1.032	1.00
142_F	154_I	1.032	1.00
970_L	974_L	1.031	1.00
696_A	849_L	1.030	1.00
570_F	629_L	1.029	1.00
532_L	1018_Y	1.029	1.00
912_L	916_L	1.028	1.00
98_T	106_Q	1.027	1.00
108_Q	112_Q	1.024	1.00
705_A	714_V	1.023	1.00
786_Q	800_S	1.022	1.00
187_W	774_G	1.021	1.00
429_E	432_H	1.020	1.00
371_A	489_T	1.017	1.00
838_A	841_F	1.016	1.00
639_E	643_T	1.014	1.00
977_S	981_I	1.012	1.00
251_L	260_V	1.012	1.00
890_Y	941_I	1.011	1.00
371_A	409_A	1.010	1.00
691_E	694_T	1.007	1.00
417_E	421_A	1.007	1.00
246_F	268_V	1.007	1.00
977_S	1013_T	1.004	1.00
946_F	968_M	1.001	1.00
444_G	885_A	1.000	1.00
591_Q	653_L	1.000	1.00
280_R	590_Q	0.999	1.00
981_I	1009_M	0.998	1.00
537_G	541_V	0.997	1.00
682_L	704_A	0.996	1.00
592_V	653_L	0.996	1.00
542_V	549_G	0.995	1.00
30_L	380_F	0.994	1.00
420_I	427_P	0.992	1.00
640_N	644_A	0.992	1.00
681_E	824_E	0.991	1.00
382_I	480_L	0.990	1.00
415_N	438_I	0.987	1.00
214_I	745_N	0.987	1.00
637_G	641_S	0.987	1.00
46_S	87_N	0.986	1.00
163_K	175_V	0.985	1.00
601_K	646_I	0.984	1.00
534_R	537_G	0.983	1.00
596_Y	627_I	0.983	1.00
367_I	492_L	0.982	1.00
548_A	551_A	0.982	1.00
439_Q	443_V	0.981	1.00
553_L	912_L	0.981	1.00
20_M	374_V	0.980	1.00
303_S	307_K	0.979	1.00
572_T	596_Y	0.979	1.00
360_Q	515_N	0.979	1.00
102_I	106_Q	0.977	1.00
444_G	889_L	0.977	1.00
370_I	488_L	0.976	1.00
427_P	431_T	0.974	1.00
581_T	584_N	0.973	1.00
641_S	644_A	0.970	1.00
48_T	87_N	0.970	1.00
80_S	90_I	0.970	1.00
725_F	781_P	0.969	1.00
537_G	1026_V	0.968	1.00
216_G	748_I	0.966	1.00
207_I	757_V	0.966	1.00
533_L	1025_V	0.966	1.00
544_L	548_A	0.965	1.00
517_L	520_K	0.965	1.00
964_E	968_M	0.961	1.00
45_V	90_I	0.959	1.00
341_F	345_V	0.959	1.00
281_Y	286_A	0.959	1.00
143_I	284_K	0.957	1.00
739_V	744_I	0.957	1.00
138_M	307_K	0.956	1.00
451_A	881_V	0.954	1.00
982_L	985_L	0.953	1.00
141_A	286_A	0.951	1.00
514_F	518_F	0.950	1.00
686_G	692_K	0.949	1.00
550_M	911_L	0.948	1.00
13_W	17_I	0.948	1.00
947_A	1024_F	0.947	1.00
198_L	251_L	0.947	1.00
898_S	1023_F	0.946	1.00
684_D	853_V	0.945	1.00
437_Q	949_E	0.942	1.00
595_Y	653_L	0.942	1.00
701_L	825_I	0.941	1.00
231_N	276_S	0.940	1.00
784_I	805_T	0.940	1.00
70_N	819_G	0.939	1.00
383_L	388_F	0.939	1.00
189_D	777_F	0.939	1.00
756_Y	770_Y	0.936	1.00
545_L	548_A	0.935	1.00
94_F	107_V	0.934	1.00
700_L	845_L	0.934	1.00
539_Y	542_V	0.933	1.00
839_M	861_S	0.933	1.00
178_F	290_A	0.933	1.00
522_T	526_T	0.932	1.00
169_T	309_E	0.931	1.00
460_S	870_Q	0.931	1.00
593_T	607_V	0.931	1.00
148_S	320_S	0.927	1.00
814_L	821_P	0.926	1.00
163_K	177_L	0.925	1.00
706_Q	845_L	0.924	1.00
760_F	769_V	0.924	1.00
374_V	484_V	0.923	1.00
