GREMLIN Database
MDTE - Multidrug resistance protein MdtE
UniProt: P37636 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12240
Length: 385 (347)
Sequences: 22039 (17490)
Seq/√Len: 938.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
74_K91_Q3.1091.00
88_S171_N2.8461.00
334_E347_S2.7601.00
318_T330_L2.7401.00
40_T354_R2.7281.00
84_N177_T2.5851.00
331_R353_D2.4381.00
321_I331_R2.3671.00
306_Q343_W2.3441.00
57_V211_D2.3111.00
119_R123_N2.3041.00
257_K275_I2.2851.00
316_K332_E2.2751.00
43_P351_A2.2491.00
239_P253_T2.2411.00
303_L342_Q2.1921.00
254_G274_A2.1621.00
76_N91_Q2.1061.00
44_G342_Q2.1011.00
91_Q171_N2.0951.00
126_A130_K2.0911.00
143_R147_N2.0671.00
94_P98_Q2.0531.00
84_N87_D2.0521.00
43_P300_N2.0511.00
125_Q134_V2.0501.00
105_K164_T2.0311.00
67_Q169_Y2.0141.00
88_S173_T1.9871.00
112_L157_K1.9741.00
110_K152_N1.9551.00
125_Q142_A1.9141.00
241_Q253_T1.9121.00
136_R140_D1.9121.00
350_Q353_D1.9051.00
44_G303_L1.8881.00
76_N88_S1.8691.00
82_K179_V1.8661.00
181_G203_Q1.8551.00
241_Q251_S1.8541.00
212_L291_A1.8541.00
336_S344_V1.8531.00
122_F126_A1.7941.00
327_V368_K1.7881.00
250_Y282_D1.7871.00
119_R150_E1.7771.00
329_Q365_P1.7721.00
126_A143_R1.7671.00
147_N150_E1.7541.00
129_L139_Y1.7511.00
56_T210_V1.7371.00
146_L150_E1.7331.00
334_E346_T1.7301.00
49_L292_L1.7291.00
240_V274_A1.7101.00
85_Q177_T1.7021.00
211_D271_T1.6981.00
154_T157_K1.6911.00
336_S346_T1.6711.00
335_A343_W1.6591.00
209_Y273_R1.6411.00
129_L136_R1.6161.00
72_I185_V1.6151.00
115_A146_L1.5951.00
212_L274_A1.5931.00
117_N121_T1.5851.00
108_L153_V1.5701.00
328_V356_I1.5531.00
109_A112_L1.5501.00
322_L369_A1.5421.00
138_D141_T1.5151.00
122_F139_Y1.4981.00
239_P255_T1.4901.00
18_L21_C1.4861.00
161_E164_T1.4831.00
102_N105_K1.4781.00
321_I353_D1.4771.00
78_I81_D1.4751.00
337_K344_V1.4741.00
119_R146_L1.4681.00
60_E204_R1.4671.00
72_I90_Y1.4611.00
101_L160_V1.4421.00
311_H317_A1.4411.00
45_S299_Q1.4331.00
122_F146_L1.4331.00
41_L302_L1.4321.00
319_A333_I1.4281.00
51_E292_L1.4251.00
112_L116_S1.4231.00
244_L289_V1.4181.00
98_Q167_L1.4161.00
35_E370_R1.4151.00
210_V289_V1.4141.00
213_T271_T1.4051.00
61_V201_T1.3881.00
56_T208_I1.3841.00
139_Y143_R1.3801.00
306_Q341_D1.3791.00
108_L160_V1.3791.00
41_L352_G1.3781.00
123_N126_A1.3761.00
298_R344_V1.3751.00
18_L22_D1.3731.00
63_E198_S1.3631.00
141_T145_Q1.3611.00
204_R207_P1.3501.00
37_G358_S1.3481.00
51_E290_T1.3441.00
241_Q292_L1.3441.00
38_V371_A1.3431.00
304_V355_V1.3381.00
108_L112_L1.3281.00
73_I93_D1.3131.00
116_S119_R1.3121.00
115_A119_R1.3121.00
150_E154_T1.3101.00
38_V354_R1.3071.00
45_S300_N1.2911.00
153_V157_K1.2901.00
215_S218_D1.2901.00
89_L200_V1.2901.00
121_T125_Q1.2851.00
70_G92_I1.2841.00
241_Q294_D1.2831.00
38_V322_L1.2741.00
301_V344_V1.2661.00
