GREMLIN Database
YHHS - UPF0226 protein YhhS
UniProt: P37621 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12219
Length: 405 (363)
Sequences: 169827 (121598)
Seq/√Len: 6382.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
104_G116_L3.9181.00
82_P141_G3.8951.00
99_G120_G3.8081.00
92_G127_G3.6081.00
101_L184_L3.2091.00
65_A122_V3.1591.00
96_S120_G2.9391.00
73_A130_F2.9171.00
143_V151_V2.8421.00
89_G130_F2.8131.00
78_D339_G2.7551.00
114_L118_C2.7331.00
113_S116_L2.7331.00
115_L119_L2.7081.00
333_V341_A2.6491.00
94_F190_A2.6451.00
96_S127_G2.5791.00
214_R218_G2.4831.00
149_G276_N2.4401.00
147_H150_R2.3951.00
51_S54_W2.3901.00
83_K87_V2.3271.00
232_A356_T2.3261.00
263_A312_L2.3021.00
290_V317_G2.2621.00
297_L310_G2.2471.00
280_G331_K2.2251.00
69_S126_I2.2141.00
144_G147_H2.2091.00
96_S123_I2.2061.00
228_A352_S2.1901.00
54_W114_L2.1841.00
77_A134_G2.0951.00
374_L378_G2.0581.00
23_V158_V2.0381.00
334_P337_N2.0361.00
305_W309_I2.0021.00
103_A116_L1.9941.00
177_G181_A1.9641.00
267_T316_A1.9081.00
103_A120_G1.8811.00
81_G84_K1.8641.00
98_L187_M1.8511.00
273_N277_R1.8341.00
299_G374_L1.7931.00
94_F194_I1.7501.00
279_G282_N1.7321.00
96_S124_L1.7291.00
212_P215_A1.6991.00
101_L187_M1.6951.00
58_V117_L1.6901.00
65_A69_S1.6891.00
75_R79_S1.6821.00
61_L118_C1.6751.00
303_M306_M1.6601.00
100_Y120_G1.6481.00
69_S72_H1.6481.00
61_L122_V1.6301.00
74_G78_D1.6251.00
69_S129_S1.6161.00
294_G317_G1.6161.00
104_G113_S1.6101.00
299_G377_A1.6071.00
184_L188_G1.5981.00
287_C320_L1.5921.00
236_V360_A1.5911.00
224_G348_F1.5841.00
294_G310_G1.5791.00
50_F54_W1.5771.00
50_F114_L1.5731.00
371_V374_L1.5461.00
292_I384_L1.5371.00
172_V176_W1.5371.00
211_L214_R1.5201.00
87_V194_I1.5111.00
385_L389_R1.5111.00
271_F320_L1.5101.00
292_I381_A1.4931.00
362_L366_W1.4911.00
115_L118_C1.4581.00
260_F315_G1.4581.00
72_H75_R1.4401.00
181_A184_L1.4381.00
116_L120_G1.4121.00
150_R276_N1.4051.00
84_K88_F1.4021.00
305_W308_K1.3991.00
84_K87_V1.3921.00
278_I281_L1.3821.00
272_P276_N1.3711.00
285_M384_L1.3691.00
91_C194_I1.3661.00
94_F187_M1.3571.00
214_R217_L1.3531.00
77_A82_P1.3511.00
89_G127_G1.3481.00
76_Y85_I1.3461.00
263_A267_T1.3381.00
80_L85_I1.3261.00
367_A371_V1.3251.00
371_V375_A1.3241.00
140_V148_I1.3191.00
178_G181_A1.3191.00
168_P258_T1.3151.00
195_L199_P1.3121.00
141_G338_Q1.3081.00
30_Y159_T1.3031.00
76_Y80_L1.3011.00
270_L273_N1.3011.00
296_L300_V1.3001.00
78_D340_A1.2901.00
233_G380_V1.2831.00
145_S148_I1.2761.00
52_A365_S1.2591.00
215_A218_G1.2491.00
64_F354_G1.2461.00
235_G353_L1.2411.00
94_F191_L1.2361.00
88_F92_G1.2331.00
289_S384_L1.2331.00
100_Y117_L1.2251.00
92_G96_S1.2221.00
274_G278_I1.2171.00
267_T270_L1.2151.00
244_F248_K1.2011.00
285_M388_W1.1991.00
282_N285_M1.1931.00
278_I282_N1.1911.00
255_F259_L1.1831.00
281_L285_M1.1831.00
286_I290_V1.1771.00
370_P374_L1.1761.00
98_L102_T1.1671.00
273_N276_N1.1651.00