313_L	317_F	0.922	1.00
246_F	769_V	0.922	1.00
449_L	478_M	0.922	1.00
416_V	434_S	0.920	1.00
530_R	960_E	0.918	1.00
525_Y	533_L	0.918	1.00
791_N	794_G	0.917	1.00
307_K	330_T	0.917	1.00
697_R	701_L	0.915	1.00
68_N	117_S	0.915	1.00
198_L	203_V	0.914	1.00
682_L	700_L	0.913	1.00
653_L	658_K	0.913	1.00
717_N	815_E	0.912	1.00
897_F	901_L	0.912	1.00
207_I	246_F	0.912	1.00
394_T	469_Q	0.907	1.00
910_A	1004_G	0.907	1.00
203_V	771_V	0.907	1.00
16_A	374_V	0.907	1.00
592_V	625_A	0.907	1.00
595_Y	600_E	0.905	1.00
684_D	825_I	0.905	1.00
138_M	303_S	0.904	1.00
247_G	266_A	0.904	1.00
185_R	269_E	0.904	1.00
431_T	494_A	0.903	1.00
307_K	314_S	0.902	1.00
588_V	653_L	0.902	1.00
963_I	967_R	0.899	1.00
985_L	989_I	0.898	1.00
779_M	783_N	0.896	1.00
193_L	196_Y	0.895	1.00
759_D	766_V	0.894	1.00
908_V	1011_A	0.891	1.00
7_D	432_H	0.891	1.00
243_P	270_L	0.891	1.00
549_G	552_V	0.890	1.00
603_N	645_I	0.889	1.00
281_Y	606_S	0.889	1.00
913_A	917_R	0.889	1.00
536_T	1026_V	0.888	1.00
412_V	442_L	0.887	1.00
681_E	822_S	0.887	1.00
785_N	805_T	0.885	1.00
362_F	366_I	0.884	1.00
432_H	436_G	0.884	1.00
423_D	430_A	0.884	1.00
872_P	876_A	0.883	1.00
743_D	746_Q	0.883	1.00
152_Y	272_A	0.882	1.00
546_I	908_V	0.881	1.00
174_S	292_K	0.881	1.00
283_G	593_T	0.879	1.00
734_A	802_Y	0.876	1.00
525_Y	529_T	0.875	1.00
947_A	965_A	0.873	1.00
591_Q	655_S	0.872	1.00
727_V	748_I	0.871	1.00
952_Q	958_P	0.869	1.00
962_I	966_A	0.869	1.00
62_T	90_I	0.868	1.00
190_P	773_A	0.868	1.00
685_N	854_G	0.867	1.00
905_L	1019_F	0.866	1.00
656_I	660_V	0.864	1.00
725_F	807_W	0.863	1.00
1016_A	1020_V	0.861	1.00
693_L	853_V	0.860	1.00
876_A	880_V	0.860	1.00
533_L	1022_V	0.860	1.00
310_L	314_S	0.860	1.00
186_I	266_A	0.860	1.00
71_G	110_K	0.857	1.00
48_T	123_Q	0.853	1.00
338_Q	341_F	0.851	1.00
144_S	320_S	0.851	1.00
201_S	746_Q	0.850	1.00
302_T	305_A	0.846	1.00
439_Q	486_M	0.845	1.00
252_K	260_V	0.844	1.00
156_D	160_S	0.844	1.00
102_I	105_V	0.842	1.00
580_A	585_T	0.842	1.00
448_V	938_K	0.841	1.00
131_K	134_S	0.840	1.00
155_A	159_A	0.840	1.00
704_A	714_V	0.839	1.00
438_I	446_A	0.837	1.00
691_E	695_Q	0.837	1.00
204_I	750_T	0.833	1.00
166_L	309_E	0.832	1.00
711_V	842_M	0.832	1.00
574_A	658_K	0.830	1.00
153_D	156_D	0.830	1.00
346_E	349_I	0.829	1.00
883_F	893_W	0.826	1.00
522_T	967_R	0.825	1.00
682_L	855_Y	0.825	1.00
654_S	659_A	0.824	1.00
564_E	640_N	0.824	1.00
120_E	124_Q	0.824	1.00
44_T	91_T	0.823	1.00
958_P	1025_V	0.823	1.00
516_T	520_K	0.822	1.00
839_M	857_W	0.821	1.00
540_M	1022_V	0.819	1.00
879_L	900_M	0.818	1.00
609_T	625_A	0.818	1.00
833_K	838_A	0.818	1.00
