GREMLIN Database
YHII - Uncharacterized protein YhiI
UniProt: P37626 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12224
Length: 355 (307)
Sequences: 16106 (12789)
Seq/√Len: 729.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
60_T77_K3.3311.00
70_R219_D3.2991.00
74_V213_E2.8791.00
282_A313_A2.6711.00
285_S314_R2.6641.00
133_A137_T2.5261.00
267_E281_P2.4841.00
157_R161_E2.4101.00
140_R157_R2.3771.00
91_I206_A2.3731.00
62_L77_K2.3011.00
139_S148_I2.2701.00
77_K213_E2.2441.00
70_R73_E2.2101.00
80_T84_Q2.1731.00
140_R144_Q2.1301.00
126_Q171_K2.1161.00
139_S156_D2.1151.00
74_V215_K2.1061.00
44_E251_T2.0311.00
98_Q199_Q2.0271.00
87_R202_E2.0051.00
160_A164_R1.9941.00
283_T316_P1.9741.00
133_A164_R1.9571.00
71_E219_D1.9371.00
269_R279_R1.9301.00
53_K211_D1.9161.00
136_H153_L1.8531.00
152_Q155_D1.8461.00
87_R206_A1.8421.00
143_A150_A1.8331.00
129_L160_A1.8251.00
251_T310_R1.8021.00
68_F221_R1.8001.00
267_E283_T1.7891.00
62_L74_V1.7801.00
249_Y312_K1.7711.00
196_E199_Q1.7701.00
133_A160_A1.7651.00
143_A153_L1.7521.00
283_T314_R1.7241.00
269_R281_P1.7221.00
268_A313_A1.7151.00
131_S135_R1.7031.00
126_Q167_L1.6881.00
136_H140_R1.6711.00
168_E171_K1.6681.00
167_L171_K1.6441.00
223_Q243_V1.6361.00
88_L91_I1.6271.00
136_H160_A1.6251.00
43_I250_M1.6241.00
129_L133_A1.6141.00
94_I202_E1.6051.00
286_F312_K1.5961.00
87_R91_I1.5961.00
150_A154_D1.5871.00
119_Q174_V1.5831.00
94_I98_Q1.5781.00
119_Q178_K1.5501.00
84_Q88_L1.5451.00
250_M333_G1.5421.00
58_I227_A1.5321.00
84_Q209_I1.5301.00
95_K98_Q1.5271.00
94_I195_V1.5191.00
122_V174_V1.5101.00
91_I202_E1.5081.00
252_F335_A1.5051.00
21_I25_W1.4991.00
123_N126_Q1.4931.00
89_E201_T1.4811.00
136_H157_R1.4781.00
129_L164_R1.4771.00
64_K67_K1.4661.00
23_A27_L1.4581.00
164_R168_E1.4581.00
122_V167_L1.4571.00
203_R206_A1.4561.00
56_G78_M1.4451.00
101_V192_Q1.4451.00
234_A237_G1.4411.00
76_A214_L1.4371.00
24_W27_L1.4301.00
86_Q204_R1.4291.00
153_L157_R1.4261.00
94_I199_Q1.4041.00
155_D159_A1.4041.00
252_F313_A1.3961.00
58_I76_A1.3951.00
68_F245_L1.3861.00
105_Q192_Q1.3791.00
189_I192_Q1.3741.00
130_D134_K1.3651.00
122_V171_K1.3601.00
159_A162_S1.3591.00
129_L167_L1.3591.00
116_R119_Q1.3561.00
86_Q89_E1.3541.00
206_A210_D1.3411.00
75_L240_L1.3391.00
175_S178_K1.3191.00
101_V195_V1.3171.00
291_A309_F1.3111.00
216_A242_M1.3071.00
207_A211_D1.3051.00
204_R208_D1.3001.00
59_D79_D1.2901.00
87_R209_I1.2811.00
138_R154_D1.2761.00
141_S145_R1.2681.00