174_S202_V1.2641.00
39_V357_V1.2641.00
207_P275_I1.2601.00
107_S110_K1.2591.00
180_S200_V1.2581.00
122_F143_R1.2571.00
243_N292_L1.2401.00
115_A150_E1.2361.00
192_T195_Q1.2351.00
98_Q102_N1.2251.00
255_T275_I1.2231.00
63_E201_T1.2141.00
69_G193_A1.2021.00
263_V270_V1.1961.00
157_K161_E1.1951.00
116_S120_I1.1841.00
182_K201_T1.1801.00
97_L170_A1.1761.00
242_L276_F1.1741.00
333_I345_V1.1731.00
112_L153_V1.1721.00
302_L351_A1.1701.00
116_S147_N1.1691.00
88_S91_Q1.1541.00
123_N127_S1.1531.00
74_K187_V1.1471.00
110_K114_T1.1421.00
258_F273_R1.1401.00
317_A335_A1.1361.00
77_F87_D1.1351.00
322_L354_R1.1331.00
118_A149_A1.1281.00
90_Y200_V1.1261.00
101_L105_K1.1131.00
137_Q141_T1.1091.00
224_E237_S1.1081.00
115_A153_V1.1071.00
105_K109_A1.1051.00
183_S200_V1.1051.00
313_A330_L1.1041.00
127_S131_T1.1011.00
211_D273_R1.0961.00
183_S186_T1.0941.00
103_S159_A1.0941.00
108_L157_K1.0931.00
321_I329_Q1.0881.00
101_L164_T1.0831.00
306_Q338_A1.0811.00
219_F270_V1.0791.00
210_V291_A1.0781.00
78_I183_S1.0771.00
121_T141_T1.0741.00
260_D271_T1.0661.00
59_Y207_P1.0661.00
17_M21_C1.0641.00
127_S130_K1.0631.00
243_N251_S1.0591.00
339_I342_Q1.0511.00
79_E182_K1.0461.00
309_V343_W1.0431.00
100_E103_S1.0421.00
210_V242_L1.0381.00
114_T152_N1.0361.00
114_T117_N1.0341.00
109_A154_T1.0291.00
218_D221_R1.0271.00
111_A156_A1.0271.00
72_I191_V1.0241.00
90_Y172_V1.0151.00
126_A139_Y1.0121.00
256_L274_A1.0121.00
124_R140_D1.0101.00
75_R187_V1.0041.00
94_P170_A1.0031.00
40_T352_G1.0021.00
73_I91_Q0.9971.00
67_Q71_I0.9971.00
209_Y275_I0.9941.00
309_V317_A0.9871.00
247_G250_Y0.9811.00
255_T277_P0.9791.00
47_N294_D0.9751.00
56_T283_L0.9711.00
55_R268_G0.9671.00
324_K329_Q0.9531.00
66_P172_V0.9491.00
56_T289_V0.9491.00
264_D267_T0.9461.00
278_N281_G0.9441.00
140_D143_R0.9401.00
62_A176_I0.9401.00
103_S107_S0.9391.00
244_L247_G0.9341.00
243_N290_T0.9331.00
321_I324_K0.9291.00
114_T148_E0.9231.00
207_P277_P0.9211.00
174_S177_T0.9171.00
59_Y209_Y0.9161.00
47_N297_S0.9151.00
338_A343_W0.9131.00
191_V199_L0.9091.00
77_F200_V0.9051.00
132_N136_R0.9001.00
145_Q149_A0.8871.00
247_G252_Q0.8781.00
326_D368_K0.8771.00
114_T145_Q0.8761.00
34_P367_I0.8711.00
49_L294_D0.8681.00
69_G192_T0.8681.00
82_K177_T0.8651.00
45_S297_S0.8641.00
111_A149_A0.8641.00
304_V319_A0.8571.00
294_D297_S0.8561.00
105_K160_V0.8531.00
90_Y183_S0.8501.00
184_S201_T0.8491.00
90_Y199_L0.8491.00
313_A316_K0.8491.00
152_N156_A0.8461.00
152_N155_V0.8441.00
256_L272_L0.8431.00
320_L365_P0.8421.00
160_V164_T0.8361.00
330_L365_P0.8341.00
356_I363_I0.8321.00
77_F183_S0.8321.00
82_K281_G0.8301.00
43_P302_L0.8281.00
162_Q166_N0.8271.00
243_N249_R0.8271.00
48_V221_R0.8261.00
107_S159_A0.8241.00
104_A156_A0.8231.00
125_Q138_D0.8231.00
214_Q272_L0.8221.00
336_S343_W0.8191.00