209_V	740_A	0.816	1.00
679_D	828_E	0.816	1.00
81_T	813_R	0.815	1.00
521_S	525_Y	0.815	1.00
737_M	797_A	0.814	1.00
592_V	595_Y	0.814	1.00
655_S	658_K	0.813	1.00
744_I	799_L	0.812	1.00
4_Y	8_R	0.812	1.00
58_E	62_T	0.812	1.00
404_L	980_F	0.811	1.00
692_K	852_G	0.811	1.00
533_L	963_I	0.810	1.00
200_P	750_T	0.808	1.00
646_I	650_M	0.808	1.00
687_N	853_V	0.808	1.00
1010_F	1014_V	0.808	1.00
158_V	289_I	0.808	1.00
754_S	772_Q	0.806	1.00
939_N	1012_A	0.806	1.00
184_M	760_F	0.806	1.00
739_V	791_N	0.804	1.00
643_T	647_Q	0.804	1.00
49_Y	57_V	0.802	1.00
818_N	856_S	0.801	1.00
694_T	823_M	0.800	1.00
751_A	787_W	0.800	1.00
922_D	1000_A	0.800	1.00
77_Y	817_Y	0.800	1.00
519_E	522_T	0.799	1.00
684_D	689_G	0.799	1.00
273_E	768_K	0.798	1.00
533_L	962_I	0.798	1.00
191_Q	786_Q	0.798	1.00
583_V	587_K	0.797	1.00
404_L	979_A	0.797	1.00
167_S	174_S	0.797	1.00
955_G	961_A	0.796	1.00
555_L	558_P	0.795	1.00
137_L	303_S	0.795	1.00
530_R	534_R	0.794	1.00
419_V	423_D	0.794	1.00
606_S	628_S	0.794	1.00
278_V	582_M	0.793	1.00
397_G	401_A	0.792	1.00
404_L	408_D	0.791	1.00
50_P	123_Q	0.790	1.00
693_L	823_M	0.790	1.00
95_E	98_T	0.790	1.00
10_V	893_W	0.790	1.00
518_F	522_T	0.790	1.00
347_A	351_V	0.789	1.00
530_R	959_I	0.789	1.00
465_E	468_R	0.788	1.00
177_L	180_S	0.787	1.00
441_A	949_E	0.786	1.00
381_A	385_A	0.786	1.00
457_A	475_I	0.784	1.00
139_V	290_A	0.783	1.00
1013_T	1016_A	0.782	1.00
13_W	495_T	0.782	1.00
203_V	206_Q	0.781	1.00
714_V	827_G	0.781	1.00
781_P	785_N	0.781	1.00
699_E	848_K	0.781	1.00
413_V	493_C	0.780	1.00
422_E	433_K	0.780	1.00
557_T	911_L	0.780	1.00
839_M	865_A	0.779	1.00
718_G	823_M	0.779	1.00
188_L	771_V	0.778	1.00
449_L	980_F	0.778	1.00
450_S	475_I	0.778	1.00
1023_F	1027_V	0.777	1.00
317_F	321_L	0.777	1.00
751_A	773_A	0.776	1.00
586_T	611_G	0.776	1.00
650_M	658_K	0.776	1.00
25_L	29_N	0.775	1.00
47_A	82_S	0.775	1.00
232_A	725_F	0.775	1.00
917_R	1007_G	0.774	1.00
46_S	89_S	0.774	1.00
240_L	760_F	0.774	1.00
629_L	642_V	0.773	1.00
488_L	492_L	0.773	1.00
584_N	655_S	0.772	1.00
749_S	753_G	0.772	1.00
1025_V	1029_H	0.771	1.00
69_M	111_L	0.770	1.00
94_F	103_A	0.769	1.00
725_F	805_T	0.769	1.00
921_N	926_Q	0.769	1.00
361_N	364_A	0.768	0.99
253_V	259_Q	0.767	0.99
543_Y	547_C	0.766	0.99
278_V	611_G	0.766	0.99
74_G	97_G	0.765	0.99
597_L	600_E	0.765	0.99
383_L	473_T	0.764	0.99
203_V	251_L	0.763	0.99
547_C	908_V	0.762	0.99
203_V	262_L	0.762	0.99
337_I	395_M	0.761	0.99
837_D	841_F	0.760	0.99
288_G	608_F	0.759	0.99
358_F	975_M	0.759	0.99
47_A	125_Q	0.757	0.99
850_P	853_V	0.757	0.99
733_K	801_A	0.755	0.99
246_F	249_I	0.754	0.99
708_P	711_V	0.754	0.99
