MDTE - ECOLI - GREMLIN Contacts

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MDTE - Multidrug resistance protein MdtE

UniProt:	P37636	Sequences: MNRRRKLLIPLLFCGAMLTACDDKSAENAAAMTPEVGVVTLSPGSVNVLSELPGRTVPYEVAEIRPQVGGIIIKRNFIEGDKVNQGDSLYQIDPAPLQAELNSAKGSLAKALSTASNARITFNRQASLLKTNYVSRQDYDTARTQLNEAEANVTVAKAAVEQATINLQYANVTSPITGVSGKSSVTVGALVTANQADSLVTVQRLDPIYVDLTQSVQDFLRMKEEVASGQIKQVQGSTPVQLNLENGKRYSQTGTLKFSDPTVDETTGSVTLRAIFPNPNGDLLPGMYVTALVDEGSRQNVLLVPQEGVTHNAQGKATALILDKDDVVQLREIEASKAIGDQWVVTSGLQAGDRVIVSGLQRIRPGIKARAISSSQENASTESKQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12240
Length:	385 (347)
Sequences:	22039 (17490)
Seq/√Len:	938.9

ECOLI - MDTE ACRE ACRA MDTA MACA CUSB EMRK EMRA YDHJ YIBH AAEA YIAV YHII MDTN YBHG
BACSU - YVRP YKNX

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
74_K	91_Q	3.109	1.00
88_S	171_N	2.846	1.00
334_E	347_S	2.760	1.00
318_T	330_L	2.740	1.00
40_T	354_R	2.728	1.00
84_N	177_T	2.585	1.00
331_R	353_D	2.438	1.00
321_I	331_R	2.367	1.00
306_Q	343_W	2.344	1.00
57_V	211_D	2.311	1.00
119_R	123_N	2.304	1.00
257_K	275_I	2.285	1.00
316_K	332_E	2.275	1.00
43_P	351_A	2.249	1.00
239_P	253_T	2.241	1.00
303_L	342_Q	2.192	1.00
254_G	274_A	2.162	1.00
76_N	91_Q	2.106	1.00
44_G	342_Q	2.101	1.00
91_Q	171_N	2.095	1.00
126_A	130_K	2.091	1.00
143_R	147_N	2.067	1.00
94_P	98_Q	2.053	1.00
84_N	87_D	2.052	1.00
43_P	300_N	2.051	1.00
125_Q	134_V	2.050	1.00
105_K	164_T	2.031	1.00
67_Q	169_Y	2.014	1.00
88_S	173_T	1.987	1.00
112_L	157_K	1.974	1.00
110_K	152_N	1.955	1.00
125_Q	142_A	1.914	1.00
241_Q	253_T	1.912	1.00
136_R	140_D	1.912	1.00
350_Q	353_D	1.905	1.00
44_G	303_L	1.888	1.00
76_N	88_S	1.869	1.00
82_K	179_V	1.866	1.00
181_G	203_Q	1.855	1.00
241_Q	251_S	1.854	1.00
212_L	291_A	1.854	1.00
336_S	344_V	1.853	1.00
122_F	126_A	1.794	1.00
327_V	368_K	1.788	1.00
250_Y	282_D	1.787	1.00
119_R	150_E	1.777	1.00
329_Q	365_P	1.772	1.00
126_A	143_R	1.767	1.00
147_N	150_E	1.754	1.00
129_L	139_Y	1.751	1.00
56_T	210_V	1.737	1.00
146_L	150_E	1.733	1.00
334_E	346_T	1.730	1.00
49_L	292_L	1.729	1.00
240_V	274_A	1.710	1.00
85_Q	177_T	1.702	1.00
211_D	271_T	1.698	1.00
154_T	157_K	1.691	1.00
336_S	346_T	1.671	1.00
335_A	343_W	1.659	1.00
209_Y	273_R	1.641	1.00
129_L	136_R	1.616	1.00
72_I	185_V	1.615	1.00
115_A	146_L	1.595	1.00
212_L	274_A	1.593	1.00
117_N	121_T	1.585	1.00
108_L	153_V	1.570	1.00
328_V	356_I	1.553	1.00
109_A	112_L	1.550	1.00
322_L	369_A	1.542	1.00
138_D	141_T	1.515	1.00
122_F	139_Y	1.498	1.00
239_P	255_T	1.490	1.00
18_L	21_C	1.486	1.00
161_E	164_T	1.483	1.00
102_N	105_K	1.478	1.00
321_I	353_D	1.477	1.00
78_I	81_D	1.475	1.00
337_K	344_V	1.474	1.00