178_G202_V0.8181.00
164_T168_Q0.8171.00
102_N161_E0.8161.00
77_F180_S0.8151.00
114_T118_A0.8141.00
263_V268_G0.8141.00
81_D87_D0.8131.00
68_V97_L0.8131.00
322_L326_D0.8131.00
298_R301_V0.8111.00
58_P285_P0.8111.00
91_Q94_P0.8061.00
73_I94_P0.8051.00
117_N144_T0.8021.00
176_I202_V0.8011.00
100_E166_N0.7991.00
324_K327_V0.7951.00
42_S351_A0.7951.00
184_S198_S0.7941.00
94_P171_N0.7931.00
46_V339_I0.7901.00
143_R146_L0.7891.00
328_V369_A0.7871.00
322_L328_V0.7831.00
246_N250_Y0.7821.00
121_T137_Q0.7811.00
310_T318_T0.7771.00
39_V305_P0.7721.00
66_P191_V0.7721.00
120_I140_D0.7711.00
82_K205_L0.7701.00
252_Q280_N0.7691.00
224_E259_S0.7661.00
8_L12_L0.7661.00
124_R128_L0.7641.00
328_V363_I0.7621.00
208_I285_P0.7621.00
60_E187_V0.7621.00
100_E162_Q0.7611.00
117_N141_T0.7601.00
39_V42_S0.7571.00
320_L330_L0.7571.00
223_K238_T0.7561.00
331_R350_Q0.7551.00
149_A153_V0.7541.00
36_V356_I0.7501.00
224_E238_T0.7481.00
214_Q222_M0.7461.00
324_K331_R0.7441.00
75_R90_Y0.7411.00
320_L328_V0.7361.00
79_E183_S0.7361.00
54_G289_V0.7351.00
66_P90_Y0.7341.00
120_I123_N0.7341.00
242_L254_G0.7331.00
212_L293_V0.7311.00
59_Y275_I0.7311.00
364_R367_I0.7301.00
324_K353_D0.7281.00
345_V349_L0.7281.00
33_T368_K0.7271.00
64_I175_P0.7261.00
145_Q148_E0.7241.00
318_T332_E0.7201.00
237_S255_T0.7191.00
142_A145_Q0.7191.00
107_S155_V0.7141.00
319_A355_V0.7131.00
101_L167_L0.7121.00
165_I169_Y0.7111.00
149_A152_N0.7111.00
72_I199_L0.7101.00
307_E358_S0.7091.00
57_V209_Y0.7071.00
71_I190_L0.7061.00
322_L356_I0.7051.00
48_V296_G0.7031.00
67_Q96_P0.6981.00
95_A165_I0.6961.00
242_L291_A0.6961.00
117_N120_I0.6951.00
104_A107_S0.6891.00
159_A163_A0.6891.00
179_V205_L0.6871.00
60_E186_T0.6851.00
335_A345_V0.6851.00
331_R348_G0.6841.00
33_T370_R0.6831.00
259_S272_L0.6831.00
239_P294_D0.6821.00
50_S218_D0.6801.00
246_N249_R0.6801.00
112_L115_A0.6771.00
59_Y204_R0.6751.00
41_L349_L0.6751.00
336_S348_G0.6731.00
354_R371_A0.6701.00
245_E290_T0.6691.00
61_V203_Q0.6661.00
144_T148_E0.6651.00
65_R195_Q0.6631.00
165_I168_Q0.6601.00
52_L212_L0.6591.00
114_T149_A0.6561.00
100_E104_A0.6551.00
304_V308_G0.6541.00
138_D142_A0.6511.00
50_S295_E0.6511.00
148_E152_N0.6511.00
107_S111_A0.6511.00
13_F17_M0.6481.00
106_G151_A0.6451.00
106_G158_A0.6441.00
57_V61_V0.6401.00
69_G190_L0.6371.00
129_L134_V0.6361.00
52_L218_D0.6361.00
313_A318_T0.6341.00
135_S138_D0.6321.00
13_F16_A0.6301.00
121_T145_Q0.6271.00
308_G357_V0.6261.00
209_Y257_K0.6251.00
342_Q346_T0.6231.00
111_A114_T0.6181.00
134_V138_D0.6171.00
326_D371_A0.6161.00
73_I76_N0.6161.00
77_F81_D0.6141.00
65_R198_S0.6141.00
41_L353_D0.6141.00
320_L363_I0.6121.00
195_Q198_S0.6101.00
305_P308_G0.6101.00
52_L214_Q0.6081.00
302_L348_G0.6061.00
284_L287_M0.6051.00
39_V304_V0.6041.00
257_K273_R0.6011.00