331_P	334_E	0.753	0.99
696_A	700_L	0.753	0.99
136_I	139_V	0.752	0.99
566_D	635_R	0.750	0.99
938_K	979_A	0.749	0.99
169_T	302_T	0.748	0.99
221_G	226_A	0.748	0.99
575_Q	657_N	0.747	0.99
159_A	163_K	0.747	0.99
250_L	253_V	0.747	0.99
861_S	865_A	0.747	0.99
686_G	852_G	0.747	0.99
194_N	788_Y	0.746	0.99
424_K	429_E	0.746	0.99
914_T	1004_G	0.746	0.99
188_L	266_A	0.745	0.99
428_K	494_A	0.744	0.99
166_L	289_I	0.744	0.99
231_N	620_Q	0.744	0.99
604_V	612_G	0.743	0.99
816_R	821_P	0.742	0.99
379_T	480_L	0.742	0.99
204_I	755_S	0.742	0.99
118_L	122_V	0.741	0.99
750_T	771_V	0.741	0.99
445_I	979_A	0.741	0.99
140_A	143_I	0.740	0.99
747_T	789_V	0.740	0.99
653_L	660_V	0.740	0.99
679_D	860_L	0.740	0.99
2_A	435_M	0.738	0.99
539_Y	1019_F	0.738	0.99
943_I	966_A	0.736	0.99
717_N	824_E	0.736	0.99
709_N	844_D	0.735	0.99
63_Q	67_Q	0.735	0.99
921_N	929_L	0.735	0.99
52_A	57_V	0.734	0.99
756_Y	759_D	0.734	0.99
799_L	802_Y	0.733	0.99
868_S	872_P	0.733	0.99
553_L	915_D	0.733	0.99
37_Q	296_G	0.732	0.99
849_L	855_Y	0.732	0.99
184_M	243_P	0.732	0.99
572_T	625_A	0.730	0.99
898_S	1020_V	0.730	0.99
501_P	504_G	0.730	0.99
249_I	262_L	0.729	0.99
958_P	1029_H	0.729	0.99
361_N	417_E	0.729	0.99
299_A	330_T	0.729	0.99
554_F	911_L	0.728	0.99
346_E	350_L	0.728	0.99
191_Q	194_N	0.727	0.99
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310_L	313_L	0.543	0.95
551_A	554_F	0.543	0.95
420_I	426_P	0.543	0.95
24_G	377_L	0.543	0.95
5_F	487_S	0.543	0.95
570_F	642_V	0.543	0.95
138_M	310_L	0.542	0.95
453_F	474_L	0.542	0.95
348_I	351_V	0.541	0.95
533_L	959_I	0.541	0.95
171_G	302_T	0.541	0.95
945_E	949_E	0.541	0.95
546_I	550_M	0.540	0.95
561_F	867_S	0.540	0.95
16_A	484_V	0.540	0.95
330_T	334_E	0.540	0.95
752_F	787_W	0.540	0.95
518_F	974_L	0.539	0.95
49_Y	121_A	0.538	0.95
966_A	970_L	0.538	0.95
746_Q	750_T	0.538	0.95
104_Q	108_Q	0.538	0.95
839_M	843_A	0.538	0.95
517_L	527_D	0.537	0.95
375_V	379_T	0.537	0.95
482_V	486_M	0.536	0.95
653_L	659_A	0.536	0.95
138_M	291_I	0.536	0.95
41_P	94_F	0.536	0.95
207_I	769_V	0.535	0.95
251_L	264_D	0.535	0.95
869_N	873_A	0.535	0.95
37_Q	133_S	0.535	0.95
952_Q	955_G	0.535	0.95
836_G	864_E	0.534	0.95
404_L	938_K	0.534	0.95
739_V	743_D	0.534	0.95
344_L	348_I	0.532	0.94
899_V	943_I	0.531	0.94
747_T	751_A	0.531	0.94
342_K	345_V	0.530	0.94
529_T	963_I	0.530	0.94
446_A	485_A	0.530	0.94
537_G	549_G	0.530	0.94
883_F	900_M	0.530	0.94
724_M	808_T	0.529	0.94
988_V	991_H	0.529	0.94
57_V	62_T	0.528	0.94
5_F	8_R	0.528	0.94
213_Q	239_R	0.527	0.94
483_F	487_S	0.527	0.94
695_Q	698_N	0.527	0.94
166_L	169_T	0.526	0.94
856_S	862_Y	0.526	0.94