60_T229_P1.2591.00
135_R155_D1.2511.00
126_Q130_D1.2501.00
74_V77_K1.2401.00
199_Q203_R1.2371.00
105_Q188_I1.2351.00
161_E164_R1.2301.00
59_D77_K1.2291.00
202_E206_A1.2261.00
102_A105_Q1.2191.00
254_L262_L1.2061.00
222_V240_L1.2041.00
115_T178_K1.1981.00
281_P316_P1.1931.00
269_R338_R1.1851.00
86_Q208_D1.1821.00
83_L212_S1.1781.00
254_L311_V1.1781.00
137_T141_S1.1771.00
220_G242_M1.1651.00
93_Q197_A1.1601.00
132_V163_A1.1551.00
128_E162_S1.1511.00
67_K73_E1.1501.00
262_L284_I1.1461.00
101_V105_Q1.1461.00
98_Q195_V1.1451.00
122_V126_Q1.1381.00
100_A194_R1.1361.00
140_R153_L1.1351.00
124_Q166_A1.1341.00
125_R163_A1.1331.00
137_T140_R1.1301.00
151_Q155_D1.1151.00
49_D238_R1.1131.00
80_T212_S1.1011.00
135_R151_Q1.0991.00
233_L239_V1.0961.00
162_S166_A1.0941.00
96_E194_R1.0941.00
251_T312_K1.0911.00
174_V178_K1.0881.00
272_L333_G1.0841.00
262_L337_V1.0751.00
278_L326_Y1.0701.00
195_V199_Q1.0691.00
154_D157_R1.0501.00
61_I229_P1.0441.00
22_V26_L1.0381.00
88_L203_R1.0371.00
47_E241_N1.0361.00
52_S214_L1.0341.00
89_E93_Q1.0301.00
96_E100_A1.0211.00
64_K225_R1.0121.00
166_A169_S1.0071.00
63_V73_E1.0071.00
48_V218_R1.0021.00
269_R336_W1.0001.00
224_Y241_N0.9951.00
255_P258_Q0.9921.00
284_I311_V0.9891.00
194_R197_A0.9891.00
90_A198_A0.9851.00
270_L315_I0.9711.00
141_S144_Q0.9691.00
76_A239_V0.9671.00
65_E224_Y0.9631.00
216_A219_D0.9601.00
263_K266_G0.9591.00
130_D133_A0.9591.00
20_A24_W0.9521.00
244_D247_D0.9461.00
103_A187_N0.9441.00
134_K154_D0.9401.00
55_A235_A0.9381.00
188_I192_Q0.9361.00
201_T204_R0.9291.00
254_L337_V0.9271.00
121_L173_Q0.9261.00
49_D241_N0.9171.00
125_R128_E0.9131.00
119_Q123_N0.9101.00
91_I95_K0.9091.00
172_A175_S0.9011.00
68_F219_D0.8991.00
92_A200_A0.8981.00
159_A163_A0.8961.00
24_W28_R0.8921.00
225_R228_E0.8891.00
271_I279_R0.8871.00
271_I336_W0.8861.00
61_I76_A0.8831.00
125_R170_A0.8811.00
100_A103_A0.8791.00
128_E131_S0.8761.00
43_I327_V0.8681.00
270_L333_G0.8651.00
69_V75_L0.8631.00
41_G333_G0.8611.00
93_Q96_E0.8591.00
98_Q102_A0.8521.00
270_L282_A0.8521.00
97_A100_A0.8501.00
338_R341_E0.8471.00
124_Q128_E0.8421.00
250_M335_A0.8391.00
143_A148_I0.8341.00
114_E176_A0.8341.00
173_Q176_A0.8331.00
63_V240_L0.8321.00
253_F308_M0.8311.00
59_D62_L0.8301.00
52_S233_L0.8281.00
207_A210_D0.8281.00
134_K137_T0.8281.00
169_S173_Q0.8241.00
253_F310_R0.8201.00
194_R198_A0.8201.00
187_N190_Q0.8161.00
87_R205_I0.8161.00
85_E207_A0.8151.00
250_M270_L0.8151.00
288_A310_R0.8091.00