60_S358_P1.1551.00
352_S356_T1.1521.00
378_G382_I1.1511.00
304_P308_K1.1421.00
195_L198_I1.1381.00
337_N340_A1.1361.00
90_L194_I1.1351.00
80_L84_K1.1301.00
148_I331_K1.1201.00
139_G155_N1.1191.00
294_G313_L1.1181.00
363_V367_A1.1151.00
32_T35_L1.1111.00
83_K202_T1.1101.00
215_A337_N1.1101.00
220_V224_G1.1071.00
168_P172_V1.1041.00
296_L377_A1.1041.00
201_P204_K1.1011.00
374_L377_A1.1001.00
54_W118_C1.0991.00
269_L273_N1.0991.00
53_F57_L1.0931.00
294_G314_A1.0891.00
309_I312_L1.0861.00
25_F131_A1.0811.00
173_F181_A1.0731.00
99_G102_T1.0701.00
67_L354_G1.0641.00
81_G85_I1.0641.00
93_C127_G1.0631.00
87_V197_A1.0611.00
279_G283_V1.0581.00
291_E380_V1.0521.00
361_G365_S1.0471.00
205_A210_P1.0421.00
292_I296_L1.0381.00
196_L199_P1.0381.00
289_S293_I1.0351.00
264_F319_S1.0341.00
57_L358_P1.0321.00
288_F383_A1.0311.00
60_S354_G1.0301.00
329_A345_Y1.0271.00
150_R154_W1.0271.00
40_L55_A1.0261.00
266_G269_L1.0241.00
287_C321_V1.0231.00
245_Y250_W1.0211.00
381_A385_L1.0191.00
18_R142_V1.0161.00
246_D253_A1.0161.00
65_A125_G1.0141.00
221_W225_M1.0091.00
87_V198_I1.0041.00
119_L123_I0.9991.00
71_P75_R0.9961.00
31_L166_G0.9961.00
84_K202_T0.9931.00
62_Q125_G0.9921.00
335_Q338_Q0.9901.00
188_G192_V0.9881.00
95_L99_G0.9801.00
375_A379_L0.9781.00
82_P137_L0.9751.00
99_G116_L0.9731.00
53_F365_S0.9631.00
67_L347_V0.9581.00
287_C317_G0.9581.00
121_R125_G0.9561.00
62_Q128_Q0.9561.00
57_L61_L0.9501.00
278_I283_V0.9451.00
78_D82_P0.9441.00
47_V180_Q0.9441.00
226_A387_T0.9331.00
21_S196_L0.9321.00
81_G202_T0.9271.00
285_M289_S0.9241.00
85_I88_F0.9231.00
191_L195_L0.9221.00
297_L300_V0.9161.00
309_I313_L0.9111.00
290_V294_G0.9071.00
243_L247_A0.9041.00
375_A378_G0.9031.00
56_G240_F0.9021.00
116_L119_L0.9011.00
140_V338_Q0.8981.00
292_I380_V0.8971.00
56_G60_S0.8961.00
45_H52_A0.8951.00
292_I377_A0.8951.00
102_T184_L0.8931.00
42_G47_V0.8911.00
301_A310_G0.8901.00
377_A381_A0.8881.00
27_F162_A0.8831.00
266_G270_L0.8831.00
61_L65_A0.8821.00
101_L180_Q0.8821.00
54_W57_L0.8821.00
217_L221_W0.8801.00
82_P202_T0.8781.00
74_G339_G0.8761.00
231_S349_M0.8761.00
262_C266_G0.8761.00
306_M309_I0.8721.00
295_L299_G0.8691.00
173_F177_G0.8631.00
211_L215_A0.8631.00
143_V147_H0.8631.00
263_A266_G0.8611.00
288_F384_L0.8601.00
245_Y248_K0.8581.00
138_W200_R0.8571.00
285_M288_F0.8561.00
88_F91_C0.8551.00
227_L345_Y0.8531.00
87_V91_C0.8501.00
160_Y264_F0.8501.00
197_A200_R0.8481.00
19_I143_V0.8461.00
286_I289_S0.8421.00
282_N286_I0.8401.00
104_G180_Q0.8401.00
184_L187_M0.8301.00
294_G297_L0.8281.00
39_V174_Y0.8271.00
58_V118_C0.8231.00
70_R346_T0.8191.00
330_V342_L0.8191.00
181_A185_I0.8151.00
258_T262_C0.8151.00
93_C190_A0.8151.00
275_I324_A0.8111.00
150_R273_N0.8051.00
301_A306_M0.8031.00
97_G186_I0.8031.00
320_L324_A0.8031.00
152_I327_V0.8021.00
323_P327_V0.8011.00
386_L390_L0.7981.00
362_L365_S0.7941.00
188_G191_L0.7931.00