119_R	146_L	1.468	1.00
60_E	204_R	1.467	1.00
72_I	90_Y	1.461	1.00
101_L	160_V	1.442	1.00
311_H	317_A	1.441	1.00
45_S	299_Q	1.433	1.00
122_F	146_L	1.433	1.00
41_L	302_L	1.432	1.00
319_A	333_I	1.428	1.00
51_E	292_L	1.425	1.00
112_L	116_S	1.423	1.00
244_L	289_V	1.418	1.00
98_Q	167_L	1.416	1.00
35_E	370_R	1.415	1.00
210_V	289_V	1.414	1.00
213_T	271_T	1.405	1.00
61_V	201_T	1.388	1.00
56_T	208_I	1.384	1.00
139_Y	143_R	1.380	1.00
306_Q	341_D	1.379	1.00
108_L	160_V	1.379	1.00
41_L	352_G	1.378	1.00
123_N	126_A	1.376	1.00
298_R	344_V	1.375	1.00
18_L	22_D	1.373	1.00
63_E	198_S	1.363	1.00
141_T	145_Q	1.361	1.00
204_R	207_P	1.350	1.00
37_G	358_S	1.348	1.00
51_E	290_T	1.344	1.00
241_Q	292_L	1.344	1.00
38_V	371_A	1.343	1.00
304_V	355_V	1.338	1.00
108_L	112_L	1.328	1.00
73_I	93_D	1.313	1.00
116_S	119_R	1.312	1.00
115_A	119_R	1.312	1.00
150_E	154_T	1.310	1.00
38_V	354_R	1.307	1.00
45_S	300_N	1.291	1.00
153_V	157_K	1.290	1.00
215_S	218_D	1.290	1.00
89_L	200_V	1.290	1.00
121_T	125_Q	1.285	1.00
70_G	92_I	1.284	1.00
241_Q	294_D	1.283	1.00
38_V	322_L	1.274	1.00
301_V	344_V	1.266	1.00
174_S	202_V	1.264	1.00
39_V	357_V	1.264	1.00
207_P	275_I	1.260	1.00
107_S	110_K	1.259	1.00
180_S	200_V	1.258	1.00
122_F	143_R	1.257	1.00
243_N	292_L	1.240	1.00
115_A	150_E	1.236	1.00
192_T	195_Q	1.235	1.00
98_Q	102_N	1.225	1.00
255_T	275_I	1.223	1.00
63_E	201_T	1.214	1.00
69_G	193_A	1.202	1.00
263_V	270_V	1.196	1.00
157_K	161_E	1.195	1.00
116_S	120_I	1.184	1.00
182_K	201_T	1.180	1.00
97_L	170_A	1.176	1.00
242_L	276_F	1.174	1.00
333_I	345_V	1.173	1.00
112_L	153_V	1.172	1.00
302_L	351_A	1.170	1.00
116_S	147_N	1.169	1.00
88_S	91_Q	1.154	1.00
123_N	127_S	1.153	1.00
74_K	187_V	1.147	1.00
110_K	114_T	1.142	1.00
258_F	273_R	1.140	1.00
317_A	335_A	1.136	1.00
77_F	87_D	1.135	1.00
322_L	354_R	1.133	1.00
118_A	149_A	1.128	1.00
90_Y	200_V	1.126	1.00
101_L	105_K	1.113	1.00
137_Q	141_T	1.109	1.00
224_E	237_S	1.108	1.00
115_A	153_V	1.107	1.00
105_K	109_A	1.105	1.00
183_S	200_V	1.105	1.00
313_A	330_L	1.104	1.00
127_S	131_T	1.101	1.00
211_D	273_R	1.096	1.00
183_S	186_T	1.094	1.00
103_S	159_A	1.094	1.00
108_L	157_K	1.093	1.00
321_I	329_Q	1.088	1.00
101_L	164_T	1.083	1.00
306_Q	338_A	1.081	1.00
219_F	270_V	1.079	1.00
210_V	291_A	1.078	1.00
78_I	183_S	1.077	1.00
121_T	141_T	1.074	1.00
260_D	271_T	1.066	1.00
59_Y	207_P	1.066	1.00
17_M	21_C	1.064	1.00
127_S	130_K	1.063	1.00
243_N	251_S	1.059	1.00
339_I	342_Q	1.051	1.00
79_E	182_K	1.046	1.00
309_V	343_W	1.043	1.00
100_E	103_S	1.042	1.00
210_V	242_L	1.038	1.00
114_T	152_N	1.036	1.00
114_T	117_N	1.034	1.00
109_A	154_T	1.029	1.00
218_D	221_R	1.027	1.00
111_A	156_A	1.027	1.00
72_I	191_V	1.024	1.00