93_Q97_A0.8091.00
197_A201_T0.8071.00
130_D161_E0.8041.00
225_R240_L0.8041.00
16_L20_A0.7991.00
190_Q194_R0.7961.00
121_L169_S0.7951.00
63_V222_V0.7951.00
93_Q201_T0.7931.00
128_E159_A0.7921.00
139_S152_Q0.7921.00
115_T174_V0.7891.00
139_S151_Q0.7881.00
249_Y285_S0.7871.00
95_K196_E0.7861.00
121_L124_Q0.7841.00
81_R207_A0.7841.00
170_A173_Q0.7811.00
192_Q196_E0.7811.00
148_I152_Q0.7781.00
45_A329_T0.7781.00
57_R232_V0.7781.00
93_Q194_R0.7751.00
156_D159_A0.7741.00
76_A240_L0.7731.00
90_A205_I0.7671.00
210_D215_K0.7641.00
264_L287_V0.7641.00
35_G340_N0.7611.00
171_K175_S0.7601.00
210_D213_E0.7561.00
53_K57_R0.7531.00
39_S252_F0.7531.00
163_A166_A0.7521.00
9_A12_V0.7521.00
22_V25_W0.7501.00
90_A202_E0.7501.00
77_K80_T0.7471.00
46_T244_D0.7451.00
226_V241_N0.7441.00
12_V16_L0.7421.00
132_V159_A0.7391.00
71_E217_P0.7381.00
43_I248_V0.7381.00
205_I208_D0.7311.00
80_T213_E0.7301.00
98_Q101_V0.7291.00
128_E166_A0.7261.00
268_A282_A0.7241.00
86_Q205_I0.7241.00
274_A331_L0.7231.00
166_A170_A0.7221.00
83_L87_R0.7191.00
271_I277_D0.7161.00
271_I334_V0.7151.00
50_I240_L0.7151.00
58_I233_L0.7151.00
38_V334_V0.7131.00
309_F331_L0.7121.00
90_A93_Q0.7101.00
131_S158_A0.7091.00
59_D80_T0.7091.00
128_E132_V0.7091.00
9_A13_V0.7071.00
198_A201_T0.7051.00
34_E341_E0.7031.00
117_A173_Q0.7011.00
52_S239_V0.7001.00
84_Q87_R0.6941.00
247_D314_R0.6921.00
115_T119_Q0.6891.00
218_R242_M0.6881.00
200_A203_R0.6841.00
267_E338_R0.6831.00
55_A232_V0.6831.00
132_V156_D0.6821.00
53_K82_V0.6821.00
55_A234_A0.6811.00
97_A191_A0.6781.00
62_L73_E0.6761.00
90_A94_I0.6761.00
157_R160_A0.6751.00
272_L275_A0.6741.00
103_A106_A0.6721.00
54_I208_D0.6711.00
163_A167_L0.6711.00
158_A162_S0.6701.00
114_E117_A0.6681.00
228_E231_E0.6671.00
121_L125_R0.6641.00
115_T177_S0.6621.00
131_S134_K0.6621.00
152_Q156_D0.6591.00
275_A280_I0.6591.00
284_I313_A0.6541.00
85_E200_A0.6541.00
82_V208_D0.6531.00
38_V336_W0.6511.00
285_S312_K0.6501.00
198_A202_E0.6501.00
252_F311_V0.6471.00
131_S155_D0.6421.00
140_R143_A0.6421.00
86_Q90_A0.6421.00
135_R139_S0.6411.00
270_L313_A0.6391.00
117_A121_L0.6381.00
149_S152_Q0.6331.00
317_P325_E0.6311.00
191_A194_R0.6311.00
50_I217_P0.6301.00
57_R79_D0.6301.00
25_W29_P0.6281.00
36_F336_W0.6271.00
301_S304_R0.6261.00
25_W28_R0.6221.00
318_E324_L0.6201.00
58_I61_I0.6181.00
259_A309_F0.6171.00
264_L285_S0.6121.00
168_E172_A0.6111.00
82_V86_Q0.6111.00
291_A307_L0.6101.00
100_A104_A0.6101.00
313_A335_A0.6091.00
