GREMLIN Database
YHIN - Uncharacterized protein YhiN
UniProt: P37631 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12229
Length: 400 (389)
Sequences: 3783 (2833)
Seq/√Len: 143.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
256_N322_T4.9781.00
349_L369_M3.8121.00
182_L356_A3.6851.00
78_T81_D3.4821.00
348_E358_K3.3961.00
304_V313_D3.3031.00
5_D153_E3.2671.00
11_A38_P3.2031.00
157_I368_V2.8921.00
387_A391_A2.8741.00
18_C156_V2.8591.00
350_S355_E2.8451.00
30_L126_R2.6501.00
5_D28_R2.6451.00
183_N348_E2.6391.00
254_S323_D2.6131.00
156_V394_L2.5891.00
173_G368_V2.5651.00
225_R260_D2.4781.00
7_I150_V2.4271.00
91_I113_M2.4141.00
182_L358_K2.3451.00
344_V364_F2.2641.00
43_L111_V2.2631.00
52_F93_W2.1151.00
7_I152_C2.0751.00
117_E120_K2.0681.00
183_N345_D2.0481.00
388_W392_Q2.0401.00
7_I32_I2.0361.00
141_F359_V2.0191.00
213_P223_V1.9931.00
38_P125_F1.9631.00
262_D265_T1.9571.00
84_D88_K1.9471.00
82_F86_V1.9381.00
16_M118_C1.9091.00
14_A365_I1.8911.00
133_S179_Q1.8771.00
34_N130_E1.8471.00
82_F384_W1.8361.00
83_I93_W1.8281.00
91_I110_I1.8251.00
108_Q112_D1.7691.00
21_L391_A1.7621.00
332_E336_T1.7591.00
235_L240_V1.7501.00
190_G341_L1.7461.00
22_A391_A1.7361.00
145_L148_M1.7211.00
7_I143_L1.7061.00
32_I150_V1.7041.00
305_S308_Q1.7021.00
105_D109_Q1.6981.00
158_A365_I1.6891.00
23_G121_G1.6861.00
94_H105_D1.6851.00
195_T330_G1.6721.00
276_N307_K1.6711.00
95_E101_L1.6711.00
21_L24_Q1.6661.00
117_E121_G1.6351.00
24_Q117_E1.6031.00
118_C123_V1.6011.00
174_Y340_T1.5991.00
185_L345_D1.5941.00
76_R389_A1.5931.00
188_R341_L1.5931.00
5_D30_L1.5911.00
81_D84_D1.5751.00
173_G177_A1.5741.00
229_L236_S1.5711.00
52_F86_V1.5681.00
73_A354_M1.5661.00
28_R124_T1.5621.00
27_R394_L1.5571.00
254_S325_R1.5561.00
381_Q385_S1.5551.00
21_L392_Q1.5481.00
157_I364_F1.5391.00
87_N93_W1.5371.00
214_S240_V1.5351.00
134_V155_L1.5331.00
355_E360_P1.5231.00
145_L150_V1.5171.00
38_P127_L1.5151.00
206_V209_G1.5121.00
319_S323_D1.4961.00
36_K128_R1.4891.00
161_G340_T1.4861.00
7_I30_L1.4821.00
152_C155_L1.4791.00
23_G123_V1.4701.00
175_K178_E1.4611.00
165_P335_R1.4601.00
71_K75_A1.4591.00
364_F368_V1.4501.00
89_H117_E1.4481.00
39_G111_V1.4231.00
40_R43_L1.4081.00
126_R150_V1.4041.00
391_A394_L1.3981.00
135_A142_T1.3951.00
38_P115_V1.3901.00
69_F346_T1.3861.00
374_W378_Y1.3851.00
194_F328_P1.3671.00
20_A117_E1.3631.00
195_T332_E1.3551.00
144_D149_T1.3451.00
16_M115_V1.3431.00
56_Y378_Y1.3331.00
76_R392_Q1.3321.00