90_Y	172_V	1.015	1.00
126_A	139_Y	1.012	1.00
256_L	274_A	1.012	1.00
124_R	140_D	1.010	1.00
75_R	187_V	1.004	1.00
94_P	170_A	1.003	1.00
40_T	352_G	1.002	1.00
73_I	91_Q	0.997	1.00
67_Q	71_I	0.997	1.00
209_Y	275_I	0.994	1.00
309_V	317_A	0.987	1.00
247_G	250_Y	0.981	1.00
255_T	277_P	0.979	1.00
47_N	294_D	0.975	1.00
56_T	283_L	0.971	1.00
55_R	268_G	0.967	1.00
324_K	329_Q	0.953	1.00
66_P	172_V	0.949	1.00
56_T	289_V	0.949	1.00
264_D	267_T	0.946	1.00
278_N	281_G	0.944	1.00
140_D	143_R	0.940	1.00
62_A	176_I	0.940	1.00
103_S	107_S	0.939	1.00
244_L	247_G	0.934	1.00
243_N	290_T	0.933	1.00
321_I	324_K	0.929	1.00
114_T	148_E	0.923	1.00
207_P	277_P	0.921	1.00
174_S	177_T	0.917	1.00
59_Y	209_Y	0.916	1.00
47_N	297_S	0.915	1.00
338_A	343_W	0.913	1.00
191_V	199_L	0.909	1.00
77_F	200_V	0.905	1.00
132_N	136_R	0.900	1.00
145_Q	149_A	0.887	1.00
247_G	252_Q	0.878	1.00
326_D	368_K	0.877	1.00
114_T	145_Q	0.876	1.00
34_P	367_I	0.871	1.00
49_L	294_D	0.868	1.00
69_G	192_T	0.868	1.00
82_K	177_T	0.865	1.00
45_S	297_S	0.864	1.00
111_A	149_A	0.864	1.00
304_V	319_A	0.857	1.00
294_D	297_S	0.856	1.00
105_K	160_V	0.853	1.00
90_Y	183_S	0.850	1.00
184_S	201_T	0.849	1.00
90_Y	199_L	0.849	1.00
313_A	316_K	0.849	1.00
152_N	156_A	0.846	1.00
152_N	155_V	0.844	1.00
256_L	272_L	0.843	1.00
320_L	365_P	0.842	1.00
160_V	164_T	0.836	1.00
330_L	365_P	0.834	1.00
356_I	363_I	0.832	1.00
77_F	183_S	0.832	1.00
82_K	281_G	0.830	1.00
43_P	302_L	0.828	1.00
162_Q	166_N	0.827	1.00
243_N	249_R	0.827	1.00
48_V	221_R	0.826	1.00
107_S	159_A	0.824	1.00
104_A	156_A	0.823	1.00
125_Q	138_D	0.823	1.00
214_Q	272_L	0.822	1.00
336_S	343_W	0.819	1.00
178_G	202_V	0.818	1.00
164_T	168_Q	0.817	1.00
102_N	161_E	0.816	1.00
77_F	180_S	0.815	1.00
114_T	118_A	0.814	1.00
263_V	268_G	0.814	1.00
81_D	87_D	0.813	1.00
68_V	97_L	0.813	1.00
322_L	326_D	0.813	1.00
298_R	301_V	0.811	1.00
58_P	285_P	0.811	1.00
91_Q	94_P	0.806	1.00
73_I	94_P	0.805	1.00
117_N	144_T	0.802	1.00
176_I	202_V	0.801	1.00
100_E	166_N	0.799	1.00
324_K	327_V	0.795	1.00
42_S	351_A	0.795	1.00
184_S	198_S	0.794	1.00
94_P	171_N	0.793	1.00
46_V	339_I	0.790	1.00
143_R	146_L	0.789	1.00
328_V	369_A	0.787	1.00
322_L	328_V	0.783	1.00
246_N	250_Y	0.782	1.00
121_T	137_Q	0.781	1.00
310_T	318_T	0.777	1.00
39_V	305_P	0.772	1.00
66_P	191_V	0.772	1.00
120_I	140_D	0.771	1.00
82_K	205_L	0.770	1.00
252_Q	280_N	0.769	1.00
224_E	259_S	0.766	1.00
8_L	12_L	0.766	1.00
124_R	128_L	0.764	1.00
328_V	363_I	0.762	1.00
208_I	285_P	0.762	1.00
60_E	187_V	0.762	1.00
100_E	162_Q	0.761	1.00
117_N	141_T	0.760	1.00
39_V	42_S	0.757	1.00
320_L	330_L	0.757	1.00
223_K	238_T	0.756	1.00
331_R	350_Q	0.755	1.00