527_D	532_L	0.526	0.94
442_L	486_M	0.526	0.94
648_R	652_A	0.525	0.94
368_P	979_A	0.525	0.94
397_G	473_T	0.525	0.94
351_V	399_V	0.524	0.94
255_Q	258_S	0.524	0.94
366_I	496_I	0.524	0.94
536_T	959_I	0.524	0.94
427_P	494_A	0.524	0.94
952_Q	957_T	0.524	0.94
33_A	469_Q	0.524	0.94
367_I	493_C	0.524	0.94
209_V	743_D	0.523	0.94
2_A	6_I	0.523	0.94
137_L	140_A	0.523	0.94
364_A	417_E	0.523	0.94
524_H	531_S	0.522	0.94
139_V	178_F	0.521	0.94
654_S	657_N	0.521	0.94
596_Y	650_M	0.520	0.94
445_I	977_S	0.520	0.94
537_G	544_L	0.520	0.94
169_T	306_V	0.520	0.94
601_K	637_G	0.519	0.94
716_P	825_I	0.519	0.94
704_A	707_S	0.519	0.94
270_L	767_K	0.518	0.94
696_A	855_Y	0.518	0.94
120_E	123_Q	0.517	0.94
196_Y	265_V	0.516	0.94
336_S	392_T	0.516	0.94
882_V	933_I	0.516	0.94
785_N	804_S	0.515	0.94
37_Q	295_A	0.515	0.94
553_L	556_R	0.515	0.94
355_M	406_V	0.515	0.94
901_L	1020_V	0.515	0.94
445_I	890_Y	0.515	0.94
527_D	534_R	0.514	0.93
525_Y	532_L	0.514	0.93
130_D	133_S	0.513	0.93
69_M	72_L	0.513	0.93
977_S	980_F	0.512	0.93
467_Y	471_S	0.511	0.93
216_G	727_V	0.511	0.93
554_F	559_T	0.511	0.93
30_L	384_S	0.511	0.93
12_A	491_A	0.510	0.93
549_G	555_L	0.510	0.93
393_L	399_V	0.510	0.93
408_D	445_I	0.510	0.93
21_L	880_V	0.510	0.93
186_I	265_V	0.509	0.93
925_F	1000_A	0.509	0.93
632_W	635_R	0.509	0.93
155_A	287_A	0.509	0.93
141_A	324_V	0.508	0.93
874_L	877_I	0.508	0.93
58_E	82_S	0.508	0.93
410_I	975_M	0.508	0.93
879_L	933_I	0.507	0.93
401_A	404_L	0.507	0.93
544_L	547_C	0.507	0.93
10_V	13_W	0.507	0.93
52_A	82_S	0.507	0.93
314_S	318_P	0.507	0.93
573_T	622_N	0.507	0.93
690_H	718_G	0.506	0.93
914_T	920_S	0.506	0.93
683_L	824_E	0.505	0.93
755_S	771_V	0.505	0.93
169_T	172_V	0.504	0.93
348_I	369_T	0.504	0.93
958_P	961_A	0.504	0.93
72_L	110_K	0.504	0.93
210_Q	240_L	0.503	0.93
906_G	1020_V	0.502	0.93
871_A	926_Q	0.502	0.93
604_V	646_I	0.502	0.93
312_R	316_Y	0.502	0.93
16_A	19_M	0.501	0.93
48_T	86_G	0.501	0.93
376_I	398_M	0.501	0.93
639_E	642_V	0.501	0.93
893_W	896_P	0.501	0.93
895_I	952_Q	0.500	0.92
16_A	487_S	0.500	0.92
686_G	689_G	0.500	0.92

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4k0jA	3	0.9277	100	0.209	Contact Map
4mt1A	3	0.9624	100	0.272	Contact Map
3ne5A	3	0.9595	100	0.276	Contact Map
3w9iA	3	0.9826	100	0.278	Contact Map
4dx5A	3	0.9894	100	0.294	Contact Map
3aqpA	1	0.6673	100	0.724	Contact Map
4r86A	1	0.2797	100	0.747	Contact Map
2ew9A	1	0.1427	83.8	0.981	Contact Map
4n8nA	1	0.0964	77.3	0.982	Contact Map
4q2lA	1	0.0617	67.8	0.983	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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