171_P175_K1.3281.00
278_S281_N1.3141.00
13_A42_I1.3141.00
80_W84_D1.3131.00
83_I101_L1.3091.00
17_F387_A1.2931.00
16_M38_P1.2931.00
73_A389_A1.2921.00
79_Q385_S1.2891.00
36_K40_R1.2861.00
133_S144_D1.2861.00
9_I157_I1.2791.00
107_A111_V1.2781.00
115_V119_E1.2751.00
6_A154_K1.2551.00
172_F176_I1.2411.00
112_D115_V1.2361.00
235_L253_V1.2251.00
157_I177_A1.2251.00
257_L324_W1.2201.00
196_L326_V1.2111.00
30_L124_T1.1991.00
104_D109_Q1.1971.00
166_G335_R1.1951.00
190_G245_S1.1921.00
92_A109_Q1.1891.00
389_A393_D1.1851.00
180_F359_V1.1831.00
94_H104_D1.1801.00
190_G372_T1.1741.00
49_R96_K1.1731.00
21_L387_A1.1711.00
235_L326_V1.1631.00
24_Q121_G1.1611.00
231_T236_S1.1601.00
349_L364_F1.1520.99
6_A156_V1.1510.99
228_L235_L1.1470.99
87_N92_A1.1450.99
215_V223_V1.1440.99
126_R148_M1.1440.99
129_S145_L1.1400.99
136_K359_V1.1400.99
194_F331_T1.1390.99
137_D142_T1.1390.99
21_L388_W1.1370.99
53_T101_L1.1330.99
380_F384_W1.1320.99
212_V239_A1.1240.99
154_K394_L1.1210.99
70_C386_S1.1200.99
52_F110_I1.1200.99
233_R332_E1.1200.99
310_N313_D1.1180.99
20_A121_G1.1170.99
129_S148_M1.1020.99
206_V210_V1.1010.99
245_S372_T1.1000.99
11_A125_F1.1000.99
200_L324_W1.0990.99
134_V176_I1.0990.99
86_V110_I1.0970.99
136_K140_G1.0950.99
213_P225_R1.0940.99
354_M390_C1.0920.99
136_K180_F1.0790.99
13_A380_F1.0720.99
349_L354_M1.0700.99
84_D87_N1.0680.99
240_V253_V1.0670.99
82_F381_Q1.0660.99
32_I126_R1.0640.99
64_S371_V1.0640.99
274_H285_V1.0510.99
263_L319_S1.0480.99
30_L153_E1.0470.99
163_S340_T1.0460.99
344_V368_V1.0460.99
355_E361_G1.0420.99
371_V382_W1.0370.99
35_G40_R1.0340.99
197_H329_N1.0310.99
32_I152_C1.0310.99
178_E186_P1.0260.99
77_F82_F1.0250.99
39_G42_I1.0250.99
5_D27_R1.0140.99
204_L209_G1.0120.99
6_A22_A1.0090.99
118_C125_F1.0050.99
89_H113_M1.0030.99
313_D316_A0.9960.99
198_K327_Q0.9950.99
17_F21_L0.9940.98
69_F351_S0.9920.98
382_W386_S0.9890.98
18_C365_I0.9870.98
25_A392_Q0.9870.98
316_A319_S0.9870.98
43_L108_Q0.9830.98
45_S380_F0.9810.98
182_L348_E0.9770.98
390_C394_L0.9750.98
19_S31_L0.9680.98
224_F242_Q0.9670.98
294_R298_L0.9660.98
16_M39_G0.9650.98
42_I45_S0.9630.98
154_K363_Y0.9630.98
369_M386_S0.9610.98
371_V386_S0.9560.98
6_A27_R0.9530.98
188_R249_P0.9520.98
129_S150_V0.9510.98
112_D116_D0.9420.98
346_T369_M0.9400.98
315_Q319_S0.9390.98
209_G212_V0.9380.98
68_H71_K0.9370.98
86_V114_L0.9370.98
208_A229_L0.9360.98
217_T221_G0.9360.98
187_T340_T0.9360.98
135_A144_D0.9340.98
