GREMLIN Database
ACPT - 4'-phosphopantetheinyl transferase AcpT
UniProt: P37623 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12221
Length: 195 (167)
Sequences: 1950 (1656)
Seq/√Len: 128.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
110_S154_D3.0431.00
27_Q30_R2.9061.00
79_A90_C2.8991.00
68_W87_E2.8951.00
81_L88_V2.8431.00
135_R155_S2.6661.00
142_Q161_L2.5371.00
58_K68_W2.4691.00
52_I60_A2.4191.00
18_P38_R2.4171.00
79_A173_L2.2951.00
112_G154_D2.1691.00
113_E136_K2.1591.00
140_V150_I2.1461.00
22_R34_W2.0501.00
135_R163_V2.0281.00
25_A30_R1.9431.00
22_R35_L1.9411.00
93_E134_T1.9341.00
30_R33_R1.8901.00
105_A114_H1.8851.00
11_T23_E1.8661.00
44_T80_L1.8401.00
45_L69_F1.8211.00
140_V145_G1.7941.00
81_L90_C1.7851.00
34_W38_R1.7841.00
105_A108_V1.7131.00
18_P34_W1.6991.00
44_T82_L1.6851.00
120_V128_M1.6831.00
74_S93_E1.6351.00
147_A150_I1.6211.00
122_P125_Q1.6151.00
140_V148_W1.6151.00
29_P33_R1.6061.00
21_L34_W1.6021.00
58_K87_E1.5781.00
126_L130_W1.5701.00
33_R76_D1.5361.00
116_E132_I1.5101.00
49_P52_I1.5011.00
135_R165_H1.4981.00
52_I62_A1.4891.00
20_G24_Q1.4781.00
40_L78_I1.4561.00
106_N114_H1.4491.00
131_R165_H1.4131.00
166_C173_L1.4071.00
134_T174_A1.3561.00
116_E128_M1.3461.00
165_H174_A1.3291.00
75_G94_V1.3071.00
81_L175_I1.2941.00
18_P42_S1.2841.00
145_G148_W1.2801.00
140_V147_A1.2781.00
139_I143_R1.2491.00
72_S79_A1.2281.00
50_E62_A1.2200.99
40_L80_L1.2020.99
16_P19_P1.2000.99
37_G78_I1.2000.99
95_I130_W1.1900.99
16_P20_G1.1820.99
58_K70_N1.1630.99
14_A18_P1.1560.99
140_V153_V1.1560.99
117_M120_V1.1500.99
138_A176_C1.1380.99
28_G32_E1.1310.99
26_P30_R1.1130.99
21_L53_Y1.1120.99
38_R42_S1.1070.99
41_L71_L1.1020.99
124_Q127_E1.0990.99
132_I155_S1.0800.99
96_R130_W1.0780.99
128_M131_R1.0680.99
46_S49_P1.0650.99
14_A34_W1.0630.99
135_R174_A1.0560.99
71_L80_L1.0550.99
38_R71_L1.0460.98
11_T19_P1.0360.98
15_A18_P1.0350.98
58_K69_F1.0340.98
42_S45_L1.0210.98
49_P61_F1.0200.98
28_G31_R1.0130.98
127_E172_S0.9960.98
140_V146_S0.9920.98
73_H92_I0.9910.98
37_G71_L0.9870.98
77_D92_I0.9820.98
161_L168_L0.9750.98
168_L173_L0.9610.97
83_S88_V0.9550.97
131_R172_S0.9490.97
36_A78_I0.9430.97
148_W152_S0.9370.97
139_I142_Q0.9360.97
54_G60_A0.9350.97
155_S163_V0.9300.97
19_P23_E0.9260.97
128_M132_I0.9250.97
69_F80_L0.9220.96
34_W37_G0.9020.96
15_A42_S0.9020.96
38_R41_L0.9000.96
148_W153_V0.8960.96
29_P75_G0.8840.96
117_M132_I0.8810.95
109_F153_V0.8760.95
104_L109_F0.8730.95
117_M128_M0.8510.95
83_S86_G0.8470.94
22_R25_A0.8390.94
40_L79_A0.8370.94
11_T22_R0.8360.94
111_L115_A0.8230.93
114_H118_D0.8230.93
161_L176_C0.8090.93
30_R78_I0.8090.93
19_P27_Q0.8000.93
91_D137_E0.8000.93
13_S43_H0.7980.92
74_S134_T0.7980.92
48_L51_I0.7960.92
102_R125_Q0.7900.92
74_S171_L0.7750.91
41_L80_L0.7720.91
102_R105_A0.7710.91