97_G124_L0.7911.00
213_F217_L0.7901.00
313_L317_G0.7901.00
103_A113_S0.7901.00
39_V43_Y0.7891.00
69_S73_A0.7881.00
24_M193_A0.7881.00
380_V384_L0.7881.00
42_G46_D0.7861.00
86_V138_W0.7811.00
308_K312_L0.7811.00
171_V254_A0.7811.00
75_R340_A0.7781.00
187_M191_L0.7771.00
293_I297_L0.7771.00
47_V179_L0.7761.00
62_Q66_T0.7711.00
97_G187_M0.7711.00
34_G163_M0.7711.00
343_A347_V0.7661.00
133_T136_T0.7651.00
73_A129_S0.7651.00
129_S133_T0.7641.00
169_L172_V0.7631.00
32_T121_R0.7611.00
91_C94_F0.7511.00
164_A262_C0.7511.00
133_T137_L0.7501.00
91_C95_L0.7471.00
229_L379_L0.7451.00
259_L308_K0.7441.00
289_S292_I0.7431.00
358_P362_L0.7421.00
140_V152_I0.7421.00
89_G134_G0.7421.00
227_L231_S0.7411.00
186_I189_V0.7391.00
300_V374_L0.7381.00
245_Y307_A0.7381.00
267_T271_F0.7361.00
68_L71_P0.7351.00
59_I239_T0.7331.00
32_T186_I0.7331.00
86_V197_A0.7321.00
283_V286_I0.7291.00
372_I375_A0.7231.00
58_V114_L0.7211.00
130_F134_G0.7201.00
165_M168_P0.7201.00
327_V331_K0.7191.00
163_M261_S0.7181.00
28_A32_T0.7141.00
121_R124_L0.7141.00
23_V154_W0.7121.00
53_F56_G0.7121.00
236_V376_A0.7111.00
270_L274_G0.7101.00
368_G371_V0.7101.00
152_I330_V0.7091.00
359_L362_L0.7091.00
230_A321_V0.7071.00
100_Y103_A0.7071.00
140_V330_V0.7051.00
50_F55_A0.7051.00
172_V175_H0.7041.00
157_I269_L0.7031.00
388_W391_K0.7031.00
351_L355_V0.6991.00
25_F86_V0.6981.00
385_L388_W0.6971.00
33_I66_T0.6961.00
167_A258_T0.6951.00
222_L389_R0.6921.00
121_R132_G0.6911.00
388_W392_K0.6881.00
260_F311_V0.6881.00
162_A166_G0.6851.00
240_F361_G0.6841.00
53_F358_P0.6811.00
274_G283_V0.6811.00
225_M229_L0.6791.00
25_F197_A0.6791.00
57_L118_C0.6761.00
100_Y124_L0.6751.00
64_F67_L0.6751.00
138_W142_V0.6721.00
379_L383_A0.6701.00
221_W224_G0.6681.00
146_L150_R0.6681.00
243_L246_D0.6661.00
43_Y179_L0.6651.00
281_L391_K0.6651.00
306_M310_G0.6651.00
174_Y182_L0.6651.00
19_I151_V0.6641.00
90_L193_A0.6641.00
98_L184_L0.6641.00
256_A308_K0.6611.00
389_R392_K0.6591.00
259_L263_A0.6581.00
93_C128_Q0.6581.00
180_Q184_L0.6571.00
288_F321_V0.6561.00
95_L98_L0.6561.00
157_I265_V0.6551.00
26_N155_N0.6551.00
52_A247_A0.6521.00
27_F165_M0.6521.00
148_I330_V0.6511.00
94_F98_L0.6511.00
73_A76_Y0.6501.00
160_Y265_V0.6501.00
310_G313_L0.6491.00
67_L350_D0.6491.00
31_L186_I0.6491.00
35_L182_L0.6491.00
250_W304_P0.6461.00
382_I386_L0.6451.00
181_A188_G0.6451.00
212_P337_N0.6401.00
185_I188_G0.6401.00
200_R204_K0.6391.00
291_E317_G0.6381.00
171_V255_F0.6381.00
56_G361_G0.6371.00
308_K311_V0.6341.00
99_G103_A0.6341.00
297_L301_A0.6341.00
287_C324_A0.6321.00
171_V258_T0.6311.00
77_A85_I0.6311.00
17_L20_V0.6271.00
157_I160_Y0.6241.00
296_L299_G0.6231.00
192_V196_L0.6231.00
68_L72_H0.6221.00
198_I201_P0.6221.00
119_L122_V0.6221.00
255_F258_T0.6211.00
241_I311_V0.6201.00
60_S357_G0.6191.00
70_R343_A0.6181.00
239_T242_T0.6181.00
369_V372_I0.6171.00
215_A336_Q0.6141.00
225_M228_A0.6121.00