216_I243_I0.9310.98
136_K139_T0.9260.98
86_V93_W0.9240.98
85_L89_H0.9240.98
6_A394_L0.9230.98
195_T329_N0.9190.97
177_A364_F0.9180.97
116_D119_E0.9170.97
287_L321_L0.9080.97
85_L117_E0.9060.97
248_Q251_E0.9040.97
174_Y187_T0.8980.97
26_G29_V0.8960.97
156_V365_I0.8950.97
31_L118_C0.8940.97
192_V331_T0.8930.97
363_Y393_D0.8920.97
13_A384_W0.8920.97
200_L298_L0.8890.97
345_D348_E0.8890.97
203_E297_Q0.8850.97
32_I129_S0.8830.97
53_T381_Q0.8820.97
74_L78_T0.8820.97
271_R311_V0.8810.97
261_V265_T0.8790.97
11_A33_D0.8730.97
348_E356_A0.8730.97
20_A24_Q0.8710.97
162_L334_Y0.8690.96
157_I176_I0.8660.96
385_S388_W0.8600.96
17_F391_A0.8600.96
66_N346_T0.8570.96
365_I387_A0.8560.96
281_N284_A0.8550.96
49_R105_D0.8530.96
57_V62_Y0.8520.96
115_V125_F0.8520.96
83_I87_N0.8500.96
31_L38_P0.8450.96
142_T149_T0.8420.96
55_L95_E0.8420.96
258_L321_L0.8350.96
162_L187_T0.8350.96
21_L25_A0.8300.95
182_L359_V0.8290.95
33_D127_L0.8240.95
194_F240_V0.8230.95
188_R252_F0.8230.95
64_S70_C0.8200.95
230_F292_V0.8190.95
31_L123_V0.8150.95
261_V269_E0.8150.95
356_A362_L0.8110.95
263_L323_D0.8100.95
277_Q285_V0.8090.95
211_A225_R0.8090.95
96_K100_Q0.8040.95
141_F180_F0.8040.95
267_L314_Q0.8010.94
111_V115_V0.7970.94
155_L361_G0.7960.94
16_M31_L0.7950.94
116_D120_K0.7920.94
52_F101_L0.7920.94
98_L226_E0.7890.94
18_C391_A0.7850.94
9_I368_V0.7840.94
204_L291_L0.7840.94
134_V180_F0.7830.94
132_L144_D0.7830.94
50_C86_V0.7830.94
19_S123_V0.7810.94
229_L238_P0.7800.94
214_S239_A0.7800.94
279_L301_I0.7780.94
338_E375_L0.7760.93
173_G344_V0.7740.93
28_R153_E0.7740.93
34_N172_F0.7720.93
356_A364_F0.7680.93
209_G228_L0.7650.93
66_N69_F0.7650.93
9_I131_V0.7640.93
118_C122_N0.7620.93
266_F287_L0.7620.93
208_A238_P0.7610.93
224_F239_A0.7590.93
299_G320_T0.7550.93
267_L318_I0.7550.93
27_R154_K0.7520.92
194_F247_W0.7490.92
253_V328_P0.7430.92
24_Q88_K0.7420.92
279_L296_Q0.7420.92
22_A29_V0.7410.92
58_E79_Q0.7390.92
279_L309_L0.7390.92
30_L150_V0.7380.92
20_A85_L0.7350.92
137_D140_G0.7350.92
386_S390_C0.7350.92
359_V362_L0.7340.91
292_V296_Q0.7330.91
8_I29_V0.7320.91
70_C382_W0.7310.91
8_I18_C0.7300.91
91_I104_D0.7290.91
256_N259_P0.7290.91
37_K111_V0.7280.91
183_N356_A0.7240.91
218_A251_E0.7220.91
266_F318_I0.7190.91
205_Q232_H0.7180.91
126_R129_S0.7160.90
316_A320_T0.7150.90
19_S118_C0.7120.90
210_V227_N0.7120.90
267_L271_R0.7110.90
215_V254_S0.7100.90
18_C387_A0.7070.90
279_L299_G0.7070.90
249_P341_L0.7070.90
333_G336_T0.7040.90