104_L108_V0.7560.90
18_P21_L0.7460.90
134_T140_V0.7450.90
72_S92_I0.7410.89
68_W83_S0.7400.89
15_A38_R0.7300.89
74_S94_V0.7260.88
102_R117_M0.7250.88
21_L31_R0.7240.88
41_L45_L0.7120.87
149_Q153_V0.7090.87
75_G171_L0.7070.87
111_L151_V0.6960.86
57_G144_G0.6930.86
139_I146_S0.6930.86
156_T159_S0.6910.86
33_R75_G0.6910.86
59_P138_A0.6900.86
143_R148_W0.6900.86
69_F129_F0.6860.85
68_W85_E0.6770.85
104_L140_V0.6650.84
106_N118_D0.6620.83
20_G23_E0.6610.83
41_L69_F0.6590.83
130_W172_S0.6540.83
101_W126_L0.6530.82
139_I176_C0.6520.82
42_S49_P0.6520.82
38_R138_A0.6500.82
173_L177_T0.6460.82
149_Q152_S0.6430.82
30_R34_W0.6400.81
104_L129_F0.6400.81
14_A38_R0.6400.81
58_K144_G0.6350.81
10_S13_S0.6300.80
121_H125_Q0.6290.80
106_N159_S0.6290.80
142_Q176_C0.6290.80
54_G87_E0.6270.80
105_A117_M0.6250.80
72_S90_C0.6250.80
93_E105_A0.6240.80
135_R138_A0.6180.79
97_P126_L0.6130.78
49_P53_Y0.6130.78
95_I127_E0.6110.78
41_L74_S0.6100.78
44_T71_L0.6040.77
135_R156_T0.6040.77
14_A22_R0.6030.77
93_E96_R0.6020.77
41_L61_F0.6000.77
110_S136_K0.5970.77
124_Q162_S0.5930.76
108_V114_H0.5930.76
26_P37_G0.5920.76
70_N146_S0.5900.76
45_L70_N0.5860.75
120_V124_Q0.5840.75
103_W107_A0.5800.74
30_R98_R0.5790.74
29_P32_E0.5790.74
76_D171_L0.5780.74
33_R37_G0.5770.74
23_E31_R0.5770.74
121_H124_Q0.5730.74
29_P46_S0.5710.73
143_R146_S0.5710.73
109_F139_I0.5680.73
33_R36_A0.5610.72
163_V168_L0.5610.72
94_V130_W0.5600.72
11_T35_L0.5600.72
68_W86_G0.5540.71
139_I155_S0.5530.71
101_W108_V0.5520.71
165_H172_S0.5520.71
165_H168_L0.5510.71
162_S177_T0.5500.71
10_S35_L0.5490.70
40_L43_H0.5480.70
15_A34_W0.5440.70
135_R154_D0.5420.69
25_A34_W0.5410.69
109_F150_I0.5390.69
134_T165_H0.5370.69
132_I135_R0.5370.69
38_R53_Y0.5360.69
135_R139_I0.5360.69
10_S39_A0.5340.68
108_V150_I0.5320.68
162_S166_C0.5290.68
78_I132_I0.5290.68
131_R135_R0.5280.67
135_R173_L0.5280.67
110_S117_M0.5230.67
139_I144_G0.5230.67
66_P134_T0.5220.67
89_G141_K0.5200.66
93_E108_V0.5190.66
74_S97_P0.5140.65
73_H138_A0.5110.65
45_L82_L0.5100.65
139_I163_V0.5100.65
115_A119_A0.5090.65
166_C171_L0.5090.65
83_S177_T0.5080.65
109_F114_H0.5070.64
88_V92_I0.5070.64
119_A125_Q0.5030.64
14_A28_G0.5020.64
51_I61_F0.5010.63
49_P136_K0.5010.63
108_V153_V0.5000.63
59_P69_F0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1qr0A 2 0.9846 100 0.3 Contact Map
2c43A 1 0.9846 100 0.318 Contact Map
4qvhA 2 0.8821 100 0.441 Contact Map
4qjkA 1 0.8974 100 0.455 Contact Map
4jm7A 3 0.5795 99.9 0.585 Contact Map
1fthA 3 0.5026 99.6 0.686 Contact Map
3hykA 3 0.5128 99.6 0.686 Contact Map
2wasA 3 0.4769 99.5 0.693 Contact Map
1f7lA 3 0.4974 99.5 0.696 Contact Map
5cxdA 3 0.5282 99.5 0.702 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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