42_S342_Q0.6011.00
129_L132_N0.6011.00
324_K354_R0.6001.00
250_Y280_N0.5991.00
38_V357_V0.5991.00
244_L283_L0.5981.00
104_A163_A0.5961.00
156_A159_A0.5961.00
158_A161_E0.5881.00
19_T22_D0.5871.00
242_L274_A0.5861.00
60_E176_I0.5841.00
96_P166_N0.5841.00
121_T142_A0.5821.00
10_P14_C0.5821.00
83_V89_L0.5811.00
304_V309_V0.5801.00
308_G355_V0.5801.00
120_I144_T0.5801.00
94_P167_L0.5781.00
39_V342_Q0.5781.00
107_S152_N0.5771.00
155_V159_A0.5761.00
185_V189_A0.5761.00
12_L19_T0.5761.00
55_R286_G0.5751.00
11_L18_L0.5751.00
100_E163_A0.5741.00
113_S151_A0.5741.00
213_T264_D0.5741.00
46_V344_V0.5741.00
206_D281_G0.5721.00
46_V337_K0.5711.00
46_V303_L0.5681.00
210_V276_F0.5681.00
319_A348_G0.5661.00
64_I200_V0.5651.00
206_D279_P0.5651.00
270_V287_M0.5641.00
136_R143_R0.5641.00
113_S117_N0.5641.00
52_L293_V0.5611.00
216_V288_Y0.5601.00
118_A145_Q0.5581.00
58_P61_V0.5581.00
62_A202_V0.5571.00
321_I355_V0.5541.00
48_V337_K0.5541.00
125_Q128_L0.5541.00
121_T124_R0.5541.00
147_N151_A0.5521.00
40_T43_P0.5501.00
159_A162_Q0.5491.00
9_I12_L0.5491.00
326_D354_R0.5481.00
208_I276_F0.5481.00
63_E189_A0.5471.00
52_L291_A0.5471.00
54_G210_V0.5431.00
264_D271_T0.5431.00
99_A165_I0.5421.00
15_G21_C0.5421.00
10_P21_C0.5411.00
66_P199_L0.5411.00
153_V156_A0.5381.00
309_V333_I0.5381.00
163_A166_N0.5371.00
39_V43_P0.5361.00
48_V295_E0.5351.00
115_A149_A0.5341.00
166_N169_Y0.5341.00
310_T320_L0.5341.00
168_Q173_T0.5321.00
58_P203_Q0.5301.00
42_S303_L0.5291.00
252_Q283_L0.5291.00
363_I369_A0.5281.00
274_A291_A0.5251.00
263_V267_T0.5251.00
56_T244_L0.5231.00
97_L166_N0.5211.00
125_Q129_L0.5171.00
86_G173_T0.5151.00
203_Q285_P0.5151.00
189_A195_Q0.5151.00
205_L285_P0.5141.00
167_L170_A0.5121.00
119_R122_F0.5111.00
12_L16_A0.5111.00
254_G276_F0.5111.00
96_P100_E0.5101.00
136_R139_Y0.5101.00
303_L344_V0.5101.00
76_N87_D0.5091.00
140_D144_T0.5081.00
253_T277_P0.5081.00
66_P92_I0.5081.00
263_V269_S0.5071.00
212_L272_L0.5071.00
144_T151_A0.5051.00
99_A158_A0.5051.00
9_I13_F0.5051.00
16_A21_C0.5041.00
240_V293_V0.5041.00
43_P350_Q0.5031.00
212_L240_V0.5031.00
64_I176_I0.5031.00
83_V174_S0.5021.00
208_I278_N0.5021.00
322_L325_D0.5021.00
75_R183_S0.5021.00
186_T189_A0.5011.00
309_V335_A0.5011.00
203_Q261_P0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vf7A 5 0.5974 100 0.234 Contact Map
3lnnA 6 0.8545 100 0.24 Contact Map
4dk0A 5 0.7896 100 0.247 Contact Map
3ne5B 3 0.8156 100 0.271 Contact Map
4l8jA 2 0.8156 100 0.275 Contact Map
3fppA 3 0.6442 100 0.275 Contact Map
4kkuA 1 0.6883 100 0.323 Contact Map
2f1mA 2 0.6156 100 0.406 Contact Map
4tkoB 1 0.6052 100 0.48 Contact Map
2k32A 1 0.2987 99.8 0.707 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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