149_A	153_V	0.754	1.00
36_V	356_I	0.750	1.00
224_E	238_T	0.748	1.00
214_Q	222_M	0.746	1.00
324_K	331_R	0.744	1.00
75_R	90_Y	0.741	1.00
320_L	328_V	0.736	1.00
79_E	183_S	0.736	1.00
54_G	289_V	0.735	1.00
66_P	90_Y	0.734	1.00
120_I	123_N	0.734	1.00
242_L	254_G	0.733	1.00
212_L	293_V	0.731	1.00
59_Y	275_I	0.731	1.00
364_R	367_I	0.730	1.00
324_K	353_D	0.728	1.00
345_V	349_L	0.728	1.00
33_T	368_K	0.727	1.00
64_I	175_P	0.726	1.00
145_Q	148_E	0.724	1.00
318_T	332_E	0.720	1.00
237_S	255_T	0.719	1.00
142_A	145_Q	0.719	1.00
107_S	155_V	0.714	1.00
319_A	355_V	0.713	1.00
101_L	167_L	0.712	1.00
165_I	169_Y	0.711	1.00
149_A	152_N	0.711	1.00
72_I	199_L	0.710	1.00
307_E	358_S	0.709	1.00
57_V	209_Y	0.707	1.00
71_I	190_L	0.706	1.00
322_L	356_I	0.705	1.00
48_V	296_G	0.703	1.00
67_Q	96_P	0.698	1.00
95_A	165_I	0.696	1.00
242_L	291_A	0.696	1.00
117_N	120_I	0.695	1.00
104_A	107_S	0.689	1.00
159_A	163_A	0.689	1.00
179_V	205_L	0.687	1.00
60_E	186_T	0.685	1.00
335_A	345_V	0.685	1.00
331_R	348_G	0.684	1.00
33_T	370_R	0.683	1.00
259_S	272_L	0.683	1.00
239_P	294_D	0.682	1.00
50_S	218_D	0.680	1.00
246_N	249_R	0.680	1.00
112_L	115_A	0.677	1.00
59_Y	204_R	0.675	1.00
41_L	349_L	0.675	1.00
336_S	348_G	0.673	1.00
354_R	371_A	0.670	1.00
245_E	290_T	0.669	1.00
61_V	203_Q	0.666	1.00
144_T	148_E	0.665	1.00
65_R	195_Q	0.663	1.00
165_I	168_Q	0.660	1.00
52_L	212_L	0.659	1.00
114_T	149_A	0.656	1.00
100_E	104_A	0.655	1.00
304_V	308_G	0.654	1.00
138_D	142_A	0.651	1.00
50_S	295_E	0.651	1.00
148_E	152_N	0.651	1.00
107_S	111_A	0.651	1.00
13_F	17_M	0.648	1.00
106_G	151_A	0.645	1.00
106_G	158_A	0.644	1.00
57_V	61_V	0.640	1.00
69_G	190_L	0.637	1.00
129_L	134_V	0.636	1.00
52_L	218_D	0.636	1.00
313_A	318_T	0.634	1.00
135_S	138_D	0.632	1.00
13_F	16_A	0.630	1.00
121_T	145_Q	0.627	1.00
308_G	357_V	0.626	1.00
209_Y	257_K	0.625	1.00
342_Q	346_T	0.623	1.00
111_A	114_T	0.618	1.00
134_V	138_D	0.617	1.00
326_D	371_A	0.616	1.00
73_I	76_N	0.616	1.00
77_F	81_D	0.614	1.00
65_R	198_S	0.614	1.00
41_L	353_D	0.614	1.00
320_L	363_I	0.612	1.00
195_Q	198_S	0.610	1.00
305_P	308_G	0.610	1.00
52_L	214_Q	0.608	1.00
302_L	348_G	0.606	1.00
284_L	287_M	0.605	1.00
39_V	304_V	0.604	1.00
257_K	273_R	0.601	1.00
42_S	342_Q	0.601	1.00
129_L	132_N	0.601	1.00
324_K	354_R	0.600	1.00
250_Y	280_N	0.599	1.00
38_V	357_V	0.599	1.00
244_L	283_L	0.598	1.00
104_A	163_A	0.596	1.00
156_A	159_A	0.596	1.00
158_A	161_E	0.588	1.00
19_T	22_D	0.587	1.00
242_L	274_A	0.586	1.00
60_E	176_I	0.584	1.00
96_P	166_N	0.584	1.00
121_T	142_A	0.582	1.00
10_P	14_C	0.582	1.00
83_V	89_L	0.581	1.00
304_V	309_V	0.580	1.00
308_G	355_V	0.580	1.00
120_I	144_T	0.580	1.00
94_P	167_L	0.578	1.00