214_L239_V0.6071.00
89_E204_R0.6041.00
150_A153_L0.6041.00
21_I24_W0.6011.00
83_L205_I0.6011.00
256_T332_P0.6001.00
249_Y314_R0.6001.00
125_R167_L0.5981.00
97_A198_A0.5961.00
165_A168_E0.5961.00
266_G339_V0.5961.00
226_V238_R0.5951.00
151_Q154_D0.5941.00
46_T228_E0.5941.00
208_D211_D0.5941.00
125_R166_A0.5931.00
126_Q129_L0.5931.00
29_P33_P0.5921.00
97_A101_V0.5911.00
118_A170_A0.5891.00
19_A23_A0.5881.00
148_I153_L0.5871.00
10_W14_G0.5861.00
118_A177_S0.5841.00
65_E312_K0.5811.00
85_E88_L0.5801.00
265_G283_T0.5801.00
48_V242_M0.5781.00
221_R245_L0.5771.00
63_V67_K0.5761.00
187_N191_A0.5751.00
114_E118_A0.5751.00
52_S55_A0.5731.00
65_E225_R0.5711.00
123_N127_A0.5701.00
128_E163_A0.5691.00
120_S123_N0.5691.00
204_R207_A0.5691.00
175_S179_A0.5691.00
193_T196_E0.5681.00
127_A130_D0.5651.00
170_A174_V0.5641.00
121_L170_A0.5631.00
281_P317_P0.5621.00
87_R90_A0.5581.00
80_T209_I0.5531.00
135_R156_D0.5521.00
270_L335_A0.5491.00
205_I209_I0.5481.00
51_A232_V0.5481.00
39_S337_V0.5471.00
134_K150_A0.5451.00
248_V329_T0.5431.00
63_V225_R0.5411.00
238_R241_N0.5411.00
17_A21_I0.5401.00
199_Q202_E0.5401.00
127_A131_S0.5391.00
83_L208_D0.5361.00
93_Q198_A0.5361.00
90_A201_T0.5351.00
92_A193_T0.5341.00
164_R167_L0.5321.00
52_S76_A0.5311.00
101_V191_A0.5301.00
49_D231_E0.5301.00
118_A121_L0.5281.00
275_A331_L0.5271.00
99_S193_T0.5241.00
91_I94_I0.5241.00
173_Q177_S0.5211.00
203_R207_A0.5211.00
114_E177_S0.5201.00
104_A191_A0.5181.00
100_A190_Q0.5181.00
23_A26_L0.5181.00
171_K174_V0.5161.00
243_V329_T0.5151.00
15_L19_A0.5151.00
122_V170_A0.5141.00
62_L213_E0.5141.00
99_S102_A0.5131.00
121_L166_A0.5111.00
97_A194_R0.5111.00
131_S154_D0.5111.00
72_G215_K0.5101.00
189_I193_T0.5091.00
328_K331_L0.5091.00
191_A195_V0.5081.00
54_I212_S0.5081.00
146_G150_A0.5081.00
83_L209_I0.5081.00
18_V21_I0.5071.00
129_L163_A0.5061.00
268_A335_A0.5051.00
13_V17_A0.5051.00
81_R210_D0.5041.00
26_L29_P0.5010.99
254_L335_A0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tkoB 1 0.8141 100 0.285 Contact Map
4dk0A 5 0.7803 100 0.36 Contact Map
3fppA 3 0.7408 100 0.361 Contact Map
2f1mA 2 0.6535 100 0.384 Contact Map
3lnnA 6 0.7718 100 0.404 Contact Map
4l8jA 2 0.7099 100 0.427 Contact Map
1vf7A 5 0.6338 100 0.427 Contact Map
3ne5B 3 0.6451 100 0.446 Contact Map
4kkuA 1 0.5408 100 0.507 Contact Map
2k32A 1 0.3239 99.8 0.669 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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