320_T325_R0.7030.90
304_V308_Q0.7030.90
29_V123_V0.7020.90
192_V337_A0.7020.90
355_E363_Y0.7020.90
184_V187_T0.7000.89
203_E294_R0.6960.89
97_T227_N0.6940.89
40_R166_G0.6930.89
129_S147_G0.6930.89
86_V91_I0.6910.89
245_S341_L0.6890.89
193_P233_R0.6870.89
187_T334_Y0.6870.89
27_R391_A0.6860.88
137_D151_G0.6860.88
52_F91_I0.6840.88
258_L266_F0.6820.88
283_L317_L0.6800.88
17_F77_F0.6800.88
98_L227_N0.6800.88
274_H277_Q0.6790.88
70_C73_A0.6780.88
50_C110_I0.6760.88
33_D125_F0.6750.88
143_L146_N0.6730.88
278_S305_S0.6720.87
10_G15_G0.6710.87
266_F322_T0.6690.87
6_A153_E0.6660.87
275_P282_T0.6660.87
193_P332_E0.6660.87
126_R147_G0.6640.87
271_R306_L0.6640.87
132_L147_G0.6640.87
88_K120_K0.6630.87
17_F388_W0.6620.87
239_A243_I0.6600.87
62_Y378_Y0.6590.86
176_I179_Q0.6590.86
12_G15_G0.6590.86
385_S389_A0.6580.86
195_T233_R0.6580.86
164_M167_L0.6570.86
280_K289_K0.6570.86
142_T151_G0.6550.86
354_M389_A0.6540.86
171_P340_T0.6510.86
311_V314_Q0.6490.86
277_Q282_T0.6490.86
258_L287_L0.6480.86
214_S253_V0.6470.85
76_R388_W0.6450.85
295_L299_G0.6440.85
381_Q384_W0.6420.85
298_L320_T0.6410.85
92_A105_D0.6400.85
350_S357_R0.6400.85
23_G26_G0.6400.85
108_Q111_V0.6330.84
207_L210_V0.6320.84
198_K201_L0.6320.84
365_I369_M0.6310.84
74_L81_D0.6310.84
318_I322_T0.6300.84
259_P322_T0.6300.84
34_N170_S0.6290.84
133_S136_K0.6290.84
132_L142_T0.6280.84
245_S249_P0.6270.84
27_R153_E0.6260.84
17_F85_L0.6250.83
282_T306_L0.6240.83
73_A385_S0.6230.83
130_E146_N0.6230.83
154_K361_G0.6220.83
174_Y177_A0.6170.83
365_I390_C0.6170.83
273_A282_T0.6150.82
31_L121_G0.6150.82
230_F257_L0.6130.82
8_I394_L0.6120.82
5_D152_C0.6120.82
192_V333_G0.6120.82
20_A391_A0.6110.82
229_L241_L0.6100.82
22_A394_L0.6100.82
9_I172_F0.6100.82
218_A221_G0.6080.82
207_L288_P0.6070.82
252_F325_R0.6070.82
174_Y184_V0.6070.82
22_A387_A0.6060.82
270_Q274_H0.6040.81
68_H72_S0.6040.81
225_R239_A0.6040.81
196_L328_P0.6030.81
16_M20_A0.6030.81
255_I326_V0.6020.81
171_P174_Y0.6000.81
69_F72_S0.6000.81
56_Y99_G0.6000.81
18_C394_L0.5980.81
183_N358_K0.5970.81
299_G317_L0.5970.81
200_L326_V0.5970.81
271_R314_Q0.5960.80
347_N357_R0.5960.80
30_L152_C0.5960.80
58_E75_A0.5940.80
134_V141_F0.5920.80
204_L210_V0.5900.80
261_V266_F0.5890.80
44_M167_L0.5880.80
197_H327_Q0.5880.80
47_G50_C0.5860.79
136_K141_F0.5850.79
209_G213_P0.5850.79
44_M166_G0.5820.79
194_F244_S0.5810.79
258_L261_V0.5780.78
206_V211_A0.5780.78
168_G171_P0.5770.78