54_W58_V0.6121.00
224_G345_Y0.6121.00
136_T155_N0.6101.00
229_L383_A0.6091.00
86_V135_S0.6091.00
372_I376_A0.6091.00
354_G358_P0.6081.00
18_R21_S0.6081.00
312_L315_G0.6071.00
39_V182_L0.6071.00
158_V162_A0.6041.00
62_Q121_R0.6031.00
271_F274_G0.6031.00
149_G327_V0.5991.00
100_Y183_A0.5991.00
28_A189_V0.5971.00
66_T350_D0.5961.00
51_S365_S0.5951.00
63_Y357_G0.5941.00
213_F216_V0.5941.00
330_V338_Q0.5931.00
172_V255_F0.5931.00
102_T116_L0.5921.00
46_D49_G0.5921.00
32_T93_C0.5901.00
73_A133_T0.5901.00
376_A380_V0.5901.00
170_G182_L0.5891.00
383_A387_T0.5871.00
104_G115_L0.5861.00
364_M367_A0.5861.00
382_I385_L0.5861.00
227_L349_M0.5841.00
373_Y377_A0.5841.00
240_F243_L0.5841.00
355_V359_L0.5821.00
27_F158_V0.5801.00
384_L388_W0.5791.00
291_E294_G0.5781.00
21_S193_A0.5781.00
224_G228_A0.5741.00
233_G236_V0.5731.00
267_T319_S0.5711.00
364_M372_I0.5691.00
139_G151_V0.5691.00
54_W115_L0.5661.00
141_G203_V0.5641.00
274_G277_R0.5601.00
26_N30_Y0.5601.00
166_G170_G0.5591.00
338_Q342_L0.5571.00
192_V195_L0.5571.00
168_P171_V0.5561.00
285_M387_T0.5541.00
269_L272_P0.5541.00
194_I198_I0.5531.00
259_L312_L0.5511.00
240_F360_A0.5491.00
120_G123_I0.5461.00
371_V378_G0.5451.00
70_R347_V0.5441.00
299_G370_P0.5441.00
49_G52_A0.5431.00
326_G330_V0.5421.00
339_G343_A0.5421.00
368_G372_I0.5401.00
360_A372_I0.5401.00
157_I161_G0.5391.00
173_F176_W0.5381.00
212_P218_G0.5371.00
225_M386_L0.5341.00
364_M369_V0.5341.00
90_L197_A0.5331.00
178_G182_L0.5321.00
87_V90_L0.5311.00
281_L392_K0.5301.00
261_S265_V0.5301.00
387_T392_K0.5301.00
172_V177_G0.5291.00
156_G160_Y0.5281.00
70_R350_D0.5281.00
20_V23_V0.5281.00
189_V192_V0.5281.00
256_A259_L0.5261.00
171_V175_H0.5261.00
312_L316_A0.5251.00
25_F90_L0.5251.00
256_A260_F0.5251.00
228_A232_A0.5231.00
35_L170_G0.5221.00
190_A194_I0.5211.00
150_R153_S0.5211.00
285_M292_I0.5211.00
260_F264_F0.5211.00
256_A304_P0.5201.00
352_S355_V0.5191.00
211_L218_G0.5191.00
186_I190_A0.5181.00
219_R222_L0.5181.00
387_T391_K0.5171.00
250_W256_A0.5161.00
259_L262_C0.5141.00
222_L386_L0.5111.00
97_G121_R0.5111.00
245_Y256_A0.5101.00
246_D252_G0.5101.00
73_A85_I0.5091.00
137_L339_G0.5091.00
386_L389_R0.5061.00
284_A325_L0.5061.00
369_V373_Y0.5051.00
93_C131_A0.5031.00
41_P45_H0.5031.00
293_I296_L0.5021.00
57_L60_S0.5021.00
20_V24_M0.5011.00
380_V383_A0.5001.00
100_Y121_R0.5001.00
378_G385_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4j05A 3 0.9136 100 0.195 Contact Map
1pw4A 1 0.9654 100 0.198 Contact Map
4pypA 1 0.921 100 0.216 Contact Map
3wdoA 1 0.9556 100 0.239 Contact Map
4zw9A 1 0.9605 100 0.247 Contact Map
2cfqA 1 0.9679 100 0.258 Contact Map
3o7qA 1 0.9111 100 0.261 Contact Map
4ldsA 2 0.916 100 0.274 Contact Map
4gc0A 1 0.9531 100 0.277 Contact Map
4w6vA 1 0.9407 100 0.278 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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