39_V	342_Q	0.578	1.00
107_S	152_N	0.577	1.00
155_V	159_A	0.576	1.00
185_V	189_A	0.576	1.00
12_L	19_T	0.576	1.00
55_R	286_G	0.575	1.00
11_L	18_L	0.575	1.00
100_E	163_A	0.574	1.00
113_S	151_A	0.574	1.00
213_T	264_D	0.574	1.00
46_V	344_V	0.574	1.00
206_D	281_G	0.572	1.00
46_V	337_K	0.571	1.00
46_V	303_L	0.568	1.00
210_V	276_F	0.568	1.00
319_A	348_G	0.566	1.00
64_I	200_V	0.565	1.00
206_D	279_P	0.565	1.00
270_V	287_M	0.564	1.00
136_R	143_R	0.564	1.00
113_S	117_N	0.564	1.00
52_L	293_V	0.561	1.00
216_V	288_Y	0.560	1.00
118_A	145_Q	0.558	1.00
58_P	61_V	0.558	1.00
62_A	202_V	0.557	1.00
321_I	355_V	0.554	1.00
48_V	337_K	0.554	1.00
125_Q	128_L	0.554	1.00
121_T	124_R	0.554	1.00
147_N	151_A	0.552	1.00
40_T	43_P	0.550	1.00
159_A	162_Q	0.549	1.00
9_I	12_L	0.549	1.00
326_D	354_R	0.548	1.00
208_I	276_F	0.548	1.00
63_E	189_A	0.547	1.00
52_L	291_A	0.547	1.00
54_G	210_V	0.543	1.00
264_D	271_T	0.543	1.00
99_A	165_I	0.542	1.00
15_G	21_C	0.542	1.00
10_P	21_C	0.541	1.00
66_P	199_L	0.541	1.00
153_V	156_A	0.538	1.00
309_V	333_I	0.538	1.00
163_A	166_N	0.537	1.00
39_V	43_P	0.536	1.00
48_V	295_E	0.535	1.00
115_A	149_A	0.534	1.00
166_N	169_Y	0.534	1.00
310_T	320_L	0.534	1.00
168_Q	173_T	0.532	1.00
58_P	203_Q	0.530	1.00
42_S	303_L	0.529	1.00
252_Q	283_L	0.529	1.00
363_I	369_A	0.528	1.00
274_A	291_A	0.525	1.00
263_V	267_T	0.525	1.00
56_T	244_L	0.523	1.00
97_L	166_N	0.521	1.00
125_Q	129_L	0.517	1.00
86_G	173_T	0.515	1.00
203_Q	285_P	0.515	1.00
189_A	195_Q	0.515	1.00
205_L	285_P	0.514	1.00
167_L	170_A	0.512	1.00
119_R	122_F	0.511	1.00
12_L	16_A	0.511	1.00
254_G	276_F	0.511	1.00
96_P	100_E	0.510	1.00
136_R	139_Y	0.510	1.00
303_L	344_V	0.510	1.00
76_N	87_D	0.509	1.00
140_D	144_T	0.508	1.00
253_T	277_P	0.508	1.00
66_P	92_I	0.508	1.00
263_V	269_S	0.507	1.00
212_L	272_L	0.507	1.00
144_T	151_A	0.505	1.00
99_A	158_A	0.505	1.00
9_I	13_F	0.505	1.00
16_A	21_C	0.504	1.00
240_V	293_V	0.504	1.00
43_P	350_Q	0.503	1.00
212_L	240_V	0.503	1.00
64_I	176_I	0.503	1.00
83_V	174_S	0.502	1.00
208_I	278_N	0.502	1.00
322_L	325_D	0.502	1.00
75_R	183_S	0.502	1.00
186_T	189_A	0.501	1.00
309_V	335_A	0.501	1.00
203_Q	261_P	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1vf7A	5	0.5974	100	0.234	Contact Map
3lnnA	6	0.8545	100	0.24	Contact Map
4dk0A	5	0.7896	100	0.247	Contact Map
3ne5B	3	0.8156	100	0.271	Contact Map
4l8jA	2	0.8156	100	0.275	Contact Map
3fppA	3	0.6442	100	0.275	Contact Map
4kkuA	1	0.6883	100	0.323	Contact Map
2f1mA	2	0.6156	100	0.406	Contact Map
4tkoB	1	0.6052	100	0.48	Contact Map
2k32A	1	0.2987	99.8	0.707	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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