96_K105_D0.5770.78
44_M47_G0.5760.78
265_T269_E0.5730.78
274_H282_T0.5720.78
135_A149_T0.5720.78
102_F238_P0.5720.78
273_A285_V0.5720.78
97_T226_E0.5720.78
305_S311_V0.5720.78
92_A104_D0.5710.78
69_F73_A0.5700.77
89_H120_K0.5690.77
208_A232_H0.5690.77
264_E315_Q0.5690.77
131_V134_V0.5650.77
263_L322_T0.5640.77
20_A118_C0.5640.77
40_R111_V0.5640.77
206_V218_A0.5620.76
76_R393_D0.5620.76
157_I173_G0.5610.76
77_F85_L0.5600.76
248_Q341_L0.5590.76
58_E61_A0.5590.76
291_L294_R0.5580.76
228_L239_A0.5570.76
269_E272_N0.5570.76
294_R297_Q0.5560.76
287_L292_V0.5550.76
37_K43_L0.5530.75
31_L125_F0.5520.75
268_N271_R0.5520.75
66_N72_S0.5510.75
197_H200_L0.5490.75
59_P71_K0.5480.75
119_E125_F0.5480.75
217_T220_N0.5470.75
75_A352_R0.5450.74
22_A154_K0.5450.74
279_L317_L0.5450.74
9_I159_T0.5430.74
180_F362_L0.5420.74
256_N260_D0.5420.74
32_I143_L0.5410.74
295_L298_L0.5400.74
309_L314_Q0.5400.74
64_S246_Y0.5380.73
339_V373_G0.5370.73
289_K293_E0.5370.73
35_G167_L0.5350.73
173_G176_I0.5350.73
354_M386_S0.5330.73
373_G382_W0.5310.72
296_Q299_G0.5310.72
35_G39_G0.5300.72
270_Q285_V0.5300.72
64_S190_G0.5300.72
217_T254_S0.5300.72
55_L80_W0.5290.72
229_L232_H0.5280.72
37_K108_Q0.5280.72
209_G257_L0.5260.72
192_V330_G0.5250.72
175_K179_Q0.5250.72
107_A166_G0.5240.71
35_G45_S0.5240.71
55_L79_Q0.5210.71
228_L240_V0.5210.71
72_S76_R0.5180.71
182_L349_L0.5170.70
311_V315_Q0.5170.70
27_R390_C0.5160.70
55_L83_I0.5150.70
280_K293_E0.5140.70
11_A39_G0.5120.70
193_P241_L0.5120.70
67_P71_K0.5120.70
186_P248_Q0.5120.70
72_S351_S0.5120.70
47_G338_E0.5110.70
214_S255_I0.5110.70
154_K355_E0.5100.69
367_E379_N0.5090.69
18_C390_C0.5080.69
350_S353_T0.5070.69
167_L170_S0.5070.69
121_G391_A0.5070.69
109_Q112_D0.5060.69
288_P291_L0.5050.69
268_N272_N0.5050.69
212_V216_I0.5040.68
141_F144_D0.5040.68
277_Q284_A0.5030.68
32_I145_L0.5030.68
283_L292_V0.5020.68
136_K360_P0.5020.68
40_R167_L0.5000.68
232_H238_P0.5000.68
206_V213_P0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3v76A 2 0.9675 100 0.358 Contact Map
2i0zA 1 0.985 100 0.435 Contact Map
4cnkA 2 0.97 100 0.444 Contact Map
2gqfA 4 0.9825 100 0.491 Contact Map
3cesA 2 0.8025 100 0.707 Contact Map
3nlcA 1 0.945 100 0.715 Contact Map
4at0A 2 0.935 100 0.738 Contact Map
2wdqA 1 0.88 100 0.77 Contact Map
3cp8A 2 0.8325 100 0.771 Contact Map
1kf6A 1 0.9 100 0.771 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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